This document provides information about a textbook on biochemistry authored by Dr. MN Chatterjea for students of dentistry, nursing, pharmacy, and other allied health sciences. It lists the author's other publications and provides details about the publisher, Jaypee Brothers Medical Publishers. The foreword written by the Principal of Christian Dental College endorses the book for undergraduate dental students. In the preface, the author explains the scope and objectives of the third edition of the textbook.
This document provides information about a textbook on biochemistry authored by Dr. MN Chatterjea for students of dentistry, nursing, pharmacy, and other allied health sciences. It lists the author's other publications and provides details about the publisher, Jaypee Brothers Medical Publishers. The foreword written by the Principal of Christian Dental College endorses the book for undergraduate dental students. In the preface, the author explains the scope and objectives of the third edition of the textbook.
This document provides information about a textbook on biochemistry authored by Dr. MN Chatterjea for students of dentistry, nursing, pharmacy, and other allied health sciences. It lists the author's other publications and provides details about the publisher, Jaypee Brothers Medical Publishers. The foreword written by the Principal of Christian Dental College endorses the book for undergraduate dental students. In the preface, the author explains the scope and objectives of the third edition of the textbook.
This document provides information about a textbook on biochemistry authored by Dr. MN Chatterjea for students of dentistry, nursing, pharmacy, and other allied health sciences. It lists the author's other publications and provides details about the publisher, Jaypee Brothers Medical Publishers. The foreword written by the Principal of Christian Dental College endorses the book for undergraduate dental students. In the preface, the author explains the scope and objectives of the third edition of the textbook.
BIOCHEMISTRY for Dental/Nursing/Pharmacy Students Other Publications by the Same Author • Textbook of Medical Biochemistry, 7th Edn, 2000 • Clinical Chemistry: Organ Function Tests and Laboratory Investigations, 1st Edn, 1999 • Viva in Biochemistry, 1st Edn, 1999 Textbook of BIOCHEMISTRY for Dental/Nursing/Pharmacy Students (Also for Medical Science/Life Science/Agriculture/DMLT and Homeopathy/Ayurvedic Colleges, etc.)
Third Edition
Dr (Brig) MN Chatterjea BSc MBBS DCP MD (Biochemistry)
Formerly Professor and Head Department of Biochemistry Armed Forces Medical College, Pune Professor and Head Department of Biochemistry Christian Medical College, Ludhiana Professor and Head Department of Biochemistry MGM's Medical College, Aurangabad Specialist in Pathology and Biochemistry and Reader in Pathology Armed Forces Medical College Pune, India
USA Office 1745, Pheasant Run Drive, Maryland Heights (Missouri), MO 63043, USA, Ph: 001-636-6279734 e-mail: jaypee@jaypeebrothers.com, anjulav@jaypeebrothers.com
Textbook of Biochemistry for Dental/Nursing/Pharmacy Students
This book has been published in good faith that the material provided by author is original. Every effort is made to ensure accuracy of material, but the publisher, printer and author will not be held responsible for any inadvertent error(s). In case of any dispute, all legal matters are to be settled under Delhi jurisdiction only.
First Edition: 1997
Second Edition: 2004 Third Edition: 2009 ISBN 978-81-8448-531-8 Typeset at JPBMP typesetting unit Printed at Ajanta Offset & Packagings Ltd., New Delhi To the memory of my late parents CHRISTIAN DENTAL COLLEGE POST BOX NO. 109 C.M.C., LUDHIANA-141008, PUNJAB (REGISTERED SOCIETY UNDER ACT NO. XXI OF 1860 AS A CHARITABLE MINORITY INSTITUTION)
I consider this a privilege to be associated with this publication of the Textbook of Biochemistry by Dr (Brig) MN Chatterjea which is a book specially for Dental/Nursing and Pharmacy students. Biochemistry is one of the basic sciences on which the Medical Science is built upon. This subject needs special talent to make it attractive, enjoyable and understandable to students. The discipline of biochemistry has expanded in recent years and accordingly, a good knowledge is essential for all students related with allied basic sciences. The book is written in simple and lucid language, easily understandable and clinically oriented. I am sure that this book will prove handy and will be welcomed by undergraduate dental and other students.
