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Afflicted people have difficulty expressing and understanding language. According to the
researchers it is believed that homocysteine circulates in the body much more than what is needed.
This statement should present a specific viewpoint or argument about Alzheimer’s disease. A special
kind of protein, tau, makes the microtubules stable. The criteria specify that Alzheimer’s disease
must be confirmed by neuropsychological testing to arrive at a probable diagnosis. Plaques are made
of beta- amyloid (AB), a protein fragment snipped from a larger protein called. Mice expressing this
mutation have all the usual pathologies of Alzheimer's disease. Although losing brain cells is part of
the aging process, illnesses related to dementia of any kind occurs at a faster rate. AD is also
associated with aggressiveness, restlessness, mental trauma, insomnia and severe depression.
Answer: The exact causes of AD are not known, but problems with brain proteins that fail to
function normally, disrupt the work of neurons and results in a series of toxic events. Question 2.
How to prevent AD? Answer: There is no prevention to AD, but proper lifestyle might reduce the
risk. Question 3. What are medicines used in cases of AD. Keep on browsing if you are OK with
that, or find out how to manage cookies. To begin, familiarize yourself with Alzheimer’s disease
essay examples. These neurons and synapses are lost when the individual begins to develop
alzheimer's disease. This test would go a extended way toward the accurate diagnosing Alzheimer’s
and provide a concrete method of pinpointing that has this problem. Symptoms include: confusion,
difficulty, apathy, blunted emotions, and loss of inhibitions. The foremost signs of the disease is mild
memory loss that often progresses to more serious symptoms such as those described above. It's like
a masterclass to be explored at your own pace. In his book, Wells states that the autopsy findings of
persons with Alzheimer's Disease and senile dementia to be identical (Hamdy et al., 1998). Types of
Memory Loss Memory loss is one of the first noticeable problems which occurs with the onset of
Alzheimer's Disease. Highlight the need for improved orientation and care for patients. Worldwide
Journal Geriatric Psychiatry, 15, 393-400. There is growing evidence, however, which shows that
people with a higher level of education are at lower risk for developing Alzheimer's Disease than
those people with a lower level of education (Alzheimer-Europe. Undated). Long-term memory is
events which happened over an hour ago. Relating nutrition to Alzheimer has paved way for many
researches to be done on this issue (Drug Week, 2009). Accumulation of aggregated amyloid
fibrilswhich are believed to be the toxic form of the protein responsible for disrupting the cell's
calcium ion homeostasis research paper alzheimers disease, induces programmed cell death apoptosis.
Retrieved from Health Source - Consumer Edition database. They may become agitated, exhibit
aggression, and pace for hours. A neurodegenerative type of dementia, the disease starts mild and
gets progressively worse. They will have no memory of close friends or family members.
Recognizing the need for these studies the National Institute on Aging and Alzheimer's Association
(NIA-AA) published a new research framework in an effort to redefine the disease based on
biological marker, as opposed to syndromal markers. Progressive deterioration eventually hinders
independence, with subjects being unable to perform most common activities of daily living.
The main factors involved are amyloid plaques (abnormal clumps) and neurofibrillary (tangled
bundles of fibers). An international peer-reviewed journal, it publishes open access basic research
with a translational focus, as well as clinical trials, research into drug discovery and development,
and epidemiologic studies Alzheimer's disease - Wikipedia Alzheimer's disease AD is a
neurodegenerative disease that usually starts slowly and progressively worsens. The mortality rate in
these individuals was decreased than the ones who were not consuming the diet. Several diseases
may arise if this part of the brain is affected and one such disease is Alzheimer Disease. Despite the
severity of Stage three, the person with Alzheimer's Disease still responds to touch and familiar, soft
voices (Alzheimer-Europe. Undated). The Alzheimer's Association The Alzheimer's Association
provides support and assistance to families and victims of Alzheimer's Disease. However, within the
practical perspective, performing an autopsy of the people to make a definitive diagnosis is extremely
ineffective. Only one-third of patients on this medication show improvement, others will cognitively
stay about the same. You can also find more Essay Writing articles on events, persons, sports,
technology and many more. This drug also causes problems for patients who have stomach ulcers.
