Support For Education and Learning Deep Vein Thrombosis: Clinical Case Scenarios

Venous thromboembolic diseases:
the management of venous thromboembolic diseases

and the role of thrombophilia testing
Support for education and

learning
Deep vein thrombosis:
Clinical case scenarios
June 2012
NICE clinical guideline 144

These clinical case scenarios accompany the clinical guideline: ‘Venous
thromboembolic diseases: the management of venous thromboembolic
diseases and the role of thrombophilia testing’ (available at
www.nice.org.uk/guidance/CG144). Issue date: June 2012.
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DVT VTE diseases clinical case scenarios. June (2012) Page 2 of 67

Contents
Contents ............................................................................................................. 3
Introduction......................................................................................................... 4
Key to terms ....................................................................................................... 6
Clinical case scenarios: deep vein thrombosis ................................................... 7
Case scenario 1: John .................................................................................... 9
Case scenario 2: Susan ................................................................................ 21
Case scenario 3: Nita.................................................................................... 34
Case scenario 4: Gary .................................................................................. 39
Case scenario 5: Jane .................................................................................. 56
Other implementation tools............................................................................... 65
Acknowledgements .......................................................................................... 65
Appendix 1 Two-level DVT Wells scorea .......................................................... 66
Appendix 2 Two-level PE Wells scorea............................................................. 67

Introduction
Venous thromboembolism (VTE) is a condition in which a blood clot (a
thrombus) forms in a vein, most commonly in the deep veins of the legs or
pelvis. This is known as deep vein thrombosis, or DVT. The thrombus can
dislodge and travel in the blood, particularly to the pulmonary arteries. This is
known as pulmonary embolism, or PE. The term ‘VTE’ includes both DVT
and PE.
Venous thromboembolic diseases cover a spectrum ranging from asymptomatic

calf vein thrombosis to symptomatic DVT. They can be fatal if they lead to PE,
in which the blood supply to the lungs is badly blocked by the thrombus. Non-
fatal VTE can cause serious long-term conditions such as post-thrombotic
syndrome.
Thrombophilia is a major risk factor for VTE. It is an inherited or acquired

prothrombotic state that predisposes to venous thromboembolism. Other major
risk factors for VTE include a history of DVT, age over 60 years, surgery,
obesity, prolonged travel, acute medical illness, cancer, immobility and
pregnancy.
Failure to diagnose and treat VTE correctly can result in fatal PE. However,
diagnosis of VTE is not always straightforward. The NICE clinical guideline on
Venous thromboembolic diseases includes advice on the Wells score, D-dimer
measurement, ultrasound and radiological imaging. It also offers guidance on
the management of VTE, investigations for cancer in patients with VTE and
thrombophilia testing. The guideline covers adults with suspected or confirmed
DVT or PE. It does not cover children or young people aged under 18, or
women who are pregnant.
To ensure comprehensive management and continuity when developing a

programme of care for patients who are at risk of or who develop VTE, users of
this guideline are encouraged to refer to NICE guidance on
Venous thromboembolism: reducing the risk (NICE clinical guideline 92

Rivaroxaban for the prevention of venous thromboembolism after total hip or
total knee replacement in adults (NICE technology appraisal guidance 170)
Dabigatran etexilate for the prevention of venous thromboembolism after hip or

knee replacement surgery in adults (NICE technology appraisal guidance 157)
Medicines adherence (NICE clinical guideline 76)
Patient experience in adult NHS services (NICE clinical guideline 138)
(see also section 6 of the VTE diseases NICE clinical guideline).

Key to terms
The following terms are used in these clinical case scenarios and the NICE
guideline.
International normalised ratio (INR) A standardised laboratory measure of

blood coagulation used to monitor the adequacy of anticoagulation in patients
who are having treatment with a vitamin K antagonist (VKA).
Provoked deep vein thrombosis (DVT) or pulmonary embolism (PE)

DVT or PE in a patient with an antecedent (within 3 months) and transient major
clinical risk factor for VTE – for example surgery, trauma, significant immobility
(bedbound, unable to walk unaided or likely to spend a substantial proportion of
the day in bed or in a chair), pregnancy or puerperium – or in a patient who is
having hormonal therapy (oral contraceptive or hormone replacement therapy).
Proximal DVT DVT in the popliteal vein or above. Proximal DVT is sometimes
referred to as ‘above-knee DVT’.
Renal impairment Reduced renal function that may be acute or chronic. An

estimated glomerular filtration rate of less than 90 ml/minute/1.73 m2 indicates a
degree of renal impairment in chronic kidney disease. (For NICE guidance on
the classification of chronic kidney disease see Chronic kidney disease [NICE
clinical guideline 73]).
Unprovoked DVT or PE DVT or PE in a patient with:
no antecedent major clinical risk factor for VTE (see ‘Provoked deep vein
thrombosis or pulmonary embolism’ above) who is not having hormonal
therapy (oral contraceptive or hormone replacement therapy) or
active cancer, thrombophilia or a family history of VTE, because these are
underlying risks that remain constant in the patient.
Wells scores Clinical prediction rules for estimating the probability of DVT and
PE. There are a number of versions of Wells scores available. This guideline
recommends the two-level DVT Wells score and the two-level PE Wells score.

Clinical case scenarios: deep vein thrombosis
Clinical case scenarios are an educational resource that can be used for
individual or group learning. They are also available in slide set format to
support group learning. Each question should be considered by the individual or
group before referring to the answers.
These clinical case scenarios are an essential component of the workshop set
out in the Deep Vein Thrombosis training plan. They have been put together to
improve your knowledge of ‘Venous thromboembolic diseases: the
management of venous thromboembolic diseases and the role of thrombophilia
testing’ (NICE clinical guideline CG144) and its application in practice. They
illustrate how the DVT-related recommendations from the NICE guideline can
be applied to the care of adults presenting to the acute care setting. These
cases assume that you are the lead clinician throughout the patient’s acute
phase. Although it is acknowledged that in reality this is not likely, they have
been developed in this way to facilitate learning and understanding of the whole
diagnosis and management pathway. They may also be informative for those in
primary care who may be the initial point of contact for a person with signs and
symptoms of VTE diseases and who may be involved in the care of their VTE
disease after discharge from the acute setting.
You will need to refer to the NICE guideline to help you decide what steps you
would need to follow to diagnose and manage each case, so make sure that
users have access to a copy (either online at www.nice.org.uk/guidance/CG144
or as a printout). You may also want to refer to the VTE NICE pathway
(http://pathways.nice.org.uk/pathways/venous-thromboembolism and the topic
page on NHS Evidence (www.evidence.nhs.uk/topic/venous-
thromboembolism).
Each case scenario includes details of the person’s initial presentation. The
clinical decisions about recognition, referral, diagnosis and management are
then examined using a question and answer approach. Relevant
recommendations from the NICE guideline are quoted in the text (after the
answer), with corresponding recommendation numbers.