Dr JL Joshi BSc BDS MDS FOS (USA) FADI FPFA
Principal, Professor and Head Christian Dental College Ludhiana Preface to the Third Edition
I feel great pleasure and satisfaction to present the third edition of the book Textbook of Biochemistry for Dental/Nursing/Pharmacy Students to my beloved students and esteemed teachers. As already pointed out the book can be useful for students of Ayurveda, Homeopathy, DMLT Course and Home Sciences. The book can be of immense value to MBBS students also, who can use the book as a concise companion for rapid revision. Though, the main framework has been retained, extensive revisions of certain portions have been made. Topics like ‘Protein Synthesis’ have been rewritten keeping in view of the recent advances. New chapters like ‘Recombinant DNA Technology’ and ‘Biochemistry of AIDS’ hot topics have been incorporated. The overall objective has been to provide concise yet authoritative coverage of the “Basics of Biochemistry” to the Dental/Nursing/Pharmacy students, for applying the knowledge gained for understanding the disease processes. I have highlighted the important points to be remembered by the students by bold/italic prints. I have tried my utmost to ensure that the language used is simple, lucid and easily understandable by the students. My aim has been to make the book clinically oriented and I have given clinical significance and biomedical importance wherever necessary. I hope the new edition of the book will fulfil the needs and expectations of the students and teachers of Dental/Nursing/Pharmacy and allied disciplines. I shall look forward for valuable comments and fruitful suggestions, if any, for further inclusions/corrections for improving the quality of the book. I extend my appreciation and sincere thanks to Shri Jitendar P Vij (Chairman and Managing Director), Mr PG Bandhu (Director-Sales) and Mr Tarun Duneja (Director-Publishing) for their untiring work and keen efforts to bring out the new revised edition of the book.
Dr (Brig) MN Chatterjea Preface to the First Edition
It gives me immense pleasure and satisfaction in introducing a Textbook of Biochemistry for Dental/ Nursing/Pharmacy Students. The discipline of biochemistry, in recent years has expanded by leaps and bounds. The current efflorescence in the knowledge in this subject has necessitated that it should be learnt separately from physiology. A sound and comprehensive knowledge in biochemistry has now become essential for the students of dental and allied basic sciences. At present there is paucity of a comprehensive standard clinically oriented biochemistry textbook for these students. My Textbook of Medical Biochemistry is being used in certain Dental and Homeopathy Colleges. The book is rather voluminous for them and contains a few topics which are not required by them. Hence, I have attempted to extract the essential elements from the parent book and put in the present concise form. An attempt has been made in this book to present the subject pointwise, clinically oriented in simple and lucid language avoiding complicated chemical formulae so that it becomes comprehensive, and an average student of dental and basic science can easily understand the subject. No one can claim to be perfect and even with best of my efforts, there may be some flaws and shortcomings in the book. I shall be highly delighted to welcome constructive criticisms and comments, if any, along with fruitful suggestions to improve the quality of the book in its future editions. In writing a textbook, one has to take help from others and this book is no exception. I am highly indebted to all my colleagues, friends and authors consulted and referred in compiling the book. I am grateful to Mr JP Vij, CMD and Mr RK Yadav, Director (Publishing) and the staff of Jaypee Brothers Medical Publishers (P) Ltd. for giving a proper shape in bringing out the first edition of the book successfully.
Dr (Brig) MN Chatterjea Contents
1. Chemistry of Carbohydrates ......................................................................................................... 1
2. Chemistry of Lipids ...................................................................................................................... 20 3. Chemistry of Proteins and Amino Acids .................................................................................. 41 4. Plasma Proteins—Chemistry and Functions ........................................................................... 61 5. Chemistry of Nucleotides ............................................................................................................ 76 6. Chemistry of Nucleic Acids ........................................................................................................ 85 7. Chemistry of Enzymes ................................................................................................................. 93 8. Biological Oxidation ................................................................................................................... 112 9. Vitamins ........................................................................................................................................ 126 10. Chemistry of Haemoglobin ....................................................................................................... 167 11. Digestion and Absorption of Carbohydrates, Lipids and Proteins .................................. 178 12. Metabolism of Carbohydrates .................................................................................................. 192 13. Metabolism of Lipids ................................................................................................................. 243 14. Metabolism of Proteins and Amino Acids ............................................................................. 290 15. Integration of Metabolism of Carbohydrates, Lipids and Proteins .................................. 336 16. Metabolism of Purines and Pyrimidines ............................................................................... 341 17. Protein Synthesis ........................................................................................................................ 353 18. Recombinant DNA Technology ............................................................................................... 368 19. Detoxication ................................................................................................................................. 377 20. Free Radicals: Chemistry and Functions ................................................................................ 384 21. Bile Pigments: Metabolism ....................................................................................................... 388 22. Hormones: Chemistry and Functions ..................................................................................... 397 23. Metabolism of Minerals and Trace Elements ....................................................................... 455 24. Diet and Nutrition: Energy Metabolism ................................................................................ 483 25. Water and Electrolyte Balance and Imbalance ...................................................................... 513 26. Acid-Base Balance and Imbalance ........................................................................................... 528 27. Renal Function Tests .................................................................................................................. 546 28. Liver Function Tests ................................................................................................................... 556 29. Mechanism of Action of Drugs ................................................................................................ 570 30. Biochemistry of AIDS ................................................................................................................ 575 References ........................................................................................................................................ 591 Index ............................................................................................................................................... 593
