| vo\ i" Pathog 4 Assianmen Krd ney “1 RP. Sang eedh Roll no: 74use (a | | | | in the oer | | oligania. and mild te moderate hg poens ian | raltisystem discascy a8 SC & Mero Seop/e Nephvitic — ; + Glomenulan disexsea proserdin with a hephritic Syndrome ane often chanacteuiyed a inf leanmslion. “the nephritic patient usual presokt's with emalunta , ned cell casts jh urine 1 Ty Te mid. 5 sAedte nephritic Syndrome mag ecluaih Pally ang tte Pastatire toc occol Cal omerul &f haitts : Ths [8 0 poster pica lomerclay —_ | immthe Complexe etidogy , which tg olecrecyi ascally | appears | te 4 weeks afte a. $tropto coccak infection. | phar nx % kip - | » Poot Theplococeal lomeralo nephritid ecewn A a | greqoertly in children toto gers J age, buf | ohldrcn ahd odults ¢ any age ean alee of ce |2 Et > paleg enenigs : Post wtregte coceal lomeralo nephvitis 1s caus eck | by Ipataone Complex» cents ATreptococeal exrlgony and apeciic wutibed ica, which anc Jerned incdite “Wephrife genic one Typo Rig, ] nck rel {ake fre A P-haemolitic watrepte cocer * ITrepts coceal infection may be identified b culture oy may be ingoned frm elevedled titres 4 — against dtyeploceecal antigen & Thue at + ante- dtreptolysin o (ASe) ‘andi ~ deoxy nibonvclease B (anti-bwasn) - anti - Sheptrinase (Askao-e) vandi- nic ctinyl aclenine dinuclectidas e, * anh? ~hgaleronidase The inetting andlgens we maneganente planted prom the cinealition in dubendothelial Loceibony | in glomeralan capillany walls , Leading te in stu | formation immon® compolecey , where thes elist | Er ermarton neaponse Sabsequedly the aut! on enilady complesc digsociat @, wiyrate across HBM , and ne for | on the Subepitheial a7ole ¢ BM; @) Morpholo The clopate histologic picture is d enlarged hyper - | cellular gional “The hy porcellalenity 1 Caused by ; Indilfreition by deuko cpt: * Prolifanettion 4 endothelial and nes ansial cella. ‘En ephe Corey crescent formation. These ¢s algo Awellin endothelial cells , | ond the combinatian prolif eredisn > dwelling , and Leute gle infiltredion obliterates the Capillary Jamons, Thane maybe tate stifval edema and. inf lammation | wh the tubal after Cobain Neel cell casts . granalan deposits y Iya 1 and C3 and “Aometines IM lag Meh a oy and ls the &BM. “The Chanactenistic electron microscopic qindin ane discrete , amonphoay , electan -clense depertts on Ke epithelial Alde 4 the membrane , often having appearance 4 hamps 2 epreacitin the anti en vashbady Complexes at the Subepithelal * cell danface | | | | 1 | *In Linmone flurry escen ce mic Fo6COPS here arc | | | |Clinical Course - Typically , The patient 8 a ge child, Preventing with acate nephiitie 4 ndrome , havin Aadden and abrust onset gellowin ah tpidod. Ane throat ov Akh injection I-2 weeks priate FAR oleu2 lopmest ¢ Symptoms ; the Acoli include microscope o intermitfed haemebwnin , red cell casts, mild non-selective Posteinuyia hypotension jporterbitel oedema and polly sligunia +Th adults ,The deoture> ane appeal andk include sudden hgpriten sinh 1 Gedemd and. apolacmit « b.Ra id | Progressive Grlomenulenephritis : “Rapidl frogessiee glomenule nephrti ie a cdg ndvom & asgodoled with severe olomeruslar Pap ang , bat oloes nat dencte a Specific & veg ht jd 9 lomenslongohrti | | | | “dt 1é chanaclenin ed bg. napid ahd Pre gressioe | loys of nenah danction asgocided with seve olfgeia. | and Bans 4 nephratic dy ndiorme | i6) tiepcllg chedis A nambder Primany, lomeralan and Sq stoic diseaty are thanactenited ba fermation of crcaceets. RPM ane divided ints le Type.