This resource has been developed to illustrate the application of the
recommendations in ‘Venous thromboembolic diseases’ (NICE clinical guideline
144) in practice and should only be used to support learning. The
recommendations and these cases only cover the scope of the NICE guideline.
It is acknowledged that when a patient presents with suspected venous
thromboembolism there are multiple considerations including those beyond the
scope of the NICE guideline. These cases do not reflect treatment plans for
actual patients and should not be used as such. If an individual clinician has any
queries or concerns about the relationship between NICE guidance and this
educational resource they should always refer to the original guidance
published by NICE, and this should in all cases be regarded as the only
definitive statement of the guidance. The NICE clinical guideline may be found
at http://www.nice.org.uk/CG144

Case scenario 1: John
Presentation
John is a 75-year-old man with a recent (4 weeks ago) admission to hospital for
hip replacement. The procedure was performed under general anaesthetic.
During admission John received the following VTE prophylaxis (to be continued
until John no longer had significantly reduced mobility):
antiembolism stockings
pharmacological VTE prophylaxis.
John reports that his right leg has been swollen for over 2 weeks. He thought it
was healing after the operation, which is why he has not told anyone sooner. He
presented to his GP and the GP has referred him to your accident and
emergency (A&E) department.
1.1 Question
You believe John has symptoms of DVT. What would you do next?

1.1 Answer
Carry out an assessment of John’s general medical history and a physical
examination to exclude other causes.
Relevant recommendations
If a patient presents with signs or symptoms of deep vein thrombosis (DVT),
carry out an assessment of their general medical history and a physical
examination to exclude other causes. [KPI 1.1.1]
See Venous thromboembolism: reducing the risk (NICE clinical guideline
92) for VTE prophylaxis recommendations.
1.2 Question
John reports that he had a DVT 20 years ago and that he has osteoarthritis.
On admission he is apyrexial with a temperature of 37oc and his right calf and
ankle are red, blotchy and swollen with pitting oedema. His heart rate is 80
beats per minute, respiratory rate 15 breaths per minute, blood pressure is
136/80 mmHg and SpO2 96% in air.
You suspect DVT: what would you do next?

1.2 Answer
Even though John received VTE prophylaxis the diagnosis of DVT should still
be highly considered. Use the two-level DVT Wells score to estimate the clinical
probability of DVT.
Relevant recommendation
If DVT is suspected, use the two-level DVT Wells score (see appendix 1 or
table 1 in the NICE clinical guideline) to estimate the clinical probability of
DVT. [1.1.2]
1.3 Question
John’s two-level DVT Wells score is 3 (DVT likely):
Major surgery within 12 weeks requiring general or regional

anaesthesia = 1.
Pitting oedema confined to symptomatic leg = 1.
Previously documented DVT = 1.
You do not consider that an alternative diagnosis is at least as likely as DVT.
1.3 Answer
Organise a proximal leg vein ultrasound scan. Unfortunately in your
organisation this scan is not available within 4 hours of being requested.
Therefore, you offer a D-dimer test, an interim 24-hour dose of a parenteral
anticoagulant and a proximal leg vein ultrasound scan carried out within
24 hours of being requested.
The D-dimer test is positive and the proximal leg vein ultrasound scan is also
positive.

Offer patients in whom DVT is suspected and with a likely two-level DVT
Wells score either:
– a proximal leg vein ultrasound scan carried out within 4 hours of being
requested and, if the result is negative, a D-dimer test or
– a D-dimer test and an interim 24-hour dose of a parenteral anticoagulant
(if a proximal leg vein ultrasound scan cannot be carried out within
4 hours) and a proximal leg vein ultrasound scan carried out within
Repeat the proximal leg vein ultrasound scan 6–8 days later for all patients
with a positive D-dimer test and a negative proximal leg vein ultrasound
scan. [KPI 1.1.3]
1.4 Question
What would you do next?

1.4 Answer
Diagnose DVT and start treatment with low molecular weight heparin (LMWH)
as soon as possible and continue it for at least 5 days or until the INR is 2 or
above for at least 24 hours, whichever is longer.
Also start VKA within 24 hours of diagnosing DVT and arrange for John to
return to the outpatient clinic in 3 months to assess whether to continue VKA.
Diagnose DVT and treat (see section 1.2 of the NICE guideline) patients
with a positive proximal leg vein ultrasound scan. [1.1.5]
Offer a choice of low molecular weight heparin (LMWH) or fondaparinux to
patients with confirmed proximal DVT or PE, taking into account
comorbidities, contraindications and drug costs, with the following
exceptions:
– For patients with severe renal impairment (estimated glomerular filtration
rate [eGFR] < 30 ml/minute/1.73 m2) offer unfractionated heparin (UFH)
with dose adjustments based on the APTT (activated partial
thromboplastin time) or LMWH with dose adjustments based on an anti-
Xa assay.
– For patients with an increased risk of bleeding consider UFH.
– For patients with PE and haemodynamic instability, offer UFH and
consider thrombolytic therapy (see recommendations 1.2.7 and 1.2.8 in
the NICE guideline).
Start the LMWH, fondaparinux or UFH as soon as possible and continue it
for at least 5 days or until the international normalised ratio (INR) (adjusted
by a vitamin K antagonist [VKA]; see recommendation 1.2.3) is 2 or above
for at least 24 hours, whichever is longer. [KPI 1.2.1]
Offer a VKA to patients with confirmed proximal DVT or PE within 24 hours
of diagnosis and continue the VKA for 3 months. At 3 months, assess the
risks and benefits of continuing VKA treatment (see recommendations 1.2.4
and 1.2.5). [1.2.3]
Related recommendations
Offer a VKA beyond 3 months to patients with an unprovoked PE, taking

