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    Antiarrhythmic Drugs-Test-2-Questions

    Uploaded by

    Drishya Bioplannet
    1. The document provides information about various classes of antiarrhythmic drugs and their mechanisms of action and side effects. It covers sodium channel blockers (Class 1), beta blockers (Class 2), potassium channel blockers (Class 3), and calcium channel blockers (Class 4). Specific drugs discussed include quinidine, procainamide, disopyramide, flecainide, propafenone, metoprolol, and amiodarone. Contraindications and adverse effects are provided for several drugs. 2. The questions assess knowledge about the cardiac action potential phases, drug metabolism and effects, antiarrhythmic drug classes and mechanisms of action, appropriate clinical uses, and

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    Antiarrhythmic Drugs-Test-2-Questions

    Uploaded by

    Drishya Bioplannet
    133 views7 pages
    1. The document provides information about various classes of antiarrhythmic drugs and their mechanisms of action and side effects. It covers sodium channel blockers (Class 1), beta blockers (Class 2), potassium channel blockers (Class 3), and calcium channel blockers (Class 4). Specific drugs discussed include quinidine, procainamide, disopyramide, flecainide, propafenone, metoprolol, and amiodarone. Contraindications and adverse effects are provided for several drugs. 2. The questions assess knowledge about the cardiac action potential phases, drug metabolism and effects, antiarrhythmic drug classes and mechanisms of action, appropriate clinical uses, and

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    1. The document provides information about various classes of antiarrhythmic drugs and their mechanisms of action and side effects. It covers sodium channel blockers (Class 1), beta blockers (Class 2), potassium channel blockers (Class 3), and calcium channel blockers (Class 4). Specific drugs discussed include quinidine, procainamide, disopyramide, flecainide, propafenone, metoprolol, and amiodarone. Contraindications and adverse effects are provided for several drugs. 2. The questions assess knowledge about the cardiac action potential phases, drug metabolism and effects, antiarrhythmic drug classes and mechanisms of action, appropriate clinical uses, and

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    133 views7 pages

    Antiarrhythmic Drugs-Test-2-Questions

    Uploaded by

    Drishya Bioplannet
    1. The document provides information about various classes of antiarrhythmic drugs and their mechanisms of action and side effects. It covers sodium channel blockers (Class 1), beta blockers (Class 2), potassium channel blockers (Class 3), and calcium channel blockers (Class 4). Specific drugs discussed include quinidine, procainamide, disopyramide, flecainide, propafenone, metoprolol, and amiodarone. Contraindications and adverse effects are provided for several drugs. 2. The questions assess knowledge about the cardiac action potential phases, drug metabolism and effects, antiarrhythmic drug classes and mechanisms of action, appropriate clinical uses, and

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 7

    Arrhythmia/Antiarrhythmic Drugs-Test-2-Questions

    1. Cardiac Action potential: Phase 3: Repolarization

    A K+ channels open --> outward (polarizing) current

    B Na+ channels inactivate

    C Net result = gain of Na+ and loss of K+ (imbalance is corrected by Na+/K+- ATPase)

    D Voltage-sensitive Ca2+ channels close

    E Voltage-sensitive Ca2+ channels open

    2. Procaninamide is metabolized how?

    A CYP 2D6

    B CYP 3A4

    C Partly acetylated to N-acetylprocainamide (NAPA) which prolongs duration of action potential (class
    III)

    D Partly acetylated to N-acetylprocainamide (NAPA) which Shortens duration of action potential (class
    II)

    3. Class I - fast channel blockers (Na+) Which drugs are class 1C?

    A Flecainide,

    B mexiletine

    C procainamide,

    D propafenone

    E Quinidine,

    4. Class 2 Antiarrythmics are B blockers like what?

    A esmolol
    B metoprolol,

    C Pindolol

    D propafenone

    E Propranolol,

    5. Cardiac Action potential: Phase 4: Resting potential

    A --> Cell is brought to threshold of next action potential

    B Increasing depolarization due to gradual increase in Na+ permeability

    C K+ channels open

    D Net result = gain of Na+ and loss of K+ (imbalance is corrected by Na+/K+- ATPase)

    E Voltage-sensitive Ca2+ channels close

    6. antiarrhythmic drugs by class : Class 4

    A (b-blockers)

    B (Ca2+ channel blockers)

    C (K+ channel blockers)

    D (Na+ channel blockers)

    7. Miscellaneous antiarryhthmics are which drugs?

    A adenosine,

    B atropine,

    C Digoxin,

    D magnesium,

    E Potassium chloride
    8. Quinidine AE causes which of the following conditions?

