Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions

Sheet Title
1 Info
2 S1.1. Cell_lines
3 S1.2 Organoids
4 S1.3 GEMMs
5 S1.4 PDXs

Abreviations
PDX Patient-Derived Xenograft
PDO Patient-Derived Organoid
GEMMs Genetically Engineered Mouse Models
Xenograft Human-derived cells, tissues that are transplanted into a recipient of another species (mice, rats, z
Organoid line Organoid made from xenograft or tumor which has been established as a cell line
CTC Circulating Tumor Cell
BCI Bergonie Cancer Institute
CAL Centre Antoine Lacassagne
HBCx Human Breast Cancer
BCM Baylor College of Medicine
HCI Huntsman Cancer Institute
UCD University of Colorado
UACC University of Arizona Cancer Center
JAX The Jackson Laboratory
WHIM Washington Human in Mouse
MC Mike Clarke
MSKCC Memorial Sloan Kettering Cancer Center
WCRC Women’s Cancer Research Center
UM University of Michigan
MAN University of Manchester
CaMa Cancer Mammary (Mammae)
ATCC American Type Culture Collection
DSMZ German Collection of Microorganisms and Cell Cultures GmbH
UMCU Universitair Medisch Centrum Utrecht
UDL UMCU Derksen Lab
EPFL École polytechnique fédérale de Lausanne
MIND Mouse Intraductal
fs frame shift
EC ExtraCellular Domain
* Termination, STOP codon
n/a not available
p. Protein
c. Coding DNA
s and Strategic Directions

Contents
Summary information including key abbreviations
Characterisitics of ILC cell lines
Patient-derived ILC Organoid Lines
Genetically Engineered ILC Mouse Models
Patient-derived ILC xenografts

Abreviations

re transplanted into a recipient of another species (mice, rats, zebrafish et.c.)

umor which has been established as a cell line

ms and Cell Cultures GmbH

Cell Name Tissue Tumor (Classification)
ILC
SUM-44 PE Pleural effusion ILC
IPH-926 Malign/ant ascites ILC
MDA-MB-134 VI Pleural effusion NST
MDA-MB-330 Pleural effusion ILC
UACC-3133 Pleural effusion ILC
MA-11 Bone marrow mets ILC & tubular
EFM-63 Ovarian metastasis ILC
HCC-2185 Pleural effusion ILC
ILC-like
BCK4 Pleural effusion Mucinous
MDA-MB-157 Pleural effusion Medullary
MDA-MB-436 Pleural effusion NST
MDA-MB-453 Pericardial fluid n/a
MDA-MB-468 Pleural effusion n/a
CAMA-1 Pleural effusion Solid with scirrhous regions
SUM-159PT n/a Anaplastic/sarcoma
CAL-120 n/a n/a
SK-BR-3 Pleural effusion n/a
SK-BR-5 n/a n/a
AU565 Pleural effusion n/a
EVSA-T Ascitic fluid n/a
CAL-148 Pleural effusion n/a
HS578T n/a NST
ZR-75-30 Ascitic fluid NST
HCC2218 Primary NST
MPE600 Pleural effusion NST
BT549 Primary Papillary
OCUB-1F Pleural effusion n/a
OCUB-1M Pleural effusion n/a
HCC-1187 n/a NST
PDX derived cell lines
UCD178 Pleural effusion ILC
Unpublished
WCRC-25 Pleural effusion ILC (ER+)
Mouse origin
KEP1 n/a n/a
KEP2 n/a n/a
KEP3 n/a n/a
KEP6 n/a n/a
WEP2 n/a n/a
WEP3 n/a n/a
WEP7 n/a n/a
FM3A Ascites mammary carcinoma
CTC lines
CTC-ITB-01 Peripheral Blood (CTCs) mixed
BRx-07 Peripheral Blood (CTCs) ILC
Endocrine Resistant
SUM-44 PE (Tam. Res.) Pleural effusion ILC
SUM-44 PE (LTED) Pleural effusion ILC
MDA-MB-134 VI (LTED) Pleural effusion ILC
sh CDH1 lines
MDA-MB-468 Pleural effusion n/a
T47D Pleural effusion NST
MCF7 Pleural effusion NST
CRISP-R lines
MCF7 (A02, B04, B05) Pleural effusion ILC-like
MCF10A Normal breast tissue ILC-like
MCF7 (450D08, 450F09, 450G06) Pleural effusion ILC-like
T47D Pleural effusion ILC-like
Type Age at sampling Morphology Biomarkers

ILC n/a Rounded ER+, PR- (+), HER2-

ILC 72 Rounded ER-, PR-, HER2-
ILC 47 Rounded ER+, PR-, HER2-
ILC 43 Rounded ER+/-, PR-, HER2+
ILC 52 n/a ERlow, PR-, HER2+
ILC n/a Rounded ER-, PR-, HER2-
ILC 67 n/a n/a
ILC 49 n/a ER-, PR-, HER2-

