PHARMA MCQ :

All of the following statements about the use of glucocorticoids in asthma is

true except:
a) Reduces bronchial inflammation and hyperactivity to stimuli
b) Have delayed onset of action
c) Given as prophylactic medications, used alone or combined with β-agonists
d) They are bronchodilators

All of the following statements about histamine is true except:

a) Increases blood pressure
b) Stimulates gastric acid secretion
c) Causes dilatation of capillaries
d) Causes constriction of bronchial smooth muscles

Which of the following pharmacologic agents antagonizes adenosine?

a) Theophylline
b) Glucocorticoids
c) Cromolyn sodium
d) Terbutaline

which of the following is anti-tussive ?

a)robitussion
b)flovent
c) copri
d) Codeine

which of the following is categorized as anti-viral?

a)theophylline
b)Robitussin
c) Tamiflu
d) Ciprofloxacin

these drugs are used to decrease the blood flow to the upper respiratory tract
and decrease the excessive production of mucus ?
a) antivirals
b) decongestant
c) antitussives
d) bronchodilators

these drugs are called H1 blockers ?

a) antivirals
b) antitussives
c) anti-histamines
d) bronchodilators

Mucinex is categorised as ?
a) anti-viral
b) expectorant
c) bronchodilators
d) anti-tussives

 Allergic rhinitis can be best treated with (choose the best answer):
a) Beta-2 adrenergic agonists
b) Antihistamines
C) Antibiotics
d)Corticosteroids

. Beta-2 adrenergic agonists help treat asthma because:

a)They stop the inflammation that is part of asthma
b)They kill bacteria
c)They help to constrict the airways
d) They help to expand the airways

May precipitate acute asthma:

  a)exercise
 b) aspirin
c) respiratory infection
d)  A, B, C

Prophylactic antiasthmatic drug probably acts by preventing release of

bronchoconstrictive mediators from mast cells?
a) beclomethasone
b) cromolyn
c) metaproterenol
d) albuterol

d-a-a-d-c-b-c-b-b-d-d-b-

——————————————

Which of the following anticancer drugs affect on M phase:

(A) paclitaxel.
(b) Bleomycin
(c)Methotrexate
(d) Asparaginase

Which of the following is true about theophylline:

(A) narrow theraputic index.
(B) need to monitor its serum level frequently.
(C) all of the above.

Glucocorticoids use in asthma because:

(A) its ability to bronchodilation.
(B) have anti-inflammatory action.
(C) non of the above.

hormones responsible …….LH/FSH........ Release estrogen.

contraceptives indicated in obese women and suffering from atherosclerosis :

(A) progestron only.
(B) estrogen - progestron.

the effect of antibiotics on contraceptives:

(A) antibiotics decreased its biovailability
(B) Increase it’s efficacy
(c) no effect.

the drug of choice used in treatment of vomiting caused by chemotherapy:

(A) odansetron.
(C) flucimides
which of the following is true about Ranitidin:
(A) first drug used in ulcer.
(B) best drug suppressing nocturnal ulcer.
(C) it’s proton pump inhibitor.
(D) more potent than omeprazole

21- PPI better than H2 blockers because:

(A) faster.
(B) stronger.
(C) ability to heal.
(D) all of the above

drugs used in prophylaxis of asthma : Cromolyn and nidocromile

all of the following anti-cancer drugs used in S phase except:

(A) 5-FU.
(B) 6-TG.
(C) Tamoxifen

drug used for decrease levels of uric acid (hyperuricamia) :

(a) esomeprazole
(b) Allopurinol.
(C) guansterone

............... is a pyrimidine analog anticancer drug and indicated inacute

myelocytic leokemia :
(A) florouracil.
(B) cytosin
(C) Metformin

-............ Is cytotoxic anticancer inhibit of mitotic spindle formation by

binding to tubulin and it's major side effect is neurotoxicity :
(A) vincristin.
(B) florouracil.
(C) cytosin
(D) Metformin

—————————————————————-

Q1) Select the alkylating agent from the following :

a) Flurorouracil
b) Cyclophoaphamide
c) Doxorubicin
d) Vincristine

Q2) What is the mechanism of Action of Methotrexate ? anticancer

drug (s phase )

