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clean ingredients that

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We bring together the best of nature, science & technology,
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compliant
 Award winning ingredient
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World's first Curcuma longa

ingredient with a complete
clinical package at 250mg
one-a-day dose.
-3 human pharmacokinetic trials confirming in-study
bio-equivalence of 250mg TurmXTRA™ 60N with 1575mg
Turmeric Extract (95% curcuminoids)

-2 clinical trials in healthy human subjects have proven the

efficacy of TurmXTRA™ 60N in improving joint comfort and
providing with muscle relief

-1 clinical trial in subjects with osteoarthritis has established

clinical efficacy of TurmXTRA™ 60N in improving joint mobility
and comfort while reducing anti-inflammatory markers

Higher consumer compliance All-natural

A low dose once a day provides higher No use of synthetic excipients and
consumer compliance. surfactants.

Application ease Application versatility

TurmXTRA™ 60N's ~ 250mg once daily Water dispersibility offers versatility
dose provides efficacy and in applications such as powdered
unprecedented flexibility in combining beverages, stick packs, capsules,
turmeric with complementary ingredients tablets, gummies & chews, shots
to enhance your formulation. & RTDs

A complete clinical package

3 PK
STUDIES 3 CLINICAL STUDIES
(J O I N T, D O M S, OA) 1 M E TA - A N A LY S I S A N D
SY S T E M AT I C R E V I E W

Any of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose,
treat cure, or prevent any disease.
TurmXTRA™ mark is a registered trademark of Nutriventia Limited.
 A complete clinical package
3 P H A R M AC O K I N E T I C S T U DY

S T U DY 1 A N D S T U DY 2 –

One 250 mg dose of TurmXTRA™60N is clinically substantiated to show equivalence

to three 500 mg doses of standard 95% turmeric extract. Our 2 separate Human PK
studies drew the same set of results which guaranteed consistent quality of
TurmXTRA™60N.

Pharmacokinetic study 1 Pharmacokinetic study 2

90 60
TurmXTRA™60N TurmXTRA™60N
80

Mean plasma concentration of total

Mean plasma concentration of total

50
Std 95%TE Std 95%TE
70

curcuminoids (ng/mL)
curcuminoids (ng/mL)

60 40

50
30
40

30 20

20
10
10

0 0
0 4 8 12 16 20 24 0 4 8 12 16 20 24
Time (h) Time (h)

Source: Thanawala S, Shah R, Alluri KV, Somepalli V, Vaze S, Upadhyay V. Comparative bioavailability of curcuminoids
from a water-dispersible high curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over,
comparative, pharmacokinetic study. J Pharm Pharmacol. 2021 Apr 27;73(6):816-823. doi: 10.1093/jpp/rgab028.
PMID: 33755149.

S T U DY 3 -

One 250 mg dose of TurmXTRA™60N is clinically substantiated to show comparable

kinetics to three 500 mg doses of a branded turmeric extract plus piperine taken at
three different time intervals.

Pharmacokinetic study 3

70 TurmXTRA™60N
Mean plasma concentration of total

60 Branded TE+
5mg piperine
curcuminoids (ng/mL)

50

40

30

20

10

0
0 5 6 10 12 15 20

Source: Thanawala S, Shah R, Doyle L, Upadhyay V. Comparative pharmacokinetics of curcuminoids from water
dispersible turmeric extract against a curcuminoids-piperine combination : An open label, randomized, balanced,
2-Treatment, 2-Sequence, 2-Period Crossover Study. Alt Ther. 2024 Apr; 30 (4) : 18-23

Any of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose,
treat cure, or prevent any disease.
TurmXTRA™ mark is a registered trademark of Nutriventia Limited.
S T U DY 4 - J O I N T H E A LT H S T U DY

Our randomized, double-blind placebo-controlled Joint comfort Mobility

study on 96 healthy volunteers showed the 19% improvement
2x improvement
efficacy of TurmXTRA™60N on joint health with
significant results.

