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Cancer Literature Review

Triple negative breast cancer (TNBC) is an aggressive type of breast cancer characterized by a lack of estrogen, progesterone, and HER2 receptors. It poses significant challenges due to fewer treatment options and poorer clinical outcomes compared to other breast cancer subtypes. This literature review examines the definition and molecular characteristics of TNBC, along with current and emerging treatment approaches such as chemotherapy, immunotherapy, and targeted therapies aimed at unique molecular perturbations in TNBC. Ongoing research discussed includes modulating epigenetic proteins, androgen receptors, and mTOR and PARP inhibitors to develop more effective therapies for TNBC patients.

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100% found this document useful (2 votes)
65 views7 pages

Cancer Literature Review

Triple negative breast cancer (TNBC) is an aggressive type of breast cancer characterized by a lack of estrogen, progesterone, and HER2 receptors. It poses significant challenges due to fewer treatment options and poorer clinical outcomes compared to other breast cancer subtypes. This literature review examines the definition and molecular characteristics of TNBC, along with current and emerging treatment approaches such as chemotherapy, immunotherapy, and targeted therapies aimed at unique molecular perturbations in TNBC. Ongoing research discussed includes modulating epigenetic proteins, androgen receptors, and mTOR and PARP inhibitors to develop more effective therapies for TNBC patients.

Uploaded by

c5p8vze7
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Title: Navigating the Complexity of Cancer Literature Reviews

Embarking on the journey of crafting a comprehensive literature review on cancer can be a daunting
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At a median follow up of 23 monthslocal recurrence was seen in 9.7% and distant metastasis in
40.32% of cases.Most common site of distant metastasis was Brain (14.52%) followed by Liver
(11.29%) and Lung (11. 29%).The median disease free survival (DFS) and time to local failure in the
study was 11 and 12.5 months respectively. When BRCA1 mutation carriers develop breast cancer, it
is usually basal-like; given the central role of BRCA1 in DNA repair, this could have profound
therapeutic implicatio. You can also conduct your study on the many problems that the patients have
to go through like strained family relations, social acceptance, and economic problems. Majority of
patients were locally advanced (82.3%) and 79% had positive nodes at the time of presentation.
Methods:- Patients diagnosed with breast carcinoma (tissue diagnosis) presenting to our institution
were evaluated for their ER, PR and HER2Neu status. A detailed research on immunotherapy
utilization in TNBC has emphasized its part in constraining tumor cell activity. Download Free PDF
View PDF Free PDF CLINICAL BEHAVIOUR OF METASTATIC TRIPLE NEGATIVE BREAST
CARCINOMA: AN INSTITUTIONAL REVIEW. The basal-like molecular subtype exhibits a
unique molecular profile and set of risk factors, aggressive and early pattern of metastasis, limited
treatment options, and poor prognosis. Most, though not all, triple-negative breast cancers will be
basal-like on gene expression micorarrays. Another interesting aspect is the psychological mind frame
of the patients. Although metastatic breast cancer is not curable, meaningful improvements in
survival have been seen, coincident with the introduction of newer systemic therapies. You can
conduct study on the prevention, incidence, or cure of the research. Initial metastasis in the cohort
was around 24.2% despite most tumours being locally advanced. A reduction in cancer growth
through AMPK activation by some drugs has directed research towards developing AMPK agonists
and antagonists. Therapeutic benefits of AMPK modulation, androgen receptor (AR) antagonists,
epi-drugs, immunotherapy, mTOR inhibition, PARP inhibition, platinum-based chemotherapy and
various such modalities have been discussed. Am Beispiel des Akustikusneurinoms Elisabetta
Longhi 2021, Acta Facultatis Philosophicae Universitatis Ostraviensis Studia Germanistica More and
more patients are seeking advice on medical internet forums, which give them the chance to
communicate easily with other laypeople as well as with doctors. Examining a forum on acoustic
neuroma, this paper investigates the features of this specific type of medical discourse, in particular
how the medium influences the way of communicating information, as well as the changing role of
laypeople and moderators in the online environment. Download Free PDF View PDF Free PDF
Wissenstransfer in medizinischen Internetforen. Breast cancer starts as a local disease, but it could
metastasize to the lymph nodes and distant organs. To find more possible treatments like
chemotherapy, lumpectomy, radiation therapy and other gene therapy we first need to understand the
concept behind occurrence and reoccurrence of TNBC. Methods The linear relationship and
intraclass correlation (ICC) between rCBFR measured with FE-PE2I (R1) and. The measurements
were performed at frequencies of (5kHz to 0.5 MHz) at room temperature. The current treatment
alternatives, along with the potential therapeutic targets for TNBC have been enlisted here.