(Hamdy, et al., 1998). Although these most common medications slow or stop the progression of
Alzheimer's Disease for a time, neither drug can change the inevitable progression of Alzheimer's
Disease. (Hamdy et al., 1998). Medication and Difficult Behaviors There are many medications
available to manage behavior problems which often accompany people with Alzheimer's Disease or a
related dementia. Some people afflicted with Alzheimer's Disease tell their doctor that they do not
want their family to know. They can make decisions about finances and even perhaps participate in
research which may benefit others. Apart from these, blood and urine tests are also done along with
proper neurological and physical examinations. The effects on other body systems, its signs and
symptoms and any other complications will be highlighted as well. Once the disease may be
correctly diagnosed, it may be treated and, generally, the twelve signs and signs and signs and
symptoms are relieved or greatly improved. During this stage, because of increased memory loss, the
person with Alzheimer's Disease may forget that people have visited them and complain that no one
comes to visit. Although the disease does not have any possible cure but it can be managed by
certain therapies and medications. Because an overabundance of cerebral fluid across the brain,
which must be relieved surgically. Explore the emotional, financial, and societal challenges posed by
Alzheimer’s disease, including the strain on healthcare resources and the need for increased support
and awareness. The following is the disease process broken down into stages. As the fastest ageing
region within Latin America, the Caribbean Hispanic Islands of the Dominican Republic, Puerto
Rico and Cuba have had sharp increases in dementia cases within the last decade. Medications
Which Slow Down the Disease Although there is no cure for Alzheimer's Disease, there are
currently medications available which slow the disease progression. By clicking “Check Writers’
Offers”, you agree to our terms of service and privacy policy. Signs associated with this disease
include: memory loss which causes disruption to ones’ daily life, getting lost in familiar areas,
repeating questions, problems handling money or paying bills as well as the inability to finish daily
task at home, work or leisure. Making small decisions such as, deciding to drink coffee instead or tea
is very important to the person. Dr. Gelb discusses in depth how copying geometric puzzles and
counting backwards by seven does not reflect everyday skills. Further, many caregivers cite support
groups and respite care as invaluable resources that help them cope with the changes of the disease.
It lists risk factors and describes symptoms of the three main stages so physicians and family can
recognize warning signs. Seizures and limb paralysis are common (Alzheimer-Europe. Undated).
Parkinson's Disease includes problems with ambulation, writing, and dressing. As being a
neuropathologist, Alzheimer studied the issue a 51 year-old lady. The risk factors include increasing
age, genetics and down syndrome specifically.
Family members face difficulties as the person’s condition deteriorates and are unable to recognise
loved ones. Long-term memory is events which happened over an hour ago. There are many things
cause Alzheimer ’s, but the main causing is age and some genes and gets worse and worse when
people became older. This might include data on the effectiveness of different treatment methods,
research findings on the progression of Alzheimer’s disease, or testimonies from healthcare
professionals and family members of Alzheimer’s patients. When a person has Alzheimer's Disease
and has an understanding of the disease and what the diagnosis will encompass, the knowledge
empowers them to make decisions, and take an active role in their plan of care. The cause of death is
usually an external factor, such as infection of pressure ulcers or pneumonianot the disease itself.
They wander and make poor decisions because of cognitive problems (Hamdy et al., 1998).
Disadvantages to the special care units are they tend to keep the same staff and close relationships
develop with the residents and with family members as well. Devote separate paragraphs to each
aspect of Alzheimer’s disease. A Japanese pedigree of familial Alzheimer's disease was found to be
associated with a deletion mutation of codon of APP, research paper alzheimers disease. The
incidence rate was calculated to be 45% as the individuals consuming folate were decreasing their
risk of acquiring Alzheimer by 55%. These cognitive declines disrupt daily life due to their severity.