ILC 65 Rounded ER+, PR+, HER2-

ILC-like n/a Spindle ER-, PR-, HER2-
ILC-like 43 Neuron-type cells ER-, PR-, HER2-
ILC-like 48 Rounded ER-, PR-, HER2+
ILC-like 51 Rounded ER-, PR-, HER2-
ILC-like 28 Rounded ER+, PR+, HER2-
ILC-like 71 n/a ER-, PR-, HER2-
ILC-like 43 Rounded ER-, PR-, HER2-
ILC-like 43 Rounded ER-, PR-, HER2+
ILC-like - n/a ER-, PR-, HER2+
ILC-like - n/a n/a
ILC-like 58 Rounded ER-, PR-
ILC-like 58 n/a ER-, PR-, HER2-
ILC-like 74 n/a ER-, PR-, HER2-
ILC-like 47 Rounded ER+, PR-, HER2+
ILC-like 38 Rounded ER-, PR-, HER2+
ILC-like 44 Rounded n/a
ILC-like 72 Rounded ER-, PR-, HER2-
ILC-like 53 Rounded ER-, PR-
ILC-like 53 n/a n/a
ILC-like n/a n/a n/a

ILC n/a n/a

ILC n/a Rounded ER-, PR-, HER2-

n/a n/a n/a n/a

n/a n/a n/a n/a
n/a n/a n/a n/a
n/a n/a n/a n/a
n/a n/a n/a n/a
n/a n/a n/a n/a
n/a n/a n/a n/a
n/a n/a Rounded n/a

ILC-like 77 Mixed epithelial–mesenchyER+, PR+, HER2-

ILC n/a n/a n/a

ILC n/a n/a ER+, PR- (+), HER2-

ILC n/a n/a ER+, PR- (+), HER2-
ILC 47 n/a n/a

ILC-like 51 Rounded -
ILC-like (experimental) 54 Rounded ER+, PR+, HER2-
ILC-like (experimental) 69 Rounded ER+, PR+, HER2-

ILC-like (experimental) 69 n/a n/a

ILC-like (experimental) 36 n/a n/a
ILC-like (experimental) 69 n/a n/a
ILC-like (experimental) 54 n/a n/a
E-cadherin CDH1 CDH1 (exon deletion)

p.F423LfsX8 c.1269delT n/a

p.V82fsX93 c.240_241insGGTG n/a
p.L230EfsX4 r.688_832del145 exon 6
wt wt n/a
n/a n/a n/a
wt wt n/a
n/a n/a n/a
n/a n/a n/a

n/a Promoter Methylation n/a

n/a Promoter Methylation n/a
n/a Promoter Methylation n/a
p.Trp638Ter (p.W638X) c.1913G>A n/a
wt wt n/a
p.Y523_G571del c.1712-1G>A n/a
n/a Promoter Methylation n/a
n/a Promoter Methylation n/a
n/a c.1_1936del1936 exons 2 through 12
p.I178TfsX32 c.532-1G>C n/a
n/a - n/a
p.V216_T229del c.687+1_687+2delGT n/a
p.D402N, deep deletion n/a
n/a Promoter Methylation n/a
p.Glu243Ter - p.E243X c.727G>T n/a
n/a c.1-832del n/a
p.Y380_K440del c.1138-21_1138del22 exon 9
n/a Promoter Methylation n/a
p.Val17fs*1 c.49_163del115 exon 2
n/a n/a n/a
n/a n/a n/a

n/a n/a n/a

p.Q706* 2240C>T n/a

n/a null n/a

n/a null n/a
n/a null n/a
n/a null n/a
n/a null n/a
n/a null n/a
n/a null n/a
n/a n/a n/a

p.D402N c.1204G>A n/a

n/a n/a n/a

n/a n/a n/a

n/a n/a n/a
n/a n/a n/a

- - -
- - -
- - -

frameshift mutations n/a n/a

n/a n/a n/a
n/a n/a n/a
n/a n/a n/a
PIK3CA p53 (TP53) PTEN

n/a p.E28fsX16 (82_84delinsCA) n/a

n/a p.E285K (c.853G>A) c.950_953delTACT
WT p.E285K (c.853G>A) (homo) WT
WT c.659C>T (homo) WT
n/a n/a n/a
n/a n/a n/a
n/a n/a n/a
n/a n/a n/a

n/a n/a n/a

WT c.261_286del26 (homo) WT
WT p.E204fs*7 WT
H1047R (c.3140A>G)_hetero c.991_1182del192 (homo) p.Glu307Lys (c.919G>A) (hetero)
WT p.R273H (c.818G>A) (homo) c.253+1G>T (homo)
WT c.839G>C (homo) p.Asp92His (c.274G>C) (hetero)
p.H1047L (c.3140A>T) p.V157_R158insL (c.472_473ins3) -
n/a c.672+2T>G -
WT p.R175H (c.524G>A) (homo) WT
c.3140A>G (hetero) p.A161D (c.482C>A) (homo) WT
n/a p.R175H -
WT c.722C>G (homo) c.951delACTT (homo)
p.H1047R, p.D350N WT p.Q298*
WT c.469G>T (homo) WT
WT WT WT
n/a p.R283C (c.847C>T) -
n/a WT -
n/a p.R249S (c.747G>T) p.Val275fs*1 (c.821delG)
n/a - -
n/a - -
n/a - -

