ACCORDING TO EC-REGULATIONS 1907/2006 (REACH), 1272/2008 (CLP) & 2015/830

Date : 15/12/2020
Version :3

SAFETY DATA SHEET

Methanol

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE

COMPANY/UNDERTAKING
1.1 Product identifier
Product Name Methanol
Chemical Name Methyl alcohol
Chemical Formula CH4O
CAS No. 67-56-1
EC No. 200-659-6
REACH Registration No. 01-2119433307-44-0254

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified Use(s) • Formulation and (re)packing of substances and mixtures
• Use as a fuel in industrial settings
• Use as a fuel in professional settings
• Industrial use in cleaning agents
Uses Advised Against None known.

1.3 Details of the supplier of the safety data sheet

Company Identification Qatar Fuel Additives Company Ltd.
Address Mesaieed Industrial City,
PO Box 22700, Doha,
State of Qatar.
Telephone (+) 974-4477 3400
E-mail info@qafac.com.qa
Only representative of a non-Community manufacturer
Company Identification MUNTAJAT B.V.
Address Prinses Margrietplantsoen 78-A
2595 BR, La Haye
Pays Bas
Telephone +31(0)70 219 7000
E-mail REACH@muntajatbv.com
Website www.muntajatbv.com

1.4 Emergency telephone number

National Poisons Information Service +44 (0) 111
(Birmingham Centre)
For Spill, Leak, Fire, Exposure or Within USA and Canada: 1-800-424-9300
Accident, Call CHEMTREC Day or Night Outside USA and Canada: +1 703-741-5970 and +1-703-527-3887 (collect calls
accepted)

SECTION 2: HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture
Regulation (EC) No. 1272/2008 (CLP) Flam. Liq. 2 :Highly flammable liquid and vapour.
Acute Tox. 3 :Toxic if swallowed.
Acute Tox. 3 :Toxic in contact with skin.
Acute Tox. 3 :Toxic if inhaled.
STOT SE 1 :Causes damage to organs.

2.2 Label elements

According to Regulation (EC) No. 1272/2008 (CLP)
Product Name Methanol.

Hazard Pictogram(s)

GHS02 GHS06 GHS08

Signal Word(s) Danger

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Hazard Statement(s) H225: Highly flammable liquid and vapour.

H301: Toxic if swallowed.
H311: Toxic in contact with skin.
H331: Toxic if inhaled.
H370: Causes damage to organs.

Precautionary Statement(s) P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition
sources. No smoking.
P260: Do not breathe vapour.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P308+P311: IF exposed or concerned: Call a POISON CENTER/doctor.
P370+P378: In case of fire: Use water spray or fog, alcohol resistant foam, dry
chemical or carbon dioxide to extinguish.

2.3 Other hazards

None known.

2.4 Additional Information

For full text of H/P Statements see section 16.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances
HAZARDOUS CAS No. EC No. %W/W Hazard Statement(s) Hazard
INGREDIENT(S) Pictogram(s)
Methanol 67-56-1 200-659-6 ≥99 Flam. Liq. 2 H225 GHS02
01-2119433307-44-XXXX Acute Tox. 3 H301 GHS06
Acute Tox. 3 H311 GHS08
Acute Tox. 3 H331
STOT SE 1 H370
methyl acetate 79-20-9 201-185-2 <0.015 Flam. Liq. 2 H225 GHS02
01-2119459211-47-XXXX Eye Irrit. 2 H319 GHS07
STOT SE 3 H336
acetic acid 64-19-7 200-580-7 <0.005 Flam. Liq. 3 H226 GHS02
01-2119475328-30-XXXX Skin Corr. 1A H314 GHS05
Acetone 67-64-1 200-662-2 <0.003 Flam. Liq. 2 H225 GHS02
01-2119471330-49-XXXX Eye Irrit. 2 H319 GHS07
STOT SE 3 H336
Ethanol 64-17-5 200-578-6 <0.005 Flam. Liq. 2 H225 GHS02
01-2119457610-43-XXXX
butanone 78-93-3 201-159-0 <0.001 Flam. Liq. 2 H225 GHS02
01-2119457290-43-XXXX Eye Irrit. 2 H319 GHS07
STOT SE 3 H336

3.2 Mixtures
Not applicable.

SECTION 4: FIRST AID MEASURES

4.1 Description of first aid measures
Inhalation Remove person to fresh air and keep comfortable for breathing. Call a POISON
CENTER/doctor if you feel unwell.
Skin Contact Take off immediately all contaminated clothing. Rinse skin with water.
Eye Contact Flush eyes with water for at least 15 minutes while holding eyelids open. If
symptoms persist, obtain medical attention.
Ingestion Rinse mouth. Immediately call a POISON CENTER/doctor.

4.2 Most important symptoms and effects, both acute and delayed
Toxic by inhalation, in contact with skin and if swallowed. Causes damage to
organs.

4.3 Indication of any immediate medical attention and special treatment needed
IF exposed or concerned: Call a POISON CENTER/doctor.

SECTION 5: FIREFIGHTING MEASURES

5.1 Extinguishing media
Suitable extinguishing media Use water spray or fog, alcohol resistant foam, dry chemical or carbon dioxide to
extinguish.
Unsuitable extinguishing media Do not use water jet.

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5.2 Special hazards arising from the substance or mixture

Highly flammable liquid and vapour. Vapours are heavier than air and may travel
considerable distances to a source of ignition and flashback. Decomposes in a fire
giving off toxic fumes: Carbon monoxide, Carbon dioxide.

5.3 Advice for firefighters

Fire fighters should wear complete protective clothing including self-contained
breathing apparatus. Evacuate the area and keep personnel upwind. If it is safe to
do so, containers should be removed from fire area because they are likely to
rupture under fire conditions. Water spray should be used to cool containers.

SECTION 6: ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures
Ensure adequate ventilation. Remove all ignition sources. Do not breathe vapour.
Wear appropriate personal protective equipment, avoid direct contact. Take off
immediately all contaminated clothing and wash it before reuse. Wash hands and
exposed skin thoroughly after handling.

6.2 Environmental precautions

Do not allow to enter drains, sewers or watercourses.

6.3 Methods and material for containment and cleaning up

Shut off leaks if without risk. Adsorb spillages onto sand, earth or any suitable
adsorbent material. Transfer to a lidded container for disposal or recovery.

6.4 Reference to other sections

See Also Section 8, 13.

SECTION 7: HANDLING AND STORAGE

7.1 Precautions for safe handling
Keep away from heat, hot surfaces, sparks, open flames and other ignition sources.
No smoking. Ground and bond container and receiving equipment. Use explosion-
proof electrical/ventilating/lighting/equipment. Use non-sparking tools. Take action to
prevent static discharges. Use only outdoors or in a well-ventilated area. Do not
breathe vapour. Wear protective gloves/protective clothing/eye protection/face
protection. Wash hands and exposed skin thoroughly after handling. Do not eat,
drink or smoke when using this product.

7.2 Conditions for safe storage, including any incompatibilities

Keep container tightly closed. Store in a well-ventilated place. Keep cool. Store
locked up.
Storage temperature Ambient.
Storage life Stable under normal conditions.
Incompatible materials Strong oxidising agents.

7.3 Specific end use(s)

• Formulation and (re)packing of substances and mixtures
• Use as a fuel in industrial settings
• Use as a fuel in professional settings
• Industrial use in cleaning agents

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters
8.1.1 Occupational Exposure Limits

SUBSTANCE CAS No. LTEL (8 hr LTEL (8 hr STEL (ppm) STEL (mg/m³) Note
TWA ppm) TWA mg/m³)
Methanol 67-56-1 200 266 250 333 Sk
Methanol 67-56-1 200 260 IOELV, Skin
methyl acetate 79-20-9 200 616 250 770
acetic acid 64-19-7 10 25 20 50
acetic acid 64-19-7 10 25 20 50 IOELV
Acetone 67-64-1 500 1210 1500 3620
Acetone 67-64-1 500 1210 IOELV
Ethanol 64-17-5 1000 1920
butanone 78-93-3 200 600 300 899 Sk, BMGV
butanone 78-93-3 200 600 300 900 IOELV

Region Source

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EU EU Occupational Exposure Limits

United Kingdom UK Workplace Exposure Limits EH40/2005 (Fourth edition, published 2020)

Remark Notes
Sk Can be absorbed through the skin. The assigned substances are those for which there are concerns that
dermal absorption will lead to systemic toxicity.
IOELV Indicative Occupational Exposure Limit Value
Skin The possibility of significant uptake through the skin.
BMGV Biological monitoring guidance values are listed in Table 2.

