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Review Questions of Lecture 7 Tissue Repair PDF

1. Repair refers to restoring tissue architecture and function after injury through regeneration and/or healing. Regeneration completely restores damaged tissue to normal, while healing results in scar formation through connective tissue growth. 2. During tissue repair, the remnants of injured tissue, vascular endothelial cells, and fibroblasts proliferate. 3. Checkpoint controls prevent DNA replication or mitosis of damaged cells, while cyclins and cyclin-dependent kinases regulate cell cycle progression from G1. Tissues are divided into labile, stable, and permanent groups based on proliferative capacity.

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203 views2 pages

Review Questions of Lecture 7 Tissue Repair PDF

1. Repair refers to restoring tissue architecture and function after injury through regeneration and/or healing. Regeneration completely restores damaged tissue to normal, while healing results in scar formation through connective tissue growth. 2. During tissue repair, the remnants of injured tissue, vascular endothelial cells, and fibroblasts proliferate. 3. Checkpoint controls prevent DNA replication or mitosis of damaged cells, while cyclins and cyclin-dependent kinases regulate cell cycle progression from G1. Tissues are divided into labile, stable, and permanent groups based on proliferative capacity.

Uploaded by

Ahmed Younus
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Review questions of regeneration & healing by fibrosis

Q1-Define the followings repair , regeneration, healing???


ANSWER
Repair: refers to the restoration of tissue architecture and function after an
injury. This occurs by regeneration and/or healing.

Regeneration: is the complete restoration of the damaged components of


the affected tissue i.e. the tissue essentially returns to a normal state.

Healing:is a reparative process characterized by laying down of connective


(fibrous) tissue that results in scar formation.
Q2- What are the cell types proliferate during tissue repair??
ANSWER
1. The remnants of the injured tissue
2. Vascular endothelial cells
3. Fibroblasts
Q3-Fill in the blanks:
1- Checkpoint controls prevent DNA replication or mitosis of damaged
cells
2- Progression through the cell cycle from G1 is regulated by proteins
called cyclins, which form complexes with enzymes called cyclin-
dependent kinases (CDKs).
3- The tissues of the body are divided into three groups based on
proliferative capacities continuously dividing tissues (labile
tissues) , stable tissues, permanent Tissues
4- Labile cells include hematopoietic cells in the bone marrow and the
majority of surface epithelia
5- Stable cells constitute the parenchyma of most solid tissues, such as
liver & kidney. They also include endothelial cells, fibroblasts, and
smooth muscle cells
6- Skeletal muscle is usually classified as a permanent tissue
7- Stem cells are characterized by two important properties:
1. Self-renewal capacity
2. Asymmetric replication.
8- Cell proliferation can be triggered by
1. Growth factors, 2. Hormones, 3. Cytokines and 4. Signals from
the ECM
9- The ECM is a dynamic, constantly remodeling macromolecular
complex synthesized locally, which assembles into a network that
surrounds cells.
10- ECM occurs in two basic forms:
1. Interstitial matrix
2. Basement membrane
11- Interstitial matrix Its major constituents are fibrillar and nonfibrillar
collagens, as well as fibronectin, elastin, proteoglycans, hyaluronate
12- Basement membrane major constituents are amorphous nonfibrillar
type IV collagen and laminin.
13- Functions of the ECM
1. Mechanical support
2. Control of cell growth
3. Maintenance of cell differentiation .
4. Scaffolding for tissue renewal
5. Establishment of tissue microenvironments
6. Storage and presentation of regulatory molecules
14-Components of the Extracellular Matrix
1. Fibrous structural proteins
2. Water-hydrated gels
3. Adhesive glycoproteins

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