AD damages the brain cells and tissues resulting in loss of an essential portion of the brain. It has
been found that mitochondria in younger females are protected against amyloid-beta toxicity and
they tend to generate oxygen that is less reactive. Research done on the relation of the nutritional
status of an individual has shown that Vitamin D may have a direct relation with the onset of
Alzheimer. Is incapable of conversing with you on recent event s but can speak of things that
occurred even before you were born. Adobe Express Go from Adobe Express creation to Issuu
publication. After a thorough examination of peer-reviewed articles and a recent literature review, it
was revealed that there is an association between the risk of Alzheimer's disease and pesticide
exposure, primarily limited to those with a history of occupational pesticide exposure. Alzheimer’s is
caused by a combination of genetics, lifestyle and environmental factors over time though the exact
reason causing Alzheimer’s is yet to be found. This accounts for Alzheimer’s disease and a link has
been found out between diabetes type 3 and this neurological condition (BBC News, 2005) Estrogen
another hormone in women is known to have a direct link with Alzheimer Disease in women. This
lesion, known as AMY plaque, function as the cause within the onset and development of
Alzheimer’s. Retrieved from Health Source - Consumer Edition database. The enzymes which carry
out these processes are BACE-1 or. Studies recently have shown younger people, the average is
twenty-six, showing symptoms of Alzheimer's Disease. Between 3 and 5.4 million people in the U.S.
have Alzheimer's, and family caregivers provide the vast majority of their care. In Alzheimer much
of this APP is endocytosed after which it undergoes several processes to form the neurotoxic protein
(Mumm 2000). The amyloid hypothesis postulated that extracellular amyloid beta A. According to the
researchers it is believed that homocysteine circulates in the body much more than what is needed.
This may be associated with the neuropsychiatric symptoms and research paper alzheimers disease
prognosis in mild dementia. A German neurologist named Alois Alzheimer discovered Alzheimer’s
disease in 1906 after studying the case of a middle-aged woman named Auguste D. The diagnosis at
this stage can be mild cognitive impairment (MCI).
Alzheimer's disease is characterised by loss of neurons and synapses in the cerebral cortex and certain
subcortical regions. These images are only for website preview and not for any other use. The effects
on other body systems, its signs and symptoms and any other complications will be highlighted as
well. Begin your essay by explaining the nature of Alzheimer’s, including its symptoms, stages, and
the way it affects cognitive functions like memory and decision-making. It helps to exclude brain
tumors and head injuries. People with Alzheimer disease also develop deposits of stuff (protein and
fiber) that prevent the cells from working properly. If you would like to deposit a peer-reviewed
article or book chapter, use the “Scholarly Articles and Book Chapters” deposit option.
Neurofibrillary tangles are a group of filaments which are found in the cytoplasm of the neurons that
usually surround the nucleus. One family member who placed his mother in a special care unit for
Alzheimer's Disease said he knew it was just a matter of time before he needed to place his mother.
Partial Glutamate Antagonists help to inactivate the neurotransmitter Glutamate so that it cannot
activate many nerve cells. Certain drugs are used for symptom alleviation (like anti-depressants,
anxiolytics, anti-psychotics etc.). It takes seven years for it to make its way to stage 4. Cognex was
the first medication approved in the United States to treat mild to moderate symptoms of
Alzheimer's Disease. The hormone insulin and estrogen are linked with Alzheimer Disease and to
balance these hormones in the body it is necessary that extensive researches are carried out.
(Exercise, estrogen, and executive function, 2008). The sickness is responsible for at least 500,000
annual deaths in the Country, but it affects many more people than that. Letting the person with
Alzheimer's Disease make decisions and allowing him or her choices is important. It may start with
impaired reasoning and judgement or struggling with finding specific words during a conversation.