8.1.2 Biological limit value

Substances CAS No. Sampling Tissues Control Biological Comments

parameters monitoring
guidance value
butanone 78-93-3 70 μmol butan-2-one/L in urine Post shift

8.1.3 PNECs and DNELs

DNEL / DMEL Oral Inhalation Dermal

Industry - Long Term - Local effects 130 mg/m³
Industry - Long Term - Systemic effects 130 mg/m³ 20 mg/kg bw/day
Industry - Short term - Local effects 130 mg/m³
Industry - Short term - Systemic effects 130 mg/m³ 20 mg/kg bw/day
Consumer - Long Term - Local effects 26 mg/m³
Consumer - Long Term - Systemic effects 4 mg/kg bw/day 26 mg/m³ 4 mg/kg bw/day
Consumer - Short term - Local effects 26 mg/m³
Consumer - Short term - Systemic effects 4 mg/kg bw/day 26 mg/m³ 4 mg/kg bw/day
Environment PNEC
Aquatic Compartment (including sediment) Fresh water: 20.8 mg/l
Intermittent release (Fresh water): 1540 mg/l
Sea water: 2.08 mg/l
Fresh water (Sediment): 77 mg/kg dw
Sea water (Sediment): 7.7 mg/kg dw
Terrestrial Compartment Sewage Treatment Plant: 100 mg/l
Atmospheric Compartment Soil: 100 mg/kg dw

8.2 Exposure controls

8.2.1. Appropriate engineering controls Use non-sparking ventilation systems, approved explosion-proof equipment, and
intrinsically safe electrical systems. Use with ventilation, local exhaust ventilation or
breathing protection.
8.2.2. Personal protection equipment
Eye Protection Wear protective eye glasses for protection against liquid splashes.

Skin protection Wear suitable protective clothing and gloves.

Breakthrough time of the glove material: refer to the information provided by the
gloves’ producer.

Respiratory protection Wear suitable respiratory protection.

Thermal hazards Not applicable.

8.2.3. Environmental Exposure Controls Do not allow to enter drains, sewers or watercourses.

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties
Appearance Liquid.
Colour : Clear, Colourless.
Odour Mild, Characteristic.
Odour threshold 100 ppm

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pH 5.9-6.0
Melting point/freezing point -97.8°C
Initial boiling point and boiling range 64.6°C
Flash Point 15.6°C [Open cup]
Evaporation rate Not available.
Flammability (solid, gas) Not applicable.
Upper/lower flammability or explosive 6.7-36 Vol-%
limits
Vapour pressure 12.8 kPa @ room temperature
Vapour density 1.1 (Air = 1)
Density (g/ml) Not available.
Relative density 0.7928 @ 20°C
Solubility(ies) Solubility (Water) : Miscible.
Solubility (Other): Miscible with: Ethanol, Ether, Ketones, Benzene, Most organic
solvents. Soluble in: Acetone, Chloroform.
Partition coefficient: n-octanol/water Log Pow: -0.77
Auto-ignition temperature 464°C
Decomposition Temperature (°C) Not available.
Viscosity Kinematic Viscosity: 0.00737 cm2/s @ 20°C
Explosive properties Not explosive.
Oxidising properties Not oxidising.

9.2 Other information

None.

SECTION 10: STABILITY AND REACTIVITY

10.1 Reactivity
Stable under normal conditions.

10.2 Chemical Stability

Stable under normal conditions.

10.3 Possibility of hazardous reactions

No hazardous reactions known if used for its intended purpose.

10.4 Conditions to avoid

Keep away from heat, sources of ignition and direct sunlight.

10.5 Incompatible materials

Strong oxidising agents.

10.6 Hazardous decomposition products

No hazardous decomposition products known.

SECTION 11: TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects
Acute toxicity - Ingestion Toxic if swallowed.
LD50 (rat): 1187 mg/kg
Acute toxicity - Skin Contact Toxic in contact with skin.
LD50 (rabbit): 17100 mg/kg bw
Acute toxicity - Inhalation Toxic if inhaled.
LC50 (rat) (6 hour(s)): 43700 mg/m³
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008.
Although the lethal dose of methanol is high for most experimental animals, these data are not employed for classification. The
classification is only based upon the experiences in humans and classifies methanol as acutely toxic by oral, dermal and
inhalative exposure and, furthermore, as capable of inducing serious irreversible effects upon single exposure by all of these
routes. As a result, the substance is considered to be classified for acute toxicity category 3.

Skin corrosion/irritation Not classified.

Serious eye damage/irritation Not classified.
Skin sensitization data It is not a skin sensitiser.
Respiratory sensitization data Not classified.
Germ cell mutagenicity There is no evidence of mutagenic potential.
Carcinogenicity No evidence of carcinogenicity.
Reproductive toxicity No evidence of reproductive effects.
Lactation None anticipated.
STOT - single exposure Causes damage to organs. No data.
STOT - repeated exposure Not classified.
Aspiration hazard None anticipated.

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11.2 Other information

Not known.

SECTION 12: ECOLOGICAL INFORMATION

12.1 Toxicity
Toxicity - Aquatic invertebrates Low toxicity to invertebrates.
Acute: EC50 (Daphnia magna)(96 hour): 18260 mg/l
Chronic: NOEC (Daphnia magna): 208 mg/l
Toxicity - Fish Low toxicity to fish.
Acute: LC50 (Lepomis macrochirus)(96 hour): 15400 mg/l
Chronic: NOEC (Pimephales promelas): 450 mg/l
Toxicity - Algae Low toxicity to algae.
EC50 (Pseudokirchneriella subcapitata) (96 hour): 22000 mg/l
Toxicity - Sediment Compartment Not classified.
Toxicity - Terrestrial Compartment Not classified.

12.2 Persistence and degradability

Readily biodegradable. Unlikely to persist.

12.3 Bioaccumulative potential

The substance has low potential for bioaccumulation.
Bioconcentration factor (BCF): <10

12.4 Mobility in soil

Miscible with water. The substance is predicted to have high mobility in soil.

12.5 Results of PBT and vPvB assessment

Not classified as PBT or vPvB.

12.6 Other adverse effects

Not known.

SECTION 13: DISPOSAL CONSIDERATIONS

13.1 Waste treatment methods
Dispose of this material and its container as hazardous waste. Dispose of empty
containers and wastes safely. Decontaminate empty containers before recycling.
Send to a licensed recycler, reclaimer or incinerator.

13.2 Additional Information

Disposal should be in accordance with local, state or national legislation.

SECTION 14: TRANSPORT INFORMATION

14.1 UN number
UN No. 1230

14.2 UN proper shipping name

UN proper shipping name METHANOL

14.3 Transport hazard class(es)

ADR/RID
ADR/RID Class 3
ADR Classification Code FT1
Special Provisions 279
Limited Quantities 1L
Excepted Quantities E2
Emergency Action Code •2WE
Mixed Packing Instructions for Packages P001 IBC02
Special Packing Provisions for Packages
Mixed Packing Instructions for Packages MP19
Packing Instructions for Portable Tanks T7
Special Provisions for Portable Tanks TP2
Tank Code for Tanks L4BH
Special Provisions for Tanks TU15
Vehicle for Tank Carriage FL
ADR Transport Category 2
Tunnel Restriction Code D/E
Special Provisions for Carriage - Loading, CV13 CV28
Unloading and Handling

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Special Provisions for Carriage - S2 S19

Operation
ADR HIN 336
IMDG
IMDG Class 3
Special Provisions 279
Limited Quantities 1L
Excepted Quantities E2
Mixed Packing Instructions for Packages P001 IBC02
Packing Instructions for Portable Tanks T7
Special Provisions for Portable Tanks TP2
IMDG EMS F-E, S-D
Stowage and Handling Category B SW2
ICAO/IATA
IATA Proper Shipping Name METHANOL
Excepted Quantities E2
Passenger and Cargo Aircraft Limited Y341
Quantities Packing Instructions
Passenger and Cargo Aircraft Limited 1L
Quantities Max net Qty
Passenger and Cargo Aircraft Packing 352
Instructions
Passenger and Cargo Aircraft Max net 1L
Qty
Cargo Aircraft Packing Instructions 364
Cargo Aircraft Max net Qty 60L
Special Provisions A113
Emergency Response Guidebook (ERG) 3L
Code
Labels
Labels 3 +6.1

14.4 Packing group

Packing group II

14.5 Environmental hazards

Environmental hazards Not classified as a Marine Pollutant.

