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Brain Metastases Survival Prognosis

The document provides a Diagnosis-Specific Graded Prognostic Assessment (DS-GPA) worksheet to estimate survival rates from newly diagnosed brain metastases. It lists prognostic factors such as age, Karnofsky Performance Status (KPS) score, number of brain metastases, cancer subtype, and median survival times ranging from 3 to 25 months depending on the total prognostic score. A table also defines the KPS scale which rates a patient's ability to care for themselves from fully active to deceased.

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Raissa Mansilla
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301 views2 pages

Brain Metastases Survival Prognosis

The document provides a Diagnosis-Specific Graded Prognostic Assessment (DS-GPA) worksheet to estimate survival rates from newly diagnosed brain metastases. It lists prognostic factors such as age, Karnofsky Performance Status (KPS) score, number of brain metastases, cancer subtype, and median survival times ranging from 3 to 25 months depending on the total prognostic score. A table also defines the KPS scale which rates a patient's ability to care for themselves from fully active to deceased.

Uploaded by

Raissa Mansilla
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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DIAGNOSIS-SPECIFIC GRADED PROGNOSTIC ASSESSMENT (DS-GPA) WORKSHEET

TO ESTIMATE SURVIVAL FROM NEWLY DIAGNOSED BRAIN METASTASES (Sperduto PW et al., 2012)
Prognostic Factor 0 0,5 1,0 Patient Score
Non-small-cell Age, years >60 50-60 <50
and small-cell KPS <70 70-80 90-100
Lung cancer Extracranial MTX Present - Absent
No. of BM >3 2-3 1
Median survival (months): 0 - 1.0 = 3.0 / 1,5-2,0=5,5 / 2,5-3,0=9,4 / 3,5-4,0 = 14,8 Total:
Prognostic Factor 0 1,0 2,0 Patient Score
Melanoma KPS < 70 70-80 90-100
No. of BM >3 2-3 1
Median survival (months): 01,0 = 3,4 / 1,52,0 = 7,7 / 2,5 3,0 = 15,1 / 3,5 4,0 = 25,3 Total:
Prognostic factor 0 1,0 2,0 Patient Score
Renal cell
KPS < 70 70-80 90-100
carcinoma
No. of BM >3 2-3 1
Median survival (months): 0-1,0 = 3,3 / 1,5-2,0 = 7,3 / 2,5 - 3,0 = 11,3 / 3,5 - 4,0 = 14,8 Total:
Prognostic Factor 0 1 2 3 4 Patient Score
GI cancers
KPS <70 70 80 90 100
Median survival (months): 0 1,0 = 3,1 / 2,0 = 4,4 / 3,0 = 6,9 / 4,0 = 13,5 Total:
Prognostic Factor 0 0,5 1,0 1,5 2,0 Patient Score
KPS 50 60 70-80 90-100 n/a
Breast cancer
Subtype Basal n/a LumA HER2 LumB
Age, years 60 < 60 n/a n/a n/a
Median survival (months): 0-1,0 = 3,4 / 1,5 2,0 = 7,7 / 2,5 3,0 = 15,1 / 3,5 4,0 = 25,3 Total:
Breast cancer subtype denitions: Basal: triple [ - ] / LumA: ER / PR [+], (HER2) [ - ] / LumB: triple [+] / HER2: ER / PR [ - ], (HER2) [+].

VERSO
UNIVERSIDADE FEDERAL FLUMINENSE
HOSPITAL UNIVERSITRIO ANTNIO PEDRO
DEPARTAMENTO DE NEUROCIRURGIA

KARNOFSKY PERFORMANCE STATUS (KPS)


Definio Escore Critrios
Apto para o trabalho; 100 Normal; nenhuma queixa; Nenhuma evidncia de doena.
Apto para atividades normais; 90 Capacitado para atividades normais. Pequenos sinais e sintomas.
Nenhum cuidado especial
necessrio. 80 Atividade normal com esforo; alguns sinais e sintomas de doena.
Cuidados para si.
Inapto para o trabalho; 70
Incapaz para seguir com atividades normais ou trabalho ativo
Apto para viver em casa e cuidar de
Requer ajuda ocasional, porm apto a cuidar de muitas de suas
muitas de suas necessidades; 60
necessidades pessoais.
Assistncia e suporte necessrios
so variveis. Requer ajuda considervel e frequente;
50
Assistncia mdica ou especializada.
40 Incapacitado. Requer cuidado especial e assistncia.
Inapto para cuidar de si mesmo; Severamente incapacitado.
30
Requer cuidados hospitalares ou Admisso hospitalar indicada, mas a morte no iminente.
equivalentes especializado; Muito doente. Admisso hospitalar necessria.
20
Doena pode estar progredindo Necessita de terapia e cuidados intensivos.
rapidamente; 10 Moribundo. Processo de fatalidade progredindo rapidamente.
0 Morte.

FRENTE

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