Agreement No.

CIRM _2267 _

CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE

INDEPENDENT CONSULTANT AGREEMENT

THIS AGREEMENT to fumish certain consultant services is made by and between the California
I¡stitute for Regenerative Medicine hereinafter called (CIRM), and National Academy of Sciences
(Consultant).

r. NATURE AND PLACE(S) OF SERVTCE

A. The Consultant shall fumish to CIRM the following described services including a time
schedule by which the Consult¿nt is to produce or províde specified materials or perform
certain consulting services as well as reports onthe progress of the services:

i. See attachment A.

B. If the Consultant is an entity other than an individuàI, CIRM requires that staffbe assigned
according to Attachment A to perform the work set forth herein. No reassignment of work to
individuals other than those described in Attachment A may be made without the written
approval of CIRM.

C. Place(s) of performance of such services shall be:

Consultant's location: CIRM's location:

[500 5ù Steet, NW
Washington, DC 20001 I 210 King Steet
t I San Francisco,C[94lDT

D. CIRM will provide working space, equipment, fumiture, utilities, and services, as follows:
None

II. TERMOFAGREEMENT

A. The term of this Agreement shall be from July 1, 2011 through November 30,2012.

B. CIRM reserves the rÌght to terminate this Agreement subject to 30 days written notice to
the Consultant. Consultant may submit a written notice to termìnate this Agreement
only if CIRM should substantially fail to perform its responsibilities as provided herein.
In addition, CIRM may tenninate this Agreement immediately for cause. The term "for
cause" shall mean that the Consultant fails to meet the terms, conditions, and/or
responsibilities of this AgreemenL In ttris instance, the termination shall be effectíve as
ofthe date indicated on CIRM's notification to the Consultant.

C. The term of this Agreement may be extended by the mutual, written consent of both
parties.
 m, COMPENSATION AND E)GENSES

A. CIRM shall pay the Consultant for services performed on the following basis:

1, Professional Fees:*

MAXIMUM TO BE PAID UNDERTHIS AGREEMENT

s699.247

+Consultant shall be responsible for covering the

costs of all expenses it incurs in
performing the services contemplated by this Agreement, including the costs of tavel for the Consultant's
employees, members, and others whom Consultant invites to participate in performing such services.

B. Payments shall be made in four installments of $174,811.75 eact¡ upon the Consultanfs
submission of invoices indicating the Agreement Number. Consultant shall invoice
CIRM for the first tlree inst¿llments on July 1, 2011, January l,2Ol2, and July l,20lZ.
The invoice for the final payment shall be submitted upon oompletion of the services
specified herein. Consultant must submit a completed Payee Data Record (State
Standard Form 204) before CIRM will issue pàyment. Each invoice shall include the
Consultanfs tÐçayer identification number (Social Securþ or employer identification
number). Invoices shall be submitted to:

California Institute for Regenerative Medícine

Finance Officer
210 King Street
San Francisco,CA 94107

Payment wÍll be made in accordance witt¡ and within the time specified in, Government Code Chapter 4.5,
commencing with Seøion'927.

IV. REPORTING

In perforrning consulting services under this Agreemen! the Consultant shall be accountable to
CIRM and shall provide progress reports to CIRM upon CIRM,s request.

V, NOTIFICATION

Notices conceming this Agreement shall be addressed as follows:

CIRM: TO CONSULTANT:

California Institute for Regenerative Medicine National Academy of Sciences

General Counsel Office of Confacts and Grants
210 King Street 500 5th Sreeq NW
SanFrancisco,CA 94107 Washington, DC 20001

VI. TA)GS

The compensation stated in Article III íncludes all applícable taxes and will not be changed
hereafter as the result of Consultant's failure to include any applicable tax or as the result of any
change in the Consultanfs tax liabilities. The Consultant acknowledges that compensdion payable
hereunder may be subject to wittrholding of state and federal income ta:<, including state income
tax subjeø to withholding pursuantto California Revenue and Ta"ïation Code Sections l866l-
18677.

CIRM Conhacting Policy Appendix I (approvedSllg/2010) Page 2

 Vtr. INDEPENDENT CONTRACTOR STATUS

A. Both parties agree that in the performance of this Agreement the Consultant shall not be an
agent or employee of CIRM, shall not be covered by the State's Worker's Compensation
Insurance or Unemployment Insurance, shall not be eligible to participât€ in State employee
retirement programs, and shall not be entitled to any other Cmlvt .tnploy". benefits,

B. The Consultant shall be solely responsíble for the conduct and control of the work to be
pêrformed by the Consultant under this Agreement, except that the Consultant is accountable
to CIRM for the results of such work. The Consultant's services for CIRM shall be performed
in accordance with currently approved methods and ethical standa¡ds applicable to the
Consultanf s professional capacity.

C. California St¿te Conüact Code 10515 (a) states: No person, firm, or subsidiary thereof who
has been awarded a consulting services contact may submit a bid for, nor be awarded a
contract on or after July l, 2003, for the provision ofservices, procurement ofgoods or
supplies, or any other related action that is required, suggested, or othen¡'ise deemed
appropriate in the end product of the consulting services contact.

\rIII. ASSIGNMENT OR SUB CONTRACTING

The Consultant may not assign or transfer this Agreement, or any interest or claim, or subcontact
any portion of the work, without the prior written approval of CIRM. The witbholding or granting
of such approval is totally discretionary with CIRM. If CIRM consents to such assignment or
tansfer, the terms and conditions ofthis Agreement shall be binding upon any assignee or
trærsferee.

rx. PROPERTY RIGTilS, INCLUDING PATENTS AND COPYRIGHTS

All written and other tangible material ("Material") produced pursuant to this Agreement by the
Consultant shall be the property of the Consultant. The Consultant shall give CIRM a non-
exclusive, irrevocable and paid up license to use the Material..

x, CONSULTANÎS LIABILITY AND INSURANCE REQUIREMENTS

A. The Consultant agrees to defend and, at CIRM's electiorq indemni$ and hold haffiless
CIRM, its officers, agents, and employees from its actual liabilþ, including reasonable
costs and expenses to which they may be subject to, resulting from injuries or damages
sustained by any person or persons or propefy by virtue of performance of this
Agreement, but only to the extent arising from the negligence, wrongful act or wrongful
omission of the Consultant, or any subcontractor, ttreír employees and agents.

B. The Consultant shall furnish a Certificate of Insurance or stâtement of self-insurance

(contractual liabílþ included) showing minimum coverage as follows:

1. General Liability: Comprehensive or Commercial Form (Minimum Limits)

(Ð General Aggregate (BI, PD)* $2,000,000

(iÐ Products,CompletedOperations
Aggregate $2,000,000
(iiÐ Personal and Advertising Injury $1,000,000
(iv) Each Occurrence $1,000,000

* (not applicable to comprehensive form)

CIRM Contacting Policy Appendix I (approved 8119/2010) Page 3

 However, if such insurance is written on a claims-made form following
termination of this Agreemen! coverage shall survive for a period no lãss than
three y,ears. coverage must include a primary and Non-contibutory provision
and a severability oflnterest provision. coverage shall also provide for a
retroactive date of placement coinciding with the effective date orthis
Agreement.

