Lip Reconstruction: Donald Baumann, M.D., and Geoffrey Robb, M.D
Lip Reconstruction: Donald Baumann, M.D., and Geoffrey Robb, M.D
ABSTRACT
                                         Lip reconstruction poses a particular challenge to the plastic surgeon in that the
                               lips are the dynamic center of the lower third of the face. Their role in aesthetic balance,
                               facial expression, speech, and deglutination is not replicated by any other tissue substitute.
       L  ip reconstruction poses a particular challenge to          modifications associated with them. This can be quite
the plastic surgeon in that the lips are the dynamic center          confusing and often a source of miscommunication.
of the lower third of the face. Their role in aesthetic              Surgical techniques to reconstruct the lips can be differ-
balance, facial expression, speech, and deglutination is             entiated by three main criteria: Is the reconstruction
not replicated by any other tissue substitute. The goals of          dynamic or static? Is the orbicularis oris muscle sphincter
lip reconstruction are both functional and aesthetic, and            reestablished or is tissue interposed within it? Is the
the surgical techniques employed are often overlapping.              donor tissue from the remaining lip, local cheek tissue, or
The aesthetic goals of lip reconstruction are to provide             distant tissue? These aspects of flap design must be
adequate replacement of external skin while maintaining              considered as they impact the ultimate aesthetic and
the aesthetic balance of the vermiliocutaneous junction              functional outcome. As an example, a dynamic recon-
and lip aesthetic units. The functional goals of lip                 struction with remaining lip tissue that re-creates the
reconstruction are to maintain intraoral mucosal lining              orbicularis sphincter will likely be superior in terms of lip
and to preserve the surface area of the oral aperture. The           appearance and orbicularis function to a static recon-
competence of the orbicularis muscle sphincter must also             struction that uses remote tissue interposed between the
be maintained, as this is critical to achieving a functional         remaining orbicularis muscle.
recovery.1,2 Ideally, cutaneous sensation is preserved or                   This discussion will focus on representative flaps
reestablished to provide proprioceptive feedback for                 from each category above. Webster-Bernard cheek
speech, animation, and management of secretions.                     advancement flaps, Abbe cross-lip flaps, Karapandzic
       There have been countless flaps described to                  rotation advancement flaps, and free-flap reconstructions
reconstruct the lips with numerous eponyms and                       will be presented. The principles described are broadly
1
 Department of Plastic Surgery, The University of Texas M. D.        Soft Tissue Facial Reconstruction; Guest Editor, James F. Thornton,
Anderson Cancer Center, Houston, Texas.                              M.D.
   Address for correspondence and reprint requests: Donald              Semin Plast Surg 2008;22:269–280. Copyright # 2008 by Thieme
Baumann, M.D., Assistant Professor, Department of Plastic Surgery,   Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001,
The University of Texas M. D. Anderson Cancer Center, 1515           USA. Tel: +1(212) 584-4662.
Holcombe Boulevard, Unit 443, Houston, TX 77030 (e-mail:             DOI 10.1055/s-0028-1095886. ISSN 1535-2188.
dpbauman@mdanderson.org).
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      applicable to other flap designs and modifications of the      and skin. The mucosa must be aligned and everted to
      above flaps that are used in lip reconstruction.               provide a watertight mucosal seal. The deep and super-
                                                                     ficial fibers of the orbicularis muscle must be reapproxi-
                                                                     mated to allow tension-free muscle coaptation and avoid
      ANATOMY                                                        attenuation or muscle dehiscence. Incisions that cross
      Lip reconstruction requires familiarity with the surface       the white roll should be oriented perpendicularly to
      anatomy, underlying muscular anatomy, and neurovas-            allow precise realignment of the while roll to avoid
      cular anatomy of the lower face. The upper lip is              a noticeable vermiliocutaneous mismatch or notch.
      composed of the philtrum and tubercle centrally, the           Subtle misalignment of the lip can be aesthetically
      paired philtral columns laterally, and the white roll of the   distracting, even in the absence of significant soft tissue
      vermiliocutaneous junction. The orbicularis oris muscle        loss. This remainder of this discussion will focus on lip
      maintains oral competence by acting as a circumoral            defects with significant tissue loss that require flap
      sphincter. Its horizontal fibers link the modiolus and         reconstruction.
      philtral columns producing a tightening of the upper lip.
