PULSE

DUPLICATOR
Most cited in-vitro cardiovascular
hydrodynamic testing system
Product Code: 18363

The ViVitro Pulse Duplicator simulates the function of the heart (left
or right) by generating pulsatile flow through prosthetic heart valves
placed in the Model Left Heart. Powered by the ViVitro SuperPump, it is
composed of the ViVitro Model Left Heart, Flow Measuring System and
ViVitest Data Acquisition System. The ViVitro Pulse Duplicator System
is used by the US Food and Drug Administration and is recognised by
regulatory bodies worldwide including TÜV, BSI and the Chinese SFDA.
The Pulse Duplicator System assesses the performance of cardiovascular devices and
prosthetic heart valves under simulated cardiac conditions. It simulates physiological or
other complex flow variations while allowing the user to vary the peripheral resistance and
compliance of the system. Pressure ports and flow measuring locations allow for data to be
collected from aortic or mitral sites. Transparent viewpoints allow multiple viewing angles of
the valve including inflow and outflow.

Combined with the ViVitest software control system, it quickly, easily and reliably collects and
analyzes physiological flow and pressure data. The ViVitest software also allows the user to
easily modify and customize waveforms.

> Features
• Meets ISO 5840 requirements to collect and analyze flow and pressure
readings in real-time
• Controls pulsatile fluid flows to simulate cardiac flow conditions including
arrhythmia, normal, hypo and hypertensive states at specified cardiac
outputs and beat rates
• Measures wall pressures in the atrium, ventricle, and aortic outflow
• Measures flow at the aortic or mitral sites
ViViTRO LABS 2023 • ViVitroLabs.com

• Simulates cardiovascular peripheral resistance and compliance

• Ventricle membrane replicates natural chamber flow
• Enables echo imaging, Doppler flow measurements, and PIV for
interrogation of flow field regions
> Testing Capabilities and Applications
• Transcatheter valves (Aortic or Mitral)
• Surgical valves (Mechanical and Biological)
• Stentless valves
• Structural heart and peripheral vascular devices
• Occluder and Closure Devices (with customization)
• Evaluate LVAD or other assist devices (with customization)

> Specifications
Pump & MLH 53 x 92 x 45 cm
DAS & Flow System 48 x 33 x 32 cm
Dry Weight: Actuator + Model Left 18 kg
Heart + VIA
Temperature Range Ambient up to 40°C ± 1.0°C
Flow Rate 0 – 15 L/min
Heart Beat Rate 3 – 200 BPM
Valve size
Aortic Up to Ø 35mm
Mitral Up to Ø 35mm*

* Ø 55mm with Large Atrium Accessory

13
Left Heart Model
Product Code: SD2001-1

The ViVitro Left Heart Model emulates the pressures and flows of the left heart allowing insertion of
valves and other devices into the Pulse Duplicator system for testing. It includes transparent elements
to visualize valve function and adjacent flow fields. Ports are available for transducers to measure wall
pressures in the left atrium, left ventricle, aortic outflow tract, and downstream of the aortic valve.

Large Atrium Chamber (Mitral)

Product Code: 21179

The Large Atrium chamber allows devices with an

outer diameter of up to 55mm to be tested in the
Pulse Duplicator.
• Expands the mitral device testing capabilities of
the system
• Quick-release system allows fast device changes
ViViTRO LABS 2023 • ViVitroLabs.com

• Accurate flow measurements from flow probe

at Atrium inflow
• Enhanced visibility using large viewing window
for mitral device inflow
• Customizable Valve Mounting
• Easily added to a ViVitro Pulse Duplicator
ViVitest Data Acquisition
System (DAS)
Product Code: 08530 // Related Part Numbers: 08311 I/O Module, AP9991 AmPack

ViVitest is part of the ViVitro Data Acquisition System (DAS) family of The software is pre-installed
software products. Combined with the Pulse Duplicator System, it on a laptop and tested with all
collects hydrodynamic testing data to meet ISO 5840 requirements. hardware and A-D converters
ViVitest software controls the SuperPump while simultaneously prior to shipment. Each
measuring pressure and flow data. It monitors, processes, and system includes the following
reports data such as regurgitant fraction, effective orifice area (EOA), components:
and other valve performance indicators. • I/O Module – inputs/outputs
signals from the software
A calibration wizard walks new users through the set-up process for • AmPack - Pressure Measuring
quick system preparation for testing. Output files are available in System including transducers
and amplifier
.CSV format for easy analysis in Excel and MatLab.
• Laptop + connecting cables
• ViVitest Software (compatible
ViVitest features an intuitive User Interface
with Windows 7 & 10)

ViViTRO LABS 2023 • ViVitroLabs.com

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