14.6 Special precautions for user

Special precautions for user Not known.

14.7 Transport in bulk according to Annex II of Marpol and the IBC Code
No information available

SECTION 15: REGULATORY INFORMATION

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
European Regulations - Authorisations and/or Restrictions On Use
Candidate List of Substances of Very High Concern for Not listed
Authorisation
REACH: ANNEX XIV list of substances subject to authorisation Not listed
REACH: Annex XVII Restrictions on the manufacture, placing on Methanol (67-56-1), methyl acetate (79-20-9), Acetone (67-
the market and use of certain dangerous substances, mixtures 64-1), Ethanol (64-17-5), butanone (78-93-3), acetic acid
and articles (64-19-7)
Community Rolling Action Plan (CoRAP) Methanol (67-56-1), butanone (78-93-3)
Regulation (EC) N° 850/2004 of the European Parliament and of Not listed
the Council on persistent organic pollutants
Regulation (EC) N° 1005/2009 on substances that deplete the Not listed
ozone layer
Regulation (EU) N° 649/2012 of the European Parliament and of Not listed
the Council concerning the export and import of hazardous
chemicals

National regulations
Other Not known.

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15.2 Chemical Safety Assessment

A REACH chemical safety assessment has been carried out.

SECTION 16: OTHER INFORMATION

The following sections contain revisions or new statements: 1-16

LEGEND

Hazard Pictogram(s)

GHS02 GHS06 GHS08

GHS05: GHS: Corrosion

GHS07: GHS: Exclamation mark

Hazard classification Flam. Liq. 2 : Flammable liquid, Category 2

Flam. Liq. 3 : Flammable liquid, Category 3
Acute Tox. 3 : Acute toxicity, Category 3
Skin Corr. 1A : Skin corrosion/irritation, Category 1A
Eye Irrit. 2 : Serious eye damage/irritation, Category 2
STOT SE 3 : Specific target organ toxicity — single exposure, Category 3
STOT SE 1 : Specific target organ toxicity — single exposure, Category 1

Hazard Statement(s) H225: Highly flammable liquid and vapour.

H226: Flammable liquid and vapour.
H301: Toxic if swallowed.
H311: Toxic in contact with skin.
H314: Causes severe skin burns and eye damage.
H319: Causes serious eye irritation.
H331: Toxic if inhaled.
H336: May cause drowsiness or dizziness.
H370: Causes damage to organs.

Precautionary Statement(s) P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition
sources. No smoking.
P233: Keep container tightly closed.
P240: Ground and bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/equipment.
P242: Use non-sparking tools.
P243: Take action to prevent static discharges.
P260: Do not breathe vapour.
P264: Wash hands and exposed skin thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P302+P352: IF ON SKIN: Wash with plenty of water.
P303+P361+P353: IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for
breathing.
P308+P311: IF exposed or concerned: Call a POISON CENTER/doctor.
P312: Call a POISON CENTER/doctor if you feel unwell.
P330: Rinse mouth.
P361+P364: Take off immediately all contaminated clothing and wash it before
reuse.
P370+P378: In case of fire: Use water spray or fog, alcohol resistant foam, dry
chemical or carbon dioxide to extinguish.
P403+P235: Store in a well-ventilated place. Keep cool.
P405: Store locked up.
P501: Dispose of contents in accordance with local, state or national legislation.

Acronyms ADR : European Agreement concerning the International Carriage of Dangerous

Goods by Road
CAS : Chemical Abstracts Service
CLP : Regulation (EC) No 1272/2008 on classification, labelling and packaging of
substances and mixtures
DNEL : Derived No Effect Level

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EC : European Community
IATA : International Air Transport Association
IBC : Intermediate Bulk Container
ICAO : International Civil Aviation Organization
IMDG : International Maritime Dangerous Goods
LTEL : Long term exposure limit
PBT : Persistent, Bioaccumulative and Toxic
PNEC : Predicted No Effect Concentration
REACH : Registration, Evaluation, Authorisation and Restriction of Chemicals
RID : Regulations concerning the International Carriage of Dangerous Goods by Rail
STEL : Short term exposure limit
STOT : Specific Target Organ Toxicity
UN : United Nations
vPvB : very Persistent and very Bioaccumulative

Key literature references and sources for Regulation (EC) No. 1272/2008 (CLP)
data used to compile the SDS

Disclaimers Information contained in this publication or as otherwise supplied to Users is believed

to be accurate and is given in good faith, but it is for the Users to satisfy themselves
of the suitability of the product for their own particular purpose.
Qatar Fuel Additives Company Ltd. gives no warranty as to the fitness of the product
for any particular purpose and any implied warranty or condition (statutory or
otherwise) is excluded except to the extent that exclusion is prevented by law.
Qatar Fuel Additives Company Ltd. accepts no liability for loss or damage (other than
that arising from death or personal injury caused by defective product, if proved),
resulting from reliance on this information. Freedom under Patents, Copyright and
Designs cannot be assumed.