into account the patient’s risk of VTE recurrence and whether they are at
increased risk of bleeding. Discuss with the patient the benefits and risks of
extending their VKA treatment. [KPI 1.2.4]
Consider extending the VKA beyond 3 months for patients with unprovoked
proximal DVT if their risk of VTE recurrence is high and there is no
additional risk of major bleeding. Discuss with the patient the benefits and
risks of extending their VKA treatment. [KPI 1.2.5]
Consider pharmacological systemic thrombolytic therapy for patients with PE
and haemodynamic instability (see also recommendation 1.2.1 on
pharmacological interventions for DVT and PE). [1.2.7]
Do not offer pharmacological systemic thrombolytic therapy to patients with
PE and haemodynamic stability (see also recommendation 1.2.1 on
Additional information
When offering a choice of low molecular weight heparin (LMWH) or
fondaparinux to patients with confirmed proximal DVT or PE (recommendation
1.2.1) the guidance developers noted that it is very important to consider the
individual patient circumstances, such as comorbidities and contraindications in
order to offer the most suitable agent for the patient. Important considerations
include:
Renal status: Dose adjustment and monitoring may be required as patients

with renal impairment may accumulate excessive amounts of these drugs in
the body. LMWH and fondaparinux should be used with caution for people
with renal impairment, and UFH should be considered as an alternative.
UFH has a short half-life and is predominantly metabolised in the liver
compared to LMWHs that are predominantly excreted through the kidneys.
UFH therefore may be more suitable for patients who are at risk of bleeding
or have renal impairment.
Risk of bleeding or need for surgery or thrombolysis: As in renal
impairment patients, UFH is an alternative option for patients with uncertain
risk of bleeding or if the patient may have to undergo surgical procedures or

thrombolysis. Unfractionated heparin has a shorter half-life and is more
easily reversed if required.
Risk of HIT: Based on clinical experience the guidance developers
identified that there may be a lower risk of HIT in people receiving LMWH
compared to UFH. If the patient has a history of HIT, fondaparinux is an
alternative option because it is a synthetic pentasaccharide and not
associated with HIT.
Appropriate dose: Dosing errors in administering LMWH to patients have
been the subject of a National Patient Safety Agency alert (NPSA Rapid
response 14); doses were frequently not adjusted to the appropriate clinical
indication, weight or renal function. Patients should be weighed prior to
receiving LMWH to ensure that they are prescribed the correct dose,
especially in obese patients. Renal function should also be considered in all
patients, although renal function testing should not delay the first dose it
should be taken into account for subsequent doses.
Patient preferences: Both UFH and LMWH are of porcine origin. This may
be a concern to some patients. If this is a concern, fondaparinux may be
considered as a suitable alternative for some of these patients.
Route of administration for UFH: Both the intravenous route and the
subcutaneous route were included for UFH in the evidence review.
However, the main group of patients where UFH is likely to be used are
those with risk of bleeding or accumulation due to severe renal impairment.
The intravenous route has advantages over the subcutaneous route in
patients where accumulation or bleeding may be problematic. If problems
arise, the action of UFH can be limited by turning off the infusion. Protamine
sulphate can be administered as indicated.
1.5 Question
Would you consider catheter-directed thrombolytic therapy and/or an inferior
vena caval filter for John?

1.5 Answer
No, do not consider catheter-directed thrombolytic therapy for John because he
reports that his symptoms have existed for longer than 14 days.
Do not offer John an inferior vena caval filter because he is able to have
anticoagulation treatment and does not have recurrent PE or DVT.
Consider catheter-directed thrombolytic therapy for patients with
symptomatic iliofemoral DVT who have:
– symptoms of less than 14 days’ duration and
– good functional status and
– a life expectancy of 1 year or more and
– a low risk of bleeding. [KPI 1.2.6]
Offer temporary inferior vena caval filters to patients with proximal DVT or
PE who cannot have anticoagulation treatment, and remove the inferior
vena caval filter when the patient becomes eligible for anticoagulation
treatment. [1.2.10]
Consider inferior vena caval filters for patients with recurrent proximal DVT
or PE despite adequate anticoagulation treatment only after considering
alternative treatments such as:
– increasing target INR to 3–4 for long-term high-intensity oral
anticoagulant therapy or
– switching treatment to LMWH. [1.2.11]
Related recommendation
Ensure that a strategy for removing the inferior vena caval filter at the
earliest possible opportunity is planned and documented when the filter is
placed, and that the strategy is reviewed regularly. [1.2.12]
1.6 Question
In addition to the pharmacological treatment you have started, what other
treatment should be offered to John to treat the DVT?

1.6 Answer
A week after diagnosis, or when swelling is reduced sufficiently, John should be
offered below-knee graduated compression stockings with an ankle pressure
greater than 23 mmHg, if there are no contraindications.
By this point it is likely that John will have left the acute setting, so to ensure he
receives this treatment refer him at the time of diagnosis to the relevant
healthcare professional/department responsible for providing stockings (this
may be his GP or the orthotic department).
Also ask his GP to ensure that the stockings are worn for at least 2 years and
are replaced two or three times a year or in line with the manufacturer’s
instructions.
Offer below-knee graduated compression stockings with an ankle pressure
greater than 23 mmHg to patients with proximal DVT a week after diagnosis
or when swelling is reduced sufficiently and if there are no
contraindications1, and:
– advise patients to continue wearing the stockings for at least 2 years
– ensure that the stockings are replaced two or three times per year or
according to the manufacturer’s instructions
– advise patients that the stockings need to be worn only on the affected
leg or legs. [KPI 1.2.9]
1.7 Question
What information would you give John about his treatment? Would you offer
John self-management of his INR?
1
Prescribers should refer to specific product information and contraindications before offering
graduated compression stockings.