Q3)which of the following cytotoxic anti-cancer drug works by

inhibition of tubulin polymerizarion ?
a)Vinblastine
b) Etoposide
c) Mitoxantrone
d) Paclitaxel

Q4) omeprazole is consider ________ than ranitidine

1) the treatment of choice at all times
2) less effective
3) same efficacy but less strong in nocturnal hypotension
4) stronger but less strong in nocturnal hypotension

Q5) all of the following anti-cancer drugs used in G1 phase except:

(A) 5-FU.
(B) 6-TG.
(C) Tamoxifen.

(D) Asparginase

Q6) nly class of antiulcer drugs that can eradicate Helicobacter

pylori and cure associated gastritis:
A) sucralfate (Carafate)
B) colloidal bismuth
C) H2 blockers
D) Anticholinergic agents

Q7) Antacid: melt-alkali syndrome:

A) aluminum hydroxide
B) magnesium hydroxide
C) calcium carbonate
D) sodium bicarbonate

Q8) All of the following drugs act by reducing gastric acid secretion except:
a) Omeprazole
b) Famotidine
c) Ranitidine
d) Sucralfate

Q9) All of the following are the mechanism of action of Granisetron ?

except
a) D2 antagonism
b) 5-HT4 agonism
c) 5-HT3 antagonism
d) 5-HT4 antagonism

Q10) Which of the following is the most effective drug for motion sickness?
a) Hyoscine
b) Chlorpromazine
c) Prochlorperazine
d) Haloperidol

Q11) which of the following is not a quick relief medication for asthma ?
a) epinephrine
b) Montelukast
c) flunisolide
d) predisnolone

Q12) which of the following is NOT TRUE about B2- adrenergic agonists :
a) it’s a bronchidilator
b) cause bronchodilation by decreasing cAMP
c) works on the sympathetic nervous system
d) it has nervosness as side effect.

Q13) which of the followning can be adminstrated orally or by inhalation ?

a) albuterol
b) Metaproterenol
c) Aminophylline
d) Theophylline

Q14) OMALIZUMAB: is ?
a) anti-tussive
b) synthesised antibody that is targeted against IgE
c) loosens bronchial secretion so they can be eliminated by coughing.
D) “ Alpha-Adrenergic agonists”

Q15) Anti-dote of Acetomenophen ?

a) cemidtine
b) Ziletuon
c) Acetylcysteine
d) Naphazoline

——————————————————————

1- the main excitatory neurotransmitter :

a- norepinephrine
b- Glutamate
c- GABA

2- which of the following describe mechanism of action of Diazepam:

a- inhibit the GABA receptors
b- facilitation to GABAa receptors to Cl influx.

3- The pancreas produces a hormone involved in the regulation of blood

sugar, called:
a- Cortisol
b- T3
c- T4
d- Insulin

4- A person with hypothyroidism should be treated with:

a-Fludrocortisone
b-Insulin
c-Hydrocortisone
d-Levothyroxine

5- People with Addison's disease are deficient in:

a- adrenal hormones
b-thyroid hormones
c-parathyroid hormones
d-T3 and T4

6- drug of choice used in depression :

(A) imipramine.
(B) amitriptyline.
(C) phenelzine.
(D) tranylcypromine.
(E) fluoxetine.

7- which of the following is not an action of phenobarbital:

(A) anticonvulsant.
(B) analgesia.
(C) hypnotic.
(D) respiratory deressent.

8- drug cause respiratory depression and it's action reversed by flumazenil:

(A)midazolam.
(B)phenobarbital

9- drug of choice to treat hyperglycemia in obese patient is:

(A)Metformin
(B)sulfonylurea
(C)Insulin

10- which of the following is incorrect relation :

(A) Humalog - Rapid acting insulin.
(B) Novolog - used after meal.
(C) most widely used - NPH.
(D) regular insulin - used in gestational.
(E) long acting insulin - Glargine.