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Table of Contents
1. Exposure Scenario 1: Formulation and (re)packing of substance and mixtures .................................................................................... 11
1.1 Formulation of preparations (ERC 2) ............................................................................................................................................................... 11
1.2 Use in closed process, no likelihood of exposure (PROC 1) ........................................................................................................................... 11
1.3 Use in closed, continuous process with occasional controlled exposure (PROC 2) ....................................................................................... 11
1.4 Use in closed batch process (synthesis or formulation) (PROC 3) .................................................................................................................. 12
1.5 Use in batch and other process (synthesis) where opportunity for exposure arises (PROC 4) ...................................................................... 12
1.6 Mixing or blending in batch processes for formulation of preparations and articles (multistage and/or significant contact) (PROC5) .......... 13
1.7 Transfer of chemicals from / to vessel / large containers at non-dedicated facilities (PROC8a) .................................................................... 13
1.8 Transfer of chemicals from / to vessel / large containers at dedicated facilities (PROC 8b) ........................................................................... 13
1.9 Transfer of chemicals into small containers (dedicated filling line) (PROC 9) ................................................................................................. 14
1.10 Use of laboratory reagents in small scale laboratories (PROC 15) ............................................................................................................... 14
1.11 Exposure estimation .................................................................................................................................................................................... 15
1.12 Guidance to DU to evaluate whether he works inside the boundaries set by the ES .......................................................................... 17
2. Exposure Scenario 2: Use as a fuel in industrial settings ......................................................................................................................... 18
1.1 Industrial use of substances in closed systems (ERC 7) ................................................................................................................................. 18
1.2 Use in closed process, no likelihood of exposure (PROC 1) ........................................................................................................................... 18
1.3 Use in closed, continuous process with occasional controlled exposure (PROC 2) ....................................................................................... 18
1.4 Use in closed batch process (synthesis or formulation) (PROC 3) .................................................................................................................. 19
1.5 Transfer of chemicals from / to vessel / large containers at non-dedicated facilities (PROC8a) .................................................................... 19
1.6 Transfer of chemicals from / to vessel / large containers at dedicated facilities (PROC 8b) ........................................................................... 20
1.7 Using material as fuel sources, limited exposure to unburned product to be expected (PROC 16) ............................................................... 20
1.8 Hand-mixing with intimate contact and only PPE available (PROC 19) .......................................................................................................... 20
1.9 Exposure estimation ...................................................................................................................................................................................... 21
1.10 Guidance to DU to evaluate whether he works inside the boundaries set by the ES .......................................................................... 23
3. Exposure Scenario 3: Use as a fuel in professional setting ...................................................................................................................... 24
1.1 Industrial use of substances in closed systems (ERC 8b) .................................................................................................................... 24
1.2 Use in closed process, no likelihood of exposure (PROC 1) ........................................................................................................................... 24
1.3 Use in closed, continuous process with occasional controlled exposure (PROC 2) ....................................................................................... 24
1.4 Use in closed batch process (synthesis or formulation) (PROC 3) .................................................................................................................. 25
1.5 Transfer of chemicals from / to vessel / large containers at non-dedicated facilities (PROC8a) .................................................................... 25
1.6 Transfer of chemicals from / to vessel / large containers at dedicated facilities (PROC 8b) ........................................................................... 26
1.7 Using material as fuel sources, limited exposure to unburned product to be expected (PROC 16) ............................................................... 26
1.8 Hand-mixing with intimate contact and only PPE available (PROC 19) .......................................................................................................... 26
1.9 Exposure estimation ...................................................................................................................................................................................... 27
1.10 Guidance to DU to evaluate whether he works inside the boundaries set by the ES .......................................................................... 29
4. Exposure Scenario 4: Industrial use in cleaning agent .............................................................................................................................. 30
1.1 Industrial use of processing aids (ERC 8b) ........................................................................................................................................... 30
1.2 Use in closed process, no likelihood of exposure (PROC 1) ........................................................................................................................... 30
1.3 Use in closed, continuous process with occasional controlled exposure (PROC 2) ....................................................................................... 30
1.4 Use in closed batch process (synthesis or formulation) (PROC 3) .................................................................................................................. 31
1.5 Use in batch and other process (synthesis) where opportunity for exposure arises (PROC4) ....................................................................... 31
1.6 Industrial spraying (PROC 7) ............................................................................................................................................................................ 32
1.7 Transfer of chemicals from / to vessel / large containers at non-dedicated facilities (PROC 8a) ................................................................... 32
1.8 Transfer of chemicals from / to vessel / large containers at dedicated facilities (PROC 8b) ........................................................................... 32
1.9 Roller application or brushing (PROC 10) ........................................................................................................................................................ 33
1.10 Treatment of articles by dipping and pouring (PROC 13) .............................................................................................................................. 33
1.11 Exposure estimation .................................................................................................................................................................................... 34
1.12 Guidance to DU to evaluate whether he works inside the boundaries set by the ES .......................................................................... 36

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Methanol

1. Exposure Scenario 1: Formulation and (re)packing of substance and mixtures

SECTION 1: Title of exposure scenario

Formulation and (re)packing of substance and mixtures

Contributing scenario controlling environmental exposure

Formulation of preparations ERC2

Contributing scenario controlling worker exposure

Use in closed process, no likelihood of exposure PROC1

Use in closed, continuous process with occasional controlled exposure PROC2

Use in closed batch process (synthesis or formulation) PROC3

Use in batch and other process (synthesis) where opportunity for exposure arises PROC4

Mixing or blending in batch processes for formulation of preparations and articles (multistage PROC5
and/or significant contact)
Transfer of chemicals from / to vessel / large containers at non-dedicated facilities PROC8a

Transfer of chemicals from / to vessel / large containers at dedicated facilities PROC8b

Transfer of chemicals into small containers (dedicated filling line) PROC9

Use of laboratory reagents in small scale laboratories PROC15

SECTION 2: Conditions of use

2.1 Contributing scenario controlling environmental exposure:

1.1 Formulation of preparations (ERC 2)
As no environmental hazard was identified no environmental-related exposure assessment and risk characterization was
performed
2.2 Contributing scenario controlling worker exposure:
1.2 Use in closed process, no likelihood of exposure (PROC 1)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 240 cm²

Exposed skin surface, Short term, Systemic effects: 240 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: No

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: No
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.3 Contributing scenario controlling worker exposure:
1.3 Use in closed, continuous process with occasional controlled exposure (PROC 2)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High

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Methanol

Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 480 cm²

Exposed skin surface, Short term, Systemic effects: 480 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.4 Contributing scenario controlling worker exposure:
1.4 Use in closed batch process (synthesis or formulation) (PROC 3)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 240 cm²

Exposed skin surface, Short term, Systemic effects: 240 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.5 Contributing scenario controlling worker exposure:
1.5 Use in batch and other process (synthesis) where opportunity for exposure arises
(PROC 4)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 480 cm²

Exposed skin surface, Short term, Systemic effects: 480 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

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Methanol

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.6 Contributing scenario controlling worker exposure:
1.6 Mixing or blending in batch processes for formulation of preparations and articles
(multistage and/or significant contact) (PROC5)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 480 cm²

Exposed skin surface, Short term, Systemic effects: 480 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.7 Contributing scenario controlling worker exposure:
1.7 Transfer of chemicals from / to vessel / large containers at non-dedicated facilities
(PROC8a)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 960 cm²

Exposed skin surface, Short term, Systemic effects: 960 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.8 Contributing scenario controlling worker exposure:
1.8 Transfer of chemicals from / to vessel / large containers at dedicated facilities (PROC
8b)

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Methanol

Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 960 cm²

Exposed skin surface, Short term, Systemic effects: 960 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 95%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.9 Contributing scenario controlling worker exposure:
1.9 Transfer of chemicals into small containers (dedicated filling line) (PROC 9)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 480 cm²

Exposed skin surface, Short term, Systemic effects: 480 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Place of use: Indoor
Domain: Industrial
2.9 Contributing scenario controlling worker exposure:
1.10 Use of laboratory reagents in small scale laboratories (PROC 15)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 240 cm²

Exposed skin surface, Short term, Systemic effects: 240 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

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Methanol

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
SECTION 3: 1.11 Exposure estimation

3.1. Environment

As no environmental hazard was identified no environmental-related exposure assessment and risk characterization was
performed
3.2. Worker

Contributing scenario controlling worker exposure: Use in closed process, no likelihood of exposure (PROC 1)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Inhalation, Systemic effects, 0.013351 mg/m³ 130 mg/m³ 0.000103
Long Term
Inhalation, Systemic effects, 0.053403 mg/m³ 130 mg/m³ 0.000411
Short term
Dermal, Systemic effects, 0.034286 mg/kg bw/day 20 mg/kg bw/day 0.001714
Long Term
Dermal, Systemic effects, 0.034286 mg/kg bw/day 20 mg/kg bw/day 0.001714
Short term
Combined routes, Systemic 0.036193 mg/kg bw/day - 0.001817
effects, Long Term
Combined routes, Systemic 0.041915 mg/kg bw/day - 0.002125
effects, Short term
Contributing scenario controlling worker exposure: Use in closed, continuous process with occasional controlled exposure
(PROC 2)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 0.274286 mg/kg bw/day 20 mg/kg bw/day 0.013174
Long Term
Dermal, Systemic effects, 0.274286 mg/kg bw/day 20 mg/kg bw/day 0.013174
Short term
Inhalation, Systemic effects, 3.338 mg/m³ 130 mg/m³ 0.025675
Long Term
Inhalation, Systemic effects, 13.351 mg/m³ 130 mg/m³ 0.102698
Short term
Combined routes, Systemic 0.7511mg/kg bw/day - 0.039389
effects, Long Term
Combined routes, Systemic 2.182 mg/kg bw/day - 0.116413
effects, Short term
Contributing scenario controlling worker exposure: Use in closed batch process (synthesis or formulation) (PROC 3)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Long Term
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Short term
Inhalation, Systemic effects, 6.675 mg/m³ 130 mg/m³ 0.051349
Long Term
Inhalation, Systemic effects, 26.702 mg/m³ 130 mg/m³ 0.205397
Short term