J Business Auto Liability: (Minimum Limits) for Owned, Scheduled, Non-

owned, or Hired Automobiles with a combined single limit of no less than
$1,000,000 per occrüïence. [Alternative: Business Áúo Liabilþ is waived
because consultant will not drive in the course of performing services for
crRM.l

3. Workers' Compensation; as required under Califomia State Law.

4. Professional Liability Insurance: (Minimum Limits)

(1) Each occrurence $2,000,000

(2) ProjeøAggregat€ $2,000,000

If this insurance is written on a claims-made form, it shall continue for three

years following termination ofthÍs Agreement. The insurance shall have a
retroactive date of placement prior to or coinciding with the effective date of this
Agreemenl The insurance must include Contractual Liability Coverage and
Defense and Indemnification of CIRM by the contracting party.

5. Other insurance in amounts as from time to time may reasonably be required by

the mutual consent of CIRM and the Consultant against such other insurable
hazards relating to perfonnance.

6. Certificate(s) of Insurance shall name CIRM as an additional insured under 1,2

and 4 above, obligate the insurer to notiff CIRM at least thirty (30) days prior to
-
cancellation of or changes in any of the required insurance and include a
provision that the coverage will be primary and will not participate with nor be
excess to any valid and collectible insurance program ofself-insurance carried
or maintained by CIRM. Premiums on all insurance policies shall be paid
directly by the ConsultanL

)fl. RECORDS ABOI.IT INDWIDUALS

A. The Consultant will not create or maintain any records under this Agreement on
individuals to accomplish a CIRM firnction, as contemplated by the Information practices
Açt, Cívil Code section 1798.19.

B. The Consultant shall not use recording devices in discussions with CIRM's employees
witJrout notifying all parties to the discussion that the discussion is being recorded.

xtf. EXAMINATION OF RECORDS

The Consultant agrees t}rat CIRM and its authorized agents shall have the right to review and copy
any rÊcords and supporting documentation pertaining to the performance of this Agreement,
however, said records shall be limited to financial records conceming this Agreemãnt and project
records that are available in the Public Access File. Consultant agrees to máintain such records
for a minimum of three (3) years after final payment, unless a longer period of records retention is
stipulated' Consultant agrees to allow CIRM and Íts authorized agent's access to such records

CIRM Contacting Policy Appendix I (approved S/l9lã0l0) page 4

 during normal business hours. Further, Consultant agrees to include a similar right of access
in
any subcontract related to the performance of this Agreement.

In accordance with state law, the Consulant agrees that CIRM, its authorizpd agents, the
State
Conüoller's Office, and the Bweau of State Audits (collectively, the ..Auditors;) snáff have the
right in connection with an audít, to review and copy *y t"*ids and supporting documentation
pertaining to the performance ofthis Agreement inciuding,all financial ¿àãumerits, records
and
financial workpapers concerning this Agreement whether obtained or copied from CIRM o¡
developed by the-Consultant. Cõnsultant agrees to maintain such records for possiOie auait for
a
minimum ofthree.(3) years after final paymen! unless a longer period of recoìds retention is
stþlated. Consultant agrees to allow the Auditors access to suõh records during normal business
hours and to allow interviews of any employees who might reasonably have infõmation related to
such records. Further, Consultant agrees to include a similar right of the Auditors to audit
rccords
and interview staff in any subcontract related úo the performancè of this Agreement.

Notwithst¿nding the foregoing, minutes and working papers from the Committee meetings in
closed (deliberative) sessions a¡e considered proprietary by the Consultant and will not be
available for review by CIRM or provided to CIRM.

XIII. CONFLICT OF INTEREST

A. The consultant will not hire any officer or employee of CIRM to perform any service
covered by this Agreement. If the work is to be perfonned in connection with a federal
or state confract or gant, the consultrnt will not hire any employee of the government
agency concerned to perforrr any service covered by this Agreement.

B. The Consultant afTirms that to ttre best of his/her knowledge there exists no actual or
potential conflict between the Consultanfs family, business or financial interest and the
services provided under this Agreement, and in the event of change in eitJrer private
interests or service under this Agreement, any question regarding possible conflict of
interest which may arise as a result of such change wilr be raised with ciRM.

c. The Consultant shall not be in a reporting relationship to a CIRM employee who is a near
relative, nor shall the near relative be in a decision-making position with respect to the
Consultant.

D- the Consultant may be required to execute a Form 700 Statement of Economic Interests
as published by the Fair Political Practices Commission. Sktements of Economic
Interests are public documents, More information about Form 700 is available at
www,fupc.ca.gov.

XIV. AFFIRMATIVE ACTION

The Consultant recogaizes that as a state govemment contractor or subcontactor, the Consultant is
obligated to comply with all state laws and regulations regarding equal opportunity and aff¡mative
action in government contracts. When applicable, the Consultant agrees that all súch hws and their
implementing regulations are incorporated herein as though set forth in full. These laws include the
nondiscrimination requirements of Government Code sections 12990 and 11135, and the
nondiscrimination program and clause required by Title 2, Division 4, Chapter 5 ofthe California
Code of Regulations.

XV. CONFIDENTIALITY

The Consultant will not provide ûo CIRM or receive from CIRM any confidential information under this

CIRM Contraøing Policy Appendix I (approved Sllglàlt}) page 5

 Agreement

XVI. APPLICABLELAW

The laws of the state of carifornia shall govern this Agreement

XV[. TERMS TO BE EXCLUSIVE

This Ageement constitutes the entire understanding between the parties

regarding the subject matter
hereof and superuedes any prior understanding betñeen the parties, oral
or lritteñ ,"g*ding the same
subject matter.

XVItrI. WAIVER OR MODIFICATION OF TERMS

No waiver, amendment or other modifications of the terms ofthis Agreement

shall be bind.ing upon
either party unless expressed in wríting and sþed by both paxties hereto.

)ilX. STANDARDFORPERFORMANCE

The parties acknowledge that CIRM, in selecting the Consultant to perform

the services hereunder, is
relying upon the Consultant's reputation for excãllence in_ the performance of
the services required
hereunder. The Consultant shall perfonn the services in the m'anner of one
who isa re"ognizea
specialist in the tJ¡pes of services to be performed. All deadlines set forth
in the agreemJnt *" uinaing
and may be modified only by subsequent written agreement of the parties.
the Coãsultant shall devote
such time to performance of its, her, or his dulr¡¡ undeq this Agreement as
is reasonably necessary for
the satisfactory performance of such duties within the deadline-s set forth herein.
Noifri"t in tn"
foregoing shall be consûiued to alter the requirement that time is of the
io ttti, Ãirr.*rnt.
"rr"*"
xx. ExcLUsIoN.

