Annals of Internal Medicine䊛
In the Clinic®
                                   Fall Prevention in
                                   Community-Dwelling
                                   Older Adults                                                                                     Practice Improvement
                                   F
                                          alls are common among older adults. One
                                          in 3 adults aged 65 years or older and 1 in                                                        Risk Factors
                                          2 adults aged 80 years or older fall each
                                   year. Interventions for prevention have been
                                   identified; however, they are often not ad-                                                                 Evaluation
                                   dressed in primary care practice. Screening all
                                   older adults annually for falls can identify who
                                   will benefit from further clinical evaluation and
                                   management. Falls and the need for care from
                                                                                                                                           Management
                                   subsequent injury increase with age. They ad-
                                   versely affect quality of life and are a financial
                                   burden on the health care industry. As a result,                                                 Practice Improvement
                                   risk reduction is a key focus of prevention ef-
                                   forts, even among very elderly persons.
                                                     CME/MOC activity available at Annals.org.
         Physician Writers             doi:10.7326/AITC201812040
         Elizabeth A. Phelan, MD, MS
         Katherine Ritchey, DO, MPH    CME Objective: To review current evidence for risk factors, evaluation, management, and
         From the Division of          practice improvement of fall prevention in community-dwelling older adults.
         Gerontology and Geriatric     Funding Source: American College of Physicians.
         Medicine, Department of
         Medicine, University of       Disclosures: Drs. Phelan and Ritchey, ACP Contributing Authors, have disclosed no conflicts
         Washington, Seattle,          of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterest
         Washington.                   Forms.do?msNum=M18-1801.
                                       With the assistance of additional physician writers, the editors of Annals of Internal
                                       Medicine develop In the Clinic using MKSAP and other resources of the American
                                       College of Physicians.
                                       In the Clinic does not necessarily represent official ACP clinical policy. For ACP clinical
                                       guidelines, please go to https://www.acponline.org/clinical_information/guidelines/.
                                       © 2018 American College of Physicians
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      1. The prevention of falls in                     Falls are common among older                adding significantly to the mor-
         later life. A report of the
         Kellogg International                          adults and have serious conse-              bidity of this geriatric syndrome
         Work Group on the Pre-                         quences. The generally accepted
         vention of Falls by the
                                                                                                    (5). Short- and long-term care for
         Elderly. Dan Med Bull.                         definition of a fall is “coming to           fall-related injuries contributes
         1987;34 Suppl 4:1-24.
         [PMID: 3595217]                                rest unintentionally on the                 significantly to social and eco-
      2. Centers for Disease Con-                       ground or lower level, not due to           nomic costs. In 2015, direct
         trol and Prevention, Na-
         tional Center for Injury                       an acute event” (e.g., seizure,             medical costs were estimated to
         Prevention and Control.                        syncope, or stroke) or an over-
         Web-based Injury Statistics                                                                exceed $50 billion (6). However,
         Query and Reporting                            whelming external force to which            only 1 in 4 community-dwelling
         System (WISQARS). Lead-
         ing cause of non-fatal                         any person would be susceptible             older adults discusses falls with
         injury. 2016. Accessed at                      (1). Fall rates double with each
         www.cdc.gov/injury                                                                         hir or her health care provider
         /wisqars/nonfatal.html on                      decade of age beyond the sev-
         6 June 2018.                                                                               (7). Evidence suggests that the
                                                        enth decade, and falls are the
      3. Kannus P, Parkkari J,                                                                      risk for falling can be reduced by
         Niemi S, Palvanen M.                           third leading cause of death re-
         Fall-induced deaths
                                                        sulting from unintentional injury           20%– 40% depending on the type
         among elderly people. Am
         J Public Health. 2005;95:                      (2). They are also the leading              of intervention (8). Health care
         422-4. [PMID: 15727970]                                                                    providers must thus be proactive
      4. Sterling DA, O’Connor JA,                      cause of fatal and nonfatal injury
         Bonadies J. Geriatric falls:                   in older adults (3, 4). Even non-           in their primary and secondary
         injury severity is high and
         disproportionate to mech-                      injurious falls may precipitate             screening efforts and offer ap-
         anism. J Trauma. 2001;
         50:116-9. [PMID:                               functional decline, psychological           propriate evidence-based
         11231681]                                      stress, and loss of independence,           recommendations.
      5. King MB, Tinetti ME. Falls
         in community-dwelling
         older persons. J Am Geri-
         atr Soc. 1995;43:1146-54.
         [PMID: 7560708]
      6. Florence CS, Bergen G,
                                         Risk Factors
         Atherly A, Burns E, Stevens                    What factors increase risk for              (e.g., orthostatic hypotension),
         J, Drake C. Medical costs
         of fatal and nonfatal falls                    falls?                                      musculoskeletal (e.g., arthritis),
         in older adults. J Am Geri-
                                                        Falls typically do not have a sin-          neurologic (e.g., dementia, Par-
         atr Soc. 2018;66:693-8.
         [PMID: 29512120]                               gle cause. Like other conditions            kinson disease, stroke), and uro-
      7. Stevens JA, Ballesteros
         MF, Mack KA, Rudd RA,                          that become more common later               logic (e.g., urinary incontinence)
         DeCaro E, Adler G. Gender                      in life, they tend to result from           systems (11, 12). Extrinsic factors
         differences in seeking care
         for falls in the aged Medi-                    several factors (9) stemming from           comprise elements in a person's
         care population. Am J                                                                      surroundings that are difficult to
         Prev Med. 2012;43:59-                          the interaction of age-related
         62. [PMID: 22704747]                           changes, chronic medical condi-             navigate (e.g., cords in walkways,
      8. Gillespie LD, Robertson
         MC, Gillespie WJ, Sher-                        tions, and other individual and             steep or uneven surfaces, poor
         rington C, Gates S, Clem-
                                                        environmental variables (10).               lighting), lack or improper use of
         son LM, et al. Interven-
         tions for preventing falls                     Falls frequently have adverse ef-           an assistive device, inappropriate
         in older people living in
         the community. Cochrane                        fects on function and quality of            footwear, medications, and
         Database Syst Rev. 2012:                       life, and similar to other geriatric        alcohol or drugs (13, 14). Falls
         CD007146. [PMID:
         22972103]                                      syndromes, they are largely pre-            frequently result from the simul-
      9. Phelan EA, Vig EK, Abrass
         IB. Some considerations                        ventable and are not considered             taneous interaction of several of
         regarding geriatric syn-                       part of normal aging.                       these factors.
         dromes [Letter]. Ann In-
         tern Med. 2001;135:
         1095. [PMID: 11747404]                         Risk factors for falls are classified        Fall risk can be estimated by the
      10. Inouye SK, Studenski S,
           Tinetti ME, Kuchel GA.
                                                        as modifiable or nonmodifiable                strength of 1 risk factor or the
           Geriatric syndromes:                         and as intrinsic (dependent on              cumulative effects of several fac-
           clinical, research, and
           policy implications of a                     the individual) or extrinsic (envi-         tors. Independent risk factors
           core geriatric concept. J                    ronmental) (11) (see the Box: In-           associated with increased proba-
           Am Geriatr Soc. 2007;
           55:780-91. [PMID:                            trinsic and Extrinsic Risk Factors          bility of falling include a history of
           17493201]
      11. Tinetti ME, Speechley M,                      for Falls). Intrinsic risk factors are      falls (likelihood ratio [LR], 3), in-
           Ginter SF. Risk factors for                  age-related changes, chronic                ability to rise from a chair without
           falls among elderly per-
           sons living in the com-                      conditions, and behaviors that              using the arms (LR, 4), slow gait
           munity. N Engl J Med.
           1988;319:1701-7.
                                                        limit a person's inherent ability to        (LR, 2), self-perceived mobility
           [PMID: 3205267]                              prevent a fall. Many medical con-           problem (LR, 2), use of psychoac-
      12. Tinetti ME, Kumar C. The
           patient who falls: “It's                     ditions increase fall risk, and they        tive medications (LR, 20), demen-
           always a trade-off”.                         cover a range of organ systems,             tia (LR, 15), Parkinson disease
           JAMA. 2010;303:258-
           66. [PMID: 20085954]                         including the cardiovascular                (LR, 5), or stroke (LR, 3) (15). Indi-
            姝 2018 American College of Physicians       ITC82              In the Clinic   Annals of Internal Medicine    4 December 2018
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                 Intrinsic and Extrinsic Risk Factors for Falls
                 Intrinsic                                                                                                               13. Lord SR, Menz HB, Sher-
                                                                                                                                             rington C. Home envi-
                 Ocular: Decreased visual acuity, macular degeneration, glaucoma, cataracts,                                                 ronment risk factors for
                    reduced accommodation, reduced depth perception, vision loss,                                                            falls in older people and
                    retinopathy                                                                                                              the efficacy of home
                                                                                                                                             modifications. Age Age-
                 Cardiovascular: Bradycardia, tachyarrhythmia, orthostatic hypotension,                                                      ing. 2006;35 Suppl
                    decompensated heart failure                                                                                              2:ii55-ii59. [PMID:
                                                                                                                                             16926207]
                 Neurologic: Cognitive impairment or dementia, Parkinson disease,                                                        14. Faulkner S, Burns D.
                    cerebrovascular accident, other movement disorder, peripheral                                                            Identifying modifiable
                                                                                                                                             environmental risk fac-
                    neuropathy, gait deficits and imbalance                                                                                   tors for falls in older
                 Urologic: Incontinence (any type), nocturia                                                                                 people. Inj Prev. 2010;
                                                                                                                                             16(Suppl 1):A254.