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Methanol

Combined routes, Systemic 1.091 mg/kg bw/day - 0.058206

effects, Long Term
Combined routes, Systemic 3.952 mg/kg bw/day - 0.212254
effects, Short term
Contributing scenario controlling worker exposure: Use in batch and other process (synthesis) where opportunity for
exposure arises (PROC 4)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 1.371 mg/kg bw/day 20 mg/kg bw/day 0.068571
Long Term
Dermal, Systemic effects, 1.371 mg/kg bw/day 20 mg/kg bw/day 0.068571
Short term
Inhalation, Systemic effects, 13.351 mg/m³ 130 mg/m³ 0.102698
Long Term
Inhalation, Systemic effects, 53.403 mg/m³ 130 mg/m³ 0.410794
Short term
Combined routes, Systemic 3.279 mg/kg bw/day - 0.17127
effects, Long Term
Combined routes, Systemic 9 mg/kg bw/day - 0.479365
effects, Short term
Contributing scenario controlling worker exposure: Mixing or blending in batch processes for formulation of preparations
and articles (multistage and/or significant contact) (PROC 5)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Long Term
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Short term
Inhalation, Systemic effects, 33.377 mg/m³ 130 mg/m³ 0.256746
Long Term
Inhalation, Systemic effects, 13.351 mg/m³ 130 mg/m³ 0.102698
Short term
Combined routes, Systemic 7.511 mg/kg bw/day - 0.393889
effects, Long Term
Combined routes, Systemic 4.65 mg/kg bw/day - 0.239841
effects, Short term
Contributing scenario controlling worker exposure: Transfer of chemicals from / to vessel / large containers at non-
dedicated facilities (PROC 8a)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Long Term
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Short term
Inhalation, Systemic effects, 33.377 mg/m³ 130 mg/m³ 0.256746
Long Term
Inhalation, Systemic effects, 66.754 mg/m³ 130 mg/m³ 0.513492
Short term
Combined routes, Systemic 7.511 mg/kg bw/day - 0.393889
effects, Long Term
Combined routes, Systemic 12.279 mg/kg bw/day - 0.650635
effects, Short term
Contributing scenario controlling worker exposure: Transfer of chemicals from / to vessel / large containers at dedicated
facilities (PROC 8b)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Long Term

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Methanol

Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143

Short term
Inhalation, Systemic effects, 10.013 mg/m³ 130 mg/m³ 0.077024
Long Term
Inhalation, Systemic effects, 20.026 mg/m³ 130 mg/m³ 0.154048
Short term
Combined routes, Systemic 4.173 mg/kg bw/day - 0.214167
effects, Long Term
Combined routes, Systemic 5.604 mg/kg bw/day - 0.29119
effects, Short term
Contributing scenario controlling worker exposure: Transfer of chemicals into small containers (dedicated filling line)
(PROC 9)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 1.371 mg/kg bw/day 20 mg/kg bw/day 0.068571
Long Term
Dermal, Systemic effects, 1.371 mg/kg bw/day 20 mg/kg bw/day 0.068571
Short term
Inhalation, Systemic effects, 26.702 mg/m³ 130 mg/m³ 0.205397
Long Term
Inhalation, Systemic effects, 53.403 mg/m³ 130 mg/m³ 0.410794
Short term
Combined routes, Systemic 5.186 mg/kg bw/day - 0.273968
effects, Long Term
Combined routes, Systemic 9 mg/kg bw/day - 0.479365
effects, Short term
Contributing scenario controlling worker exposure: Use of laboratory reagents in small scale laboratories (PROC 15)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Dermal, Systemic effects, 0.068571 mg/kg bw/day 20 mg/kg bw/day 0.003429
Long Term
Dermal, Systemic effects, 0.068571 mg/kg bw/day 20 mg/kg bw/day 0.003429
Short term
Inhalation, Systemic effects, 6.675 mg/m³ 130 mg/m³ 0.051349
Long Term
Inhalation, Systemic effects, 13.351 mg/m³ 130 mg/m³ 0.102698
Short term
Combined routes, Systemic 1.022 mg/kg bw/day - 0.054778
effects, Long Term
Combined routes, Systemic 1.976 mg/kg bw/day - 0.106127
effects, Short term
SECTION 4: 1.12 Guidance to DU to evaluate whether he works inside the boundaries set by the ES

4.1 Health

Where other Risk Management Measures/Operational Conditions are adopted, then users should ensure that risks are
managed to at least equivalent levels.
4.2 Environment

Guidance is based on assumed operating conditions which may not be applicable to all sites; thus, scaling could be necessary
to define appropriate site-specific risk management measures. If scaling reveals a condition of unsafe use, additional RMMs
or a site-specific chemical safety assessment is required.

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Methanol

2. Exposure Scenario 2: Use as a fuel in industrial settings

SECTION 1: Title of exposure scenario

Use as a fuel in industrial settings

Contributing scenario controlling environmental exposure

Industrial use of substances in closed systems ERC7

Contributing scenario controlling worker exposure

Use in closed process, no likelihood of exposure PROC1

Use in closed, continuous process with occasional controlled exposure PROC2

Use in closed batch process (synthesis or formulation) PROC3

Transfer of chemicals from / to vessel / large containers at non-dedicated facilities PROC8a

Transfer of chemicals from / to vessel / large containers at dedicated facilities PROC8b

Using material as fuel sources, limited exposure to unburned product to be expected PROC16

Hand-mixing with intimate contact and only PPE available PROC19

SECTION 2: Conditions of use

2.1 Contributing scenario controlling environmental exposure:

1.1 Industrial use of substances in closed systems (ERC 7)
As no environmental hazard was identified no environmental-related exposure assessment and risk characterization was
performed
2.2 Contributing scenario controlling worker exposure:
1.2 Use in closed process, no likelihood of exposure (PROC 1)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 240 cm²

Exposed skin surface, Short term, Systemic effects: 240 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: No

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: No
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.3 Contributing scenario controlling worker exposure:
1.3 Use in closed, continuous process with occasional controlled exposure (PROC 2)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 480 cm²

Exposed skin surface, Short term, Systemic effects: 480 cm²

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Methanol

Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.4 Contributing scenario controlling worker exposure:
1.4 Use in closed batch process (synthesis or formulation) (PROC 3)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 240 cm²

Exposed skin surface, Short term, Systemic effects: 240 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.5 Contributing scenario controlling worker exposure:
1.5 Transfer of chemicals from / to vessel / large containers at non-dedicated facilities
(PROC8a)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 960 cm²

Exposed skin surface, Short term, Systemic effects: 960 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]

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Methanol

Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.6 Contributing scenario controlling worker exposure:
1.6 Transfer of chemicals from / to vessel / large containers at dedicated facilities (PROC
8b)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 960 cm²

Exposed skin surface, Short term, Systemic effects: 960 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 95%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.7 Contributing scenario controlling worker exposure:
1.7 Using material as fuel sources, limited exposure to unburned product to be expected
(PROC 16)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 240 cm²

Exposed skin surface, Short term, Systemic effects: 240 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: No

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Place of use: Indoor
Domain: Industrial
2.8 Contributing scenario controlling worker exposure:
1.8 Hand-mixing with intimate contact and only PPE available (PROC 19)
Product characteristics

Percentage (w/w) of substance in mixture/article: 10%

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

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Methanol

Exposed skin surface, Long Term, Systemic effects: 1980 cm²

Exposed skin surface, Short term, Systemic effects: 1980 cm²
Frequency and duration of use

Duration of activity: 1 - 4 hour(s)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: No

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
SECTION 3: 1.9 Exposure estimation

3.1. Environment

As no environmental hazard was identified no environmental-related exposure assessment and risk characterization was
performed
3.2. Worker