Independent Consultant warrants that it is not excluded from participation

in any governmental
sponsored progmm: inc,luding, without limitation, the Medicare, Meiicaid,
ot Ctrí*pur pìogx*,
(http://exclusions'oig'hhs.gov/search.aspx) and the Federal procurement
and NonprocurËment
Programs (htþ:/iwww.epls.gov/epls/search.do). This Agreement shall be subject
ø immediate
termination in the event that the Independent Consultant ii excluded from panrcipation
in-any federal
healthca¡e or procurement prograrn.

)Oil RESOLUTION OF DISPUTES

If the consultant d¡-sputï any action by CIRM arising under or out ofthe perforrnance
ofthis.contract,
the Consultant shall noti& CIRM of the dispute in writing and request a claims
decisíon. CIRM shall
issue a decision within 30 days of the Consultant's notice. If the ðonsultant
disagrees witll CIRM,s
claims decision, the Consult¿nt shalt submit a formal claim to the presidenr
the President of CIRM shall be fÏnal and conclusive on the claim unless the "¡ðñM:
iil" ¿rr¡iú tv
decision is arbinary,
capricious or grossþ erroneous or ifany determination offact is unsupported by
substantial evidence.
The decision may encompass facts, interpretation of the conhact an¿ åetemrin"íio*
;õ;ücations of
law. The decision shall be in writing foliowing an opportunity for the consultaniio
documentary evidence and arguments in support of the claim. Consultant shall
t;"ä;
oral or
continue with the
responsibilities under this Agreement during any dispute.

)Oü SURVIVAL.

The following sections survive the expiratíon or early termination ofthis

Agreement: IX, X, XI, XJ¡,
xv, xvl, xxl.

CIRM Contracting Policy Appendix I (approved g/tglz}l}) page 6

 INDEPENDENT CONSULTANT TTIE CALIFORNIA INSTITUTE FOR
REGENERATTVE MEDICINE

rne &ruzfl,tcr 9¿n¿GlR

W t^ñ*
Company ,A¿ ,/¿¿o/n¿ Ol S'ei¿zlclS

Item 6445-502-604700l/H&S Code 125291.20lStatutes 2004/ FY 10/11

Account/Fund to be charged

CIRM Contracting Policy Appendix I (approved 8ll9l20l0') Pa¿e7

 INSTITUTE OF MED¡CINE
Ot 7HF MI,OML AWü'I1IES

Judlth A. Salerno, M.D., M.S.

Exeq¡üw Diructor

November 22,2010

Re: NAS ProposalNo. l0-IOM-377-Al

MelissaKing
Executive Director, ICOC
Califomia Institute for Regeneræive Medicine
210 King Steet, Third Floor
SanFrancisoo,CA 94107

Robert Klein
Chainnar, Goveming Board
Califomia Institute for Regenerative Medicine
210 King Ste,et" Third Floor
SanFrancisco, CA 94107

Dear Ms. King and Mr, Klein:

We are pleased to submit the enclosed proposal, prepared by oru Board on Heatth Sciencçs
Polic¡ requesting support of the Review of the Califonria Instítute for Regenerative Medicine. The
tot¿l estimated cost of tbis project is $728,967 for the period from June t, Þ0t I to November 30,
20L2. We are requesting that the C¿lifornia I¡rstitr¡te for Regenerative Medicine provide srryport in
the aûiount of 8728,967.

The responsible staffofficer for this study is Cafharyn Liverman, Study Dircstor, Board on
Heafth Sciences Policy. She may be sontactßd a1202-334-3986 regarding pnrgram matters.
Business negotiations are the responsibility of Línd¿ Kilro¡ Contact lvfanager, Office of Contracts
and Grants. She may be reached ãt202-334-2428.

'We
appreciafe your considemtion of this mattßr.

Sincerely,
a
9¿L >''-/
4* á.. salerno, M.D., M.s.

Enclosures

500 F¡fih Strce[ t'{W Phorß; 20293É'21T1

n tln Nøfnn n *ìnr,, @neuÌng
Waefihgton, DC 20001 Fa¡c 2t2334ß94
E+nall jsaÞmo@nar.edu
wwwnas.edu
 THE NATIONAL ACADEMIES
Adu¡sus ¡o the NA¡an on Sdence, kgiawtng, and lleûúe

INSTITUTE OF MEDICINE

Heolth Sciences Policy Boord

Proposol No. i GIOM-377-O1

Review of the California Institute for Regenerative Medicine

NOVEMBER 20]O

,fr AndrewM. Pope, Ph.D.

Direclor
Gronts Boord on Heqlth Sciences Policy
Notionol Acodemy of Sciences lnstitute of Medicine
Telephone : l2Û2l 334-22 4 Telepho ne : lê021 33+1 7 39
E-moil: dwestbro@nqs.edu E-moil:' opope@nos.edu

The Nolionql Acodemies coruisls of four orgonEotlons: the Nolionol Acodemy of Sciences, lhe Nolionql Acodemy of
Engineering, lhe lnstitute of Medlcfne, ond the Notionol Reseorch Councll. The Notionql Reseorch Councilis fhe principol
opérofing ãgency of lhe Notionol Acodemy of Sciences qnd the Nolionol Acodemy of Englneering. Thl¡ proþorol h
¡ubmllled by fhê NATIONAI ACADEIITIY OF SCIENCES (NAS), whlch slrumeû lull technlcsl ond legol respondblllly under lls
À.t of Incotporsllon for läc work to be corled out under ony retullunt ogieement We qre o nonprofit publicly supporlEd
orgonizolion exempl from federsl income tox under lnternol Revenue Servlce Code section 501fCll3l, The Tqxpoyer
ldenilftcotion Number is 53-019ó932. DUNS Number is 0þ1?é-4057. Aword¡ reaulllng Írom lhl¡ proporol ¡hould be ls¡ucd lo
NATIONATACA9EMY OF SCIENCES ond poymentdhectèd lo:

Ncillonol Acqdenry d Sclences

Accountlng Offi'ce
ATIN: Cosh Monogement Section
500 Flfth Street, NW, Room T 433C
Wàshlngton DC 20001
Telephone: 202€34-3351 or 202-3.3/-.1476
(rev.2127lO?l

* T *
NANONÀL ACADEIIÍY OF SCTENCES NAÎIONAL ACAOEMY OF EilCINEERN NSTITUTE OF MÊDICINE iIATIOT.IAL RESEARCüI COUNCIL
 THE NATIONAL ACADEMIES
NATIONAL ACADDIVIY OF SCIENCES/NATIONAL .A,CAI}EMY OF ENGIIIIEERING
INSTITUTE OF MEIIICIFIE/NATIONAL RF^SEÁRCH COIINCIL

Review of tIæ Calífornia Institute þr Re gener atív e Medic ìne

Proposal No. 10-IOM-377-01

TABLE OF CONTENTS - T]ECHMC.AL PROPOSAL

D. PERTOD OF P8RFORMANC8..................,.'..,...

F. DELTVERABLES ATYD DISSEMINATION PLAI$............................

 Institute of Medicine

Review of the Caltfomia Institutefor Regenerative Medicine

A. Surnmary

The Califomi¿ Instiüúe for Regenerative Medícine (CIRM) bas requested tb¿t the Institute of
Medicine (IOM) pôvide an inãependent assessment of CIRM's prõgrams, oprations, sfrafegies,
and performance since its inception in 2005.