                 Psychological: Insomnia/sleep deprivation, depression                                                                   15. Ganz DA, Bao Y, Shekelle
                 Musculoskeletal: Osteoarthritis or inflammatory arthritis, pain,                                                             PG, Rubenstein LZ. Will
                                                                                                                                             my patient fall? JAMA.
                    lower-extremity weakness, postural instability or imbalance,                                                             2007;297:77-86. [PMID:
                    reduced flexibility                                                                                                       17200478]
                                                                                                                                         16. Nevitt MC, Cummings
                                                                                                                                             SR, Hudes ES. Risk fac-
                 Extrinsic                                                                                                                   tors for injurious falls: a
                 Medications: Anticholinergics, antidepressants,                                                                             prospective study. J
                   antipsychotics, sedative– hypnotics, benzodiazepines,                                                                     Gerontol. 1991;46:
                                                                                                                                             M164-70. [PMID:
                   opiates, antihypertensives, ␣- and -blockers,                                                                            1890282]
                   antiarrhythmics, use of more than 4 medications                                                                       17. Tinetti ME, Doucette JT,
                                                                                                                                             Claus EB. The contribu-
                 Footwear: Backless shoes and slippers; high heels; shoes                                                                    tion of predisposing and
                   lacking dorsum, arch, or heel supports; shoes with                                                                        situational risk factors to
                   heavy soles or a narrow toe box                                                                                           serious fall injuries. J Am
                                                                                                                                             Geriatr Soc. 1995;43:
                 Environment: Wet or slippery surfaces, lack of grab bars,                                                                   1207-13. [PMID:
                   uneven flooring, floor rugs, poor lighting, lack of                                                                         7594153]
                                                                                                                                         18. Tinetti ME, Doucette J,
                   handrails for steps, cords or other walkway hazards                                                                       Claus E, Marottoli R. Risk
                                                                                                                                             factors for serious injury
                                                                                                                                             during falls by older
                                                                                                                                             persons in the commu-
                                                                                                                                             nity. J Am Geriatr Soc.
               vidual risk for falling increases                male sex, low body weight (body                                              1995;43:1214-21.
               markedly with an increase in risk                mass index < 22 kg/m2), and                                                  [PMID: 7594154]
                                                                                                                                         19. Liu JY. Fear of falling in
               factors.                                         cognitive impairment. Situational                                            robust community-
                                                                                                                                             dwelling older people:
                                                                factors include falling on stairs,                                           results of a cross-
               In a prospective study of community-dwelling
                                                                displacing activity (shifting weight                                         sectional study. J Clin
               persons older than 75 years, the percentage                                                                                   Nurs. 2015;24:393-405.
               who fell within 1 year nearly doubled with       over one's center of gravity, as                                             [PMID: 24787119]
               each additional risk factor (11). Even persons   when opening a door or reaching                                          20. Scheffer AC, Schuurmans
                                                                                                                                             MJ, van Dijk N, van der
               without any of the aforementioned risk factors   into a closet), or falling from a level                                      Hooft T, de Rooij SE. Fear
                                                                                                                                             of falling: measurement
               had a 10% chance of falling, suggesting that     equal to or greater than one's                                               strategy, prevalence, risk
               advancing age by itself increases risk (11).     height (17). As with fall risk factors,                                      factors and conse-
                                                                                                                                             quences among older
                                                                each predisposing or situational                                             persons. Age Ageing.
               What factors put patients at                                                                                                  2008;37:19-24. [PMID:
                                                                factor exponentially increases risk
               risk for fall-related injuries?                                                                                               18194967]
                                                                for injury, from 0%–5% in persons                                        21. Kumar A, Carpenter H,
               Roughly half of falls result in in-                                                                                           Morris R, Iliffe S, Kend-
                                                                with no injury risk factors to 23%–                                          rick D. Which factors are
               jury (16), and 10% result in seri-
                                                                36% in persons with more than 2                                              associated with fear of
               ous injury (5). The presence of                                                                                               falling in community-
                                                                factors (17).                                                                dwelling older people?
               both predisposing factors (indi-                                                                                              Age Ageing. 2014;43:
               vidual features) and situational                                                                                              76-84. [PMID:
                                                                                                                                             24100619]
               factors (fall circumstances) pre-                A high-quality, prospective cohort study exam-                           22. Maki BE, Holliday PJ,
               dicts persons at risk for serious                ined risk factors predictive of serious injury. It                           Topper AK. Fear of falling
                                                                                                                                             and postural perfor-
               injury, which includes fractures;                followed 1103 community-dwelling persons                                     mance in the elderly. J
                                                                for 1 year. Factors that were independently as-                              Gerontol. 1991;46:
               joint dislocations, hemarthroses,                                                                                             M123-31. [PMID:
                                                                sociated with serious injury from a fall in-                                 2071833]
               and serious sprains; head injuries
                                                                cluded cognitive impairment (adjusted odds                               23. Yardley L, Smith H. A
               resulting in loss of consciousness               ratio [OR], 2.2 [95% CI, 1.5–3.2]), presence of                              prospective study of the
                                                                                                                                             relationship between
               and hospitalization; lacerations                 at least 2 chronic conditions (OR, 2.0 [CI, 1.4 –                            feared consequences of
               requiring sutures; and internal                  2.9]), balance and gait impairment (OR, 1.8                                  falling and avoidance of
                                                                                                                                             activity in community-
               injuries resulting in hospitaliza-               [CI, 1.3–2.7]), and low body mass index (OR,                                 living older people.
               tion or decreased activity (17).                                                                                              Gerontologist. 2002;42:
                                                                1.8 [CI, 1.2–2.5]). In a subset analysis of only                             17-23. [PMID:
               Predisposing factors include fe-                 persons who fell, female sex (OR, 1.8 [CI, 1.1–                              11815695]
               4 December 2018            Annals of Internal Medicine              In the Clinic                ITC83   姝 2018 American College of Physicians
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                                                      2.9]) was also more commonly associated as-          its associated morbidity (21). On
      24. Young WR, Mark Wil-                         sociated with injurious falls. The study further     a functional level, fear of falling
          liams A. How fear of                        highlighted the most important predictors of         is associated with postural
          falling can increase fall-
          risk in older adults: ap-
                                                      serious fall-related injuries (18).                  changes, reduced balance confi-
          plying psychological
          theory to practical obser-                  How does fear of falling                             dence, activity avoidance, and
          vations. Gait Posture.
          2015;41:7-12. [PMID:                        influence fall risk?                                  reduced exercise (22, 23). It is
          25278464]                                   Fear of falling has psychological                    also a strong predictor of future
      25. Vellas BJ, Wayne SJ,
          Romero LJ, Baumgartner                      consequences that increase the                       falls (24). Psychologically, per-
          RN, Garry PJ. Fear of
                                                      overall risk for falling and func-                   sons who fear falling have poorer
          falling and restriction of
          mobility in elderly fallers.                tional decline (19). Roughly 21%–                    mental health, reduced indepen-
          Age Ageing. 1997;26:
          189-93. [PMID:                              85% of community-dwelling                            dence, and poorer self-rated
          9223714]                                    older adults who have fallen and                     health (25). Fear of falling leads
      26. Panel on Prevention of
          Falls in Older Persons,                     33%– 46% of those who have not                       to activity restriction and acceler-
          American Geriatrics Soci-                                                                        ates functional decline. Recogniz-
          ety and British Geriatrics
                                                      report that they fear falling (20).
          Society. Summary of the                     Certain factors, such as difficulty                   ing this situation can enable pro-
          updated American Geri-
          atrics Society/British                      using public transportation,                         viders to encourage affected
          Geriatrics Society clinical                 poorer perceived health status,                      patients to engage in fall preven-
          practice guideline for
          prevention of falls in                      difficulty with balance, and inabil-                  tion efforts with the goal of re-
          older persons. J Am
          Geriatr Soc. 2011;59:
                                                      ity to rise from a chair, character-                 gaining confidence and eventu-
          148-57. [PMID:                              ize persons who may be at                            ally returning to previously
          21226685]
      27. Stevens JA, Phelan EA.                      greater risk for fear of falling and                 enjoyable activities.
          Development of STEADI:
          a fall prevention resource
          for health care providers.
          Health Promot Pract.