More comfort More agility More agility

~3x improvement ~2x improvement ~1.5x improvement

Time (s)

Time (s)
VAS

Change in pain (VAS) after Change in time in Change in time in

80-meter fast-paced walk 80-meter fast-paced walk 9-stair climb

Journal of Pharmacy and Pharmacology, Oxford University Press

Source: Thanawala S, Shah R, Alluri KV, Somepalli V, Vaze S, Upadhyay V. Comparative bioavailability of curcuminoids from a water-dispersible
high curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over, comparative, pharmacokinetic study. J Pharm TurmXTRA™60N Placebo
Pharmacol. 2021 Apr 27;73(6):816-823. doi: 10.1093/jpp/rgab028. PMID: 33755149.

S T U DY 5 - D E L AY E D O N S E T M U S C L E S O R E N E S S (D O M S) S T U DY

Our randomized, double-blind, placebo-controlled trial on 30 healthy and

recreationally active subjects showed the efficacy of TurmXTRA™60N in reducing
muscle soreness and increasing psychological well-being.

Higher levels of recovery Faster recovery Better Recovery

96 hrs post-workout In H&M - Fatigue Scale 72 hrs post-workout
1.5x improvement 4 times faster ~9x improvement
Percentage Recovery

Time (hr)

VAS

Change in Muscle Soreness Change in Recovery Time Change in LDH levels

Recovery as compared to placebo compared to placebo compared to placebo

Source: Thanawala S, Shah R, Karlapudi V, Desomayanandam P, Bhuvanendran A. Efficacy and Safety of TurmXTRA® 60N in Delayed Onset Muscle
Soreness in Healthy, Recreationally Active Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial. Evid Based Complement Alternat TurmXTRA™60N Placebo
Med. 2022 Aug 5;2022:9110414. doi: 10.1155/2022/9110414. PMID: 35966736; PMCID: PMC9374544.

Any of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose,
treat cure, or prevent any disease.
TurmXTRA™ mark is a registered trademark of Nutriventia Limited
S T U DY 6 - O S T E OA R T H R I T I S S T U DY

Our randomized, double-blind, placebo controlled, parallel group 90-day study on 139
subjects with mild to moderate knee osteoarthritis proved the efficacy and safety of
TurmXTRA™60N in significantly reducing pain and improving comfort & knee function.
Manuscript under publication

Visual analog scale (100 mm) Knee Injury and Osteoarthritis Outcome score
Better Comfort (VAS) Reduced Pain (KOOS) Better Knee Function
2.4 times improvement Nearly 4x times improvement 2.3 times improvement

Ease in knee mobility

KOOS – Pain score
VAS – Pain score

Change in pain (VAS) as Change in pain (KOOS) Change in knee related quality of
compared to placebo as compared to placebo life as compared to placebo

TurmXTRA™60N Placebo

H E A LT H B E N E F I T S

Joint Brain Skin

health health health

Immune Liver
health health

L I C E N S E S & C E R T I F I C AT I O N S

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 TM
Learn more >

Also known as ashwanova™

Root-only, USP compliant,

1-a-day ashwagandha
ProlanzaTM is a unique long-acting ingredient
of ashwagandha root extract which complies
to 10 USP Withanolides. It’s innovative release
pattern ensures extended clinical benefits.

Multiple randomized, double-blind, placebo controlled clinical

trials validating one-a-day dose for managing stress.

USP compliant

Validated with a full clinical package for prolonged

release and one a day dose.

3
A comprehensive clinical package
Mean plasma concentration of total

2.5
withanolidies (ng/mL)

P H A R M A C O K I N E T I C S T U DY *
2
Compared to a leading branded Ashwagandha ingredient,
ProlanzaTM showed -
1.5

Superior Relative Bioavailability 1

ProlanzaTM has a bioavailability which is nearly
12 times higher as compared to the reference product. 0.5

Extended Availability 0
Withanolides from ProlanzaTM are available in plasma for upto 0 2 4 6 8 10 12 14 16 18 20 22 24

24 hours Time (hrs.) Reference

S T U DY 2 – A S T R E S S & C O G N I T I V E H E A LT H S T U DY
A randomized, double-blind, placebo-controlled 3 month study on 100
healthy subjects with mild to moderate stress demonstrated the efficacy of
ProlanzaTM with statistically significant results as compared to placebo.

**

* S T U DY 3 – M U LT I A R M - S T R E S S S T U DY
Randomized, double-blind, placebo-controlled, 60 days, multi arm study on
126 mild to moderate stressed.