n/a n/a n/a

wt R213Q wt

wt null wt
wt null n/a
wt null n/a
wt null n/a
wt null wt
wt null wt
wt null n/a
n/a n/a n/a

n/a n/a n/a

n/a n/a n/a

n/a n/a n/a

n/a n/a n/a
n/a n/a n/a

- - -
- - -
- - -

n/a n/a n/a

n/a n/a n/a
n/a n/a n/a
n/a n/a n/a
Mutations in other genes Xenograft Doubling time (hs)

ESR1Y537S and ESR1Y537C MIND 85

n/a MIND ~200
n/a MIND 368
CTNNA1 no tumorigenic in vivo 40.8
n/a n/a n/a
n/a n/a n/a
n/a n/a n/a
n/a no tumorigenic in vivo 164

n/a Fat pad (matrigel) ~120

CTNNA1 no 67
n/a - 89
n/a MIND ~38-60
CTNNA1 - ~30-80
n/a MIND (unpublished) 114
HRAS - n/a
n/a - 50-60
n/a - ~2-3 days
n/a - n/a
SMAD4, CBLC - n/a
n/a - 50
CDKN2A, MAP2K1 - 40
n/a - n/a
n/a - 110-324
MET, RPS6KA4, KMT2A - 120
n/a - 86
n/a - n/a
n/a - n/a
n/a - n/a
CTNNA1 - n/a

n/a n/a 54

n/a

n/a yes 24
n/a n/a 24
n/a n/a 24
n/a n/a 24
n/a yes 24
n/a yes 24
n/a n/a 24
n/a n/a n/a

n/a MIND n/a

n/a prkdc-/-, il2rga-/- n/a

n/a n/a n/a

n/a n/a n/a
n/a n/a n/a

- n/a n/a
- n/a n/a
- MIND n/a

n/a n/a n/a

n/a n/a n/a
n/a n/a n/a
n/a n/a n/a
Notes Key Reference

- PMID: 8425198
- PMID: 19191266
- PMID: 10709100
α-catenin PMID: 730202
- DOI: 10.1007/978-1-4757-0019-0_7
- PMID: 8938153
- PMID: 6405069
- PMID: 9833771

Mucinous features PMID: 23247610

α-catenin PMID: 4471183
Basal B/claudin-low PMID: 8425198
- PMID: 9671407
α-catenin PMID: 327080
- PMID: 730202
Claudin-low tumor subtype PMID: 730202
- PMID: 833871
Low take rate PMID: 327080
- PMID: 20164919
Derived for the same patient as SK-BR-3 cells PMID: 17157791
- PMID: 6582512
- PMID: 1000504
- PMID: 7531416
- PMID: 864756
- PMID: 688225
H.S. Smith (California Pacific Medical Center) PMID: 9833771
- PMID: 3470538
RIKEN BRC PMID: 7873497
- PMID: 11291043
- PMID: 9833771

- PMID: 32576280

- http://d-scholarship.pitt.edu/34370/

- PMID: 17097565
- PMID: 17097565
- PMID: 17097565
- PMID: 25713299
- PMID: 25713299
- PMID: 25713299
- PMID: 25713299
lymphocytic-like PMID: 5956504

- PMID: 32667137
- PMID: 25013076

Derivative of SUM-44 PE PMID: 18974135

Derivative of SUM-44 PE PMID: 27246191
Derivative of MDA-MB-134 VI PMID: 18974135

- PMID: 28750639
- PMID: 29941485
- DOI: https://doi.org/10.1101/2021.07.22.45

- PMID: 29610289
- PMID: 25079037
- PMID: 27035620
- PMID: 33148662
Cellosaurus

https://web.expasy.org/cellosaurus/CVCL_3424
https://web.expasy.org/cellosaurus/CVCL_A625
https://web.expasy.org/cellosaurus/CVCL_0617
https://web.expasy.org/cellosaurus/CVCL_0619
https://web.expasy.org/cellosaurus/CVCL_B221
n/a
https://web.expasy.org/cellosaurus/CVCL_W957
https://web.expasy.org/cellosaurus/CVCL_3375

https://web.expasy.org/cellosaurus/CVCL_A9A5
https://web.expasy.org/cellosaurus/CVCL_0618
https://web.expasy.org/cellosaurus/CVCL_0623
https://web.expasy.org/cellosaurus/CVCL_0418
https://web.expasy.org/cellosaurus/CVCL_0419
https://web.expasy.org/cellosaurus/CVCL_1115
https://web.expasy.org/cellosaurus/CVCL_5423
https://web.expasy.org/cellosaurus/CVCL_1104
https://web.expasy.org/cellosaurus/CVCL_0033
https://web.expasy.org/cellosaurus/CVCL_5217
n/a
https://web.expasy.org/cellosaurus/CVCL_1207
https://web.expasy.org/cellosaurus/CVCL_1106
https://web.expasy.org/cellosaurus/CVCL_0332
https://web.expasy.org/cellosaurus/CVCL_1661
https://web.expasy.org/cellosaurus/CVCL_1263
https://web.expasy.org/cellosaurus/CVCL_9875
https://web.expasy.org/cellosaurus/CVCL_1092
https://web.expasy.org/cellosaurus/CVCL_3352
https://web.expasy.org/cellosaurus/CVCL_1621
https://web.expasy.org/cellosaurus/CVCL_1247