Regulation of epigenetic proteins by epi-drugs has shown to activate the apoptosis pathway, suppress
the survival pathway and has been investigated. The requirement of two different imaging
examinations is resource consuming and inconvenient for the patients. The reason behind its
aggressive type is that TNBC do not have such specific receptors as other cancers. Targeted
therapies that take advantage of the unique molecular perturbations found in triple-negative breast
cancer are needed. Human epidermal growth factor receptor 2 (HER-2), Triple negative breast cancer
(TNBC). Upfront surgery was done in 35.48% patients while 64.52% patients were started on
chemotherapy out of which 62.5% patients were amenable tosurgery. Triple Negative (ER Negative,
PR Negative, HER2Neu Negative) breast cancer subtype patients were given treatment according to
the stage and patient preferences.
Upfront surgery was done in 35.48% patients while 64.52% patients were started on chemotherapy
out of which 62.5% patients were amenable tosurgery. Absence of these enzymes is result into the
less option availability in cancer treatment. Although metastatic breast cancer is not curable,
meaningful improvements in survival have been seen, coincident with the introduction of newer
systemic therapies. To browse Academia.edu and the wider internet faster and more securely, please
take a few seconds to upgrade your browser. TNBC are highly proliferative and have p53 mutations
in 50% of cases and most BRCA1-mutated tumors fall in this category. For patients, the diagnosis of
breast cancer is fearsome; so when they know additionally that they suffer from TNBC—a subtype
with poor outcomes—this situation is often more stressful. The reason behind its aggressive type is
that TNBC do not have such specific receptors as other cancers. Download Free PDF View PDF
Free PDF Permafrost dating with the Cosmogenic radionuklides (report no. 1) Pavel Nikolskiy 2009
Download Free PDF View PDF Free PDF S. Download Free PDF View PDF Free PDF CLINICAL
BEHAVIOUR OF METASTATIC TRIPLE NEGATIVE BREAST CARCINOMA: AN
INSTITUTIONAL REVIEW. IJAR Indexing Introduction - Triple Negative Breast Cancer (TNBC)
is a type of breast cancer which is characterised by its unique molecular profile of ER,PR and
HER2Neu Negativity. Is there a Relationship between Calcium-Binding Protein and
Neurodegenerative Diseases. Targeted therapies that take advantage of the unique molecular
perturbations found in triple-negative breast cancer are needed. Approximately 60-70% of patients
are chemosensitive, while the remaining majority does not respond. The poor prognosis and an
aggressive clinical course of TNBC warrants further research for therapeutic options. Human
epidermal growth factor receptor 2 (HER-2), Triple negative breast cancer (TNBC). There are two
properties that make cancer cells malignant. At low frequency, the dielectric permittivity ( ??) and
imaginary permit. Patients and oncologists always have a dilemma on how to cope with this
aggressive disease. At a median follow up of 23 monthslocal recurrence was seen in 9.7% and distant
metastasis in 40.32% of cases.Most common site of distant metastasis was Brain (14.52%) followed
by Liver (11.29%) and Lung (11. 29%).The median disease free survival (DFS) and time to local
failure in the study was 11 and 12.5 months respectively. These receptors are estrogen (female
hormone), Progesterone (female hormone) and HER-2 (Protein; Human epidermal receptor). You
also need to make sure that your research topic will not become obsolete in the near future and that
the scope of the research is just right. You can download the paper by clicking the button above.