          2013;14:706-14. [PMID:
          23159993]                                     Risk Factors... Falls result from independent but interacting modifiable
      28. Rubenstein LZ, Vivrette
          R, Harker JO, Stevens JA,
                                                        and nonmodifiable intrinsic and extrinsic risk factors. Factors associated
          Kramer BJ. Validating an                      with the greatest risk for falls include use of psychoactive medications,
          evidence-based, self-                         impaired gait, lack of lower-extremity strength and balance, and im-
          rated fall risk question-
          naire (FRQ) for older                         paired cognition. Injurious falls are more common in women and per-
          adults. J Safety Res.                         sons with cognitive impairment, several chronic conditions, and low
          2011;42:493-9. [PMID:
          22152267]
                                                        body weight. Severity of fall-related injuries is also affected by situa-
      29. Podsiadlo D, Richardson                       tional factors that increase the impact of a fall. The greater the number
          S. The timed “Up & Go”:                       of risk factors present, the greater the risk for falls and fall-related
          a test of basic functional
          mobility for frail elderly                    injuries.
          persons. J Am Geriatr
          Soc. 1991;39:142-8.
          [PMID: 1991946]
      30. Schoene D, Wu SM,                                                                                       CLINICAL BOTTOM LINE
          Mikolaizak AS, Menant
          JC, Smith ST, Delbaere K,
          et al. Discriminative
          ability and predictive
          validity of the Timed Up
          and Go Test in identify-
          ing older people who
                                         Evaluation
          fall: systematic review                     How often should patients be                         questions require further assess-
          and meta-analysis. J Am
          Geriatr Soc. 2013;61:                       assessed for risk for falls?                         ment. To encourage adoption of
          202-8. [PMID:
          23350947]                                   Screening for falls begins with                      preventive measures by primary
      31. Jones CJ, Rikli RE, Beam
                                                      obtaining historical or self-                        care providers, the Centers for
          WC. A 30-s chair-stand
          test as a measure of                        reported information on balance,                     Disease Control and Prevention
          lower body strength in
          community-residing                          lower-extremity strength, and                        (CDC) developed the Stopping
          older adults. Res Q Exerc                   gait. The American and British                       Elderly Accidents, Deaths & Inju-
          Sport. 1999;70:113-9.
          [PMID: 10380242]                            Geriatrics Societies (AGS/BGS)                       ries (STEADI) tool kit to help
      32. Rossiter-Fornoff JE, Wolf
          SL, Wolfson LI, Buchner                     clinical practice guideline recom-                   integrate these guidelines into
          DM. A cross-sectional                       mends that all persons older than                    clinical settings (27). It suggests
          validation study of the
          FICSIT common data                          65 years be asked yearly if they                     using the following key questions
          base static balance mea-
          sures. Frailty and Inju-
                                                      have fallen 2 or more times in the                   for screening: “Have you fallen in
          ries: Cooperative Studies                   past year, were injured in a fall,                   the past year?” “Do you feel un-
          of Intervention Tech-
          niques. J Gerontol A Biol                   or have any difficulties with walk-                   steady when standing or walk-
          Sci Med Sci. 1995;50:                       ing or balance (26). Patients who                    ing?” and “Do you worry about
          M291-7. [PMID:
          7583799]                                    answer “yes” to any of these                         falling?” The CDC also offers a
            姝 2018 American College of Physicians      ITC84                  In the Clinic       Annals of Internal Medicine   4 December 2018
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                 Table 1. Functional Tests
                 Test                             Description                                         Comments
                 Timed Up-and-Go test             Assesses mobility, balance, transfer ability, and   Cut-off scores signaling high risk vary
                                                   fall risk. A person rises from a hard-backed        depending on population. Specificity
                                                   chair with arms, walks 10 feet, turns around,       (60%–87%) tends to be better than
                                                   and sits back down in chair. Assistive device       sensitivity (31%–56%).
                                                   (cane or walker) is used if the person usually
                                                   uses one.
                 Berg Balance test                14-item objective measure designed to assess        This test may be more time-consuming
                                                   static balance (i.e., sitting, standing,            than other balance tests and requires
                                                   transferring, reaching and turning).                training for administration and scoring.
                                                                                                       History of falls and score <51 or no
                                                                                                       history of falls and score <42 is
                                                                                                       predictive of falls (sensitivity 91%,
                                                                                                       specificity 82%). Score <40 associated
                                                                                                       with almost 100% fall risk.
                 Four-Stage Balance test          Tests static balance. A person moves through        Was found in 1 study as being 45%
                                                   4 stances, starting with a parallel stance,         sensitive and 74% specific to predict
                                                   semi-tandem, full tandem, and ending with a         recurrent falls. Easy to administer in
                                                   single leg stance. The goal is to hold each         clinical setting.
                                                   stance unsupported for 10 seconds.
                 Thirty-Second Sit-to-Stand       Tests lower-extremity strength. A person            Normative values are sex- and
                   test                            stands from a seated position as many times          age-specific, and completing less than
                                                   as possible in 30 seconds without using the          the normative value for sex/age
                                                   arms.                                                indicates risk for falling. Sensitivity 68%
                                                                                                        and specificity 54% for predicting falls
                                                                                                        at a cut-off of 11, regardless of sex or
                                                                                                        age.
                 Dynamic Gait Index               Assesses ability to maintain balance while          No training required; takes less than 10
                                                   walking in the presence of external                  minutes to administer; <19 indicate
                                                   demands.                                             increased risk for falling (sensitivity
                                                                                                        59%, specificity 64%).
                 Four-Square Step test            A balance test that assesses a person's ability     Exceeding 15 seconds for completion
                                                    to step forward, sideways, and backward.            indicates increased risk for falling.
                                                                                                                                   33. Vellas BJ, Wayne SJ,
                                                                                                                                       Romero L, Baumgartner
               screening questionnaire devel-                   (26). Several functional perfor-                                       RN, Rubenstein LZ, Garry
               oped to identify persons at risk                 mance tests can be used to quan-                                       PJ. One-leg balance is an
                                                                                                                                       important predictor of
               for falling who would benefit                     tify fall risk (Table 1), but many of                                  injurious falls in older
               from risk-reducing interventions.                them are impractical and unnec-                                        persons. J Am Geriatr
                                                                                                                                       Soc. 1997;45:735-8.
               This 14-item “Stay Independent”                  essary for use in most primary                                         [PMID: 9180669]
                                                                                                                                   34. Chang JT, Ganz DA.
               questionnaire is a validated fall                care and specialty care clinics.                                       Quality indicators for falls
               risk self-assessment that can be                 Therefore, the AGS/BGS and the                                         and mobility problems in
                                                                                                                                       vulnerable elders. J Am
               completed independently by an                    CDC recommend simple tests,                                            Geriatr Soc. 2007;55
               older adult and reviewed by the                  such as the Timed Up-and-Go
                                                                                                                                       Suppl 2:S327-34. [PMID:
                                                                                                                                       17910554]
               health care provider during a                    (TUG) test, Thirty-Second Sit-to-                                  35. Hilmer SN, Gnjidic D.
                                                                                                                                       The effects of polyphar-
               clinical visit (28). A score of 4 or             Stand (STS) test, and Four-Stage                                       macy in older adults.
               more on the questionnaire or an                  Balance test, to identify persons                                      Clin Pharmacol Ther.
                                                                                                                                       2009;85:86-8. [PMID:
               affirmative answer to any of the                  with mobility problems who are                                         19037203]
               key questions in the STEADI tool                 at risk for falling. The TUG test
                                                                                                                                   36. Woolcott JC, Richardson
                                                                                                                                       KJ, Wiens MO, Patel B,
               kit indicates that the patient is at             assesses gait, balance, coordina-                                      Marin J, Khan KM, et al.
                                                                                                                                       Meta-analysis of the
               risk for falling and requires fur-
                                                                tion, and strength; does not re-                                       impact of 9 medication
               ther clinical assessment.                                                                                               classes on falls in elderly
                                                                quire specialized training; and                                        persons. Arch Intern
                                                                                                                                       Med. 2009;169:1952-
               What measures are useful in                      can be administered in about 5                                         60. [PMID: 19933955]
               screening for fall risk?                         minutes (29). Its predictive ability                               37. By the American Geriat-
                                                                                                                                       rics Society 2015 Beers
               For persons with or without a his-               and diagnostic accuracy are                                            Criteria Update Expert
                                                                moderate (30). Persons who take                                        Panel. American Geriat-
               tory of falls or problems with bal-                                                                                     rics Society 2015 up-
               ance or gait, clinical guidelines                12 or more seconds to complete                                         dated Beers criteria for
                                                                                                                                       potentially inappropriate
               recommend functional assess-                     the test are at risk for falling;                                      medication use in older
               ments to evaluate gait, lower-                   those who take more than 20                                            adults. J Am Geriatr Soc.