B. Bacþround

The California Institut€ for Regenerative Medicine (CIRM) is a state agency whose mission is to
support and advance stem cell research and regenerative medicine underthe highest ethical and
medioal standanls for the discnvery and development of cures, tlrerapies, diagnostics and
research technologies to relieVe hr¡man suffering frorir ch¡onic dÌsease and injury. Established in
2005 following the passage of the California Stem Cell Research ærd Cures Initiative, the
instin¡te mekes grants and provides loans for stem cell rcsea¡cho researoh facilities, and other
research opportunities. To date, the CIRM goveming board has ¿warded 328 grants worth more
than $1 billion in 15 rounds of funding. Now in its sixfh year of openition, CIRM is seeking a
rcview its programs, initiatives, and model of ftrding medical resea¡ch.

CIRM is the first agency in the counûry created by voters to invest state monies into basic and
applied medical research. CIRM has programs to support investigator-initiated research; yormg
investigators, the training of postdoctoral fellows, graduate and undergraduate studenß, and the
creation of an instruction¡l corrse in stem cell science and æohnology. CIRMs fi:nding model
ínvolves selling sta,te bonds that provide the funds for CIRM's operations and grant programs. To
compensate the State and its oitizens for their inveshe,nt in ClRM-sponsored researoh, the
revenues generated by intellectual property arising from Institule-fi¡nded projects are shared
between tle Ínventors, the non-profit organization, and the State of California according to a
prescribed fonnula.

C, PIau of Action

Statenent ofTask

The Califomia Institr¡æ for Rege,lrerafivé Medioine (CIRM) has requested that the Institute of
Medioine (IOM) provide an indepe,nde,nt assessment of CIRM's programs, opermtions, sfiafegies,
æd performance since its inception in 2005.

Specifically, the IOM committee will review and add¡ess úre following questions:
 3

. CIRMts initiel processes - What can be leamed from tlre history and process of building
consensus in thr public and scientific coronn¡nities to support the inception and work of
CIRM?

r CfRMts progremm¡tic and scientÍfre scope - Does CIRM have the portfolio of
projects and grant opportunïties necessary to meet its scientific goals? How csn CIRM
' improve upon its existing array of pnograms? What additional programs and initiatives
are recommended to meet its goals? What impacts have been seçn ûom intenratioual
aSee'lne,lrts? Does CIRM's scie,ntific strategic plan address the range of relevant issues in
regenerative medioine within CIRM's mandated soope of work?

c CIRIVI's organizational and managenent systemc - Are the internal organizational and
manage,ment systems (in particular the board and working group stuctruçs and
oþrations, the peer review system, the conflist of interest guidelines, and the grants
rBanagement syste,m) effective in working towa¡d the instituæ's scientific goals? Are the
syste'ms that are inplace scientÍfically and ethically valid and rigorous? Do they achieve
the level of tansparency and the lwel of st¡keholder and ssientific commwity
involvement needed to meet the institute's public responsibilities and scientific goals?

¡ CIRM's funding model - IIas tbe fiÐding model for CIRM had an impact ou the work
of the institute? What æe tlie advantages of CIRM's model for covering long-term costs
of medical resea¡ch? Could aspetts of this funding model serve as a paradip for other
st¿tes or counties? What hås been the economic impact of CIRM's researoh and facilíties
' awa¡ds æd grants?

r CIRM's intellechral properfy policiec - Tffbat are the shmgths and weaknesses of
CIRM's policy for shming revenrrc generated by intellectual property? How does this
model compar€ to the model governing federally-supported research?

The principal objective of this review is to e,nsure that all aspects of CIRM's operations are
ñrnotioning at peak performance. The committeæ is asked to provide recomme,lrdations regarding
short-, mediunr-, and long-term actíons that corrld improve the performance of CIRM.

Expertise

A commíttee of approxirnately 14 members will bo appointed with CIrpertise in stenr cell

research, developmental biology, bioethics and law, resea¡ch adrninístration, progtanx evaluation,
finance, business administration, and inællectual property. Committee nominations will be
solioited ftom a variety of sources, including the meinbershiF of the National Academies,
¡elevant organizations and associations, federal agencies, and other experts in the æeas to be
addressedin the study.
 4

Worþlan
A study committee of approximately 14 mçmbers will be assembled to review data, hold public
workshops, develop findings and recom¡nendations, and prepare a re,port. The committee will
conve,ne 4 times over the course of 18 months. Two public workshops will be planned and
convened in California in conjunction with the committee's meetings to gather data and ensure
th¿t the commíttee hea¡s the perspectives of rçlevant stakeholders.

The first committ€e neeting will be largely organizational and will include the æquíred bias and
conflist of interest discussíon, provide an oven'iew of the study requírements, and discuss
available soufi)es of information The sponsor will be asked to provide the charge to the
committæ and provide backgrormd and context for the study. ln addition, the committee will
organize its fnst workshop and identify potential speakers. It is anticipated that the second and
third meetings will be held in conjunction wíth public workshops and will also include time for
the committee to dissuss the outcomes of the workshop andtask in closed se,ssion. The
committee will spend time betïveen meetings reviewing documentation and processes and will
hold discussious u¿iththe sponsor.and with grantees and other relevant stakeholders. The fourth
meeting will provide time for thc full committee to continue its deliberatíons and finalize the
re,port and its recommendations. The report wÍll then go through the National Resea¡ch Counoil's
peer review proc,ess a¡rd be subject to appropriate institr¡tional review procedures. A
prepublication oopy of the report will be delivered to the sponsors afrer 15 months with books
delivered after 18 months. The prepublication copy will be delivered to the sponsors within 10
days before the public release of the r€port

Drafttimeline:

Months Action
v2 Seek commitee nominations, assemble committee, begin baokground researth;
contapt sþkehold€rrs; initial dissussions with sponsors

3 4 Hold first committee meeting hold bias and conflict of inte¡est discussior¡ discuss
ohrge to.the commiüec and context for the sûrdy, plan wor}shops - identifr topios
and potential speakers; identify inforrr¿tion needs; dovelop plans for receiving
stakeholde,r inpuÇ disouss commissioned pàpers a¡d consuhang and identiff ûopics