1.7 Answer
Offer John verbal and written information about his anticoagulant treatment,
including monitoring, side effects, interactions and lifestyle impacts. Provide him
with an anticoagulant information booklet and an anticoagulant alert card.
Advise him to carry the anticoagulant alert card at all times.
You would not routinely offer John self-management of his INR.
Give patients having anticoagulation treatment verbal and written
information about:
– how to use anticoagulants
– duration of anticoagulation treatment
– possible side effects of anticoagulant treatment and what to do if these
occur
– the effects of other medications, foods and alcohol on oral
anticoagulation treatment
– monitoring their anticoagulant treatment
– how anticoagulants may affect their dental treatment
– taking anticoagulants if they are planning pregnancy or become pregnant
– how anticoagulants may affect activities such as sports and travel
– when and how to seek medical help. [1.3.1]
Provide patients who are having anticoagulation treatment with an
‘anticoagulant information booklet’ and an ‘anticoagulant alert card’ and
advise them to carry the ‘anticoagulant alert card’ at all times. [1.3.2]
Be aware that heparins are of animal origin and this may be of concern to
some patients (see Religion or belief: a practical guide for the NHS). For
patients who have concerns about using animal products, consider offering
synthetic alternatives based on clinical judgement after discussing their
suitability, advantages and disadvantages with the patient. [This
recommendation is from Venous thromboembolism: reducing the risk (NICE
clinical guideline 92).] [1.3.3]
Advise patients about the correct application and use of below-knee
graduated compression stockings, how long they should be worn and when

they should be replaced. [1.3.4]
Do not routinely offer self-management or self-monitoring of INR to patients
who have had DVT or PE and are having treatment with a VKA. [1.4.1]
1.8 Question
Are there any further tests or investigations you would organise in relation to
John’s diagnosis of DVT?

1.8 Answer
No further investigations are required. John’s DVT is provoked, probably as a
result of immobility caused by his elective hip replacement surgery. If John’s
DVT had been unprovoked, and depending on future anticoagulation plans, the
NICE guideline recommends screening for cancer and thrombophilia.
Do not offer thrombophilia testing to patients who have had provoked DVT
or PE. [1.6.4]
Offer all patients diagnosed with unprovoked DVT or PE who are not
already known to have cancer the following investigations for cancer:
– a physical examination (guided by the patient’s full history) and
– a chest X-ray and
– blood tests (full blood count, serum calcium and liver function tests) and
– urinalysis. [1.5.1]
Consider further investigations for cancer with an abdomino-pelvic CT scan
(and a mammogram for women) in all patients aged over 40 years with a
first unprovoked DVT or PE who do not have signs or symptoms of cancer
based on initial investigation (see recommendation 1.5.1 above). [KPI
1.5.2]
Do not offer thrombophilia testing to patients who are continuing
anticoagulation treatment. [1.6.1]
Consider testing for antiphospholipid antibodies in patients who have had
unprovoked DVT or PE if it is planned to stop anticoagulation treatment.
[1.6.2]
Consider testing for hereditary thrombophilia in patients who have had
unprovoked DVT or PE and who have a first-degree relative who has had
DVT or PE if it is planned to stop anticoagulation treatment. [1.6.3]
Do not routinely offer thrombophilia testing to first-degree relatives of people
with a history of DVT or PE and thrombophilia. [1.6.5]

Case scenario 2: Susan
Presentation
Susan is a 50-year-old woman who presents to your A&E department following
GP referral. Susan complains of pain in her left calf, which has been present for
a week. Three weeks ago she had acute appendicitis with hospital admission.
For the last day her left thigh has been painful.
2.1 Question
You believe Susan has symptoms of a suspected DVT. What would you do
next?

2.1 Answer
Carry out an assessment of Susan’s general medical history and a physical
2.2 Question
You have noted Susan’s presentation and recent medical history. Her medical
records do not indicate that she received VTE prophylaxis while in hospital. She
has no significant past medical history.
On examination her entire left leg is swollen. Left calf 38 cm, right calf 34 cm,
left thigh 56 cm, right thigh 52 cm. Her heart rate is 70 beats per minute,
respiratory rate 14 breaths per minute, blood pressure 120/80 mmHg,
temperature 36oc and SpO2 99% in air.

2.2 Answer
You would use the two-level DVT Wells score to estimate the clinical probability
of DVT.
If DVT is suspected, use the two-level DVT Wells score (see appendix 1) to
estimate the clinical probability of DVT. [1.1.2]
See Venous thromboembolism: reducing the risk (NICE clinical guideline
92) for VTE prophylaxis recommendations.
2.3 Question
Susan’s two-level DVT Wells score is 3 (DVT likely):
Recent bedridden for more than 3 days = 1.

Entire leg swollen = 1.
Calf swelling 3 cm larger than asymptomatic side = 1.
You do not think an alternative diagnosis is at least as likely as DVT.
You suspect deep vein thrombosis . With a ‘DVT likely’ score, what would you
do next?

2.3 Answer
Offer an immediate proximal leg vein ultrasound, because this is available
within 4 hours of you requesting it.
Wells score either:
scan. [KPI 1.1.3]
2.4 Question
The proximal leg vein ultrasound scan identifies an occlusive clot in the
common femoral vein. What would you do next?

2.4 Answer
Diagnose DVT and start treatment with LMWH as soon as possible and
continue it for at least 5 days or until the INR is 2 or above for at least 24 hours,
whichever is longer.
In addition to the LMWH, you should consider catheter-directed thrombolytic

therapy for Susan because she is otherwise well, has a normal life expectancy,
has a low risk of bleeding and the DVT is of less than 14 days’ duration. Expert
clinical opinion suggests that when considering catheter-directed thrombolytic
therapy, in addition to considering the eligibility criteria above, you should take
into account the availability of adequate monitoring facilities and patient
preferences. On this occasion the appropriate facilities are available to safely
administer and monitor catheter-directed thrombolytic therapy for Susan.
You would also start VKA within 24 hours of diagnosing DVT and arrange for
Susan to return to the outpatient clinic in 3 months to assess whether to
continue VKA.
exceptions:
Xa assay.
consider thrombolytic therapy (see recommendations 1.2.7 and 1.2.8 in
the NICE guideline).

and 1.2.5). [1.2.3]

include:


2.5 Question
Would you offer Susan an inferior vena caval filter?

2.5 Answer
No, because Susan is able to have anticoagulation treatment.
treatment. [1.2.10]
2.6 Question
In addition to the pharmacological treatment you have started, what other
treatment should be offered to Susan to treat the DVT?