https://web.expasy.org/cellosaurus/CVCL_ZV46

n/a
n/a
n/a
n/a
n/a
n/a
n/a
https://web.expasy.org/cellosaurus/CVCL_3869

n/a
n/a

n/a
n/a
n/a

n/a
n/a
n/a

n/a
n/a
n/a
n/a
cBioPortal

n/a
n/a
https://www.cbioportal.org/patient?studyId=ccle_broad_2019&caseId=MDAMB134VI_BREAST
n/a
n/a
n/a
n/a
n/a

n/a
n/a
n/a
n/a
n/a
https://www.cbioportal.org/patient?studyId=ccle_broad_2019&caseId=CAMA1_BREAST
n/a
n/a
https://www.cbioportal.org/patient?studyId=ccle_broad_2019&caseId=SKBR3_BREAST
n/a
https://www.cbioportal.org/patient?studyId=ccle_broad_2019&caseId=AU565_BREAST
n/a
https://www.cbioportal.org/patient?sampleId=CAL148_BREAST&studyId=ccle_broad_2019
n/a
https://www.cbioportal.org/patient?sampleId=ZR7530_BREAST&studyId=ccle_broad_2019
https://www.cbioportal.org/patient?studyId=ccle_broad_2019&caseId=HCC2218_BREAST
n/a
n/a
n/a
n/a
n/a

n/a

n/a

n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a

n/a
n/a

n/a
n/a
n/a

n/a
n/a
n/a
n/a
n/a
n/a
Availability

Asterand
DSMZ
ATCC
ATCC
ATCC
-
-
Discontinued in ATCC

Prof. Britta M. Jacobsen

ATCC
ATCC
ATCC
ATCC
ATCC
Asterand
DSMZ
ATCC
ATCC
ATCC
DSMZ
DSMZ
ATCC
ATCC
ATCC
Dr F Waldman
ATCC
-
-
ATCC

-
-
-
-
-
-
-
-

-
-

-
-
-

-
-
-
-
-
-
Name Model Type Cinical (Biomarker) Organoids (Biomarkers)
T35 Z542 ILC ER+, PR+, HER2- ER+, PR-, HER2+
T66 R1239 ILC ER+, PR+, HER2+ ER+, PR+, HER2+
T74 X2675 ILC (apocrine) ER+, PR+, HER2- ER+, PR+, HER2-
T105 W1144 ILC ER+, PR+, HER2- ER+, PR+, HER2-
P008 P008 ILC ER+, PR-, HER2- ER-, PR-, HER2-
KCL320 KCL320 ILC ER+, PR+, HER2- ER-, PR-, HER2-
Male ILC
UDL-MBC6 UDL-MBC6 ILC n/a n/a
Mouse primary ILC
UDL-WEP9 UDL-WEP9 PILC ER-, PR-, Her2- ER-, PR-, Her2-
UDL-WEP10 UDL-WEP10 PILC ER-, PR-, Her2- ER-, PR-, Her2-
CDH1 PIK3CA TP53
n/a n/a n/a
n/a n/a n/a
n/a n/a n/a
n/a n/a n/a
p.(Ser180Tyr) none c.G527T:p.C176F
splice variant g.68823627G>A c.G1624A:p.E542K c.G1010A:p.R337H and c.C489A:p.Y163X

c.85del p.(His29fs) c.3140A>T p.(His1047Leu) n/a

null wt null
null wt null
Morhological features Source
High degree of tubule formation, well differentiated Prof. Hans Clevers
Discohesive, lots of vacuoles, signet ring cells Prof. Hans Clevers
Loose cells without any organization, intracytoplasmicProf. Hans Clevers
n/a Prof. Hans Clevers
n/a Prof. Clare Isacke
n/a Prof. Clare Isacke

n/a Prof. Patrick Derksen/Prof. Van Diest

n/a Prof. Patrick Derksen

n/a Prof. Patrick Derksen
Reference
PMID: 29224780
PMID: 29224780
PMID: 29224780
PMID: 29224780
DOI: 10.1158/1538-7445.AM2021-LB245
DOI: 10.1158/1538-7445.AM2021-LB246

not published yet

not published yet

not published yet
 Deletion/Activation Deletion/Activation

Cdh1;Trp53 K14-Cre;Cdh1F/F;Trp53F/F (KEP)

