Understanding Energy Metabolism
Understanding Energy Metabolism
Energy - is defined as the capacity to do work; the force or power that enables the body to
do its work.
The ultimate source of all energy in living organisms is the sun. Through the process of
photosynthesis, green plants intercept a portion of the sunlight reaching their leaves and
capture it within the chemical bonds of glucose. Proteins, fats, and other carbohydrates are
synthesized from this basic carbohydrate to meet the needs of the plant. Animals and humans
obtain these nutrients and the energy they contain by consuming plants and the flesh of other
animals. The body makes use of the energy from carbohydrates, proteins, fats, and alcohol in
the diet. Energy provided from the macronutrients is locked in chemical bonds within food and
is released when food is metabolized. Energy must be supplied regularly to meet the energy
needs for the body’s survival.
Energy has six forms: heat, chemical, mechanical, electrical, solar and nuclear. Four of these
are important to the human body. The body stores chemical energy that generates electrical
energy for the creation of nerve impulses needed to produce heat to keep the body
temperature at 37°C (98.6°F) even on cold days and to induce mechanical work through muscle
contraction for body movements (Williams, 2002).
When used in nutrition, energy deals mostly with the chemical energy locked in foodstuffs by
reason of the chemical process.
Metabolism – is derived from the Greek word “metabolismos” which means to change or alter.
Metabolism is the chemical process of transforming foods into complex tissue elements and of
transforming complex body substances into simple ones. It involves all types of changes that
occur in food nutrients after they have been absorbed from GIT and to the cellular activity
involved in utilizing these nutrients. It is the totality of the chemical processes in the body by
which substances are changed into other substances to sustain life, thus, the dynamic concept
underlying all life is change.
THE CALORIE
The unit of energy commonly used in human nutrition is the kilogram calorie (kcal). The
calorie is the standard unit in measuring heat. It is the unit of measurement for the energy
that our body gets from food. Calories are not eaten. They are by-products when
carbohydrates, protein and fats are oxidized in the body.
One calorie is the amount of heat required to raise the temperature of 1 kg of water to 1°C
at normal atmospheric pressure or in common measure, it is approximately the amount of heat
required to raise the temperature of 4 lbs. of water to 1°F.
Food energy is measured in kilocalories (kilogram calorie or kcal), which is commonly used
in human nutrition.
Calorie is from the Latin word “calor” meaning heat. It is a measure of heat. The energy
required to do the work of the body is measured as the amount of heat produced by the body’s
work. The energy value of food expressed as the number of kilocalorie a specified portion of the
food will yield when oxidized in the body.
Kilocalorie is derived from the French word “chilioi” meaning thousand and “calor”
meaning heat. The general term calorie refers to a unit of heat measure and is used alone to
designate the small calorie or as a general term in common language for the large calorie
(kilocalorie). The calorie used in nutritional science and in the study of the metabolism is the
large calorie in order to be more accurate and to avoid the use of very large number in
calculations.
The calories in food represent stored energy. To produce energy, the body uses these
calories in a manner similar to the way of burning fire woods produces light and heat. The body
breaks apart complex chemical molecules and puts together new ones (Metabolism as known).
Answer: Because the amount of energy involved in the metabolism of food is fairly large, the
kilocalorie (1000 calories) is commonly used to measure it. A popular convention is to designate
kilocalorie by Calorie (with a capital “C”). However in this text, kilocalorie is abbreviated as kcal.
Another commonly used unit of measurement is the joule. One joule is equal to the energy
expended when 1 kilogram is moved through a distance of 1 meter by a force of 1 Newton. The
relationship between calories and joules is as follows (Panlasigui, 1996):
The energy in foods is present as chemical energy; it can be measured by the heat evolved
when the food is oxidized or combusted. Although energy transformations normally involve
friction and heat conduction, which cause the changes of one form of energy to another to be
incomplete, various forms of energy normally can be converted completely to heat. The caloric
value of a food may be determined by burning weighed samples of the food in an oxygen
atmosphere in an apparatus called a calorimeter, which is designed to allow measurement of
the heat released by combustion of the fuel or food. The total amount of heat produced or
consumed when a chemical system changes from an initial state to a final state is independent
of the way this change is brought about (the law of Hess or the law of constant heat sums).