                                                                                                                                       2015;63:2227-46.
               extremity strength, and balance                  seconds are at greatest risk. The                                      [PMID: 26446832]
               4 December 2018           Annals of Internal Medicine           In the Clinic          ITC85    姝 2018 American College of Physicians
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               Table 2. Core Elements of a Fall-Focused History and Physical Examination
               Fall History                                           Physical Examination
               Symptoms (prodromal): Dizziness/light-                 Head, eyes, ears, nose and throat: Vision acuity, peripheral vision
                 headedness, palpitations
               Prior falls                                            Cardiovascular: Orthostatic vitals, rate, rhythm, murmurs
               Location: Bedroom, bathroom, outside home,             Neurologic: Cognitive screen, sensation, proprioception and balance,
                 community                                              motor function and reflexes, cerebellar testing, gait
               Timing: Postprandial, time of day, relationship        Psychologic: Depression screen
                 to medications
               Activity: Situation before fall—walking or just        Musculoskeletal: Standing posture, range of motion (particularly in joints
                 stood upright                                         of lower extremities, head and neck, trunk), muscle tone and bulk, foot
                                                                       and footwear assessment
                                                       STS and Four-Stage Balance tests                     tation of the fall history is one of
                                                       are quick, office-based screening                     the quality indicators for fall pre-
      38. Stevens JA. The STEADI                       tools that gauge lower-extremity                     vention and management (34).
          tool kit: a fall prevention
          resource for health care                     strength and balance, respec-                        Medication review is a key com-
          providers. IHS Prim Care                     tively, are easy to administer, and
          Provid. 2013;39:162-6.
                                                                                                            ponent of the risk assessment
          [PMID: 26766893]                             provide useful information to                        because many medications in-
      39. Kempen GI, Yardley L,
          van Haastregt JC, Zijlstra
                                                       complement the TUG test (31,                         crease risk for falling (see the
          GA, Beyer N, Hauer K,                        32). Per the AGS/BGS guideline,                      Box: Medications that Increase
          et al. The Short FES-I: a
          shortened version of the                     any person who has gait or bal-                      the Risk for Falling). The clinician
          Falls Efficacy Scale-                         ance abnormalities requires a fall
          International to assess                                                                           should review the clinical neces-
          fear of falling. Age Age-                    risk assessment.                                     sity of all medications— use of 4 or
          ing. 2008;37:45-50.
          [PMID: 18032400]                                                                                  more is an independent risk factor
      40. Tinetti ME, Richman D,                       A longitudinal cohort study investigated the
          Powell L. Falls efficacy as
                                                                                                            for falling (35). Medications with
          a measure of fear of                         predictive ability of a simple, static balance       central nervous system effects,
          falling. J Gerontol. 1990;                   test on risk for falling and serious injury.
          45:P239-43. [PMID:                                                                                including those with anticholin-
          2229948]                                     Community-dwelling adults aged 60 years or
                                                                                                            ergic and sedating properties, are
      41. Applegate WB, Blass JP,                      older (n = 316) had a physical examination
          Williams TF. Instruments
                                                       that included single-leg balance testing, de-        most strongly associated with fall-
          for the functional assess-
          ment of older patients. N                    fined as the ability to stand on 1 leg unsup-         ing and should be tapered, re-
          Engl J Med. 1990;322:                                                                             duced, or discontinued whenever
          1207-14. [PMID:                              ported for 5 seconds. At 3 years, age older than
          2183053]                                     73 years was the only significant independent         possible (36). These include antip-
      42. Tinetti ME, Gordon C,
          Sogolow E, Lapin P,                          predictor of falls, and impaired single-leg bal-     sychotics, tricyclic antidepressants,
          Bradley EH. Fall-risk                        ance was the only independent predictor of           serotonin reuptake inhibitors, cen-
          evaluation and manage-
          ment: challenges in
                                                       injurious falls (relative risk [RR], 2.13 [CI,       trally acting antihypertensives, opi-
          adopting geriatric care                      1.04 – 4.34]) (33).                                  ates, sedative-hypnotics, and
          practices. Gerontologist.
          2006;46:717-25. [PMID:                       What should the clinical                             nonbenzodiazepine- and
          17169927]
      43. Tricco AC, Thomas SM,                        assessment of an at-risk patient                     benzodiazepine-receptor agonists
          Veroniki AA, Hamid JS,
          Cogo E, Strifler L, et al.                    include?                                             (37).
          Comparisons of interven-
          tions for preventing falls
                                                       The fall risk assessment involves                    Selection of appropriate labora-
          in older adults: a system-                   a focused examination of the pa-                     tory and radiologic tests should be
          atic review and meta-
          analysis. JAMA. 2017;                        tient with attention to vital signs,                 guided by concerns identified dur-
          318:1687-99. [PMID:                          including orthostatic blood pres-
          29114830]                                                                                         ing the fall risk assessment. Testing
      44. Reeve E, Wiese MD,                           sure assessments; hearing and
          Hendrix I, Roberts MS,                                                                            may include hematocrit measure-
                                                       vision; the neurologic system,
          Shakib S. People's atti-                                                                          ment; measurement of thyroid-
          tudes, beliefs, and expe-                    including both central and pe-
          riences regarding polyp-                                                                          stimulating hormone, vitamin B12,
          harmacy and willingness                      ripheral systems and cognition;
          to deprescribe. J Am                                                                              and 25-hydroxyvitamin D levels;
                                                       and the cardiovascular and mus-
          Geriatr Soc. 2013;61:                                                                             and dual-energy x-ray absorptiom-
          1508-14. [PMID:                              culoskeletal (including examina-
          24028356]                                                                                         etry (DEXA) scanning.
      45. Martin P, Tannenbaum                         tion of the feet) systems. Details
          C. A realist evaluation of                   of the fall itself should also be                    A meta-analysis that included 22 studies with
          patients' decisions to
          deprescribe in the EM-                       noted, such as timing, location,                     a total of 79 081 participants clarified which
          POWER trial. BMJ Open.                       situational factors, and related
          2017;7:e015959.
                                                                                                            medication classes increase risk for falling
          [PMID: 28473524]                             symptoms (Table 2). Documen-                         (36). The Bayesian unadjusted OR estimates
            姝 2018 American College of Physicians       ITC86                  In the Clinic       Annals of Internal Medicine        4 December 2018
Downloaded From: https://annals.org/ by a York University User on 12/03/2018
               were highest for antidepressants (OR, 1.68 [CI,       ing (ADLs), such as getting
               1.47–1.91]), neuroleptics and antipsychotics          dressed, preparing meals, or                 Medications That Increase the
               (OR, 1.59 [CI, 1.37–1.83]), benzodiazepines           showering. The questionnaire                 Risk for Falling
               (OR, 1.57 [CI, 1.43–1.72]), and sedatives and         categorizes people as having             Antipsychotics
               hypnotics (OR, 1.47 [CI, 1.35–1.62]). Even after      mild, moderate, or high concern          Sedative/hypnotics
               adjustment, OR estimates still indicated that                                                  Antidepressants
                                                                     about falling, with higher scores
               neuroleptics and antipsychotics, antidepressants,                                              Antihypertensives (central-acting)
               and benzodiazepines were associated with in-          correlating with greater concern
                                                                     and risk (40). It is particularly use-   Diuretics
               creased risk (ORs, 1.39 [CI, 0.94 –2.00], 1.36 [CI,
                                                                     ful in the outpatient setting for        Antiarrhythmics
               1.13–1.76], and 1.41 [CI, 1.20 –1.71], respec-
               tively). Antihypertensives (OR, 1.24 [CI, 1.01–       addressing fall-related functional       Opiates
               1.50]), diuretics (OR, 1.07 [CI, 1.01–1.14]),         impairment and identifying older
               -blockers (OR, 1.01 [CI, 0.86 –1.17]), and non-      adults who would benefit from
               steroidal anti-inflammatory drugs (OR, 1.21 [CI,       durable medical equipment, a
               1.01–1.44]) were associated with reduced or non-      home safety assessment, or an                Basic Home Safety
               significant risk. Opiates were also not associated     occupational therapy evaluation.             Recommendations
               with elevated risk (OR, 0.96 [CI, 0.78 –1.18]).                                                Entrances: Railings and steps in
               However, subsequent studies have informed the         What should a home safety                   good condition, adequate
               current recommendation from the AGS Beers Cri-        assessment include?                         lighting
               teria for Potentially Inappropriate Medication Use    In addition to the FES-I, func-          Kitchen: Common items in reach-
               in Older Adults to avoid opiates in persons with a    tional and fall risk assessments            able places, rubber-backed
               history of falls or fracture, excluding indications                                               mats
                                                                     can alert the provider that a
               for acute pain management (moderate-quality                                                    Bathroom: Nonslip bathmat,
               evidence, strong recommendation) (37).                home safety assessment should               grab bars for toilet and
                                                                     be considered. Functional histo-            bath/shower, raised toilet seat,
               Fall risk can be classified as low                     ries can be obtained by stan-               adequate lighting
               or high depending on the pa-                          dardized assessments, such as            Stairs: Clutter removed, railings in
               tient's self-reported measures                        the Katz ADL and the Barthel In-            good repair, color contrast
                                                                                                                 strips on steps
               and performance on functional                         dex (41). If the functional or fall
                                                                                                              Hallways: Clutter removed,
               tests (38). Any person who has                        history suggests concerns related
                                                                                                                 night-lights
               fallen, feels unsteady when walk-                     to environmental factors, recom-
               ing, or worries about falling and                     mending home modifications
                                                                                                                                    46. Burton E, Cavalheri V,
               has a gait, balance, or strength                      (see the Box: Basic Home Safety                                    Adams R, Browne CO,
               impairment on examination is                          Recommendations) or referring                                      Bovery-Spencer P, Fen-
                                                                                                                                        ton AM, et al. Effective-
               likely to fall. Persons with these                    the person to occupational ther-                                   ness of exercise pro-
                                                                                                                                        grams to reduce falls in
               characteristics and those who                         apy would be reasonable (16).                                      older people with de-
               have fallen 2 or more times or                        The CDC also offers a self-                                        mentia living in the
                                                                                                                                        community: a systematic
               had an injurious fall are consid-                     guided home safety assessment                                      review and meta-
                                                                                                                                        analysis. Clin Interv Ag-
               ered to be at high risk. Risk stratifi-                (Check for Safety) that older                                      ing. 2015;10:421-34.