Contributing scenario controlling worker exposure: Use in closed process, no likelihood of exposure (PROC 1)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Inhalation, Systemic effects, 0.013351 mg/m³ 130 mg/m³ 0.000103
Long Term
Inhalation, Systemic effects, 0.053403 mg/m³ 130 mg/m³ 0.000411
Short term
Dermal, Systemic effects, 0.034286 mg/kg bw/day 20 mg/kg bw/day 0.001714
Long Term
Dermal, Systemic effects, 0.034286 mg/kg bw/day 20 mg/kg bw/day 0.001714
Short term
Combined routes, Systemic 0.036193 mg/kg bw/day - 0.001817
effects, Long Term
Combined routes, Systemic 0.041915 mg/kg bw/day - 0.002125
effects, Short term
Contributing scenario controlling worker exposure: Use in closed, continuous process with occasional controlled exposure
(PROC 2)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 0.274286 mg/kg bw/day 20 mg/kg bw/day 0.013714
Long Term
Dermal, Systemic effects, 0.274286 mg/kg bw/day 20 mg/kg bw/day 0.013714
Short term
Inhalation, Systemic effects, 3.338 mg/m³ 130 mg/m³ 0.025675
Long Term
Inhalation, Systemic effects, 13.351 mg/m³ 130 mg/m³ 0.102698
Short term
Combined routes, Systemic 0.7511mg/kg bw/day - 0.039389
effects, Long Term
Combined routes, Systemic 2.182 mg/kg bw/day - 0.116413
effects, Short term
Contributing scenario controlling worker exposure: Use in closed batch process (synthesis or formulation) (PROC 3)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Long Term
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Short term

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Inhalation, Systemic effects, 6.675 mg/m³ 130 mg/m³ 0.051349

Long Term
Inhalation, Systemic effects, 26.702 mg/m³ 130 mg/m³ 0.205397
Short term
Combined routes, Systemic 1.091 mg/kg bw/day - 0.058206
effects, Long Term
Combined routes, Systemic 3.952 mg/kg bw/day - 0.212254
effects, Short term
Contributing scenario controlling worker exposure: Transfer of chemicals from / to vessel / large containers at non-
dedicated facilities (PROC 8a)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Long Term
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Short term
Inhalation, Systemic effects, 33.377 mg/m³ 130 mg/m³ 0.256746
Long Term
Inhalation, Systemic effects, 66.754 mg/m³ 130 mg/m³ 0.513492
Short term
Combined routes, Systemic 7.511 mg/kg bw/day - 0.393889
effects, Long Term
Combined routes, Systemic 12.279 mg/kg bw/day - 0.650635
effects, Short term
Contributing scenario controlling worker exposure: Transfer of chemicals from / to vessel / large containers at dedicated
facilities (PROC 8b)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Long Term
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Short term
Inhalation, Systemic effects, 10.013 mg/m³ 130 mg/m³ 0.077024
Long Term
Inhalation, Systemic effects, 20.026 mg/m³ 130 mg/m³ 0.154048
Short term
Combined routes, Systemic 4.173 mg/kg bw/day - 0.214167
effects, Long Term
Combined routes, Systemic 5.604 mg/kg bw/day - 0.29119
effects, Short term
Contributing scenario controlling worker exposure: Using material as fuel sources, limited exposure to unburned product
to be expected (PROC 16)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 0.068571 mg/kg bw/day 20 mg/kg bw/day 0.003429
Long Term
Dermal, Systemic effects, 0.041143 mg/kg bw/day 20 mg/kg bw/day 0.002057
Short term
Inhalation, Systemic effects, 33.377 mg/m³ 130 mg/m³ 0.256746
Long Term
Inhalation, Systemic effects, 80.105 mg/m³ 130 mg/m³ 0.61619
Short term
Combined routes, Systemic 4.837 mg/kg bw/day - 0.260175
effects, Long Term
Combined routes, Systemic 11.485 mg/kg bw/day - 0.618248
effects, Short term
Contributing scenario controlling worker exposure: Hand-mixing with intimate contact and only PPE available (PROC 19)

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Methanol

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Dermal, Systemic effects, 1.697 mg/kg bw/day 20 mg/kg bw/day 0.084857
Long Term
Dermal, Systemic effects, 1.697 mg/kg bw/day 20 mg/kg bw/day 0.084857
Short term
Inhalation, Systemic effects, 20.062 mg/m³ 130 mg/m³ 0.154048
Long Term
Inhalation, Systemic effects, 66.754 mg/m³ 130 mg/m³ 0.513492
Short term
Combined routes, Systemic 4.588 mg/kg bw/day - 0.238905
effects, Long Term
Combined routes, Systemic 11.233 mg/kg bw/day - 0.598349
effects, Short term
SECTION 4: 1.10 Guidance to DU to evaluate whether he works inside the boundaries set by the ES

4.1 Health

Where other Risk Management Measures/Operational Conditions are adopted, then users should ensure that risks are
managed to at least equivalent levels.
4.2 Environment

Guidance is based on assumed operating conditions which may not be applicable to all sites; thus, scaling could be necessary
to define appropriate site-specific risk management measures. If scaling reveals a condition of unsafe use, additional RMMs
or a site-specific chemical safety assessment is required.

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Methanol

3. Exposure Scenario 3: Use as a fuel in professional setting

SECTION 1: Title of exposure scenario

Use as a fuel in professional setting

Contributing scenario controlling environmental exposure

Wide dispersive indoor use of reactive substances in open systems ERC8b

Wide dispersive outdoor use of reactive substances in open systems ERC8e

Contributing scenario controlling worker exposure

Use in closed process, no likelihood of exposure PROC1

Use in closed, continuous process with occasional controlled exposure PROC2

Use in closed batch process (synthesis or formulation) PROC3

Transfer of chemicals from / to vessel / large containers at non-dedicated facilities PROC8a

Transfer of chemicals from / to vessel / large containers at dedicated facilities PROC8b

Using material as fuel sources, limited exposure to unburned product to be expected PROC16

Hand-mixing with intimate contact and only PPE available PROC19

SECTION 2: Conditions of use

2.1 Contributing scenario controlling environmental exposure:

1.1 Industrial use of substances in closed systems (ERC 8b)
Wide dispersive outdoor use of reactive substances in open systems (ERC 8e)
As no environmental hazard was identified no environmental-related exposure assessment and risk characterization was
performed
2.2 Contributing scenario controlling worker exposure:
1.2 Use in closed process, no likelihood of exposure (PROC 1)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 240 cm²

Exposed skin surface, Short term, Systemic effects: 240 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: No

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: No
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Professional
2.3 Contributing scenario controlling worker exposure:
1.3 Use in closed, continuous process with occasional controlled exposure (PROC 2)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

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Exposed skin surface, Long Term, Systemic effects: 480 cm²

Exposed skin surface, Short term, Systemic effects: 480 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 80%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Professional
2.4 Contributing scenario controlling worker exposure:
1.4 Use in closed batch process (synthesis or formulation) (PROC 3)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 960 cm²

Exposed skin surface, Short term, Systemic effects: 960 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Professional
2.5 Contributing scenario controlling worker exposure:
1.5 Transfer of chemicals from / to vessel / large containers at non-dedicated facilities
(PROC8a)
Product characteristics

Percentage (w/w) of substance in mixture/article: 5 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 480 cm²

Exposed skin surface, Short term, Systemic effects: 480 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: No

Conditions and measures related to personal protection, hygiene and health evaluation

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Methanol

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Professional
2.6 Contributing scenario controlling worker exposure:
1.6 Transfer of chemicals from / to vessel / large containers at dedicated facilities (PROC
8b)
Product characteristics

Percentage (w/w) of substance in mixture/article: 5 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 960 cm²

Exposed skin surface, Short term, Systemic effects: 960 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: No

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Professional
2.7 Contributing scenario controlling worker exposure:
1.7 Using material as fuel sources, limited exposure to unburned product to be expected
(PROC 16)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 240 cm²

Exposed skin surface, Short term, Systemic effects: 240 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: No

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Professional
2.8 Contributing scenario controlling worker exposure:
1.8 Hand-mixing with intimate contact and only PPE available (PROC 19)
Product characteristics

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Methanol

Percentage (w/w) of substance in mixture/article: 10%

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 1980 cm²

Exposed skin surface, Short term, Systemic effects: 1980 cm²
Frequency and duration of use

Duration of activity: 1 - 4 hour(s)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: No

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Professional
SECTION 3: 1.9 Exposure estimation

3.1. Environment

As no environmental hazard was identified no environmental-related exposure assessment and risk characterization was
performed
3.2. Worker