Thus the complete oxidation of a compound, such as glucose, to CO 2 and H2O produces the
same amount of heat whether the process is carried out in a calorimeter or by metabolism
within the body.
Heats of combustion are not accurate reflections of the amount of energy available to the
body, however, because the body does not completely absorb and metabolize ingested
nutrients. The energy lost in the excreta (feces and urine) must be subtracted from the total
energy value of the food to obtain the amount of energy available to the body from
consumption of the food. The caloric values of foods reported in food composition tables are
"physiological fuel values," also referred to as "available energy" or "metabolizable energy"
values. They are not total energy values.
Bomb Calorimeter - device used for measuring calories (stored fuel in food), designed for
measuring all the heat produced by the complete oxidation of an accurately measured
amount of any food. The apparatus is insulated thoroughly against loss of heat and the
amount of heat produced is measured by the change in temperature of a measured
amount of water.
Using a bomb calorimeter to burn food is a means of releasing all the food
sample’s available energy. (See page 24 of textbook)
The physiological fuel value of a food or a food component may be determined by measuring
the heat of combustion of the food in a calorimeter and then multiplying the heat of combustion
by correction factors for incomplete digestion and incomplete oxidation of the food in the body.
In about 1900, Wilbur Olin Atwater and his associates at the Connecticut (Storrs) Agriculture
Experiment Station used this approach to determine the physiological fuel values of a number
of food components (i.e., the protein, fat, and carbohydrate isolated from various foods). They
determined factors appropriate for individual foods or groups of foods, and they proposed the
general physiological fuel equivalents of 4.0, 8.9, and 4.0 kcal per gram of dietary protein, fat,
and carbohydrate respectively for application to the mixed American diet. These factors are
commonly rounded to 4, 9, and 4 kcal per gram (17, 36, and 17 kJ per gram) respectively for
protein, fat, and carbohydrate. The conversion factors determined by Atwater and his
associates remain in use in the twenty-first century, and energy values of foods are calculated
using these factors. The energy values (physiological fuel values) reported in food composition
tables are commonly estimated by determination of the proximate composition of each food
(i.e., the water, protein, fat, carbohydrate, and ash contents) followed by multiplication of the
amount of each energy-yielding component by the appropriate conversion factor.
The Atwater system (after Wilbur Olin Atwater) or derivatives of this system are used for the
calculation of the available energy of foods.
The calorie value of nutrients determined by the bomb calorimeter must be modified to take
account of losses in digestion and excretion.
4 kcal/g for CHO (17J) Note:
9 kcal/g for Fat (38J) 1 kcal = 4.184 joules
4 kcal/g for CHON (17J)
A slice of cake which contains 3 g CHON, 1 g fat and 15 g CHO will provide the following
kcal:
The amount of energy spent in a day differs for each individual. As expected, people spend
energy when they are physically active, but they also spend energy when they are resting
quietly. In general, there are three components of energy expenditure.
Energy is expended by the human body in the form of resting energy expenditure (REE) or
energy to meet basal metabolism (BM), energy expended for physical activity (PA) and energy
to cover the effects of food on metabolism, earlier known as specific dynamic action (SDA) of
food and now referred to as dietary-induced thermogenesis (DIT) or thermic effect of food
(TEF).
The amount of energy spent in a day differs for each individual. Except in extremely active
individuals, the REE or basal metabolism constitutes the largest portion (60% to 65%) of the
total energy expenditure (TEE). The TEF represents approximately the smallest component
(10%) of the total daily energy expenditure. The contribution of physical activity is the most
variable component of TEE, which may be as low as 100 kilocalories per day in sedentary
people or as high as 3000 kcal per day in very active people.
1. Direct Calorimetry – monitors the amount of heat produced by a person placed inside a
structure large enough to permit moderate amounts of activity. These structures are
referred to as whole-room calorimeters. Direct calorimetry provides a measure of energy
expended in the form of heat but provides no information on the kind of fuel being oxidized.
The method is also limited by the confined nature of the testing conditions. Hence the
measurement of TEE using this method is not representative of a free-living (i.e., engaged
in normal daily activities) individual in a normal environment because physical activity within
the chamber is limited. Itshigh cost and complex engineering and the scarcity of appropriate
facilities around the world also limit the use of this method. Its application is for scientific
research only.