               cation can guide providers in                         adults can complete indepen-                                       [PMID: 25709416]
                                                                                                                                    47. Slaughter SE, Wagg AS,
               choosing intervention options,                        dently (38). This is appropriate                                   Jones CA, Schopflocher
               help determine the need for in-                       for anyone at risk for falling be-                                 D, Ickert C, Bampton E,
                                                                                                                                        et al. Mobility of Vulnera-
               depth assessment, and direct deci-                    cause it offers important, general                                 ble Elders study: effect of
                                                                                                                                        the sit-to-stand activity on
               sions about referral to geriatric                     recommendations for aging suc-                                     mobility, function, and
               specialists.                                          cessfully at home and is freely                                    quality of life. J Am Med
                                                                                                                                        Dir Assoc. 2015;16:138-
                                                                     available on the CDC Web site.                                     43. [PMID: 25271194]
               What tools measure fear of                                                                                           48. Kendrick D, Kumar A,
               falling?                                              When should patients be                                            Carpenter H, Zijlstra GA,
                                                                                                                                        Skelton DA, Cook JR,
               For at-risk persons, the provider                     referred to a specialist?                                          et al. Exercise for reduc-
                                                                                                                                        ing fear of falling in
               should explore fears related to                       There is no specific guideline on                                   older people living in the
               falling and the degree to which                       patient referral to specialty care                                 community. Cochrane
                                                                                                                                        Database Syst Rev. 2014:
               they may cause functional impair-                     for assessment or management                                       CD009848. [PMID:
               ment. Such impairment can be                          of fall risk. However, referral to a                               25432016]
                                                                                                                                    49. Stevens JA, Burns E. CDC
               qualified and quantified using                          geriatrics specialist or fall clinic                               Compendium of Effective
                                                                                                                                        Fall Interventions: What
               either the long (16-item) or short                    could be considered for persons                                    Works for Community-
               (7-item) Falls Efficacy Scale-                         with recurrent falls (≥2 in the past                               Dwelling Older Adults,
                                                                                                                                        3rd Edition. Accessed at
               International (FES-I) (39). This as-                  year); those who continue to fall                                  www.cdc.gov/homean-
               sessment elicits concerns about                       despite preventive measures;                                       drecreationalsafety/falls
                                                                                                                                        /compendium.html on
               falls during activities of daily liv-                 those who are medically, socially,                                 28 June 2018.
               4 December 2018               Annals of Internal Medicine           In the Clinic          ITC87    姝 2018 American College of Physicians
Downloaded From: https://annals.org/ by a York University User on 12/03/2018
               Table 3. Interventions for Fall Prevention and Their Evidence Ratings
               Intervention                                        USPSTF†     AGS/BGS‡      Cochrane Collaboration§
               Strength and balance exercise                       B           A             Effective (16 trials)
               Tai chi                                             B           A             Reduced risk for falling (7 trials)
               Home modification                                    I*          A             Effective (6 trials)
               Medication—Reduction in psychoactive                I*          B             2 positive trials
                  medications
               Medication—Reduction in number or dose              —           B             —
               Postural hypotension management                     —           C             —
               Vitamin D supplementation for fall prevention       D           B             Not effective overall (13 trials)
               Vision screening and management                     —           I             Harmful effect in 1 trial
               Hearing screening and management                    —           —             —
               Foot/shoe screening and management                  —           C             Reduced rate of falls in 2 trials
               Education alone                                     —           D             1 negative trial
               Cardiac pacing for carotid sinus hypersensitivity   —           B             Reduced rate of falls in 3 trials
               First eye cataract surgery                          —           B             1 positive trial
               Multifactorial interventions                        C           A             Effective in reducing rate of but not risk for falling
                                                                                               (19 trials)
               AGS = American Geriatrics Socieity; BGS = British Geriatrics Society; USPSTF = U.S. Preventive Services Task Force.
               † From reference 55. Ratings: A = recommended with high certainty of benefit; B = recommended with moderate certainty of
               benefit; C = selectively offer based on professional judgment and patient preferences; D = recommended against based on
               moderate or high certainty of no benefit or that harms outweigh the benefit; I = insufficient evidence; I* = evidence report finding
               of insufficient evidence/not part of summary recommendation.
               ‡ From reference 26. Ratings: A = strongly recommended; B = recommended; C = no recommendation; D = recommended
               against; I = insufficient evidence.
               § From reference 8. “Effective” and “not effective” based on authors' main conclusions.
                                                        or physically complex; or those                 referred if the provider does not
                                                        who have had an injurious fall                  have the skills or experience to
                                                        (26). The patient should also be                manage fall risk factors (42).
      50. Gardner MM, Buchner                             Evaluation... Older adults should be asked yearly if they have fallen,
          DM, Robertson MC,                               feel unsteady when walking, or have gait or balance difficulty. The risk
          Campbell AJ. Practical
          implementation of an                            assessment should review the intrinsic and extrinsic causes of falls, with
          exercise-based falls pre-                       particular emphasis on risk factors that can also increase risk for injury.
          vention programme. Age
          Ageing. 2001;30:77-83.                          Standardized assessments and functional testing can help guide the
          [PMID: 11322678]                                health care provider in identifying potentially modifiable risk factors.
      51. Clemson L, Fiatarone                            Referral is necessary only if the clinician does not feel equipped to
          Singh MA, Bundy A,
          Cumming RG, Manol-                              implement screening or preventive measures.
          laras K, O’Loughlin P,
          et al. Integration of bal-
          ance and strength train-
          ing into daily life activity
          to reduce rate of falls in
                                                                                                                CLINICAL BOTTOM LINE
          older people (the LiFE
          study): randomised par-
          allel trial. BMJ. 2012;
          345:e4547. [PMID:
          22872695]
      52. Shubert TE, Smith ML,
          Jiang L, Ory MG. Dissem-
          inating the Otago exer-
                                         Management
          cise program in the
          United States: perceived
                                                        What is the role of single clinical             serious ones (e.g., fractures)
          and actual physical per-                      interventions in preventing                     (8, 43).
          formance improvements
          from participants. J Appl                     falls?