Another interesting aspect is the psychological mind frame of the patients. Am Beispiel des
Akustikusneurinoms Elisabetta Longhi 2021, Acta Facultatis Philosophicae Universitatis Ostraviensis
Studia Germanistica More and more patients are seeking advice on medical internet forums, which
give them the chance to communicate easily with other laypeople as well as with doctors. The
management and treatments available for TNBC are discussed in this review. TNBC patients have a
unique pattern of relapse, which occurs mostly in the first 3 years following diagnosis. A reduction in
cancer growth through AMPK activation by some drugs has directed research towards developing
AMPK agonists and antagonists. They are generally aggressive nature, present with different
metastatic patterns and there are no targeted therapies till date. To find more possible treatments like
chemotherapy, lumpectomy, radiation therapy and other gene therapy we first need to understand the
concept behind occurrence and reoccurrence of TNBC. The measurements were performed at
frequencies of (5kHz to 0.5 MHz) at room temperature.
To find more possible treatments like chemotherapy, lumpectomy, radiation therapy and other gene
therapy we first need to understand the concept behind occurrence and reoccurrence of TNBC.
Breast cancer is one of the most concerning diseases in the world. According to the Research studies,
women who have BRCA1 mutations are at higher risk for triple negative breast cancer. Therefore, a
dual-phase imaging concept, i.e. imaging of both cortical blood flow and DAT imaging with the
same radiotracer would be more convenient and cost-effective. The requirement of two different
imaging examinations is resource consuming and inconvenient for the patients. Is there a
Relationship between Calcium-Binding Protein and Neurodegenerative Diseases. Am Beispiel des
Akustikusneurinoms Elisabetta Longhi 2021, Acta Facultatis Philosophicae Universitatis Ostraviensis
Studia Germanistica More and more patients are seeking advice on medical internet forums, which
give them the chance to communicate easily with other laypeople as well as with doctors. Absence
of these enzymes is result into the less option availability in cancer treatment. Download Free PDF
View PDF Free PDF Vesicular stomatitis virus inhibits mitotic progression and triggers cell death
Papia Chakraborty 2009, EMBO reports Download Free PDF View PDF Free PDF A
microfoundations approach to studying innovation in multinational subsidiaries Ajai Gaur 2018,
Global Strategy Journal Download Free PDF View PDF Free PDF Aced (Driven 4) K Bromberg 1
165 - traducere auto Q E D. Then don’t wait till the third year to start the work. Although metastatic
breast cancer is not curable, meaningful improvements in survival have been seen, coincident with the
introduction of newer systemic therapies. Breast cancer starts as a local disease, but it could
metastasize to the lymph nodes and distant organs. The basal-like molecular subtype exhibits a
unique molecular profile and set of risk factors, aggressive and early pattern of metastasis, limited
treatment options, and poor prognosis. It is heterogeneous in its clinical course and certainly in its
molecular characteristics. There are two properties that make cancer cells malignant. To identify the
clinical behaviour of TNBC, we evaluated the 62 patients of metastatic TNBC presenting in our
department in last 3 years. TNBC are highly proliferative and have p53 mutations in 50% of cases
and most BRCA1-mutated tumors fall in this category. Therapeutic benefits of AMPK modulation,
androgen receptor (AR) antagonists, epi-drugs, immunotherapy, mTOR inhibition, PARP inhibition,
platinum-based chemotherapy and various such modalities have been discussed. Keywords: TNBC
(Triple Negative Breast Cancer), Metastasis, tumor, ER-negative, PR-negative, HER2-neu negative,
BRCA1 mutations, Overall Survival, Lungs, Mathematical Models, Recurrence, Chemokines,
Chemotherapy. Istanbul 2015. Oksijen Bas?m ve Matbaac?l?k, 189 sayfa (170 resim ile birlikte). The
current treatment alternatives, along with the potential therapeutic targets for TNBC have been
enlisted here. Human epidermal growth factor receptor 2 (HER-2), Triple negative breast cancer
(TNBC). The measurements were performed at frequencies of (5kHz to 0.5 MHz) at room
temperature. DURUGONUL (Ed.), Manisa Muzesi Heykelt?rasl?k Eserleri. Majority of patients
were locally advanced (82.3%) and 79% had positive nodes at the time of presentation. At low
frequency, the dielectric permittivity ( ??) and imaginary permit. It should be wide enough to be
significant but should be narrow enough to be covered within the designated time frame. The
management and treatments available for TNBC are discussed in this review. Promising results of
platinum-based neoadjuvant chemotherapy have been reported to prevent recurrences, compared to
the standard scheduled therapy. To browse Academia.edu and the wider internet faster and more
securely, please take a few seconds to upgrade your browser.