11-which of the following is incorrect relation:

(A) albutrol - short acting B2 agonist.
(B) Astemizole - generation 2 H1 antagonist.
(C) montelukast - inhibit 5-lipoxgenase

12- Lomustine anti-cancer drug side effects include:

(A)renal and neuronal tissues.
(B)no side effects

13-1which of the following antacids its major side effect is constipation:

a- calcium bicarbonate
b- aluminum salts.
c- magnesium salts
d-sodium bicarbonate

14- the drug of choice used in treatment of vomiting caused by chemotherapy:

(A)odansetron.
(B)flunazil
(C)lorazepam
(D) carbamazepine

15- Substance secreted into the blood by a neuron is

a- Neurohormone
b- Neuromodulator
c- Neuromediator
d- Neurotransmitter

16- Which of the following is a leukotriene receptor blocker?

(a) Alprostadil
(b) Aspirin
(c) Ibuprofen
(d) LTC4
(e) Zafirlukast

17- The most likely mechanism involved in the antiseizure activity of

carbamazepine is
(a) Block of sodium ion channels
(b) Block of calcium ion channels
(c) Facilitation of GABA actions on chloride ion channels
(d) Glutamate receptor antagonism
(e) Inhibition of GABA transaminase

18-Which of the fo llow ing c lasses of compounds stimulates the release of

insulin from pancreatic β-cells?
(a) Progestins
(b) Biguanides
(c) Thiourylenes
(d) Sulfonylureas

19- Cortisol is anti-dote for :

(a) calcitonin
(b) Vitamin D
(c ) dexamethasone

20- Which of the following is mast cell stabilizers

that is used for asthma prophylaxis?
(a) Aminophyline
(b) Cromolyn
(c) Epinephrine
(d) Ipratropium

———————————————————

1- Hydralazine is:
a. Dilates veins but not arterioles
c. Works best as single therapy for hypertension – often in combination
d. In patients with ischaemic heart disease, may provoke angina or ischaemic
arrythmias – due to reflex tachycardia

2- In normal cells, which of the following drugs shortens the refractory

period?
a.lidociane

b. Amiodarone

c. Quinidine

d. Procainamide

3- Which of the following statements regarding Verapamil is CORRECT?

1. It is a dihydropyridine
2. It inhibits activated and inactivated sodium channels
3. It is a positive inotrope
4. It is an example of a class IV antiarrhythmic

4- A 55 year old man who is on medication for hypertension and high

cholesterol has episodes of chest pain from time to time when he is shovelling
snow. These episodes are relieved by taking a nitroglycerin tab under his
tongue. The most likely cause of this man's symptoms is:
a.Angina (stable)
b.Heart attack (myocardial infarction)
c.Muscle strain
d.Pneumonia

5-Which of the following drugs inhibit carbonic anhydrase enzyme :

(A) tranexamic acid.
(B) furosemide.
(C) acetazolamide.

6- Which of the following is selective for arteriolar dilation only?

a. Glyceryl trinitrate
b. Nifedipine
c. Prazosin
d. Hydralazine
e. Clonidine
7-Which Diuretic has medium efficacy and contraindicated in hyperglycemia :
a.Furosemide.
b.hydrochlorthiazade

8- Which of the following drugs convert supraventricular tachycardia to sinus

rhythm is:
a. digoxin.
b.adenosine.

9-If digoxin taken with potassium losing drug, potassium level will be
decrease and will :
a. increase digoxin serum level.
b. decrease digoxin serum level.

10-Variant (Prinzmetal) angina is characterized by increase in demand during

exertion?
a.true
b.false    

11. With respect to the treatment of angina, ALL members of this drug class

would cause reflex tachycardia?
a. calcium blockers
b. beta blockers
c. nitrates
d. A and C
e. all of the above

12. Excessive anticoagulant effect in bleeding due to warfarin can be reversed

by:
 A) stopping the drug
 B) large doses of vitamin K
 C) factor IX concentrates
 D) cholestyramine
 E) diuretics
13.(True/False) Warfarin crosses the placental barrier: 
A) true
B) false

14. Mouse/human chimeric monoclonal antibody -- blocks IIb/IIIb platelet

receptor
A) ticlopidine
 B) timolol
 C) abciximab
 D) eicosapentaenoic acid
 E) streptokinase