    A Dilated Cardiomyopathy

    B PVCs

    C SA & AV block or asystole

    D torsades de pointes

    E ventricular tachycardia (exacerbated by hyperkalemia)

    9. Cardiac action potential : Phase 1: Initial repolarization

    A --> transient outward current

    B K+ channels rapidly open & close

    C Na+ channels inactivate

    D Na+ channels open

    E Upstroke ends as Na+ channels are inactivated

    10. Block fast inward Na+ channels • Decreased Na+ entry slows rate of rise of Phase 0 depolarization •
    Cause in excitability and conduction velocity • Different properties depending on their affinity for Na+
    channel • Possess use / state-dependence

    A Anti Arrhythmic Class 1

    B Anti Arrhythmic Class 2

    C Anti Arrhythmic Class 3

    D Anti Arrhythmic Class 4

    11. cells discharging at abnormally high frequency are preferentially blocked Definition ?

    A Na+ gated dependence

    B Refractory dependence

    C Use/state dependence
    12. Quinidine, procainamide, disopyramide belong to what class of antiarrhythimics

    A Class I : 1 A

    B Class I : 1 B

    C Class I : 1 C

    13. • Quinidine sulfate = rapid oral absorption • Forms active metabolites (CYP 3A4) What does it
    inhibit? (3)

    A CYP 2D6

    B CYP 3A4

    C CYP 3E5

    D CYP 4E3

    E P-glycoprotein

    14. Cinchonism (blurred vision, tinnitus, headache, psychosis) is caused by which of the following drugs?

    A Disopyramide

    B Esmmolol

    C Losartan

    D Procainamide

    E Quinidine

    15. Contraindications/ extreme caution for Quinidine?

    A Chronic Renal Failure/ Bilateral renal stenosis

    B Complete heart block/ Incomplete heart block

    C History of Torsades de Pointes

    D Myocarditis/ Severe myocardial damage


    E Prolonged QT interval/ Uncompensated heart failure

    16. Class 3 antiarrhytmics work by?

    A Blocking the repol of K+ channels prolonging repol, and thus increasing QRS interval

    B Blocking the repol of K+ channels prolonging repol, and thus increasing QT interval

    C Blocking the repol of Na channels prolonging repol, and thus increasing QT interval

    D Blocking the repol of Na+ channels prolonging repol, and thus increasing QRS interval

    17. MOA of what drug? • Derivative of local anesthetic procaine • Similar actions to quinidine •
    Blockade of Na + channels in activated state • Blockade of K + channels • Antimuscarinic properties

    A Disopyramide

    B Gonna die

    C I'm boned

    D Procainamide

    E Quinidine

    18. Contraindications for Procanimide (3)

    A 3rd degree AV block

    B Complete heart block/2nd degree AV block

    C Systemic lupus erythematosus (SLE)

    D Torsades de Pointes

    19. Phase 0: Rapid upstroke & depolarization Cardiac action potential

    A --> transient outward current

    B -> Fast inward current

    C K+ channels rapidly open & close


    D Na+ channels open

    E Upstroke ends as Na+ channels are inactivated

    20. Strong negative inotropic effect Strong antimuscarinic properties • Causes peripheral
    vasoconstriction • Blocks K+ channels Clinical Applications • Suppression of supraventricular and
    ventricular arrhythmias Describes the MOA for which Class 1 Anti-arrhythmic?

    A Disopyramide

    B Esmolol

    C Lostartan

    D Procainamide

    E Quinidine

    21. Severe symptomatic ventricular arrhythmias, premature ventricular contraction or ventricular


    tachycardia resistant to other therapy • Severe symptomatic supraventricular arrhythmias & prevention
    of paroxysmal atrial fibrillation MOA for which antiarrhythmic

    A amioderone

    B Flecaninde

    C Lidocaine

    D Mexiletine

    E Propafenone

    22. Negative inotropic efffect (aggravates CHF) • CNS effects: dizziness, blurred vision, headache • GI
    effects: nausea, vomiting, diarrhea • Life-threatening arrhythmias & ventricular tachycardia Describes
    the AE of which Class 1C anti arrhythymic

    A Flecainide

    B Lidocaine

    C Mexiletine

    D Propafenone
    23. Flecainide, propafenone belong to what class of antiarrhythimics

    A (IA)

    B (IB)

    C (IC)

    24. Clinical Applications • Suppression of supraventricular and ventricular arrhythmias Due to


    proarrhythmic effects use should be reserved for life-threatening arrhythmias What anti-arrhythmic ?

    A Disopyramide

    B Procainamide

    C Quinidine

    25. antiarrhythmic drugs by class : Class 1

    A (b-blockers)

    B (Ca2+ channel blockers)

    C (K+ channel blockers)

    D (Na+ channel blockers)

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