Here are 10 practicals for pharmaceutical technology that can be easily performed, focusing on
key aspects of drug formulation, testing, and evaluation:
1. Preparation and Evaluation of Granules for Tablet Formation
Objective: To prepare granules using different methods (wet granulation, dry
granulation) and evaluate their properties such as flowability, particle size, and moisture
content.
Techniques: Granulation, sieving, moisture content determination.
2. Determination of pH Solubility Profile of an Acidic Drug
Objective: To study how the solubility of an acidic drug changes across a range of pH
values.
Techniques: pH adjustment, solubility measurement, and data analysis.
3. Evaluation of Powder Flow Properties Using Hausner's Ratio and Carr’s
Compressibility Index
Objective: To evaluate the flowability of pharmaceutical powders using Hausner's ratio
and Carr’s index.
Techniques: Powder density measurement, calculation of Hausner’s ratio and Carr’s
index.
4. Preparation of Suspension and Evaluation of Its Stability
Objective: To prepare a pharmaceutical suspension and evaluate its physical stability,
including sedimentation rate and redispersibility.
Techniques: Suspension preparation, visual observation, sedimentation rate
measurement.
5. Preparation and Evaluation of Suppositories
Objective: To prepare suppositories using the fusion method and evaluate their
characteristics such as weight uniformity, melting point, and release profile.
Techniques: Fusion method, melting point determination, drug release testing.
6. Measurement of Dissolution Rate of a Tablet
Objective: To perform dissolution testing to determine the rate of release of a drug from
a tablet.
Techniques: Dissolution testing using USP apparatus, sample analysis using UV
spectroscopy.
7. Determination of Partition Coefficient Using Shake Flask Method
Objective: To determine the partition coefficient of a drug between water and octanol.
Techniques: Shake-flask method, UV spectrophotometric analysis.
8. Stability Testing of a Drug Formulation Under Different Temperature
Conditions
Objective: To assess the stability of a drug formulation by storing it under various
temperature conditions and measuring any changes in physical and chemical properties.
Techniques: Temperature-controlled storage, physical and chemical analysis (e.g., visual
appearance, assay).
9. Determination of Moisture Content of Pharmaceutical Powders Using the Loss
on Drying Method
Objective: To determine the moisture content of pharmaceutical powders using the loss
on drying method.
Techniques: Moisture content determination using an oven, drying samples to constant
weight.
10. Evaluation of Tablet Hardness and Friability
Objective: To measure the hardness and friability of tablets to assess their mechanical
strength.
Techniques: Tablet hardness tester, friability tester, weight loss measurement
Based on the provided syllabus and practical guidelines, I’ve designed 10 practicals that align
with the theoretical components and cover various aspects of pharmaceutical formulation, drug
delivery systems, and advanced granulation technologies.
1. Preformulation Study of a Drug: Solubility and pH Profile
Objective: To conduct preformulation studies on a drug, focusing on its solubility in
various pH solutions.
Theory Covered: Preformulation studies, need for dosage forms, drug solubility.
Techniques: pH solubility profile, solubility testing, UV spectrophotometric analysis.
2. Preparation of Granules Using Spray Drying Technology
Objective: To prepare granules using spray drying technology and evaluate their flow
properties.
Theory Covered: Advanced granulation technologies, spray drying.
Techniques: Spray drying, particle size analysis, moisture content determination, and
flow property testing (Hausner's ratio, Carr’s index).
3. Roller Compaction for Granulation and Evaluation
Objective: To prepare granules using roller compaction and assess their physical
properties such as density, flowability, and compressibility.
Theory Covered: Roller compaction technology, granulation techniques.
Techniques: Roller compaction, bulk density, tapped density, Carr’s compressibility
index, powder flow properties.
4. Extrusion/Spheronization for Granulation
Objective: To perform extrusion and spheronization to produce spherical granules and
evaluate their physical properties.
Theory Covered: Extrusion/spheronization as granulation technology.
Techniques: Extrusion, spheronization, particle size analysis, evaluation of granule
uniformity.