2.6 Answer
A week after diagnosis, or when swelling is reduced sufficiently, Susan should
be offered below-knee graduated compression stockings with an ankle pressure
greater than 23 mmHg, if there are no contraindications.
By this point it is likely that Susan will have left the acute setting, so to ensure
she receives this treatment refer her at the time of diagnosis to the relevant
healthcare professional/department responsible providing stockings (this may
be his GP or the orthotic department).
Also ask her GP to ensure that the stockings are worn for at least 2 years, are
replaced two or three times a year and are worn in line with the manufacturer’s
instructions.
2.7 Question
What information would you give Susan about her treatment? Would you offer
Susan self-management of her INR?
2
Prescribers should refer to specific product information and contraindications before offering
graduated compression stockings.

2.7 Answer
Offer Susan verbal and written information about her anticoagulant treatment,
including monitoring, side effects, interactions and lifestyle impacts. Provide her
Advise her to carry the anticoagulant alert card at all times.
You would not routinely offer Susan self-management of her INR.
information about:
occur

2.8 Question
Are there any further tests or investigations you would organise in relation to
Susan’s diagnosis of DVT?

2.8 Answer
No further investigations are required. Susan’s PE is provoked, probably as a
result of immobility caused by her episode of appendicitis and apparent lack of
prophylaxis. If Susan’s DVT had been unprovoked, and depending on future
anticoagulation plans, NICE recommends screening for cancer and
thrombophilia.
Do not offer thrombophilia testing to patients who have had provoked DVT
or PE. [1.6.4]
1.5.2]
[1.6.2]

Case scenario 3: Nita
Presentation
Nita is a 31-year-old woman who presents to your A&E department with pain
and swelling in her right leg. She also reports that the back of her calf appears
red. She plays regular sport and says this pain feels different from previous
muscle injuries.
3.1 Question
You believe Nita has symptoms of a suspected DVT. What would you do next?

3.1 Answer
Carry out an assessment of Nita’s general medical history and a physical
3.2 Question
You have noted Nita’s presentation. She has no significant past medical history,
but reports she has taken a combined oral contraceptive pill for the past
10 years. On examination her lower right leg is swollen. Left calf 34 cm, right
calf 37 cm, left thigh 50 cm, right thigh 50 cm. Heart rate 60 beats per minute,
temperature 370c and SpO2 99% in air.

3.2 Answer
Use the two-level DVT Wells score to estimate the clinical probability of DVT.
If DVT is suspected, use the two-level DVT Wells score (see appendix 1 or
table 1 in the NICE clinical guideline) to estimate the clinical probability of
DVT. [1.1.2]
3.3 Question
Nita’s two-level DVT Wells score is 0 (DVT unlikely):
Localised tenderness along the distribution of the deep venous system = 1.

Calf swelling 3 cm larger than asymptomatic side = 1.
An alternative diagnosis is at least as likely as DVT = −2 (you are
considering a ruptured Baker’s cyst).
You still suspect DVT: what would you do next?

3.3 Answer
Offer Nita a D-dimer test.
Offer patients in whom DVT is suspected and with an unlikely two-level
DVT Wells score a D-dimer test and if the result is positive offer either:
requested or
– an interim 24-hour dose of a parenteral anticoagulant (if a proximal leg
vein ultrasound scan cannot be carried out within 4 hours) and a proximal
leg vein ultrasound scan carried out within 24 hours of being requested.
[KPI 1.1.4]
3.4 Question
Nita’s D-dimer test is negative: what would you do next?

3.4 Answer
Take into consideration alternative diagnoses. Advise Nita that it is not likely
she has a DVT, and discuss with her the signs and symptoms of DVT and when
and where to seek further medical help.
Based on initial investigations, you believe this is likely to be a muscle strain

and therefore arrange further appropriate investigations3.
Take into consideration alternative diagnoses in patients with:
– an unlikely two-level DVT Wells score and
◊ a negative D-dimer test or
◊ a positive D-dimer test and a negative proximal leg vein ultrasound
scan.
– a likely two-level DVT Wells score and
◊ a negative proximal leg vein ultrasound scan and a negative
D-dimer test or
◊ a repeat negative proximal leg vein ultrasound scan.
Advise patients in these two groups that it is not likely they have DVT, and
discuss with them the signs and symptoms of DVT and when and where to
seek further medical help. [1.1.6]
3
This action is beyond the scope of the NICE guideline but has been added to replicate the
usual diagnosis process.

Case scenario 4: Gary
Please note this case scenario also appears in the PE clinical case scenarios.
Presentation
Gary is a 52-year-old man who is an endurance cyclist. He presents to your
A&E department following referral from his GP. He reports shortness of breath
at rest and chest pain. On direct questioning he admits to pain in the right calf
for a month, which he put down to muscle sprain.
4.1 Question
You believe Gary has symptoms of a suspected PE and DVT. Which diagnostic
route should you take?

4.1 Answer
Take into consideration the ‘additional information’ below in making your
decision.
Because of Gary’s chest pain and shortness of breath, you decide to carry out
initial diagnostic investigations for PE.
If a patient presents with signs or symptoms of both DVT (for example a
swollen and/or painful leg) and PE (for example chest pain, shortness of
breath or haemoptysis), carry out initial diagnostic investigations for either
DVT or PE, basing the choice of diagnostic investigations on clinical
judgement. [1.1.14]
When developing the guideline the developers discussed the advantages and
disadvantages to the patient in following each pathway (either DVT or PE):
The ultrasound scan used in the DVT algorithm avoids radiation exposure
and the administration of contrast compared with CTPA which is used in the
PE diagnostic algorithm. A CTPA is approximately equivalent to 3.6 years of
natural background radiation (UK average 2.2 mSv per year taken from
referral guideline from the Royal College of Radiologists)
One advantage of CTPA is that it also looks at all of the other structures
within the chest including whether there is evidence of right ventricular
dilatation which has prognostic implications and can identify other causes
for the patient’s symptoms.
The DVT diagnosis algorithm may be chosen for a patient with a possible
provoked DVT and PE because there will be no change to the
pharmacological treatment as a result of diagnosis and they would be
exposed to no radiation or intravenous contrast.
4.2 Question
What would you do next to diagnose PE?

