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Prednisolone Orapred

Prednisolone is a corticosteroid with anti-inflammatory and glucocorticoid actions that is commonly used in neonates at a dose of 0.5-2 mg/kg/day divided every 12-24 hours. It carries risks of immunosuppression, hypertension, hypokalemia, hyperglycemia, growth suppression, adrenal suppression, and peptic ulcer disease. Nurses should monitor blood glucose, electrolytes, intake/output, weight, and blood pressure when administering prednisolone and taper the drug gradually after long term use to avoid adrenal insufficiency.

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22 views1 page

Prednisolone Orapred

Prednisolone is a corticosteroid with anti-inflammatory and glucocorticoid actions that is commonly used in neonates at a dose of 0.5-2 mg/kg/day divided every 12-24 hours. It carries risks of immunosuppression, hypertension, hypokalemia, hyperglycemia, growth suppression, adrenal suppression, and peptic ulcer disease. Nurses should monitor blood glucose, electrolytes, intake/output, weight, and blood pressure when administering prednisolone and taper the drug gradually after long term use to avoid adrenal insufficiency.

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Guidelines for the Use of Prednisolone (Orapred ® )

Recommended Neonatal Dose, Route, and Interval

 PO: 0.5-2 mg/kg/day divided every 12-24 hours

Chief Indications

 Corticosteroid with anti-inflammatory and glucocorticoid actions.

Possible Adverse Reactions:

1. Immunosuppression, infection
2. Hypertension, CHF
3. Hypokalemia, edema
4. Hyperglycemia, growth suppression
5. Adrenal suppression, hypothalamic pituitary adrenal (HPA) suppression
6. Peptic ulcer disease, nausea, vomiting

Contraindications & Precautions

 Hypersensitivity to prednisolone
 Systemic fungal infection or varicella infection
 Acute adrenal insufficiency may occur with abrupt withdrawal after long term use (> 7 days).
Gradual taper is required.
 May mask signs of infection

Nursing Implications
 Monitor serum blood glucose, CBC and electrolytes.
 Watch intake and output, weights and blood pressure.
 Give dose with nearest feed.

References:
1. Pediatric Dosage Handbook, 17th ed. 2010-2011.

Reviewed/Revised: 6/2010 by

Samir Alabsi, MD
Kelli DeVore, Pharm. D, BCPS
Rebecca Willson MSN, NNP-BC

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