Cdh1;Trp53 WAP-Cre;Cdh1F/F;Trp53F/F
Cdh1;Pten WAP-Cre;Cdh1F/F;PtenF/F
Cdh1;Pten WAP-Cre;Cdh1F/F;PtenF/+
Cdh1 and Pik3ca Cdh1loxP/loxP;R26-LSL-Pik3caE545K;Wap-Cre
Cdh1 and Pten Cdh1F/F;Col1a1invCAG-Cas9-IRES-Luc/+
Cdh1 and AKTE17K WapCre;Cdh1F/F;Col1a1invCAG-Akt-E17K-IRES-Luc/+
Cdh1 and Myh9 Cdh1F/F;Col1a1invCAG-Cas9-IRES-Luc/+
Cdh1;t-ASPP2 WapCre;Cdh1F/F;Col1a1invCAG-Trp53bp2-ex13-18-IRES-Luc/+
Cdh1;Pten;t-ASPP2 WapCre;Cdh1F/F;PtenF/F;Col1a1invCAG-Trp53bp2-ex13-18-IRES-Luc/+
Cdh1;t-MYPT1 WapCre;Cdh1F/F;Col1a1invCAG-Ppp1r12a-ex1-9-IRES-Luc/+
Cdh1;Pten;t-MYPT1 WapCre;Cdh1F/F;PtenF/F;Col1a1invCAG-Ppp1r12a-ex1-9-IRES-Luc/+
Cdh1;Trps1 WapCre;Cdh1F/F;Trps1F/F
 Estrogen
System Variant / Molecular Subtype
Receptor

Tg Pleomorphic ILC Negative

Tg Pleomorphic ILC Negative
Tg Classical ILC-like features Positive
Tg Classical ILC-like features Positive
Tg Immune-Related-ILC-like tumors Positive
CRISPR/Cas9 Unknown - ILC histology not tested
GEMM-ESC Typical ILC histology not tested
CRISPR/Cas9 Classical ILC-like features not tested
GEMM-ESC Classical ILC-like features not tested
GEMM-ESC/Tg Classical ILC-like features not tested
GEMM-ESC Classical ILC-like features not tested
GEMM-ESC/Tg Classical ILC-like features not tested
GEMM-ESC Classical ILC-like features not tested
 Response to
Tumor Onset ER responsiveness Metastases
endocrine therapies

5-8 months (fast growth) not tested yet not tested 48%
5-7 months not tested yet not tested 47%
2-4 months not tested yet not tested 5%
12+ months (consistent growth) not tested yet not tested 34%
5-10 weeks not tested yet not tested unknown
7 months (consistent growth) not tested yet not tested unknown
not specified not tested yet not tested unknown
not specified not tested yet not tested unknown
9-15 weeks not tested yet not tested Sporadic
5-9 weeks not tested yet not tested unknown
10-16 weeks not tested yet not tested Sporadic
5-8 weeks not tested yet not tested unknown
19 Months not tested yet not tested unknown
References Lab Year PMID

Derksen P. et al. Prof Jos Jonkers 2006 17097565

Derksen P. et al. Prof Jos Jonkers 2011 21282721
Boelens, M.C. et al. Prof Jos Jonkers 2016 27524621
Boelens, M.C. et al. Prof Jos Jonkers 2016 27524621
Yeji An et al. Prof. Sean E. Egan 2018 30332649
Annunziato S. et al. Prof. Jos Jonkers 2016 27340177
Annunziato S. et al. Prof. Jos Jonkers 2016 27340177
Kas et al. Prof. Jos Jonkers 2017 28650484
Kas et al./Schipper et al. Prof. Jos Jonkers 2017/2020 28650484/32060147
Schipper et al. Prof. Jos Jonkers 2020 32060147
Kas et al./Schipper et al. Prof. Jos Jonkers 2017/2020 28650484/32060147
Schipper et al. Prof. Jos Jonkers 2020 32060147
Cornelissen et al. Prof. Jos Jonkers 2020 31879358
Model Id Laboratory
Xenograft
SUM-44 PE Prof. Cathrin Brisken
MDA-MB-134 VI Prof. Cathrin Brisken
MDA-MB-453 Prof. Cathrin Brisken
IPH-926 Prof. Matthias Christgen
BCK4 Prof. Britta M. Jacobsen
PDXs
BCM-3561 Prof. Michael T. Lewis
BCM-4189 Prof. Michael T. Lewis
HCI-005 Prof. Alana L. Welm
HCI-006 Prof. Alana L. Welm
HCI-011 Prof. Alana L. Welm
HCI-013 Prof. Alana L. Welm
HCI-013-EI Prof. Alana L. Welm
HCI-014 Prof. Alana L. Welm
HCI-018 Prof. Alana L. Welm
HCI-031 Prof. Alana L. Welm
HCI-031OV Prof. Alana L. Welm
WHIM2,5 Prof. Matthew J. Ellis
WHIM9 Prof. Matthew J. Ellis
WHIM13 Prof. Matthew J. Ellis
WHIM13-EI Prof. Matthew J. Ellis
WHIM20 Prof. Matthew J. Ellis
WHIM23 Prof. Matthew J. Ellis
Prof. Elisabetta Marangoni, Prof. Marie-France
HBCx-7
Poupon
Prof. Elisabetta Marangoni, Prof. Marie-France
HBCx-19
Poupon
Prof. Elisabetta Marangoni, Prof. Marie-France
HBCx-36
Poupon
LA-PDX1 Prof. Richard Iggo
LA-PDX2 Prof. Richard Iggo
LA-PDX3 Prof. Richard Iggo
LA-PDX4 Prof. Richard Iggo
Met BC 5 (BB3RC33) Prof. Robert B. Clarke
Met BC 9 (BB3RC59)
Met BC 9A (BB3RC61) Prof. Robert B. Clarke
Met BC 9B (BB3RC66)
Met BC 11 (BB3RC69) Prof. Robert B. Clarke
Met BC 11A (BB3RC69) Prof. Robert B. Clarke
Met BC 13 (BB3RC77) Prof. Robert B. Clarke
BB6RC183 Prof. Robert B. Clarke
UCD178 Prof. Carol A. Sartorius
T69 Prof. Cathrin Brisken
T73 Prof. Cathrin Brisken
T78 Prof. Cathrin Brisken
T85 Prof. Cathrin Brisken
T86 Prof. Cathrin Brisken
BRx-07 (zebrafish) Prof. Daniel Haber
J000106532 The Jackson Laboratory
J000079378 The Jackson Laboratory
 Age Histological subtype
Institution Histological subtype (PDX)
collection (Clinical)