4.2 Answer
Carry out an assessment of his general medical history, a physical examination
and a chest X-ray to exclude other causes.
If a patient presents with signs or symptoms of PE, carry out an assessment
of their general medical history, a physical examination and a chest X-ray to
exclude other causes. [1.1.7]
4.3 Question
On admission Gary’s SpO2 is 93% in air, heart rate is 102 beats per minute,
temperature 370c. You still suspect PE: what would you do next?

4.3 Answer
Use the two-level PE Wells score to estimate the clinical probability of PE.
If PE is suspected, use the two-level PE Wells score (see appendix 2 or
table 2) to estimate the clinical probability of PE. [1.1.8]
4.4 Question
You calculate the two-level PE Wells score to be 7.5 (PE likely)4:
Clinical signs and symptoms of DVT = 3.

Alternative diagnosis less likely than PE = 3.
Heart rate >100 beats per minute = 1.5.
You suspect PE. With this Wells score result, what would you do next?
4
It is acknowledged that the implementation of recommendations 1.1.7 and 1.1.8 are likely to happen
simultaneously. For example, it is not likely that in reality the clinician would wait for the chest X-ray
result before commencing a Wells score. The cases have been presented in this manner in order to
illustrate implementation of each of the recommendations

4.4 Answer
Offer CTPA.
On this occasion immediate CTPA is available so you offer this.
Offer patients in whom PE is suspected and with a likely two-level PE Wells
score either:
– an immediate computed tomography pulmonary angiogram (CTPA) or
– immediate interim parenteral anticoagulant therapy followed by a CTPA,
if a CTPA cannot be carried out immediately.
Consider a proximal leg vein ultrasound scan if the CTPA is negative and
DVT is suspected. [1.1.9]
For patients who have an allergy to contrast media, or who have renal
impairment, or whose risk from irradiation is high:
– Assess the suitability of a ventilation/perfusion single photon emission
computed tomography (V/Q SPECT) scan or, if a V/Q SPECT scan is
not available, a V/Q planar scan, as an alternative to CTPA.
If offering a V/Q SPECT or planar scan that will not be available
immediately, offer interim parenteral anticoagulant therapy. [1.1.11]
4.5 Question
The CTPA is positive showing several pulmonary emboli. What would you do
next?

4.5 Answer
Diagnose PE and start treatment.
Based on your clinical decision you offer LMWH immediately and continue this
for at least 5 days or until the INR is 2 or above for at least 24 hours (whichever
is longer). You also start VKA within 24 hours of diagnosis of the PE and
continue this for 3 months. You also ensure an outpatient appointment is
booked for Gary in 3 months’ time to assess benefits and risks of continuing the
VKA.
Diagnose PE and treat (see section 1.2 of the NICE guideline) patients with
a positive CTPA or in whom PE is identified with a V/Q SPECT or planar
scan. [1.1.12]
exceptions:
Xa assay.
consider thrombolytic therapy (see recommendations 1.2.7 and 1.2.8
below).

and 1.2.5). [1.2.3]
include:


4.6 Question
Would you offer Gary systemic thrombolytic therapy, catheter-directed
thrombolytic therapy or an inferior vena caval filter to treat his PE and DVT?

4.6 Answer
No, do not offer systemic thrombolytic therapy to treat Gary’s PE because he is
not haemodynamically unstable.
Do not offer an inferior vena caval filter because Gary is able to have
anticoagulation treatment.
PE and haemodynamic stability (see also recommendation 1.2.1 in the
NICE guideline). [1.2.8]
treatment. [1.2.10]

4.7 Question
A few days after Gary’s admission the acute PE phase has been managed and
Gary is stable. You noted on admission that Gary complained of a sore leg. You
now note that his entire leg is swollen, he has calf swelling of more than 3 cm
on his sore leg. You are still concerned about DVT: what would you do next?

4.7 Answer
The anticoagulation treatment for pulmonary embolism is very similar to that for
deep vein thrombosis. Therefore if Gary does have a DVT, the treatment he
has been receiving would also be treating any possible DVT. However, the
treatment for DVT also includes graduated compression stocking to prevent
the development of post thrombotic limb. It is therefore helpful to confirm if Gary
has a DVT. You would therefore offer a proximal leg vein ultrasound.
Wells score either:
scan. [KPI 1.1.3]
4.8 Question
The proximal leg vein ultrasound scan shows a proximal DVT. What would you
do next? Would you consider catheter-directed thrombolytic therapy?

4.8 Answer
Do not offer Gary catheter-directed thrombolytic therapy because he has had
symptoms for longer than 14 days. Additionally the ultrasound did not identify
iliofemoral DVT.
In addition to the LMWH and VKA (see answer 4.5), a week after diagnosis or
when swelling is reduced sufficiently Gary should be offered below-knee
graduated compression stockings with an ankle pressure greater than
23 mmHg, if there are no contraindications.
By this point it is likely that Gary will have left the acute setting, so to ensure he
receives this treatment refer him at the time of diagnosis to the relevant
healthcare professional/department responsible for providing stockings (this
may be his GP or the orthotic department).
Also ask his GP to ensure that the stockings are worn for at least 2 years, are
replaced two or three times a year and are worn in line with the manufacturer’s
instructions.
5
Prescribers should refer to specific product information and contraindications before offering graduated
compression stockings.

4.9 Question
What information would you give to Gary about his treatment? Would you offer
him self-management of his INR?

4.9 Answer
Offer Gary verbal and written information about his anticoagulant treatment
including monitoring, side effects, interactions and lifestyle impacts. Provide him
Advise him to carry the anticoagulant alert card at all times.
You would not routinely offer Gary self-management of his INR.
information about:
occur

4.10 Question
Following this recent episode of unprovoked PE and DVT, are there any further
tests you would offer Gary?

4.10 Answer
Yes, offer the following investigations for cancer: a physical examination
(guided by his full history) and a chest X-ray and blood tests (full blood count,
serum calcium and liver function tests) and urinalysis.
If these tests do not identify signs and symptoms of cancer in Gary, consider
further investigation with an abdomino-pelvic CT scan for cancer.
If active cancer is identified it may be necessary to re-assess Gary’s PE and

DVT treatment plan.
If the plan is to stop anticoagulant treatment you should also consider

thrombophilia testing.
1.5.2]
[1.6.2]

Offer LMWH to patients with active cancer and confirmed proximal DVT or
PE, and continue the LMWH for 6 months6. At 6 months, assess the risks
and benefits of continuing anticoagulation7. [KPI 1.2.2]
6
At the time of publication (June 2012) some types of LMWH do not have a UK marketing authorisation
for 6 months of treatment of DVT or PE in patients with cancer. Prescribers should consult the summary
of product characteristics for the individual LMWH and make appropriate adjustments for renal
impairment. Informed consent for off-label use should be obtained and documented.
7
Although this use is common in UK clinical practice, at the time of publication (June 2012) none of the
anticoagulants has a UK marketing authorisation for the treatment of DVT or PE beyond 6 months in
patients with cancer. Informed consent for off-label use should be obtained and documented.

