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Categories of Cell Junctions

Tight junctions are protein ridges that fuse together between adjoining cells using claudins and occludins, forming barriers to ions and solutes at the apical margins of cells to bind cells together strongly and prevent substances from moving freely between external and internal environments. Anchoring junctions include desmosomes, the strongest type of adherens junction, and use cadherins and integrins to form strong bonds between neighboring cells and between cells and the extracellular matrix.

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Freah Genice Tolosa
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69 views1 page

Categories of Cell Junctions

Tight junctions are protein ridges that fuse together between adjoining cells using claudins and occludins, forming barriers to ions and solutes at the apical margins of cells to bind cells together strongly and prevent substances from moving freely between external and internal environments. Anchoring junctions include desmosomes, the strongest type of adherens junction, and use cadherins and integrins to form strong bonds between neighboring cells and between cells and the extracellular matrix.

Uploaded by

Freah Genice Tolosa
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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3 CATEGORIES OF CELL JUNCTIONS

1. Tight junctions: ZonulaOccludens


– ridges of proteins, ½ from each adjoining cell w/c fuse together by CHONs: claudins and occludins.
–are also dynamic and can be altered depending on body’s needs; found at apical margins
- Functions
i. Bind cells together for strength and stability
ii. Form barriers to ions and solutes- space almost obliterated.
Ex. Blood brain barrier, intestinal tract and kidneys prevent most substances from moving freely between external and
internal environment.
2. Anchoring junctions
-desmosomes – adherensjxns, strongest

-are essential adhesion structures in most epithelia that link the intermediate filament network to form strong bond between:

i. one cell to neighbor (cell-cell anchoring jxn) – use cadherins

ii. cell to extracellular matrix (cell-matrix anchoring jxn) - use integrins

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