A non-communicable disease cannot be contracted as they are considered a medical condition,
slowly progressing over an individual's life time, so essentially, they are lifelong. Do you know
someone, it could be a loved one, family member, or a friend whose personality is gradually
changing. By clicking “Check Writers’ Offers”, you agree to our terms of service and privacy policy.
These caregivers include husbands, wives and children. Treatment focuses on medications to improve
symptoms as well as psychosocial support and caregiving as the disease progresses. Huntington’s
disease is the one other differentiable type, nonetheless it, by yet, doesn’t have cure. Likewise,
reaction to treatment may be assessed (Gelb, 2000). Signs generally establish gradually and worsen
in time, ending up being serious adequate to hinder day-to-day jobs. A recent study has found that
two-third of the American population suffering from Alzheimer’s disease are women. To get the best
diagnosis possible doctors will take a full health history, from yourself, family or even friends if
needed. The tPST detects tau- peptide fragments, that are released towards the bloodstream stream
by degenerating neurons in Alzheimer’s sufferers. These parts of brains then send out impulses again
to the specific organs where a reflex action is required. Like any other decision, there are pros and
cons to facility placement.
After a thorough examination of peer-reviewed articles and a recent literature review, it was revealed
that there is an association between the risk of Alzheimer's disease and pesticide exposure, primarily
limited to those with a history of occupational pesticide exposure. Your thesis will guide the
direction of your essay and provide a structured approach to your topic. Medications help to control
sleeplessness, agitation, aggression and depression. Pick's Disease is just one type of frontal lobe
dementia. Risk factors include genetics, down syndrome, post head trauma, heart and vascular
diseases, etc. Such as the global testing, this kind of testing doubles to create a rating scale. One of
the most important advances in recent decades has been the chemical characterization of this
amyloid protein, the sequencing of its amino acid chain, and the cloning of the gene encoding its
precursor protein (on chromosome 21). Alzheimer is also believed to have genetic influences because
of which APP secretes this neurotoxic protein. Key management techniques are offered for patients,
their families and caregivers. It is important when subscribing this medication to start with small
doses and increase the dose after four to six weeks. Really, it’s the existence of these psychotic signs
and signs and signs and symptoms can result in early institutionalization (Bassiony, et all, 2000).
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Disclaimer Privacy Policy Area Volume Calculator. Side effects through a large develop step through
step and deteriorate after some time, getting to be extreme sufficient to block from each and every
day undertakings. When this happens, the cells can't send the right signals to other parts of the brain.
The association with celiac disease is unclear, with a study finding no increase in dementia overall in
those with CD, while a review found an association with several types of dementia including
Alzheimer's disease. This insulin works as a regulator of the metabolism of glucose mainly in the
brain and does not mainly have an effect on the body blood glucose levels. The sickness is
responsible for at least 500,000 annual deaths in the Country, but it affects many more people than
that. Alzheimer’s disease, a type of dementia is one of them. Adobe InDesign Design pixel-perfect
content like flyers, magazines and more with Adobe InDesign. Due to low accuracy, the C-PIB-PET
scan is not recommended to be used as an early diagnostic research paper alzheimers disease or for
predicting the development of Alzheimer's disease when people show signs of mild cognitive
impairment MCI. When she died, Alzheimer performed an autopsy determined they cerebral atrophy
(degeneration within the brain), senile plaques (protein deposits) and neurofibrillary tangles
(abnormal filaments in nerve cells) within their brain — three common pathological highlights of
individuals who’ve Alzheimer’s (Ramanathan, 1997). In the central nervous system acetylcholine is
believed to be involved in learning, memory, and mood. 21. Acetylcholine is synthesized from
choline and acetyl coenzyme A through the action of the enzyme choline acetyltransferaseand
becomes packaged into membrane-bound vesicles. The main differentiated dementia illnesses
frequently include losses of muscular control and so they could be separated within the last group. In
a small percentage, difficulties with language, executive functions, perception agnosia research paper
alzheimers disease, or execution of movements apraxia are more prominent than memory problems,
research paper alzheimers disease. Korsakoff's Syndrome is not actually a form of dementia; its
symptoms are similar to those of dementia (Alzheimer-Europe. Undated). Crutzfeldt-Jacob Disease
(CJD) usually occurs by accident during surgery, although in very few cases, it can be hereditary.