2. Indirect Calorimetry – estimates energy expenditure by determining the oxygen
consumption and carbon dioxide production of the body over a given period. The equipment
varies, but the person usually breathes into a mouthpiece or ventilated hood through which
his or her expired gases are collected (respirometer or spirometer). Indirect calorimetry has
the advantage of mobility and low equipment cost.
BASAL METABOLISM
Basal metabolism is the measure of energy needed by the body at rest to carry on vital
body processes; approximately 1 calorie per kilogram of body weight per hour for an adult. It is
the minimum amount of energy needed by the body at rest in the fasting state. It indicates the
amount of energy needed to suction the life processes; respiration, cellular metabolism,
circulation, glandular activity and the maintenance of body temperature. It accounts for more
than one-half of calorie requirements for most people.
Basal metabolic rate (BMR) is the rate of basal metabolism in a given person at a given
time and situation. It constitutes one-half of the calorie requirements of an individual.
BASAL METABOLIC RATE – is the rate at which the body spends energy for the maintenance
of physiological activities; i.e., metabolic activities of cells and tissues and to maintain
circulatory, respiratory, gastrointestinal, and renal processes (activities necessary to sustain
normal body functions and homeostasis).
BASAL ENERGY EXPENDITURE – the measurement of the basal metabolic rate; usually
expressed as kilocalories per 24 hours (kcal/24 hr).
Note: In practice, the terms REE (resting energy expenditure) and BEE (basal energy
expenditure) are often used interchangeably.
* For each decade between 60-69 years & 70 above: decrement is increased to 10%
3. BODY SIZE & SURFACE AREA (HEIGHT) – A tall lean man will have a higher basal
metabolism than a stout short person of the same weight because of the greater surface
area in the former.
The greater the body surface area or skin area, the greater the amount of heat
loss will be, and in turn, the greater the necessary heat produced by the body. Muscle
tissue requires more O2 than does adipose tissue.
4. SEX – Sex differences in metabolic rates are primarily attributable to differences in body
size and composition. Women, who generally have more fat in proportion to muscle
than men, have metabolic rates that are approximately 5% to 10% lower than men of
the same weight and height.
5. ENDOCRINE GLANDS/HORMONAL STATUS – The secretion of the endocrine glands
are the principal regulators of the metabolic rate. Thyroid gland secretion has the
greatest effect on metabolism so does adrenals and pituitary. Hyperthyroidism causes
an increase in basal energy needs by about 50-75%. Hypothyroidism resulting from
decrease thyroxine secretion can depress basal energy needs by almost 30%.
Stimulation of the sympathetic nervous system (e.g., during periods of emotional
excitement or stress) causes the release of epinephrine, which directly promotes
glyconeolysis and increases cellular activity.
The metabolic rate of women fluctuates with the menstrual cycle. An average of
359 kcal/day difference in the BMR has been measured between the low and high point,
about 1 week before ovulation, just before the onset of menstruation. The mean
increase in energy expenditure is about 150 kcal/day during the second half of the
menstrual cycle (Webb, 1986).
11. DRUGS – Certain drugs, such as barbiturates, narcotics, and muscle relaxants,
decrease the metabolic rate, as does sleep and paralysis.
12.SLEEP – During sleep, the metabolic rate falls approximately 10% to 15% below that of
waking levels. This is due to muscular relaxation and decreased activity of the
sympathetic nervous system.
Calculation of BMR:
2. Harris-Benedict Formula - developed in 1909 using information on weight, height, age &
sex.
For Males:
REE = 66.5 + (13.5 x weight in kg) + (5 x height in cm) – (6.75 x age in years)
For Females:
REE = 655.1 + (9.56 x weight in kg) + (1.85 x height in cm) – (4.68 x age in years)
BMR = 66.5 + (13.5 x 56) + (5 x 162.56) – (6.75 x 22) = 1486.8 = 1,500 kcal
PHYSICAL ACTIVITY
The second component of a person’s energy expenditure is physical activity (PA). Energy for PA
is the most variable and most changeable component of energy expenditure (Whitney et al.,
2002). It may range from as little as 10% in a person who is bedridden to as much as 50% of
TEE in an athlete. The amount of energy required for an activity depends on the number of
muscles involved, and the intensity and duration of the activity. PA includes energy expended in
voluntary exercise and during involuntary activities such as shivering, fidgeting, and maintaining
postural control.