Improvement in subjects taking ProlanzaTM as compared

to Placebo after 60 days

*Manuscript under publication

 Mimics 8-hour natural
sleep pattern
Learn more >

Timed release,
melatonin
Melotime™ is a patent-pending and
proprietary extended-release melatonin
ingredient that helps mimic the body’s
natural sleep pattern and supports
quality sleep. The unique release profile
of Melotime™ ensures a release of a
significant portion in the first hour followed
by continuous release of melatonin upto
6 hours for maintenance. This ensures a
quick on-set and maintains good quality
of sleep.

MARKET INSIGHTS

Melatonin will capture 58% ($820M) of the

health sleep market, driven by 65% of
consumers seeking supplements for sleep
management, a prevalent driver of sales.
Source - NBJ

Supports natural sleep pattern 8-hour sustained sleep

The unique release profile provides a Sustained release profile helps to get
quick onset and good quality 8 hours of sleep without side effects
restorative sleep.

PR AC T I CA L A PPL I CAT I O N S

Gummies
Tablets Melotime showed upto 50% release in
& chews
1st hour, with periodic release in a
6-hour interval for uninterrupted sleep
Stick packs
Capsules
(powder)

Any of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose,
treat, cure or prevent any disease.
Melotime ™ is a trademark of Nutriventia Limited.
S U S TA I N E D RE L E A S E PRO FI L E

Releases upto 50% in the first hour

Subsequent release per hour in smaller bursts

PH A R M AC O K I N E T I C S T U DY

Extended action through sustained release profile of Melotime™

Extended half-life (T1/2) –

5.1 h for Melotime vs 1.01 h for Melatonin IR

18000
Mean plasma concentration of

16000
14000
melatonin (pg/mL)

12000 Faster
elimination
10000
8000
6000
4000 Disturbed sleep
Slower Sound sleep
2000 elimination

0
0 1 2 3 4 5 6 7 8
Time (h)
Melotime Melatonin IR

H E A LT H B E N E F I T S

Sleep Antioxidant Weight

regulation support management

Cognitive Immune
health health

L I C E N S E S & C E R T I F I C AT I O N S

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nutriventia.com | info@nutriventia.com
Distributed in the USA by Aviva Natural Supplements
Distributed in Europe by Vivatis Pharma GmbH
 12 hour Boost for
focus & alertness
Learn more >

Long-acting caffeine
Caffeine stimulates the nervous system leading
to improved alertness, exemplified motor
coordination, and recharged focus. The most
significant issue with caffeine is that its effects
start to diminish after a couple of hours due
to quick absorption of caffeine within the body.
High and/or multiple doses leads to caffeine
tolerance which could lead to jitteriness,
headache, and nervousness collectively
known as ‘caffeine crash’. CaffXtend™ is a
unique patent product that delivers natural
caffeine for 12 hours, from a natural matrix using
our proprietary modified-release technology.

MARKET INSIGHTS

79% of active consumers consume energy

supplements to improve energy & stamina and
63% of these consumers prefer natural source
of caffeine in their sports nutrition products.
Source - NBJ

Long-acting, once a day dose All-natural

A single dose designed for an enhanced Source of natural caffeine is from
caffeine experience, lasting up to 12 coffee seeds. This caffeine is
hours, offers all-day alertness and focus embedded in a natural release
controlling matrix

H E A LT H B E N E F I T S

Improved Sports nutrition

focus & gaming
CaffXtend™ provides 400% lesser
perception of fatigue in comparison to
regular natural caffeine
P R AC T I C A L A P P L I C AT I O N S

Stick packs Hard

(powder) capsules

Any of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose,
treat, cure, or prevent any disease.
CaffXtend™ mark is a registered trademark of Nutriventia Limited.
 S U S TA I N E D R E L E A S E P R O F I L E
Clinically substantiated to reduce perception
of ‘tiredness’ for an extended duration (12
hours) from a single dose