+9 Hold secoud and third committee meetings with workshops; develop report outline
and worþlan; hold working group conferonco calls; seæk and receive input from
stakeholdffs

t0-l 2 Hold fourth coryrmfües meeting; draft and.revise the r€porg draft recommend¿tions

13-14 Report review and rcsponse to rerriew; finalize roport

l5 Deliver prepublication (uucorrected proof) to the sponsorc; public release of the

reporS post report online

l6-18 Prepare report for publication and send to publishers; deliver published books to the
sponsors
 Persorueï

The shrdy will be conducted r¡uder the IOM Board on Health Sciences Policy, which is dírected
by_-fut&ew Pope, Ph.D. The study team would consist of a senior program offi"o, progam
officer, associate p¡ogram officer, and p'rogram associate, with zupport from a fina;piat
associate, board ednrinisfrsfiye assistant, and edítorial assistant. Â ãuricuta vita for Andrer¡r M,
Pope, Ph.D., Director, Board on Health Sciences Policy, is attached.

D. Period of Perfomance

The period ofperfonnance is June 7,20L1to November 30,2012.

E. Estimate of Cosh

The total estimated cost of this project is $728,967 frr the period from Jrme l, 20l l to November
30,2012 (see attached cost estimate). IVe a¡e requesting that the Califomi¿ Institute for
Regnerative Medioine provide support in the amormt of $728,967 for this period.

F. Deliverables and llissemlnation Plan

The primary product ofthis shrdy will be atechnical reporl ¡eviewed in accordance with
National Research Council OIRC) proceúres. Sponsors, Congressional members and staü
governmeut agencies, and other relevant organiz¿tions will be bríefed by committee members on
the conclusions and recommendations contained v/ithin the final'report. Re,ports resulting ûom
this effort will be prepared in sufficient quantity to ensure their distribution to the spousor and to
other relevant parties, in accordance with Academy policy. The National Academies Press will
publish the fingl repo4 and will assíst in broader dissemin¿tion by makÍng the report available
on fhe Intemet" thrcugh the National Academies Press (wwwnap.edu). Commissioned papers
will also be prepared and disfributed in accordance rvith NRc procedures.

G. Federal Advisory Committee Act @ACA)

The Academy bas dweþed irterim polioies aud pmcedrrres ûo ímplemre,lrt Sec.tion 15 of the
Federal Advisory CornmitteeAct,5 U.S.C. App.$ 15. Sec.tion 15 includescertainrequircments
regar{ing public access and conflicts of interest tbat a¡e appliceble to agreements rmd"r which
tlre Academy, using a commiffee, provides advice or recommendations to a Fedeial agency. In
accordanc€ with Section 15 of FACA, the Academy shall submitto the govemment qponso{s)
following delivery of each applicable re,port a certification that the policies and procedure. oi-tU"
Academy that implement Sestion 15 of FACA bave been subshatíally complied with in the
perfonnance of the conÈaclgranlcooperative agreement with respect to the applicable reporL

' IilIS Acquisitiou Regulations require the posûed electonic copy to comply wiür.section 508 of the RshabilÍtgtion
Acr of r9?3 (29U .S.C.7 94d).
IL Public Infomatiou about I' e Project
In order to afford the public greater knowledge of Aoademy activities and an opportrrnity to
provide comments on those activities, the Academy may post on its website
(http//q¡ww.national-acade,mies.org) the following informatíon as appropriate r¡nder its
procedurss: (l) notices of meetings opento the publio; (2) brief descriptions of projects; (3)
committeç appointnents, if any (inoluding biographies of committee members); (4) report
information; and (5) any other pertinent information

I. Experience ¿nd Qualifications

O r gani zational Exp er i e nc e

TheNational Academy of Sciencos (NAS) was established by an Act of Congress and signed by
President Lincoln in March 1863 to "investigateo examine, experiment, and report upon any'
zubject of scienoe or æt....whenev€r called r:pon by any depætrreirt of the Governurent." The
National Research Council was cstablished by execr.úive order undçr President Wilson ín 1916,
exparding the operational capacþ of the National Academy of Sciences. The Institute of
Medicine was chartered in 1970 by the Nation¿l Academy of Sciences, under the te,ms of the
I 863 Congrcssional charter.

One central purpose of the NAS, NRC, and IOM is to advise the government on issues of
science, medicine, and technology. The Academy and iæ afEli¿ted organizations are privafe,
indepeirdent, nonprofit institutions that jointly possess¡ a unique statw as congressionally
cbartered advisers to the govemüerit. Every ye¿r many studics are requested of the Academy
and its sister organiz¿tions. kr addition to federal sorlrces, requests for studies a¡e also rec,eived
from fo¡¡ndstions and otherprivate sestor organizations. A small number of studies receive
internal support.

The NRC an¿ lOiø have a long tadition of providing policy advice from a national perspeotive.
This tadition resß on the ability of the NAS/IOM to oonvene committees of experts who a¡e
charged to deliberate important issues of health and health care policy in an objective and
indepe,ndent e,nvironment that assutes rigorous analysis. IOM can serve an important finction by
bringing rqxesentatives frbm diverse groups together to achieve conserrsus on complex iszues,

The NRC/IOM is also able to convene experts atwotkshops to disctus important science and
health-rçlated topics. The workshop swnmary highlights the key issues raised by presenters and
by workshop attendees-in ways that heþ to inform experts and the gelreral pnblic alike.

Facíl ities arú Equlpment

The meeting facilities of the Institr¡te of Medicine æe available to the constituent organizations
of the Academy complex. These ínclude the National Academy of Sciences }dain Buitding,2l0I
constitution Av€,nue, N.w., rüashingt'oa o.c.¡ s!! Fifth stest, N.w. washington,
D.c.; Ttre
Amold and l\{abel Beckman Ceuterin lrvine, California; and the J. Erik Jonsson
Woods Hole
Center in rüfoods Hole,lvfassachusetts. Th€se facilities are used to conduct hund¡eds
of
sommittee meetings eachyeor. Thus, theNational Academyof Sciences *ilf
and equipment required for the proposed projecq for both committee *"*b"r,
ñ¿de fr"ititi*
and staf.
 CunisulumVitse
AI{DREW n[¡cPmRSON POPE, pbÐ.
August 2008

Institute of Medisine Home Address:

The National Acade,nries 10446 OwenBrown Road
500 Fiffü Stre€t,N.lV. Columbiq Maryland 2t044
Washington" D.C.20001 (30i) s964313
Telephone: (202) 334- I 8EB