          Gerontol. 2018;37:79-                                                                         Home modification is also effec-
          98. [PMID: 27794055]
      53. Robertson MC, Campbell                        Several single interventions are                tive, although evidence is lacking
          AJ, Gardner MM, Devlin
          N. Preventing injuries in
                                                        beneficial in preventing falls                   on whether it reduces fall-related
          older people by prevent-                      (Table 3). Exercise has the stron-              injury as a single intervention
          ing falls: a meta-analysis
          of individual-level data. J                   gest evidence of any individual                 (43). Home modification is more
          Am Geriatr Soc. 2002;                         intervention—it reduces both falls              effective in persons at higher risk
          50:905-11. [PMID:
          12028179]                                     and fall-related injuries, including            for falling, including those with
            姝 2018 American College of Physicians        ITC88               In the Clinic    Annals of Internal Medicine          4 December 2018
Downloaded From: https://annals.org/ by a York University User on 12/03/2018
               severe vision impairment. Home                  injuries: exercise plus vision as-
               safety interventions seem to be                 sessment and management (OR,
               more effective when delivered by                0.17 [CI, 0.07– 0.38]), exercise
               an occupational therapist (8).                  plus vision and environmental
                                                               assessment and management                                    54. Agha A, Liu-Ambrose TY,
               Elimination or dose reduction of                (OR, 0.30 [CI, 0.13– 0.70]), and                                 Backman CL, Leese J, Li
               centrally acting medications is                 clinic-level quality improvement
                                                                                                                                LC. Understanding the
                                                                                                                                experiences of rural
               effective in reducing falls (8, 26).            (e.g., facilitated relay of informa-                             community-dwelling
                                                                                                                                older adults in using a
               In our clinical experience, most                tion to clinicians, clinician remind-                            new DVD-delivered
               older adults have low awareness                 ers) plus multifactorial assessment                              Otago exercise program:
                                                                                                                                a qualitative study. Inter-
               of the link between medications                 and management plus vitamin D                                    act J Med Res. 2015;4:
               and falls, but once advised of this                                                                              e17. [PMID: 26272163]
                                                               and calcium supplementation (OR,                             55. Guirguis-Blake JM, Mi-
               correlation they are typically re-              0.12 [CI, 0.03– 0.55]).                                          chael YL, Perdue LA,
                                                                                                                                Coppola EL, Beil TL. Inter-
               ceptive to reducing the number                                                                                   ventions to prevent falls
               or doses of medications. Re-                    Based on the above findings,                                      in older adults: updated
                                                                                                                                evidence report and
               search on attitudes toward medi-                clinicians should encourage                                      systematic review for the
               cations in older persons has                    exercise (focused on strength and                                US Preventive Services
                                                                                                                                Task Force. JAMA. 2018;
               found similar receptivity, with                 balance), regular vision evaluation,                             319:1705-16. [PMID:
                                                                                                                                29710140]
               68% reporting that they would                   attention to environmental safety,                           56. Grossman DC, Curry SJ,
               like to reduce medication use                   and treatment of osteoporosis to                                 Owens DK, Barry MJ,
                                                                                                                                Caughey AB, Davidson
               and 92% willing to stop use of a                help prevent fractures.                                          KW, et al; US Preventive
                                                                                                                                Services Task Force. Inter-
               medication if advised to do so by               How can fall prevention be                                       ventions to prevent falls
               their physician (44). This study                                                                                 in community-dwelling
                                                               addressed for older adults                                       older adults: US Preven-
               highlights the importance of pro-                                                                                tive Services Task Force
                                                               with dementia?                                                   recommendation state-
               vider engagement in medication
               reduction and the need to recog-                Persons with impaired cognition                                  ment. JAMA. 2018;319:
                                                                                                                                1696-704. [PMID:
               nize medication risks and harms                 are at high risk for falls and inju-                             29710141]
                                                                                                                            57. Holick MF, Binkley NC,
               in older adults (37). Recent                    ries, although most interventions                                Bischoff-Ferrari HA, Gor-
                                                               have not been tested specifically                                 don CM, Hanley DA,
               research found that discourage-                                                                                  Heaney RP, et al; Endo-
                                                               in this population subset. Exer-                                 crine Society. Evaluation,
               ment of medication discontinua-
                                                               cise has been shown to be effec-                                 treatment, and preven-
               tion by their health care provider                                                                               tion of vitamin D defi-
                                                               tive in reducing the risk for falling                            ciency: an Endocrine
               is a key barrier to older adults                                                                                 Society clinical practice
                                                               in community-living older adults
               successfully reducing psychoac-                                                                                  guideline. J Clin Endocri-
                                                               with mild to moderate dementia                                   nol Metab. 2011;96:
               tive medication use (45).                                                                                        1911-30. [PMID:
                                                               (46). However, engaging persons                                  21646368]
               What is the role of multifactorial              with dementia in routine exercise                            58. Cosman F, de Beur SJ,
                                                                                                                                LeBoff MS, Lewiecki EM,
               and multicomponent                              may be met with apathy, resis-                                   Tanner B, Randall S,
                                                                                                                                et al; National Osteopo-
               interventions?                                  tance, and behavioral distur-                                    rosis Foundation. Clini-
               Multifactorial interventions iden-              bances and is a challenge for                                    cian's guide to preven-
                                                                                                                                tion and treatment of
               tify and address fall risk factors              caregivers. A study of nursing                                   osteoporosis. Osteoporos
                                                               home residents with dementia                                     Int. 2014;25:2359-81.
               based on an individualized as-                                                                                   [PMID: 25182228]
               sessment. Multicomponent inter-                 found that focusing on maintain-                             59. Santesso N, Carrasco-
                                                                                                                                Labra A, Brignardello-
               ventions deliver a standardized                 ing lower-extremity strength                                     Petersen R. Hip protec-
               (i.e., nonindividualized) combina-              through a simple intervention of                                 tors for preventing hip
                                                                                                                                fractures in older people.
               tion of interventions that address              health care aide–prompted, re-                                   Cochrane Database Syst
                                                               peated sit-to-stand activity during                              Rev. 2014:CD001255.
               more than 1 risk factor (e.g.,                                                                                   [PMID: 24687239]
               balance and home safety).                       daily care routines on day and                               60. Aryee E, James SL, Hunt
                                                                                                                                GM, Ryder HF. Identify-
                                                               evening shifts was effective in                                  ing protective and risk
               Recent evidence from a compre-                  maintaining the ability to transfer                              factors for injurious falls
                                                                                                                                in patients hospitalized
               hensive systematic review and                   (47). For older adults with ad-                                  for acute care: a retro-
               network meta-analysis (43)                      vanced dementia who are living                                   spective case-control
                                                                                                                                study. BMC Geriatr.
               (based on 54 randomized trials                  at home, continuing to be able to                                2017;17:260. [PMID:
                                                                                                                                29115921]
               with a total of 41 596 participants             transfer independently and safely                            61. Oliver D, Healey F,
               that evaluated 39 interventions                 (e.g., in and out of bed, on and                                 Haines TP. Preventing
                                                                                                                                falls and fall-related
               plus usual care) suggests that the              off the toilet, in and out of a car)                             injuries in hospitals. Clin
               following combinations of single                are important to being able to                                   Geriatr Med. 2010;26:
                                                                                                                                645-92. [PMID:
               interventions reduce fall-related               remain at home and may be                                        20934615]
               4 December 2018          Annals of Internal Medicine            In the Clinic       ITC89   姝 2018 American College of Physicians
Downloaded From: https://annals.org/ by a York University User on 12/03/2018
                                                    more feasible than maintaining                         being disseminated in the United States (52)
                                                    an exercise routine. Recommend-                        and can also be delivered via DVD (54).
                                                    ing sit-to-stand activity is a practical               What is the role of vitamin D
      62. Dykes PC, Carroll DL,                     approach for clinicians seeking to                     and calcium in fall prevention?
          Hurley A, Lipsitz S,
          Benoit A, Chang F, et al.                 advise family caregivers of persons
          Fall prevention in acute
                                                                                                           Vitamin D helps maintain muscle
          care hospitals: a random-
                                                    who wish to age in place but are at                    strength and function. However,
          ized trial. JAMA. 2010;                   high risk for falls due to dementia                    clinical guideline recommenda-
          304:1912-8. [PMID:
          21045097]                                 and impaired mobility.                                 tions seem to conflict on whether
      63. Ganz DA, Huang C,
          Saliba D, Shier V, Berlow-                What should clinicians                                 vitamin D3 (cholecalciferol) sup-
          itz D, VanDeusen Lukas
          C, et al. Preventing falls                recommend regarding                                    plementation is effective for fall
          in hospitals: a toolkit for
                                                    exercise?                                              prevention. The AGS (26) and the
          improving quality of
          care. (Prepared by RAND                                                                          STEADI initiative (27) recom-
          Corporation, Boston                       Strength and balance exercise
                                                                                                           mend daily vitamin D in modest
          University School of                      has the strongest evidence for
          Public Health, and                                                                               (800 –1000 IU) doses, given that
          ECRI Institute under                      prevention of falls and fall-related
          Contract No. HHSA                                                                                vitamin D deficiency is common
                                                    injuries. Such exercise also seems
          290201000017I TO #1.)                                                                            and supplementation is reason-
          Rockville, MD: Agency                     to reduce fear of falling if partici-
          for Healthcare Research                                                                          ably safe and inexpensive. The
          and Quality; 2013.                        pation is sustained (48). Most
          AHRQ Publication No.
                                                                                                           Cochrane Collaboration found
                                                    older adults do not exercise to
          13-0015-EF.                                                                                      that vitamin D supplementation
      64. Ensrud KE, Crandall CJ.                   improve strength and balance.                          did not reduce falls overall but
          Osteoporosis. Ann Intern
          Med. 2017;167:ITC17-                      Community programs that in-                            seemed to do so in persons with
          ITC32. [PMID:
          28761958]
                                                    clude strength and balance exer-                       low levels (8). The U.S. Preventive
      65. Bunn F, Dickinson A,                      cise may be recommended for                            Services Task Force no longer
          Barnett-Page E, McInnes
          E. A systematic review of                 both primary and secondary fall                        recommends vitamin D supple-
          older people's percep-                    prevention (49). For older adults
          tions of facilitators and                                                                        mentation for fall prevention in
          barriers to participation                 at high risk for falls, one-on-one                     older adults who do not have
          in falls-prevention inter-
          ventions. Ageing Soc.                     exercise supervised by a physical                      osteoporosis or vitamin D
          2008;28:449-72.                           therapist is the safest initial
      66. Voukelatos A, Merom D,                                                                           deficiency (55, 56). This recom-
          Sherrington C, Rissel C,                  approach, with transition to a                         mendation is related to recent
          Cumming RG, Lord SR.