CaffXtend™'s sustained release of Caffeine

gives 12 hours of enhanced energy* and focus

*The claims of energy are more in terms of the general meaning

of the word rather than energy as referred to as ATP production

P H A R M AC O K I N E T I C S T U DY
1. Extended action through sustained 3. Significantly lower scores
release profile of CaffXtend™ for ‘tired’ and ‘jittery’
Extended Tmax – 391.57% Lesser perception of tiredness and jitters
(to reach maximum concentration)
4. Lower scores for parameters
Extended half-life T½ – 22.32% longer
indicative of ‘caffeine crash’
2. Extended efficacy through sustained No caffeine crash, hence safer
release profile of CaffXtend™ from a
Caff-VAS (Caffeine Research Visual 5. CaffXtend™ is beneficial with better
Analog Scales)** significantly higher efficacy, as compared to repeated
scores for ‘overall mood’, ‘relaxed’ caffeine dosing
and ‘alert’
Substantiated from data of human clinical trial
Better mood & more alertness compared with equal dose of natural caffeine

#Source: Shefali Thanawala, Rajat Shah, R. Abiraamasundari, R. Senthurselvi & Prabakaran

Desomayanandam (2023): Comparative Bioavailability and Benefits on Mental Functions of
Novel Extended-Release Caffeine Capsules against Immediate-Release Caffeine Capsules:
An Open-Label, Randomized, Cross-over, Single-Dose Two-Way Crossover Study, Journal
of Dietary Supplements, DOI: 10.1080/19390211.2022.2160529
5000
Sh
arp
4500 de
Mean concentration (pg/ml)

clin
spike

e
4000 Gradual
decline
diate

3500
3000
Imme

e e
as iv

2500
re ess

2000
inc ogr
Pr

1500
1000
500
0
0 2 4 6 8 10 12
Time (hrs.) Caffeine IR

L I C E N S E S & C E R T I F I C AT I O N S

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 Shields you for 24 hour
Vitamin C protection
Learn more >

24-hour optimised Vitamin C

direct compressible granules
C-Fence™ is a direct compressible granular
system of Vitamin C which is an ideal solution
for manufacturers targeting convenient and
continuous 24-hour antioxidant shield. Powered
using our modified release technology, small
bursts of Vitamin C are consistently released
periodically, providing 24 hr antioxidant support.
Unlike other sustained release products that are
time-consuming to develop and manufacture,
C-Fence™ just needs a single-step operation to
compress granules into tablets.

MARKET INSIGHTS

60% of consumers incorporate Vitamin C into

their daily routine to bolster their immune system.
Source - NBJ

Long-acting, once a day dose Assured consistency

A single dose provides 24-hour protection Each batch of C-Fence™ undergoes
making it convenient for end consumers. pre-quality evaluation by testing
tablets from a representative sample.

Saftey with low dose Natural flow

C-Fence™ averts gastric distension by Vitamin C is inherently hygroscopic,
gradually releasing controlled Vitamin C and poor flow properties. However,
bursts. C-Fence™ crafted using nature-derived
excipients and patented proprietary
process, offers seamless flow, enhancing
manufacturing convenience.

H E A LT H B E N E F I T S
C-fence™ has shown 12-hr sustained
release Vitamin C in-vitro.
Tablets

Any of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose,
treat, cure, or prevent any disease.
C-Fence™ mark is a registered trademark of Nutriventia Limited.
IN VITRO DISSOLUTION

Single dose provides a consistent

release for maximum time
Polymer matrix
Works by diffusion mechanism from
the matrix
Release in small bursts

PHARMOKINETIC

Clinically substantiated through a randomized double-blind, parallel arm, placebo-controlled clinical

trial to evaluate the pharmacokinetic profile of Vitamin C from an extended action tablet from
C-Fence™. Clinical trial shows that the 12-hour release profile correspondingly produces a sustained
level of Vitamin C in the active state in plasma providing a 24-hour in-vivo coverage.

1200 85x
Extended
Avg. concentration of Vit. C (ng/ml)

Tmax
1000

800
Cmax compared
85x 600
to baseline 0hrs
400 20x

C24 compared 200

20x
to baseline 0hrs
0
X 0 2 4 6 8 10 12 14 16 18 20 22 24
Journal of Pharmacology and
Pharmacotherapeutics, Sage Journals Time (hrs.) Placebo

H E A LT H B E N E F I T S

Brain Skin
Antioxidant
health health

Immune Cardiovascular
health health

L I C E N S E S & C E R T I F I C AT I O N S

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for more information
45 39