OIIALIT'ICATIONS

' Twenty years of experienoe in develo'ping atirecting and. managing scientifio prcjects and perconnol
in addressing contemporarybealth policy iszues. Experienco and skills include:

r Evaluating soidntific, technical and policy-related íssues and information

r lVriting and editing scientífic and polícy documents
'. Conoeptualizing, dweloping, and waluatingpmjectproposals
o Supervising and managingtechnisal staff
r Diresting and managing orpert commiüees in writing p,reparing,
s¡td disseminating soientiüc reports
r Consensus-building with oçert cornmittees
e Orgpnizing, coordínating, a¡rd conduoting national and
international symposia and wodcshops
¡ Procuring managing and monitoring program firnding and annual budgets

PROFESSIOIy4,IT EXPERIENCE

1998- Directorr Board on Eealth Sciences Policy, Institut€ ofMedicine, National Academy of Sciences.
Major Responsibility: direoting the astiv¡ty of the Board on Health Scienoes Policy. The Board's
activities seek to foster an environment conducive to productive rcserch; consider túä impact of
soientifis advances on society, inoluding social and ethical issues that accompany basie science and
technological advances; and ensure the continuous vigor ofthe basic biomedical envíronmental, and
clinic¿l research enterprises as they rel¿te to ensuring and improving the health of the public.
Responsibilities inslude quâltty control of studies ín the progrzrn, directly supervísing the shrdy
directors, direofing and/or writing sections of program reports, and servjng as s€n¡or iOM sbafffor
liaison with ottrerNRC uníts.

1988'97 Senior Progmm Offièer and Study Director. Ðivisions of Health Sciences Polþ and Health
Pno¡notion and Disease Prwention, Instit¡te of vted.ioine National Academy of ScÍences.
. Major ResponsÍbility: deveþing and directing projects in heatth sciencãs polioy and healttr
pomotio:r and disease preve,lrtion with emphasis in occupational and environment¿t issues, primary
responsibilities include oonceptualízing.and developing project proposals, managing and direoting
expert oommitúees *i {"f, re¡brt vniting and preparation, managing annual program budges, aãd
dissemination and public relations. Subjeot areas have included oral óontraceitives and breast
oaflceq early detectÍon and prwention of skin oanseg disabilitypreventÍon; inioor allergens;
informatiou technolory and clinioal medicine; occupational and environmental mediciuJ in medical
and nursing curricula; priority setting at fhe Nation¿l Institutes of Health; and orgør procure,ment and
üansplantation.
 Andrew M. Pope,PhJ).
Paige2

19S6-8S Senior Prog¡em Ofrrcer and Study llirecto¡. Boa¡d on Envirunmental Studies and
Toxicolory, National Academy oT sciencovÌ.lational Researeh council.
Major Responsibility: oversight and cooidination of sciec¡tific, financial, and
adminisbative operations, with major responsibilities in planning managemenÇ and
directíon oftoxicology and epide,miolory programs; ruperviriooãf proõssionj statr,rüittr
committees comprising 85 scientists in a variety of discíplines and an annual budget of
approximaúely $1.2 million.

1984-t6P¡ugram Oflicen Board on Environmental Studies and Toxicolory, National Academyof

Sciences/l.Iational Research Council.
I\d4ior Responsibility: coordination and dÍrestion of committee report preparation
activities¡ coucephralization and development of project proposals, waluåtion of data md
prepa¡ation of wricen materials Ín areas thst included physióIory, toxioolory, reproduction,
and rqiury confrol,

POSTDOCTORAL ßELLOWSHIPS

1982-E3 Natlonel Re¡esrch Council Fellow. Board on Environmental Studies and Toxicolory,
National Academy of Scierices/ National Research Council.
Rer¡ielì' of behavioral and bíochemical æsting methodologies in the development of a
study on lateff shronic and delayd neurptoxic effects; evduation of the deoision-making
proc€sses used by the Cornmiútee on Toxicity Dafa Elemonts in reviowing toxio substaf,ces
fottle report entitled 'Toxicity Testinç Stategias to Detemrine Needs and Prioritias;'
compløion of the NAS study entitled "Scie,nce and Creationism: A View ftom the National
Academy of Sciences;" dwelop'rrent of a study proposal which received Academy approval
' entitled "Ocoupatíonal and Environmental'Ilazards to Reproduotion;" dwelopmeãt óf"
sûrdy proposal which receíved Aoademy ap'proval entitled "Chemioal Toxicþ and Agng."

1980-82 Senior Staff FeIIow. Pharmacolory andToxicoloryBranch, Division ofVeterinary

Medical Research, FDA, Beltwille, MD.
Research emphasis foçr¡sed on tbe effecb of organophosphates oir bottr the reproductive
andnervous systems. Research projecß included: Organophosphafe induced deúyed
nourotoxioity in sheep; effects of aryl esúonse on naiure and severity of
neurohistopafhological lesions and ciroulatingplasma gonadohopins; organophosphafe
índuced cerebellar h¡poplasia and seasonal variation of acefyl-cholinestãrâsiactivity in
pregnant and non-prcgnant ewes; induced bovine pyomeba as a modol for conbolled studies
of therapeutic agents; effects of cold güess on acetyloholinesterase activity; effecs of
organophosphates on dnrg metabolizing en¿ymes in sheep and dogs. I also provided a
consultative rwiew for a New fuiimat Drug Application ior prostagliurdin.
'

EDUCATION

1980 Ph.D. University of Maryland. Reproductive Physiolory

1975 M.S. Universþ of lt4aryland. Physiolory and Biochemisty

1973 B.S. Universiff of lvfarylmd. T.oolog

 Andren'M. Pope, PhÐ. page 3
- AI}DITIONAL EDIICATIgN AND TRÂII|IING

Væious mafiagement coußes. l99B -pre.sent,

Managing in a Technical Environment. National Academy of Scíences. Ma1, l9g7.

Supsrvisory Training. National Academy of Sciences. October lggd-Ma¡ch 1992,

Public Policy and the Environment, Universþ of Maryland Gradu¿te School. School of public
Affairs, Spring
1994.

Science and Policy of Global Environmental Problems. University ofMarytand Graduate School. Sohool
of
Public Affairs. Fall 1993.

Ocoupational Health Risk Assossment Directions for the 90's. The Harvard Schoot of pubtic Health,
Occupational Health Bostoq lvIA. May 1992.

Health Risk Assessment and Health Risk Communication. Agency for Toxic Substancqs and Disease
Registry. Atlantq GA. Jauuary 1992

Clues ûo Unraveling the Association Between Illness and Environmentol E:rposure. Agency for Toxic
Substances and Disesse Regishy/American Public H¡alth.Assooíetion. Wastrington, Dt. Ñovomber 1991.

Rsgulatory Toxicolory. New England Epidemiologr hstituþ. Houston, Texas, October 1991.

Prinoiples of Epidemiolory. New England Epiderniolory Institute. Houston, Texas. Ocroberr I 991 .

Toxicolory Update. The Johns Hopkins Medical Center. June 1989.

General Principles in Toxicolory and Toxicological Patholory. Bosfon University School of Medicine.
August 1985.