ISBN: 978-605-4701-66-7 Serra Durugonul 2015, LIBRI Kitap Tanitimi, Elestiri ve Ceviri Dergisi
Download Free PDF View PDF Free PDF RELATED TOPICS Clinical research See Full PDF
Download PDF About Press Blog People Papers Topics Job Board We're Hiring. There are two
properties that make cancer cells malignant. Results:- Median age of patients was 45 years (range 28-
81). At a median follow up of 23 monthslocal recurrence was seen in 9.7% and distant metastasis in
40.32% of cases.Most common site of distant metastasis was Brain (14.52%) followed by Liver
(11.29%) and Lung (11. 29%).The median disease free survival (DFS) and time to local failure in the
study was 11 and 12.5 months respectively. You also need to make sure that your research topic will
not become obsolete in the near future and that the scope of the research is just right. Therefore, a
dual-phase imaging concept, i.e. imaging of both cortical blood flow and DAT imaging with the
same radiotracer would be more convenient and cost-effective. It is formerly known that cancer take
place due to mutation in BRCA group of genes. Is there a Relationship between Calcium-Binding
Protein and Neurodegenerative Diseases. Am Beispiel des Akustikusneurinoms Elisabetta Longhi
2021, Acta Facultatis Philosophicae Universitatis Ostraviensis Studia Germanistica More and more
patients are seeking advice on medical internet forums, which give them the chance to communicate
easily with other laypeople as well as with doctors. According to the Research studies, women who
have BRCA1 mutations are at higher risk for triple negative breast cancer. This review aims to
summarize existing as well as the feasible therapeutic courses of action for TNBC. Methods:-
Patients diagnosed with breast carcinoma (tissue diagnosis) presenting to our institution were
evaluated for their ER, PR and HER2Neu status. A reduction in cancer growth through AMPK
activation by some drugs has directed research towards developing AMPK agonists and antagonists.
Large population-based studies have identified a higher proportion of triple-negative breast tumors
among premenopausal African American women, and a suggestion that increased parity, younger age
at first-term pregnancy, shorter duration of breast feeding, and elevated hip-to-waist ratio might be
particular risk factors. TNBC patients have a unique pattern of relapse, which occurs mostly in the
first 3 years following diagnosis. You can download the paper by clicking the button above. The
reason behind its aggressive type is that TNBC do not have such specific receptors as other cancers.
Approximately 60-70% of patients are chemosensitive, while the remaining majority does not
respond. Promising results of platinum-based neoadjuvant chemotherapy have been reported to
prevent recurrences, compared to the standard scheduled therapy. A detailed research on
immunotherapy utilization in TNBC has emphasized its part in constraining tumor cell activity.