      Oblique fibers between the commissure and nasal floor
      act to evert the upper lip. The orbicularis is acted upon      CHEEK ADVANCEMENT FLAPS: WEBSTER-
artery ligation can alter the reliability of the cutaneous               Dissection is performed to release muscle fibers
circulation.                                                      and suspensory ligaments while taking great care to
                                                                  preserve the inferior and superior labial artery branches
                                                                  and the buccal motor nerve branches to the orbicularis as
ROTATION ADVANCEMENT LIP FLAP:                                    they enter the muscle at its lateral extent (Fig. 2). Bipolar
KARAPANDZIC FLAP                                                  cautery and a nerve stimulator facilitate the intramus-
The Karapandzic flap was designed to reestablish the              cular dissection. Minimal incision of the underlying
circumoral sphincter by rotating and advancing the                mucosa is performed, as the mucosal laxity will allow
remaining innervated orbicularis oris muscle.6 In theory,         advancement for closure. The overall lip circumference is
the lip is rebuilt with innervated-like tissue. However,          reduced to close the defect with a corresponding decrease
the net circumference of the lip is reduced. The                  in stoma surface area. Critical microstomia is the limit of
Karapandzic flap can be used to resurface up to near-             the flap design. Lesser degrees of microstomia can be
total defects of both the upper and lower lips, though            addressed secondarily with cross-lip flaps to transfer
superiorly based flaps for lower lip defects are more             relative lip excess to areas of deficiency.
common. The key to flap design is to assess the vertical                 The Karapandzic flap can provide a dynamic
height of the defect and translate that dimension to the          functional reconstruction with smaller innervated flaps
width of the flap. This allows a curvilinear incision to be       preserving better function. Although the flaps remain
plotted upwards toward the alar base. These incisions             innervated, the tension created by flap advancement in
can fall within the nasolabial fold or parallel to it with        the face of larger tissue loss reduces the lower lip to a
acceptable donor-site scarring.                                   tightened band.7 Subtle dynamic motion is replaced by
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      tethered scar. As with cheek advancement flaps, efface-          with both the central and lateral lower lip serving as a
      ment of the anterior gingivobuccal sulcus may require            donor site. However, when the upper lip is used as donor
      revising and deepening with a skin graft to improve              tissue, the central philtral region is preserved given the
      salivary competence.                                             delicate aesthetic balance of the central upper lip. The
                                                                       lateral upper lip serves as a donor site more commonly
                                                                       for transfer to the lower lip. Defects that are well suited
      CROSS-LIP FLAP: ABBE FLAP                                        to Abbe flaps are central full-thickness defects that do
      The cross-lip flap, or Abbe flap, is a staged flap based on      not involve the commissure.8 One advantage of the
      the labial artery. The Abbe flap is well suited for both         cross-lip flap is the ability to replace a vertical segment
      upper and lower lip reconstructions. It is more com-             of both vermilion and cutaneous lip tissue. An inferiorly
      monly used as a lower lip flap transferred to the upper lip      based Abbe flap can be extended to also include skin
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from the chin to resurface a defect extending into the             tains the oral opening as wide as possible. Flap division is
nasal floor (Fig. 3).                                              performed at 3 weeks. A compliant patient is paramount
        The defect is assessed and the flap is designed to         to the success of this flap as diet, speech, and social-
be half as wide as the defect to allow for balanced upper          ization are altered during the staged reconstruction.
