Subject Name: MEDICINAL CHEMISTRY-III Time: 10:30AM TO 01:30PM Total Marks: 80 Instructions: 1. Attempt any five questions. 2. Make suitable assumptions wherever necessary. 3. Figures to the right indicate full marks.
Q.1 (a) What are antitubercular agents? Briefly explain antibiotics antitubercular 06 agents. (b) What is combinatorial chemistry? Discuss in detail about different methodologies 05 used for synthesis? (c) Explain in brief about synthetic as antifungal agents. Give the synthesis of 05 Miconazole. Q.2 (a) Give the SAR of Tetracyclines. 06 (b) Give the IUPAC name and synthesis of following drugs. 05 i. Chloramphenicol ii. Isoniazide (c) Explain Hansch Linear Free Energy Relationship model in drug design. 05 Q.3 (a) Classify cephalosporin and represent various rings and numbering system of 06 clinically available beta-lactam antibiotic types with examples. (b) Explain SAR activities of quinolines. 05 (c) Write a note on Computer Aided Drug Design? 05 Q.4 (a) Give any three structures of macrolide antibiotics and explain why erythromycin is 06 unstable in acid media. (b) Give the synthesis of – 1) Acyclovir 2) Dapsone 05 (c) Write a note on molecular modeling. 05 Q.5 (a) What are β-lactam antibiotics? Why penicillin is not active against penicillinase 06 secreting microbes? Give some examples of penicillinase resistant penicillins. (b) Write a note on basic concepts and application of prodrugs design. 05 (c) What is malaria? How it spreads? Classify antimalarial drugs with examples. 05 Q. 6 (a) What are antiviral drugs? Explain mechanism, therapeutics uses and structures 06 of Loviride, Saquinavir and Idoxuridine. (b) Write chemical name and synthesis of sulfamethoxazole and Tolnafate. 05 (c) Give the IUPAC name, synthesis and mechanism of Mebendazole an anthelmintic 05 agent. Q.7 (a) Explain: Biguanides and dihydro triazines. 06 (b) What are Aminoglycosides? Discuss their SAR with examples. 05 (c) Draw the structures of 05 1. Mefloquine 2. Capreomycin sulphate 3. Ritonavir 4. Methanamine 5. Ivermectin