EPFL - ILC ILC (classic/pleomorphic)

EPFL 47 ILC ILC (classic/pleomorphic)
EPFL 48 ILC n/a
Hannover Medical School 72 ILC ILC
University of Colorado 65 Mucinous ILC, with mucinous features

Baylor College of Medicine 61 ILC n/a

Baylor College of Medicine n/a LCIS n/a
ILC, pleomorphic with
University of Utah 45 Mixed NST and ILC
papillary features
University of Utah n/a Mixed NST and ILC ILC (classic type)
University of Utah n/a NST ILC (classic type)
University of Utah 53 ILC n/a
University of Utah 53 ILC n/a
University of Utah 60 ILC n/a
University of Utah 59 ILC n/a
University of Utah 55 ILC + LCIS n/a
University of Utah 55 ILC + LCIS n/a
Washington University 44 NST and ILC (mixed) n/a
Washington University 57 Mixed NST and ILC n/a
Washington University 42 NST with lobular features n/a
Washington University 42 NST with lobular features n/a
Washington University 36 NST and ILC (mixed) n/a
Washington University 36 NST and ILC (mixed) n/a
Institut Curie n/a ILC n/a

Institut Curie n/a ILC n/a

Institut Curie n/a ILC n/a

BCI n/a ILC ILC
BCI n/a ILC ILC
BCI n/a ILC ILC
BCI n/a ILC ILC
University of Manchester n/a ILC n/a

University of Manchester n/a ILC n/a

University of Manchester n/a ILC n/a

University of Manchester 62 ILC n/a
University of Manchester n/a ILC n/a
University of Manchester n/a mixed IDC/ILC n/a
University of Colorado mixed IDC/ILC n/a
EPFL 74 ILC ILC
EPFL 68 ILC ILC
EPFL 78 ILC (pleomorphic) ILC
EPFL 71 ILC ILC
EPFL 81 ILC ILC
MGH ILC n/a
The Jackson Laboratory n/a ILC n/a
The Jackson Laboratory n/a ILC n/a
Source - Tissue Clinical Biomarker PDX Biomarker

Pleural effusion ER+/ PR-/ HER2- ER+/ PR+/-/ HER2-

Pleural effusion ER+/ PR-/ HER2- ER+/ PR+/-/ HER2-
Pleural effusion ER-/ PR-/ HER2+ n/a
Malignant ascites ER-/ PR-/ HER2- ER-/ PR-/ HER2-
Pleural effusion ER+/ PR+/ HER2+ ER+/ PR+/-/ HER2+

Ascites ER+/ PR+/ HER2- ER-/ PR-/ HER2- (enriched)

Ascites ER+/ PR-/ HER2- ER-/ PR-/ HER2- (enriched)
Pleural effusion ER+/ PR+/ HER2+ ER+/ PR+/ HER2+
Pleural effusion ER+/ PR+/ HER2+ ER+/ PR+/ HER2 (n/a)
Pleural effusion ER+/ PR+/ HER2- ER+/ PR+/ HER2-
Pleural effusion ER+/ PR+/ HER2- ER+/ PR+/ HER2-
Pleural effusion ER+/ PR+/ HER2- ER+/ PR+/ HER2-
Pleural effusion ER-/ PR-/ HER2- ER-/ PR-/ HER2-
Surgical sample - brain ER+/ PR-/ HER2- ER+/ PR-/ HER2-
Pleural effusion ER-/ PR-/ HER2- ER-/ PR-/ HER2-
Ovarian metastasis (murine) ER-/ PR-/ HER2- ER-/ PR-/ HER2-
Brain mets ER-/ PR-/ HER2- n/a
Not Specified ER+/ PR+/ HER2- n/a
Surgery, chest wall skin recurrence ER-/ PR-/ HER2- n/a
Surgery, chest wall skin recurrence ER-/ PR-/ HER2- n/a
Punch -- skin right clavicle ER-/ PR-/ HER2+ n/a
Punch -- skin right clavicle ER-/ PR+/ HER2- n/a
Primary breast cancer ER-/ PR+/ HER2- ER-/ PR-/ HER2+