Case scenario 5: Jane
Presentation
Jane is a 65-year-old woman with inoperable ovarian cancer and poor
functional status. She presents to your A&E department following a referral from
the oncology outpatient clinic. She complains of pain along the length of her left
leg with her left calf feeling particularly painful. She also reports that her left calf
feels hot.
5.1 Question
You believe Jane has symptoms of a suspected DVT. What would you do next?

5.1 Answer
You would carry out an assessment of her general medical history and a
physical examination to exclude other causes.
5.2 Question
You have noted Jane’s presentation and recent medical history. She has no
other significant past medical history. Her heart rate is 90 beats per minute,
temperature 37.50c, SpO2 96% in air.

5.2 Answer
You would use the two-level DVT Wells score to estimate the clinical probability
of DVT.
If DVT is suspected, use the two-level DVT Wells score (see appendix 1) to
estimate the clinical probability of DVT. [1.1.2]
5.3 Question
Jane’s two-level DVT Wells score is 2 (DVT likely):
Active cancer = 1.
Localised tenderness along the distribution of the deep
venous system = 1
You suspect DVT: what do you do next?

5.3 Answer
A proximal leg vein ultrasound is available to you within 4 hours of you
requesting it, so you offer Jane a proximal leg vein ultrasound.
Wells score either:
scan. [KPI 1.1.3]
5.4 Question
The proximal leg vein ultrasound scan identifies a DVT. What would you do
next?

5.4 Answer
Diagnose DVT and start treatment with LMWH. This should continue for
6 months. Ensure that an outpatient appointment is booked for Jane for
6 months’ time to assess the risks and benefits of continuing anticoagulation.
When developing their recommendations, the GDG noted that current
international guidelines and UK clinical practice recommend continuing
anticoagulation lifelong in patients with active cancer, based on expert clinical
experience, case series and opinion, in the absence of randomised controlled
trials.
Offer LMWH to patients with active cancer and confirmed proximal DVT or
PE, and continue the LMWH for 6 months8. At 6 months, assess the risks
and benefits of continuing anticoagulation9. [KPI 1.2.2]
The evidence suggested that using LMWH instead of VKAs offered an overall
benefit, for patients with proximal DVT or PE and active cancer
(recommendation 1.2.2). However, this means that patients will be having daily
subcutaneous injections instead of taking oral tablets. Therefore, patient
preference and practicalities, such as whether patients can reliably self-inject or
have a carer (such as a relative or district nurse) to help to administer the
injection needs to be taken into account. The ability of patients to adhere to the
treatment plan is important for its success.
8
At the time of publication (June 2012) some types of LMWH do not have a UK marketing
authorisation for 6 months of treatment of DVT or PE in patients with cancer. Prescribers should
consult the summary of product characteristics for the individual LMWH and make appropriate
adjustments for renal impairment. Informed consent for off-label use should be obtained and
documented.
9
Although this use is common in UK clinical practice, at the time of publication (June 2012)
none of the anticoagulants has a UK marketing authorisation for the treatment of DVT or PE
beyond 6 months in patients with cancer. Informed consent for off-label use should be obtained
and documented.

Additional benefits to LMWH for people with cancer:
It is difficult to maintain good INR control (which puts patients at risk of

bleeding or more VTE events) while patients are on chemotherapy. This
makes it a strong case for the use of LMWH for those patients with new
VTE, and active cancer, particularly if undergoing chemotherapy.
Patients with cancer have a higher risk of major bleeding on anticoagulation
compared to patients without cancer, which may relate to the underlying
cancer and propensity for bleeding (e.g. ulcerated gastric cancer).
Patients with impaired renal function can receive LMWH at a reduced dose,
and would therefore not be excluded. There may be an additional cost to
Factor X monitoring for such patients, however probably few actual tests
need to be conducted when patients are stabilised.
At 6 months, the need to continue anticoagulation should be reassessed and

discussed with the patient. The current recommendation of international
guidelines and UK clinical practice is to continue anticoagulation lifelong in
patients with active cancer, based on expert clinical experience, case series
and opinion, in the absence of randomised controlled trials (Khorana AA, Streiff MB,
Farge D, Mandala M, Debourdeau P, Cajfinger F et al. Venous thromboembolism prophylaxis
and treatment in cancer: a consensus statement of major guidelines panels and call to action.
Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology.
2009; 27(29):4919-4926.)
5.5 Question
Would you offer catheter-directed thrombolytic therapy or an inferior vena caval
filter to Jane?

5.5 Answer
No, do not offer Jane catheter-directed thrombolytic therapy because her
functional status indicates her life expectancy is less than 1 year.
Do not offer an inferior vena caval filter because Jane is able to have
anticoagulation treatment.
treatment. [1.2.10]
5.6 Question
What information would you give Jane about her treatment?

5.6 Answer
Offer Jane verbal and written information about her anticoagulant treatment,
including monitoring, side effects, interactions and lifestyle impacts. Provide her
Advise her to carry the anticoagulant alert card at all times.
information about:
occur
5.7 Question
Jane’s DVT is considered to be unprovoked. Bearing this in mind, are there any
other further investigations and tests you would organise?

5.7 Answer
No further tests are required. Even though Jane’s DVT is considered
‘unprovoked’ by the definition in the NICE guideline, further testing for cancer or
thrombophilia are not required because Jane is known to have active cancer.
1.5.2]
[1.6.2]

Other implementation tools
NICE has developed tools to help organisations implement the clinical guideline
on Venous thromboembolic diseases. These are available on the NICE website
(www.nice.org.uk/guidance/CG144).
PE training plan, clinical case scenarios and slide set.