Meshanisms of Neurotoxicrty, The Johns Hopkins School of Hygiene and PublÍc He¿lth, November 1983.

Intemational Symposium on Biomechanics of Trauma. hrstitr¡te for Medical Education and Research, San
.
Diego. Ocúob€r 1983.

Environmental Toxicolory. NIH Graduatp School (FAES), Spring 1983.

' Essentials of Toxicologr. NIHGraduate School (FAES), Spring 1983.

Reprodtrction: TheNew Frontier in Ocoupational and Environmental Heatth Res€arçh. Workshop sponsored
þ Rocþ Mounúain Cenþr for Occupational and Bnvironment¿l Health. April 1983.
Delayed Neurotoxicþ Ìt/orkshop. University of lllinois. June 1g82.

Biometrics. FDd Bweau of Dnrgs, Rockville, MD. Spring 1982,

Basics of Toxicolory. FDA, Bureau ofVeterinaryMedicine, Rockville, MD. Spring 19E2.

statístical Analysis sysûems (sAs). usDA, Beltsville, MD. November 1929.

Basic R¡diation Protection and conüol. university ofMaryland. January 1979.

A¡drew M. PoperPh.D. Page 4

PREDOCTORAL RESEARCH

197É80 Docto¡al student USDA Reproduction Laboratory, Beltsville, MD and Departrrent of

Veærinary Science, University of NAaryland, CollegB Parlq MD.
Releass of luteal progest€rone and Prostaglandín F in vítro during fluprostørol inducæd luteoþis;
reproduc'tive performanoe of early postpartum ma¡es in rcspons€ to a p¡ogesúerone - GnRH treaûnent
regímen; uterine histolog of the pogpartum mare.

lg74-75 Maste¡e stüdent Deparünent ofAnimal Science, University of Maryland,

College Park, MD.
Ph5niolory, biochemistry and metabolism of prostaglandins and their effects on luteolysis,

lg72-73 Spe.ctal problems studont (undergradurtc). Ph¡'siotogical psycholory, Universþ of Maryland,

College Parlç MD.
Involvement of the hippocampus in resentmemory integration.

TEAçSING E"XPERTENCE

1976-80 Lecturer and Laboratory Instruefor. Reproductive Endoorinolory,

University of lvfaryland College Parh MD

lg7+TS Laboratory fn$ructor. Reproductive Physiolory; Horse Breeding Farm Managemont,

University of lvÍaryland, College Parlq MD

1973-74 fnstructor. Biolory; Equesrian Soience, McDonogh School" McDonogh, MD

MEMBERf¡EIPS

American Assooiation fo'r the Advanceinent of Scie¡nce

Americsû Public Health Association
Caucus on Disabiþ; Bxecutíve Secretary, 1992-1994
New York Academy of Sciences
Phi Sígna Sooiety (National Biologícal Hono¡s Society).
PresidenÇ Universþ of lvlaryland Chaptø, 1976-1978
Sigma Xi
Society for Occupational and Environmental Health
Councilor, 1994-1997
Newsletfer ceeditor, 1994-L997

MILITARY SERVICE
' U.S. Air Force Reserve (aotive),1969-1975, Sh¡dent Leader/Barracks Chief, Shepard AFB,
Wiohit¿f'ails, TX. Honorable Discharge. R¿nk Sergsant

INSTrIUTE OF IUDDICTIITE AND NATIONAL ACAD,EMY OF SCIENCES RDPORTS

2001 - presentu As Direcûor of the IOM Board on Health Ssiences Policy I had varying degrees of
involvement in all ofthe roports thatwere published -approximately 10 reportdyear,
 Andrewl\fi. Pope, Ph.D.
Page 5

fnnovation and Invenüon tn Medical Devices. Wor}chop Summary. 2001. Roundtable on Ressarch
and
Døvelopment of Ðrugs, Biologics, and Medic¿l Devices. National Academy press, Washington,
D.C.

Organ Procurement and Transptentation¡ AssryÍng Cur¡ent Polleies rnd the potentiel Impact
of the
' IIHHS I'lnal Rule. 1999. Committee on Orgian Procurement and Transplantation
fotic5,. NEHonal Academy
Press, Washington, D.C.

tr'luid Resuscltrtion: Stste of the Art for lreatÍng Combat C¡sualües and Civitinn Injurier.
1999,
Committee on Fluid Resuscitation for Combat Casualtíes. National Acsdemy press, Washington,
D.C.

Toward Envlronmentat Justice: Research, Educetion, ¡nd Health Poticy Needs, lggg. commitree on
Environmental lustice. National Academy press, Washington, D.C.

Sclendfic Opportuirities and PublÍc Noeds: fmproving Priority Setting snd Public Input at the NatÍonal
Institutes of Health, 1998. Comrnittee on NIH priority:Setting procesi. Nationat Academy presq
Washington, D.C.

Ilalcion: An IndependentAssescment of Sefety and Efficaca ll¿t¡. 1997. Comrnittee on 1lalcion: An

Assessmerit of Data Adeqlacy and Conñdence. National Academy Press, Washingûo4 D.C.

Enabling Amerlca: As¡e*gl1g tbe Rote of Rehabilit¿tion ScÍence and Engineæring. 19g2.
E. Brurdt and A. Pope (ediûors). National Academy press, washingüon, D.c.

Confe¡rence on Human Health and Global Climate Change: Summaiy of the Proceedings. 1996.
v. setlow and A. Pope (ediûors). Nationat Academy press, lvashington, D.c.
Nursing, Eealth, and the Environment: Strengthening the RelatÍonship to Improve the public's Healfü.
1995. A. Popg M' Snyder, and L. Mood (edÍtors). Committee on Enhancing Environnental Healttr Content
in Nursing Practioe. National Acadeny Prass,'Washington, D.C.

Envircnmontel Medicine: htegrating a Misslng-Element lnto Medical Educ¡tion" lgg5. A, pope and D,
Rall (editors). Commitæe on Curiculum Development in Environmental Medicine. National acaaeny
Prcss, Washington, D,C.

Environmental Medicine and the Medical School Curriculun- I¡terlm Reporh 1993. Commitree on
Curriculum Development in Environmental Medicine. National Academy Pross, lVashington, D.C.

Indoor Allergens: Assessing and Controlling Adverse Heslth Effects, 1993, A. Po,pe, R patferson, and H,
Bruge (oditors). Committee on the Health EffF,Gts oflndoorAeroallergens. National Acadeny press,
ìl/ashington, D,C,

E¡vlronmental Neurntoxicology. 1992. Committee on Neurobxicolory and Models for Assessing Rislc
. Nation¿l Academy Press,'lVashington, D.C.

