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17 - Development of Foregut-Derivatives and Anomalies

This document summarizes the development of the gut tube and associated organs from the foregut, midgut, and hindgut. Key points include: - The epithelium of the gut tube and organs like the liver and pancreas develop from endoderm, while muscles, connective tissue develop from splanchnic mesoderm. - The gut is divided into the pharyngeal, foregut, midgut, and hindgut sections. - The stomach develops from the foregut and rotates, forming the lesser and greater curvatures. The mesogastrium forms ligaments like the falciform ligament. - The pancreas develops

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Dr.B.B.Gosai
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226 views22 pages

17 - Development of Foregut-Derivatives and Anomalies

This document summarizes the development of the gut tube and associated organs from the foregut, midgut, and hindgut. Key points include: - The epithelium of the gut tube and organs like the liver and pancreas develop from endoderm, while muscles, connective tissue develop from splanchnic mesoderm. - The gut is divided into the pharyngeal, foregut, midgut, and hindgut sections. - The stomach develops from the foregut and rotates, forming the lesser and greater curvatures. The mesogastrium forms ligaments like the falciform ligament. - The pancreas develops

Uploaded by

Dr.B.B.Gosai
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Dr.B.B.

Gosai
Professor in Anatomy
Ojvensha e-learning resources
 Divisions of gut tube.
 Derivatives of different parts mesogastrium.
 Development of Oesophagus.
 Development of Stomach.
 Development of Duodenum.
 Development of Liver and Gallbladder.
 Development of Pancreas.
 Langman’s Medical Embryology by T.W.Sadler

 Other reference text book:


 Keith Moore’s Developing Human
 Epithelium of gut tube and parenchyma of glands like
liver, pancreas derived from endoderm while muscles,
connective tissue and peritoneal component derived
from splanchnic mesoderm.
 Divided in to four sections:
 Pharyngeal gut: from buccopharyngeal membrane to
tracheobronchial diverticulum.
 Foregut: From caudal to pharyngeal tube to liver
outgrowth.
 Midgut: From caudal to liver to junction of right two-
thirds and left one-third of transverse colon.
 Hindgut: From left one third of transverse colon to
cloacal membrane.
 Ventral mesogastrium: forms falciform
ligament of liver and lesser omentum
 Dorsal mesogastrium: forms greater
omentum, lienorenal ligament and
gastrolienal ligament.
 Lesser sac(Omental bursa) develops
behind stomach due to rotation of
stomach.
 Oesophagus develops from foregut due to
separation of lung bud by tracheoesophageal
septum. Ventral part form trachea and dorsal
part form esophagus.
 Initially oesophagus is short but later on
elongates.
 Oesophageal atresia: absence of formation of part
of oesophagus.
 Atresia of oesophagus leads to polyhydramnios.
 Stomach develops as fusiform dilatation of
foregut.
 Rotation of 90 degrees clockwise leads to
anterior border becomes lesser curvature and
posterior border becomes greater curvature.
 Formation of mesogastrium and its derivatives:
 Peritonael ligaments and folds, lesser sac
 Pyloric stenosis: narrowing of pylorus causing
obstruction to food passage.
 Duodenum up to opening of bile duct derived from
foregut.
 Duodenum from opening bile duct till end is derived
from midgut.
 Forms C-shaped loop and rotates to the right.
 Liver develops as outgrowth from duodenum known
as hepatic diverticulum(liver bud).
 Elongation of diverticulum form bile duct and gall
bladder.
 Hepatic cords-endodermal in origin form parenchyma
of liver.
 Connective tissue, Kupffer cells and haemopoietic cells
are derived from mesoderm of septum transversum.
Development of
pancreas
•Develops from two buds:
•Ventral pancreatic bud:
form uncinate process and
inferior part of head of
pancreas.
•Dorsal pancreatic bud:
form superior part of head,
neck, body and tail of
pancreas.
•Both bud fuse due to
rotation and differntial
growth.
•Main pancreatic duct:
whole ventral duct and
distal part of dorsal duct.
•Accessory pancreatic duct:
proximal part of dorsal
duct.
During rotation or migration of ventral pancreatic bud some
pancreatic tissue surround the duodenum. Such condition is
known as Annular Pancreas.
It leads to duodenal obstruction.

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