APOE plays a major role in lipid-binding proteins in lipoprotein particles and the epsilon4 allele
disrupts this function. Ultimately, you lose the ability of muscle control which could have you
bedridden and susceptible to infections due to pressure ulcers. There is degenera tion of brain
neurons especially in the cerebra l cortex and pre sence o f neurof ibril lary tangl es and pla ques con
tai nin g be ta- am ylo id cel ls. The most noticeable deficit is in recalling new information.
An Alzheimer’s patient undergoes many behavioural and personality changes like depression,
delusion and mood swings are prevalent. Involve the reader by highlighting the significance of age,
which plays a significant role in the development and progression of the disease. In Alzheimer much
of this APP is endocytosed after which it undergoes several processes to form the neurotoxic protein
(Mumm 2000). Cleary, it is almost always hard to distinguish an Alzheimer’s patient from normal
people or individuals with other disorders. And this antioxidant is found in fruit and vegetable juices
thus it was concluded that people who regularly had vegetable and fruit juices had less probability of
catching the disease (Fruit juice may cut Alzheimers risk, 2009). Amino Acids are known to be the
basic functional units of proteins and their presence in human body is of crucial importance to their
health status. The US is the country in which the share of people w. Brain imaging procedures
include Magnetic Resonance Imaging (MRI). Key management techniques are offered for patients,
their families and caregivers. This really is frequently an illness within the brain center along with the
individual frequently shows symptoms of severe overeating, hypersexuality and euphoric
disposition. As they become aware of this forgetfulness, they may become depressed, anxious, and
irritable. For the nerve signal to continue, acetylcholine must diffuse to another nearby neuron or
muscle cell, where it will bind and activate a receptor protein. 22. 23. To date, only four of the genes
in the human genetic map (the “genome”) have been conclusively shown to affect AD development.
Researches show that 60-90% of Alzheimer’s cases exhibit various cerebrovascular pathology. Only
homozygotes with this mutation develop Alzheimer's disease. People with Alzheimer disease also
develop deposits of stuff (protein and fiber) that prevent the cells from working properly. AD not
only has detrimental effects on the patient but tends to take a significant toll on. Korsakoff's
Syndrome is not actually a form of dementia; its symptoms are similar to those of dementia
(Alzheimer-Europe. Undated). Crutzfeldt-Jacob Disease (CJD) usually occurs by accident during
surgery, although in very few cases, it can be hereditary. Sometimes, however, when the person stops
drinking and begins to eat a balanced diet, improvements in cognition may occur. This is a result of
the loss of a neurotransmitter called dopamine. Years of heavy drinking can result in a form of
dementia. The forgetfulness phase may be the first stage that is characterised with too little short-
term memory. Also, persons with Lewy Body Disease appear to be more sensitive to medications
related to behavior problems. A large percent of persons with Down's Syndrome, who live to the age
of forty or over develop Alzheimer's Disease. Dr. Gelb discusses in depth how copying geometric
puzzles and counting backwards by seven does not reflect everyday skills. If you would like to
deposit a peer-reviewed article or book chapter, use the “Scholarly Articles and Book Chapters”
deposit option. Alzheimer's is a progressive disease, where dementia symptoms gradually worsen
over a number of years. Adobe Express Go from Adobe Express creation to Issuu publication. It
provides the necessary nutrients that enhance one's immunity thus preventing the body from
infections. By continuing, you agree to our Terms and Conditions. This project, which follows two
caregivers in different stages of caregiving, works to present a detailed, intimate portrait of their
experiences with Alzheimer's. In rural areas, neighbors and friends often help the primary caregiver
by offering their services so the caregiver can have sometime away from the often stressful situation.
(Hagan, April 1998).