Costing statement – details of the likely costs and savings when the cost
impact of the guideline is not considered to be significant.
Audit support including electronic data tools – for monitoring local practice.
Acknowledgements
NICE would like to thank the National Clinical Guideline Centre and the
Guideline Development Group, especially
Gerard Stansby, Professor of Vascular Surgery, Freeman Hospital and

Newcastle University
Susan Ballard
David Berridge, Consultant Vascular Surgeon, Leeds General Infirmary
Richard Day, Consultant Physician (Geriatrics), Poole Hospital NHS
Foundation Trust
Beverley Hunt, Professor of Thrombosis and Haemostasis, King’s College,
London and Medical Director of Lifeblood
David Keeling, Consultant Haematologist, Oxford University Hospitals NHS
Trust
Steven Moser, Consultant Radiologist, Imperial College Healthcare NHS
Trust, London
Karen Sheares, Respiratory Consultant with an interest in pulmonary
vascular diseases, Papworth Hospital NHS Foundation Trust

Appendix 1 Two-level DVT Wells scorea
Clinical feature Points
Active cancer (treatment ongoing, within 6 months, or palliative) 1
Paralysis, paresis or recent plaster immobilisation of the lower

1
extremities
Recently bedridden for 3 days or more or major surgery within
1
12 weeks requiring general or regional anaesthesia
Localised tenderness along the distribution of the deep
1
venous system
Entire leg swollen 1
Calf swelling at least 3 cm larger than asymptomatic side 1
Pitting oedema confined to the symptomatic leg 1
Collateral superficial veins (non-varicose) 1
Previously documented DVT 1
An alternative diagnosis is at least as likely as DVT −2
Clinical probability simplified score
DVT likely 2 points or more
DVT unlikely 1 point or less

a
Adapted with permission from Wells PS et al. (2003) Evaluation of D-dimer in the diagnosis of
suspected deep-vein thrombosis.
A template patient record Two-level PE Wells score which you can print,
complete and then add to patient records can be downloaded from the NICE
website

Appendix 2 Two-level PE Wells scorea
Clinical feature Points

Clinical signs and symptoms of DVT
(minimum of leg swelling and pain with 3
palpation of the deep veins)
An alternative diagnosis is less likely than
3
PE
Heart rate > 100 beats per minute 1.5
Immobilisation for more than 3 days or
1.5
surgery in the previous 4 weeks
Previous DVT/PE 1.5
Haemoptysis 1
Malignancy (on treatment, treated in the
1
last 6 months, or palliative)
Clinical probability simplified scores
PE likely More than 4 points
PE unlikely 4 points or less
a
Adapted with permission from Wells PS et al. (2000) Derivation of a simple clinical model to
categorize patients' probability of pulmonary embolism: increasing the model's utility with the
SimpliRED D-dimer.
A template patient record Two-level PE Wells score which you can print,
complete and then add to patient records can be downloaded from the NICE
website

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Venous thromboembolic diseases:

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DVT VTE diseases clinical case scenarios. June (2012) Page 2 of 67

DVT VTE diseases clinical case scenarios. June (2012) Page 3 of 67

Venous thromboembolic diseases cover a spectrum ranging from asymptomatic

Thrombophilia is a major risk factor for VTE. It is an inherited or acquired

To ensure comprehensive management and continuity when developing a

Venous thromboembolism: reducing the risk (NICE clinical guideline 92

DVT VTE diseases clinical case scenarios. June (2012) Page 4 of 67

Dabigatran etexilate for the prevention of venous thromboembolism after hip or

Medicines adherence (NICE clinical guideline 76)

Patient experience in adult NHS services (NICE clinical guideline 138)

(see also section 6 of the VTE diseases NICE clinical guideline).

DVT VTE diseases clinical case scenarios. June (2012) Page 5 of 67

International normalised ratio (INR) A standardised laboratory measure of

Provoked deep vein thrombosis (DVT) or pulmonary embolism (PE)

Renal impairment Reduced renal function that may be acute or chronic. An

Unprovoked DVT or PE DVT or PE in a patient with:

DVT VTE diseases clinical case scenarios. June (2012) Page 6 of 67

DVT VTE diseases clinical case scenarios. June (2012) Page 7 of 67

DVT VTE diseases clinical case scenarios. June (2012) Page 8 of 67

DVT VTE diseases clinical case scenarios. June (2012) Page 9 of 67

You suspect DVT: what would you do next?

DVT VTE diseases clinical case scenarios. June (2012) Page 10 of 67

Major surgery within 12 weeks requiring general or regional

You do not consider that an alternative diagnosis is at least as likely as DVT.

You suspect DVT: what would you do next?

DVT VTE diseases clinical case scenarios. June (2012) Page 11 of 67

DVT VTE diseases clinical case scenarios. June (2012) Page 12 of 67

DVT VTE diseases clinical case scenarios. June (2012) Page 13 of 67

Renal status: Dose adjustment and monitoring may be required as patients

DVT VTE diseases clinical case scenarios. June (2012) Page 14 of 67

DVT VTE diseases clinical case scenarios. June (2012) Page 15 of 67

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DVT VTE diseases clinical case scenarios. June (2012) Page 17 of 67

You would not routinely offer John self-management of his INR.

DVT VTE diseases clinical case scenarios. June (2012) Page 18 of 67

DVT VTE diseases clinical case scenarios. June (2012) Page 19 of 67

DVT VTE diseases clinical case scenarios. June (2012) Page 20 of 67

DVT VTE diseases clinical case scenarios. June (2012) Page 21 of 67

You suspect DVT: what would you do next?

DVT VTE diseases clinical case scenarios. June (2012) Page 22 of 67

Recent bedridden for more than 3 days = 1.

You do not think an alternative diagnosis is at least as likely as DVT.

DVT VTE diseases clinical case scenarios. June (2012) Page 23 of 67

DVT VTE diseases clinical case scenarios. June (2012) Page 24 of 67

In addition to the LMWH, you should consider catheter-directed thrombolytic

DVT VTE diseases clinical case scenarios. June (2012) Page 25 of 67