Or¿l Conftaceptives and B¡sastC¡neer. 1991. Committee on theRelationship Between Oral Conüaceptives
and Breast Cancer. NatÍonal Academy Press, lVashinglon, DC

DisabilÍty lu America: A National Agenda for Prcvendon. 1991. A. Pope and A. Tarloy (editors).
Committee on aNatÍonal Agenda for the Prevention of Disabitities. Natibnal Academy hess, Washington,
D.C.
 Àndrew II{. Popg PhÐ. Page 6

Behaviorsl Measurres of Neu¡otoxicity. 1990, P. Flattau, R. Russell and A. pope (editors). United
St¿tes National Commiúee for the International Union of Psychological Science.' Natiónd Academy
Prcss, Washingúon" D.C.

Biologic llilarkers in Rcproductive Toxicology. 1989. Subcommittee on Reproductive and

Neurodwelopmental Toxicolory. Commitee on Biologic Markers. uational Academy press, V/ashingüon,
D.C.

Ddnking TÍoter ¡nd Ilealth (Volume g): Issues in Rlsk Assegsment 1989. Committee on Safe Drinking
' lVater. National Acadenry Press, Washington, D.C,
Injury Conhol: A Reviery of the Status and Progress of tbe Injury Control Program at fle
Centers for Iliseåse Contrcl. 1988. Committee to Review the Status and Progross of tho
þiury Confol
hogram at fie Centers for Disease ConhoL Ndional Academy Press, Washingbn, D,C,

.{ging in Todayrs Envircnment 1987, Comrnitteo on Cùemical Toxioityand Aging. Nationi Academy
Press, lVashington, D.C.

The ÀirlÍner Cabin Environment: Air Quelity and Srfef. 1986. Committpe on Airtiner Cabin Air
Quality. National Academy Press, Washingûon" D.C.

Injury in AmerÍca: A Confinulng Public Health Prcblem, 1985. Committee on Traums Resea¡ch,
National Academy Press, Washington, D.C.

ToxicÍty Tecting: Strategies to Dstemifure Needs snd PrÍodtie¡. 1984. Committee on Ideutificæion of
Toxic and Potentially Toxic Chemic¿ls for Consider¿tion þ the National Toxioolory Program. National
Academy Prcss, Washingon, D.C.

Science and Crtationigm: AView flom theNational Academy of Science¡. 19E4. Committee on Science
a¡d Creationism. National Academy of Sciences Council, National Acade,my Press, Washington, D.C.

JOJRNAL ARflCLES

Gibbons, RD., et at. 1999. Waiting for Organ TransplantatÍon. Sois¡rce 287 :237-2,38.

Brurney, W'., et al. 1999. Assessment of Safety and Effrcaoy Data for the Hypnotic ll¿lcion@: Results of an
tuiaþis by an InstÍtute of Medicine Committee, JASA 94 (448): 993-1002.

Azannff,D., et al. 1999. Report ofthe Instit¡¡te ofldedicine Committee on the Efficacy and Safety ofHalcion.
fuch Gen Psychff: 349:352.

Pope, A. M.1994. Frsm the Institute of Medicine: Ènvironmenal Me icine and the Medical Sshool
Cr¡nisulwn. JÁI\,IA 271 (6):417.

Pope, A. M' 1993. From the Institute of Medicine: Indoor Allergens-Assessing and Contolling Adverse
Hcalth Effects. I ANIA 269 QL): 272L.

Pope, A. M. 1992. Preventing SecondaryConditions, Mental Reta¡dation. 30:347-354.

Davis, D' L' and A. M. Pope. 1986. Reproductive Risks of Benzene: Neod fo¡ Additional Study, Toxicol,
Ind. Health 2t 445-451.
 AndrewM, PopqPh.D.
PageT

Pope, A, J. Heavnern I. Guarnieri and C. Knobloch. 1986. Trichlorfon induced congenÍtel cerebellar
hypoplasia in pigs. JAVMA 189: Z8t-283.

canpbell, D. L., A. M.,Pope, N. K., Das, and t. J., Abramson, 19g4. A Model for the study ofBovine
þometra. Proceedings of S¡,mposium on Dptemnination ofDoses of Veærinary phannaceuticals,
published by Ohio State UniversitSr Press, ColumbiA Ohio.

HeatmÊr, J.B. and A'M', Pope. 1984. FDA Updates: Toxicity of Orgmophosphorous Com¡rounds. JAVMA
184:30-32.

Jortner,8.S., A.M.
loPe and J.E. Heavner. 1983. Neuropathological aspeots of llaloxon-inducerl delayed
neurotoxicity in E1sA+ and EsA- sheep. Neu¡otoxicolory 241A46.{:
roqe-, eaM. and J.E Heavner. 1983. Acøtylcholinesterase activity in pregnant and non-pregnant ewes. Am.
J,
Veí Res. Mz 173È1731. :

Pope, 4.M., H'D. Guthrie, J.P. McCall and B.H. Stoud. 1983. Rele¿se of luteal progesterone and
Prostaglandin F in vito during fluprostenol induced luæolysis in the mare. Thäriogenolo g
[g:,aß423,

Pope, 4.M., D.L' Campbell and J.P. Davidson. 1978. Uterine histolory of posþartum marps neated with
progpsterone and GnRH. J. Reprod. Fert., Suppl, ZZ:587-5g1.

Pope, A.M' 1978' Foal HeatBreeding. I¡r VirginiaHorse ludustyYoarbook, Vol. 3 (virginiaHorue Counoil,
Míddleburg VA) pp. 70-73,

CO}.GRESSIO-I--åLTESTIUOTY

"*{ National Agenda for tlie Prevontion and Control of Skin Cåncer," Ad Hoo Subcomnrittpe on Consum€r and
Environmental Issues, commitrco on Governme¡rtal Affairs, u.s. Senate, June 5, 1992.

"Disability in Ameríca: Toward a National Agenda for Prevention," Subcommitee on Health and the
. Environmenf CommÍttee on Enerry and Commerce, U.S. House of Representativeq September lg,lggj,,
 IHE NAÎIONAT ACADEMIES
NAIIOML ACAÞEMY OF SCIENCËS XÀNONAL ACADEMY OF ENGINEEING

INSI¡TUIE OF MËOÍONE ¡\lAÎoNAL RS5ûîCH COUNCTL

INSTIIUTE OF MEDICINE

BOARD ON HEALTH SCIENCES POLICY

Proposol No. 10.1OM.377-01 - REVISED

EVATUAÏION OI THE CATIFORNIA INSTITUTE OF REGENERANVE MEDICINE

CIRM Summory of Costs

7 11 111 lo 111æ112

AMOUNT

Solories $2ó1,sl 6
Progrom Dkection, Manogemênt, ond Spoce Cosls $r35,346
Trovel $r 03,964
Reporls $r 0.500
Technology/Com municofion $rs.4o4
Meeting Expense $21,ô10
Other Cosfs s26.425

Subtolol: $577,765

Generol Adminislrotion Cosls st21 .182

Tolol: $699,247

Amount Requesfed From CIRM

Page I