and lower lip lengths after flap transposition. The flap                  Abbe flaps are also useful options for revising lip
survives on an axial blood supply and can be reliably              reconstructions as secondary lip-balancing procedures. If
narrowed allowing the flap to pivot and rotate into the            there is a relative deficiency in lip length after a cir-
defect. In selecting which side of the lip to set the base of      cumoral lip reconstruction, an Abbe flap can be inter-
the flap, the pivot point is placed closest to the commis-         posed to the shortened lip segment restoring balance.
sure to allow a more proximal blood supply and a more              The main disadvantages are the intervening period of lip
lateral pivot point. This allows a maximal distance from           adhesion and the potential imbalance of the vermilion
the opposite commissure to the flap pedicle and main-              and white roll on either side of the two suture lines.
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      FREE-FLAP RECONSTRUCTION OF LARGE                                    and, depending on body habitus, have the ability to be
      LIP DEFECTS                                                          folded and contoured re-creating the internal and ex-
      Free-flap reconstruction is often required for large-scale           ternal lining of the lip. When additional flap volume is
      defects with associated loss of mucosa, cheek, nasal, and            required, the anterolateral thigh flap (ALT) with or
      chin skin that exceed the availability of local soft tissue.         without the vastus lateralis muscle is well suited to
      This can be due to paucity of available soft tissue,                 reconstruct defects of the central and lower face. The
      previous radiation therapy, or previous surgery (Fig. 4).            ALT flap is ideal for large through-and-through cheek
      While free-tissue transfer can provide an abundance of               defects with lip involvement when two skin islands are
      soft tissue, care must be taken in selecting a donor                 required13,14 (Fig. 6). An advantage of internal mam-
      site with an appropriate match in color, texture, and                mary artery perforator, lateral arm, and parascapular
      pliability.                                                          flaps is color match with facial tissues; however, pedicle
              The radial forearm flap has been used extensively            length must also be taken into account when selecting
      because of its thin profile, long pedicle, and reasonable            these donor sites for lip reconstruction.
      color match9,10 (Fig. 5). Parascapular flaps have also                       Accurate assessment of three-dimensional tissue
      been used preferentially in facial reconstruction because            loss and required volume for reconstruction is para-
      of their excellent color match with facial skin.11 With              mount to the success of a lip reconstruction. Lip defects
      the advent of perforator flaps, the thoracodorsal artery             often appear more dramatic than they are in actuality
      perforator flap, internal mammary artery perforator                  because of the displacement of wound edges due to the
      flap, anterolateral thigh flaps, and lateral arm flaps               lateral pull of the facial muscles. The first step in
      have become options for facial reconstruction available              deciding on flap dimension is to reestablish the resting
      to the reconstructive microsurgeon.12 Perforator flaps               tension of the edges of the lip defect. The other lip can
      allow tissue to be thinned based on a preferential                   be used as a guide to reestablish the aesthetic dimension
      cutaneous blood supply and in theory are fascial and                 of the lip. Next, an Esmarch template is fashioned and
      muscle sparing thus reducing donor-site morbidity.                   sewn to the remaining lip elements and folded to
      These flaps typically provide reasonable color match                 account for the three-dimensional tissue requirements
                                                                                           LIP RECONSTRUCTION/BAUMANN, ROBB          275
Figure 6 Recurrent squamous cell carcinoma after previous reconstruction with vertical rectus abdominus myocutaneous
flap and radiation therapy. (A) Preoperative appearance. Note the tethered scar retraction and lateral displacement of the
commissure. Intraoral soft tissues are also contracted and fixed. (B) Full-thickness cheek defect including the lateral element of
the upper and lower lips and commissure. (C) Reconstruction with dual paddled anterolateral thigh flap and fascia lata sling
anchored to the zygomatic bone. The upper and lower lip elements were advanced to create a new commissure supported by
the underlying ALT flap. (D) Follow-up at 8 weeks. (E) Improved mouth opening. (F) Reconstructed commissure maintains
anatomic position upon mouth opening. (All photos copyright # 2007, Donald Baumann, M.D.)