Contributing scenario controlling worker exposure: Use in closed process, no likelihood of exposure (PROC 1)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Inhalation, Systemic effects, 0.0133508 mg/m³ 130 mg/m³ 0.001027
Long Term
Inhalation, Systemic effects, 0.534032 mg/m³ 130 mg/m³ 0.004108
Short term
Dermal, Systemic effects, 0.034286 mg/kg bw/day 20 mg/kg bw/day 0.001714
Long Term
Dermal, Systemic effects, 0.034286 mg/kg bw/day 20 mg/kg bw/day 0.001714
Short term
Combined routes, Systemic 0.053358 mg/kg bw/day - 0.002741
effects, Long Term
Combined routes, Systemic 0.110576 mg/kg bw/day - 0.005822
effects, Short term
Contributing scenario controlling worker exposure: Use in closed, continuous process with occasional controlled exposure
(PROC 2)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 0.274286 mg/kg bw/day 20 mg/kg bw/day 0.013174
Long Term
Dermal, Systemic effects, 0.274286 mg/kg bw/day 20 mg/kg bw/day 0.013174
Short term
Inhalation, Systemic effects, 13.351 mg/m³ 130 mg/m³ 0.102698
Long Term
Inhalation, Systemic effects, 53.403 mg/m³ 130 mg/m³ 0.410794
Short term
Combined routes, Systemic 2.182 mg/kg bw/day - 0.116413
effects, Long Term
Combined routes, Systemic 7.903 mg/kg bw/day - 0.424508
effects, Short term

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Methanol

Contributing scenario controlling worker exposure: Use in closed batch process (synthesis or formulation) (PROC 3)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Long Term
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Short term
Inhalation, Systemic effects, 26.702 mg/m³ 130 mg/m³ 0.205397
Long Term
Inhalation, Systemic effects, 106.806 mg/m³ 130 mg/m³ 0.821587
Short term
Combined routes, Systemic 3.952 mg/kg bw/day - 0.212254
effects, Long Term
Combined routes, Systemic 15.395 mg/kg bw/day - 0.828444
effects, Short term
Contributing scenario controlling worker exposure: Transfer of chemicals from / to vessel / large containers at non-
dedicated facilities (PROC 8a)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Long Term
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Short term
Inhalation, Systemic effects, 33.377 mg/m³ 130 mg/m³ 0.256746
Long Term
Inhalation, Systemic effects, 66.754 mg/m³ 130 mg/m³ 0.513492
Short term
Combined routes, Systemic 4.905 mg/kg bw/day - 0.263603
effects, Long Term
Combined routes, Systemic 9.673 mg/kg bw/day - 0.520349
effects, Short term
Contributing scenario controlling worker exposure: Transfer of chemicals from / to vessel / large containers at dedicated
facilities (PROC 8b)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Long Term
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Short term
Inhalation, Systemic effects, 16.688 mg/m³ 130 mg/m³ 0.128373
Long Term
Inhalation, Systemic effects, 33.377 mg/m³ 130 mg/m³ 0.256746
Short term
Combined routes, Systemic 2.521 mg/kg bw/day - 0.13523
effects, Long Term
Combined routes, Systemic 4.905 mg/kg bw/day - 0.263603
effects, Short term
Contributing scenario controlling worker exposure: Using material as fuel sources, limited exposure to unburned product
to be expected (PROC 16)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 0.068571 mg/kg bw/day 20 mg/kg bw/day 0.003429
Long Term
Dermal, Systemic effects, 0.041143 mg/kg bw/day 20 mg/kg bw/day 0.002057
Short term
Inhalation, Systemic effects, 66.754 mg/m³ 130 mg/m³ 0.513492
Long Term

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Methanol

Inhalation, Systemic effects, 112.147 mg/m³ 130 mg/m³ 0.862667

Short term
Combined routes, Systemic 9.605 mg/kg bw/day - 0.516921
effects, Long Term
Combined routes, Systemic 16.062 mg/kg bw/day - 0.864724
effects, Short term
Contributing scenario controlling worker exposure: Hand-mixing with intimate contact and only PPE available (PROC 19)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Dermal, Systemic effects, 1.697 mg/kg bw/day 20 mg/kg bw/day 0.084857
Long Term
Dermal, Systemic effects, 1.697 mg/kg bw/day 20 mg/kg bw/day 0.084857
Short term
Inhalation, Systemic effects, 40.052 mg/m³ 130 mg/m³ 0.308095
Long Term
Inhalation, Systemic effects, 13.351 mg/m³ 130 mg/m³ 0.102698
Short term
Combined routes, Systemic 7.419 mg/kg bw/day - 0.392952
effects, Long Term
Combined routes, Systemic 3.604 mg/kg bw/day - 0.187556
effects, Short term
SECTION 4: 1.10 Guidance to DU to evaluate whether he works inside the boundaries set by the ES

4.1 Health

Where other Risk Management Measures/Operational Conditions are adopted, then users should ensure that risks are
managed to at least equivalent levels.
4.2 Environment

Guidance is based on assumed operating conditions which may not be applicable to all sites; thus, scaling could be necessary
to define appropriate site-specific risk management measures. If scaling reveals a condition of unsafe use, additional RMMs
or a site-specific chemical safety assessment is required.

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Methanol

4. Exposure Scenario 4: Industrial use in cleaning agent

SECTION 1: Title of exposure scenario

Industrial use in cleaning agent

Contributing scenario controlling environmental exposure

Industrial use of processing aids ERC4

Contributing scenario controlling worker exposure

Use in closed process, no likelihood of exposure PROC1

Use in closed, continuous process with occasional controlled exposure PROC2

Use in closed batch process (synthesis or formulation) PROC3

Use in batch and other process (synthesis) where opportunity for exposure arises PROC4

Industrial spraying PROC7

Transfer of chemicals from / to vessel / large containers at non-dedicated facilities PROC8a

Transfer of chemicals from / to vessel / large containers at dedicated facilities PROC8b

Roller application or brushing PROC10

Treatment of articles by dipping and pouring PROC13

SECTION 2: Conditions of use

2.1 Contributing scenario controlling environmental exposure:

1.1 Industrial use of processing aids (ERC 8b)
As no environmental hazard was identified no environmental-related exposure assessment and risk characterization was
performed
2.2 Contributing scenario controlling worker exposure:
1.2 Use in closed process, no likelihood of exposure (PROC 1)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 240 cm²

Exposed skin surface, Short term, Systemic effects: 240 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: No

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: No
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.3 Contributing scenario controlling worker exposure:
1.3 Use in closed, continuous process with occasional controlled exposure (PROC 2)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High

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Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 480 cm²

Exposed skin surface, Short term, Systemic effects: 480 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.4 Contributing scenario controlling worker exposure:
1.4 Use in closed batch process (synthesis or formulation) (PROC 3)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 240 cm²

Exposed skin surface, Short term, Systemic effects: 240 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.5 Contributing scenario controlling worker exposure:
1.5 Use in batch and other process (synthesis) where opportunity for exposure arises
(PROC4)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 480 cm²

Exposed skin surface, Short term, Systemic effects: 480 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

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Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.6 Contributing scenario controlling worker exposure:
1.6 Industrial spraying (PROC 7)
Product characteristics

Percentage (w/w) of substance in mixture/article: 25 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 1500 cm²

Exposed skin surface, Short term, Systemic effects: 1500 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: No

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: Yes [Effectiveness, 90%]

Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
Ventilation: Good (30%)
2.7 Contributing scenario controlling worker exposure:
1.7 Transfer of chemicals from / to vessel / large containers at non-dedicated facilities
(PROC 8a)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100 %

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 960 cm²

Exposed skin surface, Short term, Systemic effects: 960 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.8 Contributing scenario controlling worker exposure:
1.8 Transfer of chemicals from / to vessel / large containers at dedicated facilities (PROC
8b)

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Product characteristics

Percentage (w/w) of substance in mixture/article: 10%

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 960 cm²

Exposed skin surface, Short term, Systemic effects: 960 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 95%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.9 Contributing scenario controlling worker exposure:
1.9 Roller application or brushing (PROC 10)
Product characteristics

Percentage (w/w) of substance in mixture/article: 80%

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 960 cm²

Exposed skin surface, Short term, Systemic effects: 960 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)
Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
2.10 Contributing scenario controlling worker exposure:
1.10 Treatment of articles by dipping and pouring (PROC 13)
Product characteristics