          The impact of a home-                     community class or home-based                          evidence, including a large trial
          based walking pro-
          gramme on falls in older
                                                    exercise program (such as the                          that administered a high dose of
          people: the Easy Steps                    Otago Exercise Program [50] or                         vitamin D infrequently (500 000
          randomised controlled
          trial. Age Ageing. 2015;                  the Lifestyle-integrated Func-                         IU once annually) and found an
          44:377-83. [PMID:                         tional Exercise Program [51])                          increased risk for falls and frac-
          25572426]
      67. Shubert TE. Evidence-                     when the patient is ready.                             tures among community-
          based exercise prescrip-
          tion for balance and falls                                                                       dwelling, older, at-risk adults.
          prevention: a current                     A series of trials testing the Otago Exercise Pro-
          review of the literature. J               gram found that it improved balance and re-            However, many older adults who
          Geriatr Phys Ther. 2011;
          34:100-8. [PMID:                          duced falls and fall-related injuries by 35%           are at risk for falls also have os-
          22267151]                                 (fall incidence rate ratio [IRR], 0.65 [CI, 0.57–      teoporosis, vitamin D deficiency,
      68. Sherrington C, Whitney
          JC, Lord SR, Herbert RD,                  0.75]; fall-related injury IRR, 0.65 [CI, 0.53–        or both, and ensuring that cal-
          Cumming RG, Close JC.                     0.81]) when led by a physical therapist or
          Effective exercise for the                                                                       cium and vitamin D levels are
          prevention of falls: a                    trained nurse. Developed by the New Zealand
                                                                                                           sufficient before osteoporosis
          systematic review and                     Falls Prevention Research Group in the late
          meta-analysis. J Am
                                                    1990s, the program involves an intervention-
                                                                                                           treatment initiation is important.
          Geriatr Soc. 2008;56:
          2234-43. [PMID:                           ist (typically a physical therapist) who trains at-    Thus, vitamin D supplementation
          19093923]                                                                                        (≥800 –1000 IU daily) makes clini-
      69. Peterson EW, Finlayson                    risk adults to practice 17 exercises at home to
          M, Elliott SJ, Painter JA,                improve gait stability, strength, and balance.         cal sense and is consistent with
          Clemson L. Unprece-
          dented opportunities in                   The interventionist assesses, coaches, and             recommendations from profes-
          fall prevention for occu-                 moves the trainee through progressively more           sional societies (26, 57, 58).
          pational therapy practi-
          tioners. Am J Occup                       challenging exercises over the course of 6 –12
          Ther. 2012;66:127-30.                                                                            What is the role of protectors
          [PMID: 22394521]
                                                    months. Improvements may be seen as soon
      70. National Institute on                     as 8 weeks after program initiation (52). The          for the hip and other sites?
          Aging. Prevent Falls and
                                                    program is most effective in reducing fall-            Hip protectors, which are either
          Fractures. 2017. Ac-
          cessed at www.nia.nih                     related injury among those aged 80 years or            hard plastic shields or soft foam
          .gov/health/prevent-falls                                                                        pads, have been studied for pre-
          -and-fractures on 14
                                                    older (IRR vs. those aged 65–79 years, 0.54
          June 2018.                                [CI, 0.34 – 0.87]) (53). The Otago program is          vention of hip fracture. Nearly all
            姝 2018 American College of Physicians    ITC90                    In the Clinic       Annals of Internal Medicine        4 December 2018
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               (>99%) such fractures in older                  and thus should not be used for
               adults result from a fall. A Coch-              fall prevention.
               rane meta-analysis of 3 trials of
                                                               What is the role of osteoporosis
               hip protector use in community-
                                                               screening and management?
               dwelling older adults showed no
               evidence of reduced risk for hip                Although osteoporosis is not
               fracture (RR, 1.14 [CI, 0.83–1.57])             specific to fall prevention, many
               (59). Receptivity to wearing hip                older adults at risk for falls have
               protectors is low, and from a lo-               undetected osteoporosis, and
               gistics standpoint they make                    certain types of fractures (e.g.,
               dressing and undressing the                     hip) are overwhelmingly caused
               lower body challenging. There is                by falls in this age group. It thus
               little to no evidence on the effec-             makes clinical sense to screen for
                                                               osteoporosis as part of routine
               tiveness of other wearable pro-
                                                               fall prevention care. Screening
               tective devices, such as helmets
                                                               can include measurement of
               and elbow or knee
                                                               bone mineral density by DEXA
               protectors.
                                                               scan or clinical risk assessment
               What strategies are useful in                   via such tools as the Fracture Risk
               preventing falls in hospitalized                Assessment Tool (FRAX). The
               patients?                                       U.S. Preventive Services Task
               Older adults are at risk for falls              Force recommends bone mineral
               while they are hospitalized. Per-               density testing for all women
               sons who have had a prior fall                  aged 65 years or older or at-risk
               and those with cognitive impair-                postmenopausal women
               ment due to any cause (delirium,                younger than 65 years. Although
               dementia) are at highest risk.                  evidence on screening in men is
               Factors that increase risk for in-              insufficient, it should be consid-
               jury from inpatient falls include               ered if the patient has at least 1
               joint replacement (OR, 5.58 [CI,                risk factor for osteoporosis (e.g.,
               1.84 –16.9]), psychotropic agents               smoking, androgen-deprivation
               (OR, 2.23 [CI, 1.39 –3.60]), male               therapy, history of or current ex-
               sex (OR, 2.08 [CI, 1.28 –3.45]),                cessive use of alcohol, hypogo-
               and history of a fall (OR, 2.08 [CI,            nadism, and long-term use of
               1.12–3.85]) (60).                               corticosteroids or anticonvul-
                                                               sants) because the mortality rate
               A few single interventions have                 from hip fractures in men is high.
               been found to reduce risk for                   There are a range of therapeutic
               falls in the inpatient setting.                 options as well as lifestyle
               These include medication man-                   changes that should be discussed
               agement and, for cognitively in-                with patients whose DEXA scan
               tact patients, education with                   shows a bone mineral density
               health professional follow-up                   T-score of –2.5 or less and those
               (61). Multifactorial interventions              who have higher T-scores but
               are supported by current                        whose FRAX score indicates high
               evidence (62, 63).                              risk for fracture. More information
                                                               on management can be found
               Studies of single environmental                 elsewhere (64).
               modifications (low-low beds,
               bedside [“crash”] mats, bed                     How should clinicians counsel
               alarms, floor material modification)              patients and caregivers about
               have found no evidence of benefit.               fall prevention?
               Bedside mats may actually in-                   Development of the STEADI ini-
               crease risk for falls in ambulatory             tiative stemmed in part from the
               persons. No randomized trials of                recognition that few patients
               bed rails have been done, but they              raise the issue of falls with their
               are typically considered a restraint            health care provider (7). The pro-
               4 December 2018          Annals of Internal Medicine            In the Clinic     ITC91   姝 2018 American College of Physicians
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                                                    gram provides useful guidance                  ance is essential for fall preven-
                                                    and tools for clinicians seeking to            tion (67), that balance exercises
                                                    counsel their patients and care-               must be done in a standing posi-
                                                    givers about fall prevention (see              tion at least 3 times per week on
                                                    Talking about Fall Prevention                  a routine basis for a sustained
                                                    with Your Patients at www.cdc                  effect, and that the benefit of re-
                                                    .gov/steadi/materials.html). Rec-              duction in fall risk will not be ap-
                                                    ognition of the need for patient               parent until after several months
                                                    acceptance and willingness to                  (> 50 hours) of routine balance
                                                    act on recommendations is para-                practice (68). The importance of
                                                    mount, and open discussion of                  maintaining a balance exercise
                                                    what a patient is willing to do is             regimen over time cannot be
                                                    essential for formulating a realis-            overemphasized, and it is impor-
                                                    tic care plan in partnership with              tant to recognize that this is chal-
                                                    the patient.                                   lenging for several reasons
                                                                                                   unique to this age group (e.g.,
                                                    Research has shown that the rec-
                                                    ommendation of a health profes-                personal or family illnesses; acute
                                                    sional is an important facilitator in          life stressors, such as death of a
                                                    engaging in fall prevention be-                partner, sibling, or friend). Pro-
                                                    haviors (65). Other facilitators               viders should ask about exercise
                                                    include providing a range of op-               adherence at each clinic visit.
                                                    tions to address a given risk fac-             Suggesting that patients incorpo-
                                                    tor (e.g., community- or home-                 rate exercises into their daily rou-
                                                    based exercise class), framing                 tine (e.g., standing on 1 leg while
                                                    the recommended changes in a                   brushing the teeth) is a practical
                                                    positive light (e.g., return of con-           way to encourage long-term ex-
                                                    fidence and ability to engage in                ercise adherence (51).