15. The major effect of which of the following on the action potential is a
marked prolongation of repolarization and duration of the action potential?
a. class IA
b. class IC
c. class II
d. class III
e. class IV

BONUS QUESTION:

Which would not be considered a mechanism of action of antiplatelet drugs?

a. Inhibition of ADP binding to platelet receptors
b. Inhibition of thromboxane A2 formation
c. Blockade of the glycoprotein IIb/IIIa receptors
d. Inhibition of plasminogen activation

——————————————————-

1-The autonomic nervous system is also known as

(a) Visceral
(b) Vegetative
(c) Involuntary nervous system
(d) All of the above

2- A direct-acting cholinomimetic that is lipid-soluble and often used in the

treatment of glaucoma is
(a) Acetylcholine
(b) Bethanechol
(d) Pilocarpine
(e) Neostigmine

3- The synaptic pre-ganglionic sympathetic neurons have their cell bodies in

the lateral horn of the grey matter of the
(a) Thoracic segment only
(b) Lumbar segment only
c) Both (a) and (b)
(d) None of the above

4- ‘Fight or flight’ state can be described as

(a) Sympathetic active; para-sympathetic quiescent
(b) Sympathetic active; para-sympathetic active
(c) Sympathetic quiescent; para-sympathetic active

5- Which one of the following drugs would decrease peripheral resistance

from nor-adrenergic nerves irreversibly ? 
  
a. Prazosin
b. Atropine
c. Phenylephrine
d. Phenoxybenzamine

6-  All of the following drugs produce either direct or indirect

parasympathomimetic effects, EXCEPT? 
a. Bethanechol
b. Atropine
c. Neostigmine
d. Nicotine

B
  
7- Which of the following best describes the mechanism of action of
scopolamine ?
(a) Irreversible antagonist at nicotinic receptors
(b) Irreversible antagonist at muscarinic receptors
(c) Physiologic antagonist at muscarinic receptors
(d) Reversible antagonist at muscarinic receptors
(e) Reversible antagonist at nicotinic receptors

8- Choose the correct statement from the following about α – adrenergic

receptor agonists
(a) Norepinephrine > isoproterenol > epinephrine
(b) Norepinephrine < epinephrine > isoproterenol
(c) Epinephrine ≥ norepinephrine > isoproterenol
(d) Epinephrine > isoproterenol > norepinephrine

9- Both Phentolamine and Noradrenaline are ?

(a) Agonists
(b) Competitive Antagonists
(c) Non-Competitive Antagonists

10- Drug of choice for Cardiogenic Shock ?

(a) epinephrine
(b) nor-epinephrine
(c) Dobutamine
(d) Dopamine

11- Lungs are mainly innervated by the Adrenergic receptors of ?

(a) Alpha 1
(b) Alpha 2
(c) Beta 1
(d) Beta 2
D

12- Which of the following drugs used in CHF and IHD respectivily:
1- bumetanide. 2- digoxin.
3- verapamil. 4- captopril.
5- Isosorbide. 6- pindolol.
(a) 4,2,1…..5,6,3.
(b) only 4 … 6

13- The group of items in this section consists of lettered options followed by
a set of numbered items. For each item, select the ONE lettered option that is
most closely associated with it. Each lettered option may be selected once,
more than once, or not at all.
A. nicotinic receptors in autonomic ganglia (NN)
B. nicotinic receptors at the neuromuscular junction (NM)
C. nicotinic receptors on chromaffin cells
D. muscarinic receptors in the periphery
E. muscarinic receptors in the central nervous system

1. Activation of this receptor is used in the treatment of glaucoma.

A.     B.     C.     D.     E. 
2. Blockade of this receptor is used in the treatment of motion sickness.
A.     B.     C.     D.  

D
E

14- Phenylephrine has most prominent:

(a) Alpha1 effects
(b) Beta1 effects
(c) Beta2 effects
(d) Metabolic effects
(e) CNS excitatory effects

15- the preferred drug to use for the BENIGN PROSTATIC HYPERPLASIA ?
(a) Phentolamine
(b) Adrenalien
(c) Prazosin
(d) Tamsulosin

——————————————-