Percentage (w/w) of substance in mixture/article: 100%

Physical form of the used product: Liquid
Dustiness: High
Human factors not influenced by risk management

Exposed skin surface, Long Term, Systemic effects: 480 cm²

Exposed skin surface, Short term, Systemic effects: 480 cm²
Frequency and duration of use

Duration of activity: > 4 hour(s) (default)

Frequency of use: 5 days / week(s)

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Technical conditions and measures to control dispersion from source towards the worker

Local exhaust ventilation: Yes [Effectiveness, Inhalation: 90%]

Conditions and measures related to personal protection, hygiene and health evaluation

Respiratory protection: No
Dermal protection: Gloves APF 5 [Effectiveness, Dermal: 80%]
Other given operational conditions affecting workers exposure

Place of use: Indoor

Domain: Industrial
SECTION 3: 1.11 Exposure estimation

3.1. Environment

As no environmental hazard was identified no environmental-related exposure assessment and risk characterization was
performed
3.2. Worker

Contributing scenario controlling worker exposure: Use in closed process, no likelihood of exposure (PROC 1)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Inhalation, Systemic effects, 0.013351 mg/m³ 130 mg/m³ 0.000103
Long Term
Inhalation, Systemic effects, 0.053403 mg/m³ 130 mg/m³ 0.000411
Short term
Dermal, Systemic effects, 0.034286 mg/kg bw/day 20 mg/kg bw/day 0.001714
Long Term
Dermal, Systemic effects, 0.034286 mg/kg bw/day 20 mg/kg bw/day 0.001714
Short term
Combined routes, Systemic 0.036193 mg/kg bw/day - 0.001817
effects, Long Term
Combined routes, Systemic 0.041915 mg/kg bw/day - 0.002125
effects, Short term
Contributing scenario controlling worker exposure: Use in closed, continuous process with occasional controlled exposure
(PROC 2)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 0.274286 mg/kg bw/day 20 mg/kg bw/day 0.013174
Long Term
Dermal, Systemic effects, 0.274286 mg/kg bw/day 20 mg/kg bw/day 0.013174
Short term
Inhalation, Systemic effects, 3.338 mg/m³ 130 mg/m³ 0.025675
Long Term
Inhalation, Systemic effects, 13.351 mg/m³ 130 mg/m³ 0.102698
Short term
Combined routes, Systemic 0.7511 mg/kg bw/day - 0.039389
effects, Long Term
Combined routes, Systemic 2.182 mg/kg bw/day - 0.116413
effects, Short term
Contributing scenario controlling worker exposure: Use in closed batch process (synthesis or formulation) (PROC 3)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Long Term
Dermal, Systemic effects, 0.137143 mg/kg bw/day 20 mg/kg bw/day 0.006857
Short term
Inhalation, Systemic effects, 6.675 mg/m³ 130 mg/m³ 0.051349
Long Term

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 Annex to the extended Safety Data Sheet (eSDS)

Methanol

Inhalation, Systemic effects, 26.702 mg/m³ 130 mg/m³ 0.205397

Short term
Combined routes, Systemic 1.091 mg/kg bw/day - 0.058206
effects, Long Term
Combined routes, Systemic 3.952 mg/kg bw/day - 0.212254
effects, Short term
Contributing scenario controlling worker exposure: Use in batch and other process (synthesis) where opportunity for
exposure arises (PROC 4)
Exposure route Exposure estimate - Worker DNEL Risk quantification (RCR)

Dermal, Systemic effects, 1.371 mg/kg bw/day 20 mg/kg bw/day 0.0068571

Long Term
Dermal, Systemic effects, 1.371 mg/kg bw/day 20 mg/kg bw/day 0.0068571
Short term
Inhalation, Systemic effects, 13.351 mg/m³ 130 mg/m³ 0.102698
Long Term
Inhalation, Systemic effects, 53.403 mg/m³ 130 mg/m³ 0.410794
Short term
Combined routes, Systemic 3.279 mg/kg bw/day - 0.17127
effects, Long Term
Combined routes, Systemic 9 mg/kg bw/day - 0.479365
effects, Short term
Contributing scenario controlling worker exposure: Industrial spraying (PROC 7)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Dermal, Systemic effects, 2.143 mg/kg bw/day 20 mg/kg bw/day 0.107143
Long Term
Dermal, Systemic effects, 2.143 mg/kg bw/day 20 mg/kg bw/day 0.107143
Short term
Inhalation, Systemic effects, 19.14 mg/m³ 130 mg/m³ 0.147231
Long Term
Inhalation, Systemic effects, 19.14 mg/m³ 130 mg/m³ 0.147231
Short term
Combined routes, Systemic 4.877 mg/kg bw/day - 0.254374
effects, Long Term
Combined routes, Systemic 4.877 mg/kg bw/day - 0.254374
effects, Short term
Contributing scenario controlling worker exposure: Transfer of chemicals from / to vessel / large containers at non-
dedicated facilities (PROC 8a)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Long Term
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Short term
Inhalation, Systemic effects, 33.377 mg/m³ 130 mg/m³ 0.256746
Long Term
Inhalation, Systemic effects, 66.754 mg/m³ 130 mg/m³ 0.513492
Short term
Combined routes, Systemic 7.511 mg/kg bw/day - 0.393889
effects, Long Term
Combined routes, Systemic 12.279 mg/kg bw/day - 0.650635
effects, Short term
Contributing scenario controlling worker exposure: Transfer of chemicals from / to vessel / large containers at dedicated
facilities (PROC 8b)
Exposure route Exposure estimate - DNEL Risk quantification (RCR)
Worker

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 Annex to the extended Safety Data Sheet (eSDS)

Methanol

Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143

Long Term
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Short term
Inhalation, Systemic effects, 10.013 mg/m³ 130 mg/m³ 0.077024
Long Term
Inhalation, Systemic effects, 20.026 mg/m³ 130 mg/m³ 0.154048
Short term
Combined routes, Systemic 4.173 mg/kg bw/day - 0.214167
effects, Long Term
Combined routes, Systemic 5.604 mg/kg bw/day - 0.29119
effects, Short term
Contributing scenario controlling worker exposure: Roller application or brushing (PROC 10)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Dermal, Systemic effects, 4.389 mg/kg bw/day 20 mg/kg bw/day 0.219429
Long Term
Dermal, Systemic effects, 4.389 mg/kg bw/day 20 mg/kg bw/day 0.219429
Short term
Inhalation, Systemic effects, 26.702 mg/m³ 130 mg/m³ 0.205397
Long Term
Inhalation, Systemic effects, 53.403 mg/m³ 130 mg/m³ 0.410794
Short term
Combined routes, Systemic 8.203 mg/kg bw/day - 0.424825
effects, Long Term
Combined routes, Systemic 12.018 mg/kg bw/day - 0.630222
effects, Short term
Contributing scenario controlling worker exposure: Treatment of articles by dipping and pouring (PROC 13)

Exposure route Exposure estimate - DNEL Risk quantification (RCR)

Worker
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Long Term
Dermal, Systemic effects, 2.743 mg/kg bw/day 20 mg/kg bw/day 0.137143
Short term
Inhalation, Systemic effects, 33.377 mg/m³ 130 mg/m³ 0.256746
Long Term
Inhalation, Systemic effects, 66.754 mg/m³ 130 mg/m³ 0.513492
Short term
Combined routes, Systemic 7.511 mg/kg bw/day - 0.393889
effects, Long Term
Combined routes, Systemic 12.279 mg/kg bw/day - 0.650635
effects, Short term
SECTION 4: 1.12 Guidance to DU to evaluate whether he works inside the boundaries set by the ES

4.1 Health

Where other Risk Management Measures/Operational Conditions are adopted, then users should ensure that risks are
managed to at least equivalent levels.
4.2 Environment

Guidance is based on assumed operating conditions which may not be applicable to all sites; thus, scaling could be necessary
to define appropriate site-specific risk management measures. If scaling reveals a condition of unsafe use, additional RMMs
or a site-specific chemical safety assessment is required.

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