5. Microencapsulation by Solvent Evaporation Technique
Objective: To prepare microencapsulated drug particles using the solvent evaporation
technique and evaluate their release characteristics.
Theory Covered: Microencapsulation, solvent evaporation, controlled release drug
delivery systems.
Techniques: Solvent evaporation method, particle size distribution, release rate studies.
6. Development of a Sustained Release Matrix System
Objective: To develop a sustained-release drug formulation using a matrix system and
evaluate its release profile.
Theory Covered: Sustained/controlled release drug delivery systems, matrix systems.
Techniques: Preparation of matrix tablets, dissolution testing, release rate determination.
7. Development of a Reservoir Drug Delivery System
Objective: To prepare a reservoir system for controlled drug release and evaluate its
performance.
Theory Covered: Reservoir drug delivery systems, novel drug delivery systems.
Techniques: Preparation of reservoir systems, dissolution studies, release kinetics
analysis.
8. Particle Coating by Centrifugation Granulation
Objective: To prepare coated granules using the centrifugation granulation technique and
evaluate the uniformity of coating and drug release.
Theory Covered: Particle coating, granulation techniques.
Techniques: Centrifugation granulation, coating uniformity evaluation, dissolution
testing.
9. Quality Control Testing of Tablets: Hardness, Friability, and Disintegration
Objective: To perform in-vitro quality control tests on tablet dosage forms including
hardness, friability, and disintegration time.
Theory Covered: In-vitro quality control, tablets.
Techniques: Tablet hardness tester, friability tester, disintegration test.
10. Bioavailability and Release Profile Evaluation of Microencapsulated Drug
Objective: To evaluate the bioavailability and release profile of a microencapsulated
drug formulation.
Theory Covered: Bioavailability, drug release profiles, microencapsulation techniques.
Techniques: In-vitro release testing, comparison with conventional formulations,
statistical analysis.
Here are 12 practical titles related to pharmaceutical technology, focusing on formulation,
granulation technology, drug delivery systems, and quality control of dosage forms:
1. Preformulation Study of a Drug: Solubility and pH Profile
Objective: To study the solubility of a drug in various pH solutions and its implications
on formulation.
2. Granulation Techniques: Wet Granulation vs. Dry Granulation
Objective: To compare and evaluate the effectiveness of wet and dry granulation methods
in tablet formulation.
3. Particle Size and Flowability: Determination of Bulk Density and Hausner’s Ratio
Objective: To assess the flow properties of powders using various methods, including
bulk density and Hausner’s ratio.
4. Tablet Compression: Evaluation of Tablet Hardness and Friability
Objective: To prepare and evaluate tablets for their hardness, friability, and disintegration
time.
5. Development of Sustained Release Formulation: Matrix Systems
Objective: To prepare and evaluate sustained-release tablets using a matrix drug delivery
system.
6. Microencapsulation of a Drug: Solvent Evaporation Technique
Objective: To perform microencapsulation using the solvent evaporation technique and
evaluate its drug release profile.
7. Dissolution Testing: In-vitro Release of Tablets in Different Media
Objective: To evaluate the dissolution characteristics of a tablet in various dissolution
media.
8. Quality Control of Syrups: Viscosity and pH Measurement
Objective: To determine the viscosity and pH of syrup formulations for quality control.
9. Examination of Drug Stability: Accelerated Stability Testing of Tablets
Objective: To perform accelerated stability testing on tablet formulations under different
temperature and humidity conditions.
10. Polymer Selection for Drug Delivery: Study of Release Profile in Hydrogel-based
Formulations
Objective: To formulate a hydrogel-based drug delivery system and study its release
kinetics.
11. Spray Drying Technology: Preparation of Granules for Fast Dissolving Tablets
Objective: To prepare granules using spray drying and evaluate their properties for fast-
dissolving tablets.
12. In-vitro Evaluation of Capsules: Disintegration and Dissolution Studies
Objective: To evaluate the disintegration time and dissolution profile of capsule
formulations
