DIAGNOSTIC REPORT
MC-5875
PATIENT NAME : SANJAY DOCTOR REF. DOCTOR : DR. MONICA GOEL
CODE/NAME & ADDRESS : C000141876 ACCESSION NO : 0043WI005539 AGE/SEX : 58 Years Male
FPSC KORADIA LABS PATIENT ID : SANJM130919650 DRAWN : 13/09/2023 16:32:21
SHOP NO.1, GROUND FLOOR, SHREE RAM BHUVAN
CLIENT PATIENT ID: RECEIVED : 13/09/2023 16:52:57
CHS LTD, PLOT NO.745 JEHANGIR VIMA,DALAL
ROAD PARSI COLONY DADAR EAST, ABHA NO : REPORTED :13/09/2023 20:59:56
MUMBAI 400014
9819941901
Test Report Status Final Results Biological Reference Interval Units
SEROLOGY
MALARIA ANTIGEN DETECTION, WHOLE BLOOD
PLASMODIUM FALCIPARUM ANTIGEN NOT DETECTED NOT DETECTED
PLASMODIUM VIVAX ANTIGEN DETECTED NOT DETECTED
Interpretation(s)
MALARIA ANTIGEN DETECTION, WHOLE BLOOD-Four species of the plasmodium parasites are responsible for human malaria infections P. falciparum, P. vivax, P. ovale and
P. malariae. P. falciparum and P. vivax are the most prevalent. Early detection and differentiation of malaria is of paramount importance due to incidence of cerebral malaria
and drug resistance associated with P. falciparum malaria causing most of the morbidity and mortality worldwide .As treatment depends on the species, differential diagnosis
of P. falciparum and P. vivax is extremely important for better patient care management and faster recovery.
Test Utility:
The current test is a qualitative test for detection of the P. falciparum specific histidine rich protein-2 (Pf. HRP-2) and P. vivax specific lactate dehydrogenase (pLDH) in
whole blood samples. The assay is able to detect and distinguish P. vivax and P. falciparum infections and also identify mixed infections.
Notes & Limitations:
- In case of a suspected P. falciparum case, a positive band for Pf. HRP-2 is highly predictive of infection, but a negative test result may not rule out the same. This may be
seen in patients with i) very low parasitic index (<5 parasites/HPF), as the test sensitivity and test band intensity correlated directly with the parasite density, and i)
Carriers, as Pf. HRP-2 is not secreted in the gametogony (sexual) stage. Rarely, a false negative result may be seen in individuals with a gene deletion for the production of
HRP-2.
- Pf. HRP-2 persists after successful therapy and may be detectable even after the clinical symptoms of malaria have disappeared and the parasites have apparently been
cleared from the host. Hence it should not be used for monitoring early therapeutic responses.
- In case of a stand alone P. vivax infection, the band for pLDH may be used to monitor patient progress during therapy and predict recrudescence and possible
drug-resistant infections. In case the pLDH band remains positive with the same intensity after 5-10 days, the possibility of a resistant strain has to be considered. A
negative pLDH result does not rule out P. vivax infection, as may be seen in patients with a very low parasitic index (<5 parasites/HPF).
Since the test detects P. falciparum specific HRP-2 and P. vivax specific LDH, a negative test result does not rule out infection with P. ovale and P. malariae.
- Constant exposure to the malarial parasites, as seen in areas of high endemicity, may result in positive results with doubtful clinical significance. Hence, the results must
always be correlated with clinical history and relevant epidemiological and therapeutic context. Also note that blood film examination remains the standard method for
diagnosing malaria, since it detects all Plasmodium spp. and allows visualization of parasite growth stages, which is essential for making therapeutic decisions.
Page 7 Of 9
Dr. Geetha Chandrashekhar, MD
Consultant Pathologist
View Details View Report
PERFORMED AT :
Agilus Pathlabs Private Limited
Phadke-Mahim West
Mahalakshmi Industrial Estate, Mahim WestMumbai - 400016 Patient Ref. No. 775000004686817
Tel : +91 22 48247247/022 68247247, Fax : CIN - U85I95DL1999PTC217659 Web : www.agilusdiagnostics.com