Examining a forum on acoustic neuroma, this paper investigates the features of this specific type of
medical discourse, in particular how the medium influences the way of communicating information,
as well as the changing role of laypeople and moderators in the online environment. See Full PDF
Download PDF Free Related PDFs Etiology and Treatment Options of Triple Negative Breast
Cancer (TNBC Kaiser Jamil Triple negative breast cancer (TNBC) is defined by the absence of ER,
PR and normal HER-2 expression. DURUGONUL (Ed.), Manisa Muzesi Heykelt?rasl?k Eserleri.
Therapeutic benefits of AMPK modulation, androgen receptor (AR) antagonists, epi-drugs,
immunotherapy, mTOR inhibition, PARP inhibition, platinum-based chemotherapy and various such
modalities have been discussed. You can conduct study on the prevention, incidence, or cure of the
research. To browse Academia.edu and the wider internet faster and more securely, please take a few
seconds to upgrade your browser. Breast cancer is one of the most concerning diseases in the world.
It should be wide enough to be significant but should be narrow enough to be covered within the
designated time frame. Download Free PDF View PDF Free PDF Permafrost dating with the
Cosmogenic radionuklides (report no. 1) Pavel Nikolskiy 2009 Download Free PDF View PDF Free
PDF S. Istanbul 2015. Oksijen Bas?m ve Matbaac?l?k, 189 sayfa (170 resim ile birlikte).
They have uncontrolled growth and they are metastasis (which means that they spread from one part
of the body to another). Most, though not all, triple-negative breast cancers will be basal-like on
gene expression micorarrays. Breast cancer is one of the most concerning diseases in the world. The
reason behind its aggressive type is that TNBC do not have such specific receptors as other cancers.
You also need to make sure that your research topic will not become obsolete in the near future and
that the scope of the research is just right. The management and treatments available for TNBC are
discussed in this review. The poor prognosis and an aggressive clinical course of TNBC warrants
further research for therapeutic options. The current treatment alternatives, along with the potential
therapeutic targets for TNBC have been enlisted here. Results:- Median age of patients was 45 years
(range 28-81). Download Free PDF View PDF Free PDF Wissenstransfer in medizinischen
Internetforen. TNBC are highly proliferative and have p53 mutations in 50% of cases and most
BRCA1-mutated tumors fall in this category. TNBC relapses more frequently than hormone
receptor-positive subtypes and is often associated with poor outcomes. Istanbul 2015. Oksijen
Bas?m ve Matbaac?l?k, 189 sayfa (170 resim ile birlikte). Majority of patients were locally advanced
(82.3%) and 79% had positive nodes at the time of presentation. These receptors are estrogen
(female hormone), Progesterone (female hormone) and HER-2 (Protein; Human epidermal receptor).
You can also conduct your study on the many problems that the patients have to go through like
strained family relations, social acceptance, and economic problems. At a median follow up of 23
monthslocal recurrence was seen in 9.7% and distant metastasis in 40.32% of cases.Most common
site of distant metastasis was Brain (14.52%) followed by Liver (11.29%) and Lung (11. 29%).The
median disease free survival (DFS) and time to local failure in the study was 11 and 12.5 months
respectively. For patients, the diagnosis of breast cancer is fearsome; so when they know additionally
that they suffer from TNBC—a subtype with poor outcomes—this situation is often more stressful.
While searching for the right topic on this theme, you need to make sure that your research topic is
supported with relevant articles that will help in the study. It should be wide enough to be significant
but should be narrow enough to be covered within the designated time frame. Then don’t wait till the
third year to start the work. Another interesting aspect is the psychological mind frame of the
patients. Patients and oncologists always have a dilemma on how to cope with this aggressive
disease. You can cover the disease from the doctor’s point of view or students’. Upfront surgery was
done in 35.48% patients while 64.52% patients were started on chemotherapy out of which 62.5%
patients were amenable tosurgery. According to the Research studies, women who have BRCA1
mutations are at higher risk for triple negative breast cancer. Triple Negative (ER Negative, PR
Negative, HER2Neu Negative) breast cancer subtype patients were given treatment according to the
stage and patient preferences. There are two properties that make cancer cells malignant.
