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Cerebellum Physiology for Students

The document discusses the neurophysiology of the cerebellum. It describes the functional divisions and neural circuitry of the cerebellum. Specifically, it outlines the afferent and efferent pathways to and from the cerebellum, including mossy fibers, climbing fibers, and deep cerebellar nuclei. The cerebellum is divided into anatomical regions and contains a functional unit centered on Purkinje cells that is involved in motor control and coordination.

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Yashika Rikhi
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118 views22 pages

Cerebellum Physiology for Students

The document discusses the neurophysiology of the cerebellum. It describes the functional divisions and neural circuitry of the cerebellum. Specifically, it outlines the afferent and efferent pathways to and from the cerebellum, including mossy fibers, climbing fibers, and deep cerebellar nuclei. The cerebellum is divided into anatomical regions and contains a functional unit centered on Purkinje cells that is involved in motor control and coordination.

Uploaded by

Yashika Rikhi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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llu es AN : ch ie
e b e i n a
Cer etenc dy bee atomy

Neurophysiology
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PY 10.7
Physiology of Cerebellum
Specific Learning Objectives (SLOs’)

• Describe the functional divisions of cerebellum ( Domain Knowledge :


Level Knows )
• Describe the Functional Unit -neural circuit of cerebellum ( Domain
Knowledge : Level Knows )
• Explain the physiological roles of the cerebellum ( Domain Knowledge :
Level Knows )
• Explain the abnormalities associated with cerebellar disease ( Domain
Knowledge : Level Knows How)
• Test the cerebellar. Functions ( PY 10.11 Domain Skill : Level Shows how )
At the end of the session the
Phase I students must be able to
Describe the functional divisions of cerebellum ( Domain Knowledge : Level Knows )
Describe the Functional Unit -neural circuit of cerebellum ( Domain Knowledge : Level Knows )
rain
le b
Litt • 10% of cerebral cortex
• 75% more area than the
cortex
• Extensively folded on itself
• Each fold is called FOLIUM
ANATOMICAL DIVISION
Cerebellar hemisphere Vermis

Anterior lobe

Posterior lobe

Flocculonodular lobe
ANATOMICAL DIVISION
INTERMEDIATE ZONE

VERMIS
LATTERAL LATERAL
ZONE ZONE

Flocculonodular lobe
Histology
• Outer Gray matter- cerebellar
cortex
• Molecular layer
• Purkinje cell layer
• Granular cell layer
• Inner white matter-cerebellar
medulla
• Deep cerebellar nuclei
Neural circuit of cerebellum
Afferent pathways to cerebellum (input)
Vestibular nuclei
Cerebral cortex Inferior Olivary nucleus

Cerebo Ponto cerebellar


Reticular nuclei

Olivo cerebellar
Vestibulo spinal

Reticulo cerebellar
pathway
Pons

Cerebellum
Spino cerebellar

Spinal cord
• All afferents except inferior olivary nucleus form mossy fibers.
• Afferents fibers from inferior olivary nucleus form climbing fibers.
Efferent pathway (output)

Cerebellum

Vestibular nuclei THALAMUS


Reticular formation

Cerebral cortex
Basal ganglia
Functional unit – The neuronal circuit

•Input-
• Climbing fibers
• Mossy Fibers
•Output-
• Deep cerebellar nuclei
Stellate cells
Basket cells
Functional unit – The neuronal circuit

• 30 million functional units

• Each functional unit centers on single large Purkinje


cell
Topographical representation of body
To be continued !!!

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