Primary breast cancer ER-/ PR+/ HER2- n/a

Primary breast cancer ER+/ PR+/ HER2+ ER+PR+HER2+

Primary breast cancer ER+/ PR+/ HER2- ER+/ PR+/ HER2-
Primary breast cancer ER+/ PR+/ HER2- ER+/ PR+/ HER2-
Primary breast cancer ER+/ PR+/ HER2- ER+/ PR+/ HER2-
Primary breast cancer ER+/ PR+/ HER2- ER+/ PR+/ HER2-
Ascitic fluid ER+/ PR+/ HER2- ER+/ PR+/ HER2-

Ascites sample ER+/PR+/HER2- n/a

n/a ER+/PR+ n/a

Ascitic fluid ER+/PR+/HER2- n/a
n/a ER+/PR+/HER2- n/a
n/a ER+/PR- n/a
n/a ER+/PR+/HER2- ERlow/PR−
Treatment-naïve primary BC ER+/PR+/HER2- ER+/PR+/HER2(n/a)
Treatment-naïve primary BC ER+/PR-/HER2+ ER+/PR-/HER2(n/a)
Treatment-naïve primary BC ER+/PR+/HER2- ER+/PR-/HER2(n/a)
Treatment-naïve primary BC ER+/PR-/HER2- ER+/PR+/HER2(n/a)
Treatment-naïve primary BC ER+/PR+/HER2- ER+/PR+/HER2(n/a)
CTC line ER+/PR+/HER2- n/a
Biopsy (Type Unspecified) n/a n/a
Surgical Resection (Fragment) n/a n/a
ESR1 mutations Implantation Site Matrigel Mouse Strain

ESR1Y537S and ESR1Y537C

Mammary milk ducts (intraductal) no NSG
n/a Mammary milk ducts (intraductal) no NSG
n/a Mammary milk ducts (intraductal) no SCID / bg
n/a Subcutaneously no NOD/SCID
n/a Mammary Fat Pad (inguinal) no NOD/SCID

n/a Cleared inguinal mammary fat pads no SCID / bg

n/a Cleared inguinal mammary fat pads no SCID / bg
ESR1L536P Cleared inguinal mammary fat pads yes NOD-SCID and NSG
n/a Cleared inguinal mammary fat pads yes NOD-SCID
n/a Cleared inguinal mammary fat pads yes NOD-SCID
ESR1 Y537S
Cleared inguinal mammary fat pads yes NOD-SCID
n/a Cleared inguinal mammary fat pads yes NOD-SCID
n/a Cleared inguinal mammary fat pads yes NSG
n/a Cleared inguinal mammary fat pads yes NSG
ESR1Y537S (extreme E2 dependent)
Cleared inguinal mammary fat pads yes NSG
n/a Cleared inguinal mammary fat pads yes NSG
n/a Cleared inguinal mammary fat pads yes NOD/SCID
E2-independent growthCleared
- inguinal mammary fat pads yes NOD/SCID
n/a Cleared inguinal mammary fat pads yes NOD/SCID
n/a Cleared inguinal mammary fat pads yes NOD/SCID
ESR1Y537S Cleared inguinal mammary fat pads yes NOD/SCID
n/a Cleared inguinal mammary fat pads yes NOD/SCID
n/a Interscapular fat pad no Swiss nude mice

n/a Interscapular fat pad no Swiss nude mice

n/a Interscapular fat pad no Swiss nude mice

n/a Mammary milk ducts (intraductal) no NSG
n/a Mammary milk ducts (intraductal) no NSG
n/a Mammary milk ducts (intraductal) no NSG
n/a Mammary milk ducts (intraductal) no NSG
n/a Subcutaneously (dorsal flanks) no NSG

n/a Subcutaneously (dorsal flanks) no NSG

n/a Subcutaneously (dorsal flanks) no NSG

n/a Subcutaneously (dorsal flanks) no NSG
n/a Subcutaneously (dorsal flanks) no NSG
n/a Subcutaneously (dorsal flanks) no NSG
n/a Inguinal mammary fat pad Cultrex Basement MNSG
n/a Mammary milk ducts (intraductal) no NSG
n/a Mammary milk ducts (intraductal) no NSG
n/a Mammary milk ducts (intraductal) no NSG
n/a Mammary milk ducts (intraductal) no NSG
n/a Mammary milk ducts (intraductal) no NSG
n/a Intra-peritoneally and/or peri-ocularly yes + Clondronate prkdc-/-, il2rga-/-
n/a Mammary fat pad no NSG
n/a Mammary fat pad no NSG
Reference - PubMed Reference (PMID, DOI) Model Description