EEPA varies considerably depending on body size and the efficiency of individual habits of
motion. The level of fitness also affects the energy expenditure of voluntary activity, probably
because of variations of muscle mass.
EEPA tends to decrease with age, a trend that is associated with a decline in FFM and an
increase in fat mass. Men generally have a higher EEPA than women, primarily because of their
large body size and greater FFM.
Excess postexercise oxygen consumption (EPOC) affects energy expenditure. The
duration and magnitude of physical activity have been shown to increase EPOC, resulting in an
elevated metabolic rate even after exercise has ceased. Habitual exercise does not cause a
significantly prolonged increase in metabolic rate per unit of active tissue, but it does cause an
8% to 14% higher metabolic rate in men who are moderately and highly active, respectively,
because of their increased FFM. These differences seem to be related to the individual, not to
the activity.
DIT of TEF is the significant elevation of the metabolic rate following ingestion of a meal. The
muscles that move food through the intestinal tract and the cells that manufacture digestive
and other juices need energy to participate in the digestion, absorption and metabolism of food.
The expenditure of energy for this purpose results in thermogenesis or production of heat, thus
the term thermic. The thermic effect of food is greater for high-carbohydrate foods (8%) than
that for high-fat foods (3%) (Williams, 2002) because it takes less energy to transfer absorbed
fat into adipose than to convert glucose into glycogen or, or metabolize excess into fat. The TEF
is greater for a meal eaten all at once rather than spread out over a couple of hours. Some
possible mechanisms include changes in central nervous system activity, greater production and
release of hormones (such as insulin) and enzymes, and the rate of absorption and storage of
macronutrients (Wardlaw, 1999).
I. ADULT
Factorial Method
A factorial method of measuring total energy expenditure involves calculation of each of the
three categories of energy needs.
Note: The thermic effect of food is the “cost” of processing food. In a normal mixed diet, it is
estimated to be about 10% of the total calorie intake. For instance, people who consume 1800
kcal/day use about 180 kcal to process their food. The actual thermic effect of food varies with
the composition of food eaten, the frequency of eating, and the size of meals consumed.
Although it represents an actual and legitimate use of calories, the thermic effect of food in
practice is usually disregarded when calorie requirements are estimated because it constitutes
such a small amount of energy and is imprecisely estimated.
Krause method
The most practical, frequently used and rapid method of estimating energy requirements is
based on desirable body weight (DBW) according to occupation; often used in clinics and
hospitals.
Example:
52 kg, jeepney driver
TER = (40 kcal/kg DBW) x 52 kg = 2080 kcal
TER = 2,100 kcal
1. Infants
b. 7-12 months
1. DBW (g)= birthweight (g) + (age in months x 500)
2. Children
1. Infant
2. Children
3. Adolescent
13-15 years
55 (boys) kcal/kg DBW
45 (girls) kcal/kg DBW
16-19 years
45 (boys) kcal/kg DBW
40 (girls) kcal/kg DBW
ENERGY BALANCE
Energy balance occurs when an individual’s total caloric expenditure equals the individual’s
total caloric intake. The amount taken in by an individual should be equal to the amount of
energy expended during the day thus, attaining a desirable body weight. Then the individual is
said to be in energy balance. There is no weight gain or loss.
If more energy is taken in than is expended, the person gains weight. If more energy is
expended than is taken in, the person loses weight. If food energy is restricted too severely,
individuals lose lean tissue and may not receive enough nutrients. In addition, restrictive eating
may set in motion the unhealthy cycle of restrictive dieting and binge eating.
Desirable body weight (DBW) or ideal body weight (IBW) as used in nutrition and diet
therapy refers to the weight for height found statistically to be the most compatible with health
and longevity. There are several tables or nomograms which give the DBW of adults of given
height. However, in practice, it is often necessary to compute an individual’s DBW quickly.
The concept of ideal or desirable body weight (DBW) is still debatable because weight is
made up of different components. Weight is made up of fat, muscles, organs, bones, and fluid.