| RBG: AntintnBhdlscade A nambey of dgstemic discasee Auch or 9 G0 d. pastures agrd rome ; SCE, Vasealit/s , Wegener's GPanulomateal’ , Henoch -S chenlein porpure and. ilispadhic mixed ergo glebulinanensa ane adsociakd with Cresecndic tiv Tyrew RP6N : T mune Copmploge discase - tt mall proportion Coed post - ahreococ cal AN , Pwticulanly th adally and Sometime q Non- Shepto ac ah origin | dl evelo fs RPE. hranulay depeaits immer complecer of Lath and eg along tho g lomanalan Capillary, walls» lewenin { blond Co mplerrcid Dewel and demon stron 4 a comp lec af ) ty pC ID RAN: Paver immons in : Theace includ+ caser of wegenu's granals modoaiy and micro écopic pay othewhit nodosa. The petegenesy 4 Pauci ~limmont Gb is act not | pully defined. loweven Prejortty ¥ these potterty Fone ANCA positire , implying a aefe ed in Aumoval immunity. Sonam Complement devel k cre noarmel and artt- BM ands bed 4 1 pegatim .thae ip LHe ov no glemeralan Fminunt depose t Morphologic features. resely ythe kidney e are ugcel lu enlorg ed i aol o with gmooth oaltn § fee ge! Showy Pale eorterc and congeat eal medalla Hero g-copie f irding Cilomenali Show patho anv VC crescent?’ oh the indlde 4 Bouman? capsulea- These are colledtonr | pale “Haining pay onal ella wheln commonly tend. to be elongated « * Tabada’ Tibet. epltheliok cell Show hg alae droplet * Codaine RBC cats + fibrinfy Trterstitiom: is oecle maload- and may adhow only | fibrosis Lr fla mmator celle) wsaally Lymphoc yteg eves in the and plasma cells, ane ene antensh biol tid ux - Clinical features: Genenall , tle feoturcsef RPAN ane dinilan to these o) acute an , prevesting am acute penal gailun The patties i § Goodpastures byndrant Pray presct aa acute nena farline and/or assoctellel inte palmonan haem ermhage predaciny necaned haemo sty iy. Mephrtic: dgndrome_ Nephrotic dyndrame it caused by a“ olerongmit | hh 4 lomenulan mapas walls —_ in Increaxdh | lgiaadar Te plasma proteins, The manifeffation au * Moosine proteinlur’'n. “Hy poalbumine mie. “Gennalined edema : Hyru lipiderva and [rpidayin@ Causey : The incidence, of the Sevnal canaca 4 the nephratic Sgndrome rey merit to age and geography En childten, Primang glemoule nephritis iy Ths cause th maf 4 Cases 4 the nephrotic Syn drone. nos frequct bing Lipa hephrosis “In adalty dysTenic oliseao (diabeto,cny|eldox k Ste) nl ment freyer] ctuade nephatfe Sgndrom? Hembranous Nope pe! (membranous nepphr» pathey, is chonlerne by ee hiker 4 Te {emenalan tala, wall due to the Becumulation q deporte cordsing Ly clon the Subpithe Side 4 the basement membrane. Membranouy nephropathy 15 0 fom 4 chron immune compet - redislal dixeod -In secodaa Membrancug nephropathy the hneiting arnt chy COR Sone Timey be idedi ted in He immune Complex ep. The aura oa may be endegensuy orexe genowy@ — Thy disorde, uauall prevesde with the ingidiowy onact 4 the nephretle Ag ndrem e 0% jin Sz Potties» With Non nephrstic. proteinwia- Hemélunit. ¥ mild hy pentension bre presckt rh 167 40 4 Coch CORRS, _Hinimel chang digeas. this nelative! benign dismder ig character by did duse ed facement dort precedscs o viscod. epitheltal cells ( Pode cyte), cletecTable only by elechon, leva kcqy, In glomeruli that appean virtually normal by Light mricte § Copy The peak incidence (+ between 2 and cynid age - The disease Sometimes follow a nerpinale in} ection 1 noutine Prphylatie Immun it tion