276   SEMINARS IN PLASTIC SURGERY/VOLUME 22, NUMBER 4         2008
      of the defect. Precision is required in determining the           to avoid a previously operated neck or primarily radi-
      length of the external skin deficit given the delicate            ated neck. Recipient vessels are reached through a
      balance of lip aesthetic units. The mucosal requirement           subcutaneous tunnel. The tunnel must be designed to
      can be slightly overestimated to allow excess tissue to           allow the pedicle to travel in a direct path avoiding
      deepen the gingivobuccal sulcus and limit intraoral scar          kinks, twists, or compression.
      contracture.                                                             The inset of a thinned perforator flap is performed
             Next, recipient vessels must be selected. The              by folding the flap on itself to create internal mucosal
      facial vessels are of adequate caliber and readily acces-         lining and external cutaneous coverage. Alternatively, if
      sible at the angle of the mandible. An anastomosis at             the flap cannot be folded, the cutaneous portion can be
      this level requires a pedicle length of 8 cm, which is           used for intraoral lining, and the external portion of the
      readily available with any flap design. If the facial             flap can be covered with a skin graft. The flap design
      vessels are too small or unavailable due to previous              should plan for pedicle orientation in the coronal plane to
      surgery, then recipient vessels must be sought elsewhere          avoid the pedicle being folded on itself and compressed in
      in the external carotid system. One advantage in select-          the sagittal plane. The flap inset is guided by aligning
      ing recipient vessels for a lip reconstruction is that            external lip structures and interposing flap skin island
      either side of the neck can be used allowing the surgeon          under slight tension. This is done to establish the resting
      Figure 7 T4 N0 squamous cell carcinoma of the mandible eroding through to external skin and undermining the lower lip. (A)
      Preoperative appearance. (B) Defect after hemimandibulectomy and resection of lower lip and chin-cheek skin. The defect
      required intraoral bone and soft tissue reconstruction that was provided by a fibula osteocutaneous flap. A radial forearm flap
      provided external skin coverage. (C) Radial forearm skin island. (D) Fibula inset and radial forearm flap revascularized. Lip
      reconstruction was planned with a unilateral Karapandzic flap. (E) Intraoperative result after flap inset. (F) Result at 4 weeks.
      Reconstructed right lower lip is well supported by the soft tissue framework below; however, the shortened lip length has led to
      reduction in oral opening. (G) Result at 8 months after completion of radiation therapy. Note the improved contour of radial
      forearm flap. (All photos copyright # 2007, Matthew Hanasono, M.D.)
                                                                                             LIP RECONSTRUCTION/BAUMANN, ROBB           277
tone of the lip to prevent ptosis and salivary incompe-                     If the central mimetic musculature or distal facial
tence. Attention to deepening the anterior gingivobuccal             nerve branches have been resected, the reconstructed lip
sulcus will improve the patient’s ability to manage secre-           must be supported with either a static or dynamic sling.
tions, tolerate liquids, and avoid drooling.                         Static sling free-flap reconstruction requires suspension
Figure 8 Exophytic squamous cell carcinoma of mandible and lower third of the face. (A) Preoperative appearance.
(B) Extirpative defect including angle-to-angle mandibulectomy, resection of floor of mouth, lower lip, chin and neck skin.
This defect required a dual free-flap reconstruction, bone and soft tissue intraoral reconstruction, and a large soft tissue flap for
external neck and chin coverage. Given the extent of lip and intraoral resection, there were limited options for the lip
reconstruction. The fibula skin island was used for resurfacing of the lower lip in addition to intraoral coverage. (C) Harvest of
fibula with large skin paddle. (D) Fibula inset with soft tissue platform for lip reconstruction. (E) Intraoperative result with ALT
flap resurfacing the chin and cheek and neck skin. (All photos copyright # 2007, Matthew Hanasono, M.D.)