Difference may lie in these components between sexes, ages, and physiological condition. For
example, women would have more essential fat compared to males. As a result, frame size is
now a factor in determining DBW. The breadth of the elbow bone or wrist circumference as an
index for frame size has been employed for some years now.
The Food and Nutrition Research Institute and the Philippine Pediatric Society has come
out with “Anthropometric Tables and Chart for Filipino Children” which may be used as
reference in determining the DBW. For adults, the “Weight and Height Tables for Filipinos (25-
65 years)” may be utilized. If these references are not available, the following formulas may be
used:
1. Tannhauser’s Method
Height (in cm) minus 100 (factor)
Deduct 10% of answer to adjust to Filipino standard
Example:
Given: Filipino male measuring 157 cm
Computation: = 157 cm – 100 = 57 kg (0.1)
= 57 kg – 5.7 kg = 51.3 or 51 kg
2. Hamwi Method
For the first 5 feet (small frame):
100 – 105 lbs for females
105 – 110 lbs for males
For each additional inch, add 5 lbs
Add 5 lbs. for medium frame & 10 lbs for large frames
Example: female, 5’2”, small frame
5 ft. = 105 lbs
2 in. x 5 lbs. = 10 lbs
105 lbs + 10 lbs = 115 lbs
A current weight that is 80% to 90% of DBW indicates a lean client and possibly mild
malnutrition. Weight that is 70% to 80% indicates moderate malnutrition; less than
70% may indicate severe malnutrition possibly from systematic disease, eating
disorders, cancer therapies, and other problems.
To determine % underweight:
DBW – actual weight / DBW x 100
Example: actual weight – 98 lbs, DBW – 120 lbs
120 lbs – 98 lbs = 22 lbs
22 lbs/120 lbs x 100 = 18.33% = 18% underweight
Underweight is a condition where food intake or the energy value of a diet is less than
the energy value of a diet is less than energy expenditure, thus resulting in negative
energy balance. A person with body weight 10% or lower than his DBW is underweight.
Physical signs become obvious when adipose tissues beneath the skin are lacking and
the muscles are flabby.
To determine % overweight:
Actual weight – DBW / DBW x 100
Example: actual weight – 140 lbs, DBW – 115 lbs
140 lbs – 115 lbs = 25 lbs
25 lbs/115 lbs x 100 = 21.74% = 22% overweight
Weight exceeding 10% of the IBW range is considered over weight; weight exceeding
20% of IBW is considered obesity. Overweight means excessive positive energy balance.
It is a condition which results when energy intake is higher than energy output wherein
the excess energy is converted to fat.
B. The Body Mass Index (BMI) – the ratio of body fat to muscle mass as measured from
body density. It is used to assess a person’s body weight and to monitor changes over time.
BMI is the measure of adiposity or overfat, not simply overweight. It should not be applied
to children, adolescents, adults over 65 years old, pregnant and lactating women, and
highly muscular individuals.
Weight in kg
Height in m2
= BMI
or
BMI <18.5 is associated with being under weight. BMI between 25.0 and 29.9 is
considered overweight and increase risk for health problems. A BMI of 33 or greater is
considered obese and places the client at a much higher risk for diabetes and
cardiovascular disease.
Indirect Methods:
a. Triceps skin-fold test (TSF), midarm muscle circumference (MAMC), and midarm
circumference (MAC).
b. Waist circumference – the presence of excess body fat around the abdomen out
of proportion to total body fat is considered a risk factor for ailments associated with
obesity and the metabolism syndrome.
c. Waist-hip ratio or Waist-to-hip ratio (WHR)
The WHR has been used as an indicator or measure of the health of a person, and the
risk of developing serious health conditions. Research shows that people with "apple-
shaped" bodies (with more weight around the waist) face more health risks than those
with "pear-shaped" bodies who carry more weight around the hips.
Direct Methods:
a. Underwater Weighing
A more direct measure of determining whole-body density is densitometry, which
includes underwater (hydrostatic) weighing . Underwater weighing is based on
Archimedes’ principle: the volume of an object submerged in water equals the volume of
water the object displaces. Once the volume and mass are known, the density can be
calculated. Although this method is considered the gold standard, it is not always
practical, involves significant training to perform, and requires considerable cooperation
on the part of those being measured because they must be submerged under water and
remain motionless long enough for the measurements to be made.