https://pubmed.ncbi.nlm.nih.gov/33616307/ PMID: 33616307 n/a

https://pubmed.ncbi.nlm.nih.gov/33616307/ PMID: 33616307 n/a
https://pubmed.ncbi.nlm.nih.gov/26947176/ PMID: 26947176 n/a
https://pubmed.ncbi.nlm.nih.gov/19191266/ PMID: 19191266 n/a
https://pubmed.ncbi.nlm.nih.gov/23247610/ PMID: 23247610 n/a

https://pubmed.ncbi.nlm.nih.gov/23737486/ PMID: 23737486 http://tumor.informatics.jax.org/mtbwi/pdxD

https://pubmed.ncbi.nlm.nih.gov/23737486/ PMID: 23737486 n/a
https://pubmed.ncbi.nlm.nih.gov/22019887/ PMID: 22019887 n/a
https://pubmed.ncbi.nlm.nih.gov/22019887/ PMID: 22019887 n/a
https://pubmed.ncbi.nlm.nih.gov/22019887/ PMID: 22019887 n/a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955299/#SD1
PMID: 24425047 https://www.pdxfinder.org/data/pdx/HCI-B
doi: https://doi.org/10.1101/2021.02.28.433268 PMID: 24425047 n/a
doi: https://doi.org/10.1101/2021.02.28.433269 PMID: 24425047 n/a
doi: https://doi.org/10.1101/2021.02.28.433270 PMID: 24425047 https://www.pdxfinder.org/data/pdx/HCI-B
doi: https://doi.org/10.1101/2021.02.28.433271 DOI: https://doi.org/10.1101 n/a
https://www.biorxiv.org/content/10.1101/2021.02.28.433268v1
DOI: https://doi.org/10.1101 n/a
https://pubmed.ncbi.nlm.nih.gov/24055055/ PMID: 24055055 n/a
https://pubmed.ncbi.nlm.nih.gov/24055055/ PMID: 24055055 n/a
https://pubmed.ncbi.nlm.nih.gov/24055055/ PMID: 24055056 n/a
https://pubmed.ncbi.nlm.nih.gov/24055055/ PMID: 24055057 n/a
https://pubmed.ncbi.nlm.nih.gov/24055055/ PMID: 24055058 n/a
https://pubmed.ncbi.nlm.nih.gov/24055055/ PMID: 24055059 n/a
https://pubmed.ncbi.nlm.nih.gov/17606733/ PMID: 17606733 n/a

https://pubmed.ncbi.nlm.nih.gov/17606733/ PMID: 17606733 n/a

https://pubmed.ncbi.nlm.nih.gov/17606733/ PMID: 17606733 n/a

https://pubmed.ncbi.nlm.nih.gov/27447842/ PMID: 27447842 n/a
https://pubmed.ncbi.nlm.nih.gov/27447842/ PMID: 27447842 n/a
https://pubmed.ncbi.nlm.nih.gov/27447842/ PMID: 27447842 n/a
https://pubmed.ncbi.nlm.nih.gov/27447842/ PMID: 27447842 n/a
https://pubmed.ncbi.nlm.nih.gov/26387946/ PMID: 26387946 n/a

https://pubmed.ncbi.nlm.nih.gov/26387946/ PMID: 26387946 n/a

https://pubmed.ncbi.nlm.nih.gov/26387946/ PMID: 26387946 n/a

https://pubmed.ncbi.nlm.nih.gov/26387946/ PMID: 26387946 n/a
https://pubmed.ncbi.nlm.nih.gov/26387946/ PMID: 26387946 n/a
PMID: 26387946 n/a
https://doi.org/10.1186/s13058-020-01300-y PMID: 32576280 n/a
https://pubmed.ncbi.nlm.nih.gov/30430577/ PMID: 30430577 n/a
https://pubmed.ncbi.nlm.nih.gov/30430577/ PMID: 30430577 n/a
https://pubmed.ncbi.nlm.nih.gov/30430577/ PMID: 30430577 n/a
https://pubmed.ncbi.nlm.nih.gov/30430577/ PMID: 30430577 n/a
https://pubmed.ncbi.nlm.nih.gov/30430577/ PMID: 30430577 n/a
https://pubmed.ncbi.nlm.nih.gov/31031007/ PMID: 31031007 n/a
n/a n/a https://www.pdxfinder.org/data/pdx/JAX/J0
n/a n/a https://www.pdxfinder.org/data/pdx/JAX/J0
matics.jax.org/mtbwi/pdxDetails.do?modelID=J000106532

nder.org/data/pdx/HCI-BCM/HCI-013

nder.org/data/pdx/HCI-BCM/HCI-018

nder.org/data/pdx/JAX/J000106532#summary
nder.org/data/pdx/JAX/J000079378