278   SEMINARS IN PLASTIC SURGERY/VOLUME 22, NUMBER 4         2008
      of the lateral element of the lip with rolled fascia grafts or   REVISIONS
      prosthetic or bioprosthetic materials. The vector can be         Most lip reconstructions require revision after a period of
      set using either the modiolus or zygomatic body as a             interim healing and completion of adjuvant therapy. The
      point of fixation depending on the presence or absence of        advanced tumor stage of larger lip defects often requires
      the facial nerve function. Bony anchors offer stable             radiation therapy for oncologic control. Radiation ther-
      fixation and enable fine-tuning of the vector of lip             apy inevitably alters the aesthetic outcome resulting in
      elevation.                                                       hyperpigmentation, fibrosis, edema, and pin-cushioning.
              The previously discussed aesthetic benefits of           When evaluating a patient for a lip revision, it is
      radial forearm flaps and perforator flaps including thin         important to consider the appearance and function of
      tissue mass, pliability, and color match are offset by the       the lip as well as the patient’s goals. The lip must be
      lack of functional dynamic motion. These flap donor              viewed in relation to its subunits: external skin of the
      sites all lack motor innervation and voluntary tightening        mentum and prolabium, vermilion, commissure, and
      of the lip. All lower lip static reconstructions are essen-      mucosa. Options for vermilion revisions include facial
      tially tension bands that relax with time and lose aspects       artery musculomucosal flaps,21 mucosal advancement
      of their barrier function. Dynamic slings can also be            flaps, commissureplasties, and tongue flaps. Intraoral
      incorporated into free-flap lip reconstructions to im-           scar release and skin grafting to deepen the gingivobuc-
 4. Closmann JJ, Pogrel MA, Schmidt BL. Reconstruction of             14. Jeng SF, Kuo YR, Wei FC, Su CY, Chien CY. Recon-
    perioral defects following resection for oral squamous cell           struction of concomitant lip and cheek through-and-through
    carcinoma. J Oral Maxillofac Surg 2006;64:367–374                     defects with combined free flap and an advancement flap
 5. Langstein HN, Robb GL. Lip and perioral reconstruction.               from the remaining lip. Plast Reconstr Surg 2004;113:491–
    Clin Plast Surg 2005;32:431–445                                       498
 6. Karapandzic M. Reconstruction of lip defects by local arterial    15. Yamauchi M, Yotsuyanagi T, Yokoi K, Urushidate S,
    flaps. Br J Plast Surg 1974;27:93–97                                  Yamashita K, Higuma Y. One-stage reconstruction of a
 7. Civelek B, Celebioglu S, Unlu E, Civelek S, Inal I,                   large defect of the lower lip and oral commissure. Br J Plast
    Velidedeoglu HV. Denervated or innervated flaps for the               Surg 2005;58:614–618
    lower lip reconstruction? Are they really different to get a      16. Jeng SF, Kuo YR, Wei FC, Su CY, Chien CY. Recon-
    good result? Otolaryngol Head Neck Surg 2006;134:613–                 struction of extensive composite mandibular defects with
    617                                                                   large lip involvement by using double free flaps and fascia lata
 8. Salgarelli AC, Sartorelli F, Cangiano A, Collini M. Treat-            grafts for oral sphincters. Plast Reconstr Surg 2005;115:
    ment of lower lip cancer: an experience of 48 cases. Int J Oral       1830–1836
    Maxillofac Surg 2005;34:27–32                                     17. Cordeiro PG, Santamaria E. Primary reconstruction of
 9. Jeng SF, Kuo YR, Wei FC, Su CY, Chien CY. Total lower                 complex midfacial defects with combined lip-switch proce-
    lip reconstruction with a composite radial forearm-palmaris           dures and free flaps. Plast Reconstr Surg 1999;103:1850–1856
    longus tendon flap: a clinical series. Plast Reconstr Surg        18. Ninkovic M, di Spilimbergo SS, Ninkovic M. Lower lip
Figure 2 30% skin only upper lip defect reconstructed with a peri-alar crescentric advancement flap.