                                                    activities one used to enjoy) as
                                                                                                   To facilitate management of envi-
                                                    opposed to a negative one (hav-
                                                                                                   ronmental risks, identifying and
                                                    ing to give up belongings to
                                                                                                   prioritizing hazards collabora-
                                                    which the patient may be at-
                                                                                                   tively with the patient and enlist-
                                                    tached, such as throw rugs or
                                                                                                   ing family support to accomplish
                                                    open-back shoes), and emphasiz-
                                                                                                   any changes to which the patient
                                                    ing the life-enhancing effects and
                                                                                                   is receptive is advisable. Identify-
                                                    increased opportunities to partic-
                                                                                                   ing risky behaviors (e.g., carrying
                                                    ipate in enjoyable activities (e.g.,
                                                                                                   bags of groceries, not holding
                                                    exercise class presents an oppor-
                                                    tunity for social connection).                 onto the stair railing) and encour-
                                                                                                   aging adaptive strategies (e.g.,
                                                    The patient must be made aware                 carrying 1 bag at a time, identify-
                                                    that walking (66) or upper body                ing which entrance allows the
                                                    stretching exercises will not pre-             easiest ingress into the building)
                                                    vent falls and that improving bal-             can also be helpful (69).
                                                       Management... Fall risk must be managed with a patient-centered ap-
                                                       proach. Clinicians should recommend interventions to address modifi-
                                                       able risk factors and reduce injury from falls in the context of patient
                                                       preferences and values. Maintaining the highest possible level of mo-
                                                       bility and social and daily functioning is the key goal of fall prevention
                                                       management. Engaging a caregiver can be helpful in achieving fall
                                                       risk reduction in vulnerable older adults.
                                                                                                          CLINICAL BOTTOM LINE
         姝 2018 American College of Physicians       ITC92                In the Clinic   Annals of Internal Medicine   4 December 2018
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                                                                                         Practice Improvement
               What measures do                                The National Institute on Aging
               stakeholders use to evaluate                    recommends strength and bal-
               the quality of care for patients                ance exercise, assessment of en-
               at risk for falls?                              vironmental hazards, optimiza-
               The Merit-based Incentive Pay-                  tion of hearing and vision, and
               ment System (www.aafp.org/                      medication management (70).
               news/macra-ready/20180411
                                                               The AGS (26) recommends an-
               mipstool.html) has a quality mea-
                                                               nual fall screening (asking about
               sure for fall risk assessment, which
                                                               falls in the prior year) along with
               is the percentage of patients
                                                               gait and balance assessment.
               aged 65 years or older with a his-
                                                               Anyone who has fallen two or
               tory of falls (i.e., ≥2 falls in the
                                                               more times in the prior year, pre-
               past year or any injurious fall in
                                                               sented for medical attention for a
               the past year) who had a risk as-
                                                               fall, or has difficulty on gait and
               sessment completed within 12
                                                               balance testing should have a
               months. A patient-reported his-
                                                               multifactorial fall risk assessment.
               tory of falls is sufficient. The risk
                                                               The AGS recommends the fol-
               assessment must cover balance
                                                               lowing interventions: balance
               and gait and 1 or more of the fol-
                                                               and strength exercise, home
               lowing: postural blood pressure,
                                                               modification, withdrawal or mini-
               vision, home fall hazards, and
                                                               mization of psychoactive or other
               documentation of whether medi-
                                                               medications, management of
               cations contributed to falls in the
                                                               postural hypotension, manage-
               past 12 months.
                                                               ment of foot problems and
               The Patient Protection and Afford-              footwear, and vitamin D supple-
               able Care Act established the                   mentation of at least 800 IU/d for
               Centers for Medicare & Medicaid                 persons who have vitamin D defi-
               Services' “star ratings” (www.aafp              ciency or are at increased risk for
               .org/news/practice-professional                 falls.
               -issues/20180109physiciancom-
               pare.html) of health care quality               The CDC's STEADI initiative
               for various measures that form the              (www.cdc.gov/steadi) is a health
               basis of quality bonus payments                 care provider– oriented set of
               to Medicare Advantage Plans.                    materials to facilitate implemen-
               Measures relevant to fall preven-               tation of the AGS fall prevention
               tion in 2018 include medication                 guidelines in routine clinical
               review, functional status assess-               practice. STEADI consists of 3
               ment, and osteoporosis manage-                  key strategies: screen to identify
               ment in women who have had a                    fall risk, assess modifiable risk
               fracture.                                       factors, and intervene using ef-
                                                               fective strategies to reduce the
               What do professional                            identified risk factors. Recom-
               organizations recommend                         mended clinical strategies reflect
               regarding fall prevention?                      the recommendations of the
               Several professional organiza-                  AGS/BGS and emphasize exer-
               tions endorse interventions to                  cise, vitamin D supplementation,
               prevent falls among older adults.               medication management, and
               The recommendations vary.                       home modification.
               4 December 2018          Annals of Internal Medicine            In the Clinic      ITC93   姝 2018 American College of Physicians
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         In the Clinic                         Patient Information
                                               https://medlineplus.gov/falls.html
         Tool Kit
                                               Resources related to falls in MedlinePlus from the
                                                                                                                 IntheClinic
                                                National Institutes of Health (NIH).
                                               www.bones.nih.gov/health-info/bone/osteoporosis
                                                /fracture/prevent-falls-ff
                                               www.bones.nih.gov/health-info/bone/espanol
                                                /osteoporosis/fracturas-ff-espanol
         Fall Prevention                       Recommendations in English and Spanish on prevention
                                                of falls and related fractures from the NIH Osteoporosis
                                                and Related Bone Diseases National Resource Center.
           in Community-                       www.nia.nih.gov/health/prevent-falls-and-fractures
           Dwelling Older                      www.nia.nih.gov/health/prevenga-caidas-fracturas
                                               Information in English and Spanish on prevention of falls
           Adults                                in older adults from the National Institute on Aging.
                                               www.mayoclinic.org/healthy-lifestyle/healthy-aging
                                                 /in-depth/fall-prevention/art-20047358
                                               Tips on fall prevention from the Mayo Clinic.
                                               Clinical Guidelines and Other Information for
                                                Health Professionals
                                               www.uspreventiveservicestaskforce.org/Page
                                                /Document/RecommendationStatementFinal/falls
                                                -prevention-in-older-adults-interventions1
                                               U.S. Preventive Services Task Force clinical recommenda-
                                                tions for fall prevention in older adults.
                                               www.cdc.gov/steadi/materials.html
                                               Resources for providers on preventing falls in older adults
                                                from the Centers for Disease Control and Prevention.
         姝 2018 American College of Physicians       ITC94                In the Clinic    Annals of Internal Medicine   4 December 2018
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               WHAT YOU SHOULD                                                                                         In the Clinic
                                                                                                        Annals of Internal Medicine
               KNOW ABOUT FALLS
               Am I at Risk for Falls?
               Getting older can increase your risk for falling.
                 Even a minor fall can cause serious injury. You
                 might be at higher risk for a fall if you:
               • Have eye problems, like glaucoma or cataracts
               • Have heart disease
               • Have Parkinson disease or dementia
               • Can't hold your urine (called incontinence)
               • Are not getting enough sleep
               • Have arthritis or chronic pain
               • Use certain medicines, like sedatives or
                 opiates
               How Can I Prevent Falls?
               • If you are over 65, talk with your doctor about
                 how you can prevent falling.
               • Exercise has been shown to help prevent falls.
                 It helps you stay strong and keep your                            there are no slippery surfaces or throw rugs
                 balance. Ask your doctor what exercise is safe                    that could trip you.
                 for you.
               • If you take medicines, ask your doctor if they                Questions for My Doctor
                 increase your risk for falls.                                 •   Am I at risk for falling?
               • Talk with your doctor about your risk for                     •   How can I prevent falls?
                 osteoporosis.                                                 •   Do I need to be tested for osteoporosis?
               • Check your home for safety. If you have stairs,               •   Do any of my health conditions put me at risk
                 make sure the banisters are sturdy. Make sure                     for a fall?
                                                                                                For More Information
                                                              National Institutes of Health
                                                              www.bones.nih.gov/health-info/bone/osteoporosis/fracture
                                                                                                                                               Patient Information
                                                              /prevent-falls-ff
                                                              National Institute on Aging
                                                              www.nia.nih.gov/health/prevent-falls-and-fractures
                                                              www.nia.nih.gov/health/prevenga-caidas-fracturas
      4 December 2018          Annals of Internal Medicine            In the Clinic               ITC95姝 2018 American College of Physicians
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                                                                                                                   In the Clinic
                                                                                                    Annals of Internal Medicine
     Notes
         姝 2018 American College of Physicians       ITC96                In the Clinic   Annals of Internal Medicine   4 December 2018
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