Full-Automatic Capsule Filling Machine
Qualicaps Co. provides domestic and foreign users with high quality hard gelatin capsules, PEG capsules,
and HPMC capsules.
Our high-speed fully-automatic capsule filling machine developed by Qualicaps has attained high reputation
domestically and internationally, so we developed F-series for laboratory for study of drug formulation and
manufacturing investigational new drugs.
Name of each part
1 3 ① Capsule hopper
② Oil hopper
4 ③ Operation switch panel
④ Rectifier roller
⑤ Pumping box
6
⑥ Cap disk
(insertion of cap bushing)
2
7 ⑦ Body bushing
⑧ Filling nozzle
⑨ Joining
5 9
⑩ Production discharge chute
⑪ Layer 1 filling unit
10 (Liquid filling)
8
11
● This filling machine enables filling of drugs of every dosage form and multilayer filling.
It can fill all the samples for studying drug formulation such as powder, 3-layer granule, oil, pasty liquid,
and tablet, and all the samples for clinical use. It can also fill combined formulations of incompatible
drugs such as powder and granule 2-layer.
● This filler has realized easy cleaning and exchange of size.
Because all the drug contact portions of the unit can be overhauled and cleaned, excellent results of
cleaning validation can be obtained. Use of the bushing system improved reproducibility/ease of
assembly work markedly.
● This filling machine enables high-precision filling even when only little quantity of raw
materials is to be filled.
It can perform high-precision filling by dividing into 12 sections and intermittent driving, and can perform
speed change easily.
（1 ）
Features
❶ Rectification and Transportation of Capsule
This filler is patented in 10 countries worldwide, and
is adopted for all the equipment we developed and
attains high reputation.
The filler consists of a Rectifier with excellent
accuracy of division, cap bushing, and body bushing,
and it can be disassembled/assembled easily and
precisely with the positioning pin.
❷ Separation of capsules
Each capsule body is seated in the body disc by a
vacuum shoe equipped with an O-ring. This O-ring
serves as a shock-absorber preventing cracking of the
capsule shoulders as it is placed in the bottom of
capsule disc by way of vaccum.
❸ Feed and filling of Drug Substances
The filler can fill a wide variety of oily/liquid drug
products including solid/semisolid drugs by setting the
purpose-built unit. It can control the temperature of
liquid drug products and the discharge rate with ease.
（2）
❹ Powder filling (layer 1 filling section)
This filler adopts the die-compress method, a general
filling method, which enables filling capsules with
minute quantities of drugs. The pressure shaped slag
powder on the weight control disk is filled in capsule
bodies after pushing up the shaped slag powder from
beneath, scraping excessive powder away, and
controlling the weight.
❺ Granule filling
The filler adopts the 2-layer filling unit as an individu-
ally controllable mechanism by incorporating a
volume-controllable square between the upper and
lower shutters.
It enables multi-layer filling of granule up to 3 layers.
It has realized combination filling of a huge variety of
granules, for example, slow-release formulation, drug
products dissolving in the stomach (general products),
enteric coating drug products, incompatible drugs, and
segregated granules.
❻ Tablet filling
The filler can count plural mini tablets and fill a hard
capsule with them, and also can fill a capsule with a
combination of tablets such as fast-dissolving tablets
and slow-release tablets by setting the purpose-build
unit.
（3）
❼ Replacement of filling unit
( layer 1 filling section)
The filling unit on two rails can be removed easily by
loosening the fixing bolts and pulling the unit out.
Changing of the size or overhaul cleaning can be
performed more easily by moving the filling unit to a
distant position.
❽ Joining
The filler pushes up a capsule body with the joining
pusher and houses it in the joining block, and then
pushes up the body and the block synchronously to
connect a cap to the body.
Each cavity dimension is determined based on the
know-how we have accumulated as a hard capsule
manufacturer for past many years and the leading-
edge processing technology. The harmonized combi-
nation of the knowledge and the technology allows
prevention of connection failures such as peel and
dent.
Specifications
• Dimension : 775 mm wide × 685 mm deep × 1,740 mm (excluding the hopper)
• Footprint : 5.5 m2 (2,200 mm wide × 2,400 mm)
• Weight : 770 kg
• Production capacity: 1,000 capsules to 2,600 capsules/hour
• Target capsule sizes: Sizes 000, 00, 0, 1, 2, 3, 4, 5
• Utility: Power source 2φ phase, AC200 to 220 V, 50/60 Hz, 2.0 KVA
Vacuum For transferring capsules and orientational control 1.0 Kpa, 1.5 m3/min
For separating capsules 10.0 Kpa, 1.0 m3/min
For a cleaner 1.0 Kpa, 1.0 m3/min
Compressed air 0.5 Mpa, 0.3 m3/min
• Related facilities: S-15 capsule sealing machine
AWC-L automatic weight controller (system with capsule joined length measuring device)
CWI-40 capsule/tablet weight inspection machine
CES-50 capsule inspection machine
（4 ）
Canada
Romania
Spain U.S.A
Japan
GLOBAL NETWORK
Qualicaps Co., Ltd.
321-5 Ikezawacho,Yamatokoriyama
Nara, 639-1032
Japan
Phone: 81-743-57-8920
FAX : 81-743-56-5113
www.qualicaps.co.jp/en
Capsules ● Equipment ● Technology
Mar. 2016
