Here are multiple-choice questions (MCQs) based on the provided document on drug
interactions:
### MCQ Quiz
#### 1. Definition of Drug Interactions
**Question:** Drug interactions can be broadly categorized into which two main types?
- A. Pharmacokinetic and Pharmacodynamic
- B. Pharmacologic and Therapeutic
- C. Biological and Chemical
- D. Acute and Chronic
**Answer:** A. Pharmacokinetic and Pharmacodynamic
#### 2. Risk Factors for Drug Interactions
**Question:** Which of the following is NOT a risk factor for drug interactions?
- A. Age
- B. Gender
- C. Diet
- D. Eye color
**Answer:** D. Eye color
#### 3. Drug-Drug Interaction (DDI)
**Question:** A drug-drug interaction (DDI) is defined as:
- A. A beneficial effect of drug interaction
- B. A harmful effect of drug interaction
- C. A clinically meaningful alteration in the exposure and/or response to a drug due to another
drug
- D. An interaction between a drug and a nutrient
**Answer:** C. A clinically meaningful alteration in the exposure and/or response to a drug due
to another drug
#### 4. Polypharmacy
**Question:** Polypharmacy is defined as:
- A. The use of a single drug
- B. The concomitant use of multiple drugs or the administration of more medications than are
clinically indicated
- C. The use of herbal supplements
- D. The use of over-the-counter medications
**Answer:** B. The concomitant use of multiple drugs or the administration of more
medications than are clinically indicated
#### 5. Elderly Patients and Drug Interactions
**Question:** Why are elderly patients at an increased risk of drug interactions?
- A. They have a stronger metabolism
- B. They are less likely to take multiple medications
- C. They have higher rates of polypharmacy and multiple comorbidities
- D. They have a faster renal excretion rate
**Answer:** C. They have higher rates of polypharmacy and multiple comorbidities
#### 6. Smoking and Drug Interactions
**Question:** Cigarette smoking can affect drug therapy by:
- A. Increasing the effectiveness of all medications
- B. Decreasing the risk of drug interactions
- C. Enzyme induction of cytochrome P450, increasing the risk of cancer
- D. Reducing the absorption of all drugs
**Answer:** C. Enzyme induction of cytochrome P450, increasing the risk of cancer
#### 7. Narrow Therapeutic Index (NTI) Drugs
**Question:** Which of the following is a characteristic of drugs with a narrow therapeutic
index (NTI)?
- A. Wide margin between therapeutic and toxic doses
- B. High potential for interaction due to small differences between therapeutic and toxic doses
- C. They are not affected by genetic factors
- D. They do not interact with other drugs
**Answer:** B. High potential for interaction due to small differences between therapeutic and
toxic doses
#### 8. Impact of Genetic Makeup
**Question:** An individual’s genetic makeup can influence their:
- A. Eye color and hair type
- B. Susceptibility to environmental factors
- C. Complement of metabolizing enzymes and their drug interaction profile
- D. Preference for certain foods
**Answer:** C. Complement of metabolizing enzymes and their drug interaction profile
#### 9. Absorption and Drug Interactions
**Question:** Most drug absorption occurs in which part of the gastrointestinal (GI) tract?
- A. Stomach
- B. Large intestine
- C. Proximal small intestine
- D. Esophagus
**Answer:** C. Proximal small intestine
#### 10. Enzyme Induction and Inhibition
**Question:** Which enzyme family plays a key role in many therapeutically important drug
interactions?
- A. Cytochrome (CYP) 450 enzymes
- B. Kinases
- C. Phosphatases
- D. Proteases
**Answer:** A. Cytochrome (CYP) 450 enzymes
#### 11. Case Study Analysis
**Question:** N.M. is a 68-year-old obese, Hispanic female who underwent total knee
replacement surgery and is started on warfarin therapy. Her medical history includes epilepsy
(controlled with phenytoin), hypercholesterolemia (treated with pravastatin), and hypertension
(treated with lisinopril). She has a history of smoking. Which factor is NOT a risk factor for drug
interactions in N.M.?
- A. Obesity
- B. Age
- C. Ethnicity
- D. Smoking history
**Answer:** C. Ethnicity
#### 12. Mechanisms of Drug Interactions
**Question:** What is one of the potential mechanisms for a drug interaction between warfarin
and phenytoin?
- A. Enhanced absorption of warfarin
- B. Displacement of warfarin from protein-binding sites by phenytoin
- C. Increased renal excretion of warfarin
- D. Reduced metabolism of phenytoin
**Answer:** B. Displacement of warfarin from protein-binding sites by phenytoin