Approximately 60-70% of patients are chemosensitive, while the remaining majority does not
respond. Methods The linear relationship and intraclass correlation (ICC) between rCBFR measured
with FE-PE2I (R1) and.
Most, though not all, triple-negative breast cancers will be basal-like on gene expression micorarrays.
Bone and Liver was the most common site of metastasis at diagnosis. Triple Negative (ER Negative,
PR Negative, HER2Neu Negative) breast cancer subtype patients were given treatment according to
the stage and patient preferences. Therefore, a dual-phase imaging concept, i.e. imaging of both
cortical blood flow and DAT imaging with the same radiotracer would be more convenient and cost-
effective. The basal-like molecular subtype exhibits a unique molecular profile and set of risk factors,
aggressive and early pattern of metastasis, limited treatment options, and poor prognosis. You can
download the paper by clicking the button above. IJAR Indexing Introduction - Triple Negative
Breast Cancer (TNBC) is a type of breast cancer which is characterised by its unique molecular
profile of ER,PR and HER2Neu Negativity. While searching for the right topic on this theme, you
need to make sure that your research topic is supported with relevant articles that will help in the
study. As by definition, Metastatic breast cancer, also known as Advanced or Stage IV breast cancer,
is the stage in breast cancer progression in which malignant cells from the primary tumor
successfully create new tumors in distant organs. There are two properties that make cancer cells
malignant. Conclusion:- TNBCs present in younger women show variable response to chemotherapy
and carry the worse prognosis, having high recurrence rate. TNBC patients have a unique pattern of
relapse, which occurs mostly in the first 3 years following diagnosis. Istanbul 2015. Oksijen Bas?m
ve Matbaac?l?k, 189 sayfa (170 resim ile birlikte). These receptors are estrogen (female hormone),
Progesterone (female hormone) and HER-2 (Protein; Human epidermal receptor). You can also
conduct your study on the many problems that the patients have to go through like strained family
relations, social acceptance, and economic problems. The electrical properties of the composite films,
involving dielectric constant, permittivity ( ??), imaginary permittivity ( ??), conductivity (?AC) and
loss factor tan ?, were investigated. Another interesting aspect is the psychological mind frame of
the patients. Therapeutic benefits of AMPK modulation, androgen receptor (AR) antagonists, epi-
drugs, immunotherapy, mTOR inhibition, PARP inhibition, platinum-based chemotherapy and
various such modalities have been discussed. Is there a Relationship between Calcium-Binding
Protein and Neurodegenerative Diseases. When BRCA1 mutation carriers develop breast cancer, it is
usually basal-like; given the central role of BRCA1 in DNA repair, this could have profound
therapeutic implicatio. At a median follow up of 23 monthslocal recurrence was seen in 9.7% and
distant metastasis in 40.32% of cases.Most common site of distant metastasis was Brain (14.52%)
followed by Liver (11.29%) and Lung (11. 29%).The median disease free survival (DFS) and time to
local failure in the study was 11 and 12.5 months respectively. Am Beispiel des Akustikusneurinoms
Elisabetta Longhi 2021, Acta Facultatis Philosophicae Universitatis Ostraviensis Studia Germanistica
More and more patients are seeking advice on medical internet forums, which give them the chance
to communicate easily with other laypeople as well as with doctors. Initial metastasis in the cohort
was around 24.2% despite most tumours being locally advanced. Although metastatic breast cancer is
not curable, meaningful improvements in survival have been seen, coincident with the introduction of
newer systemic therapies. For A Literature Review on Breast Cancer Some Ideas for Topics. The
requirement of two different imaging examinations is resource consuming and inconvenient for the
patients. It is heterogeneous in its clinical course and certainly in its molecular characteristics.
Upfront surgery was done in 35.48% patients while 64.52% patients were started on chemotherapy
out of which 62.5% patients were amenable tosurgery. Since many TNBC tumors express androgen
receptors (AR), many agents which antagonize AR have been implicated in the treatment of TNBC.

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