UNIVERSIDAD DE ZAMBOANGA
School of Allied Medicine (SAM)
Pharmacy Department
Course Syllabus and Topic Outline
Chemistry and Pharmacy of Organic Medicinals
SY: 2016-2017 Second Semester
Course Title
Chemistry and Pharmacy of Organic Medicinals
Course no.
Pharmaceutical Chemistry 2
Credits Units :
5 units credit (3 units lecture, 2 units laboratory
Placement
3rd Year BS Pharmacy, Second Semester
Contact Hours :
3 hours lecture and 6 hours laboratory / week
Course Description:
This course covers the Chemistry and Pharmacy of Organic Medicinals, with emphasis on those
official in the USP and NF and other Standard Compendia.
This is the study the Structure Activity Relationships of Organic Medicinals: including their
physicochemical properties in relation to their biological activity, preparation and/or synthesis, uses
and doses.
SUGGESTED TEACHING APPROACH: The study of Pharmaceutical Chemistry should include:
An introduction to the general properties and functions of drugs;
A general idea of how drugs are designed, developed, and tested;
The use of structural modification, asymmetric synthesis to get the desired optical isomer;
The drug testings made before drugs are introduced to the public;
An awareness of the contribution that science continues to make towards maintaining the health
and well-being of the worlds population.
Prerequisites : Pharm. Chemistry 1 (Inorganic Medicinal & Pharmaceutical Chemistry)
Pharmaceutical Biochemistry
General Objectives: The objectives of the syllabus are to provide students who have exceptional ability and
interest in Chemistry the opportunity to:
(a) Apply the principles of chemistry for an understanding of drug action and design
(b) Understand and apply various analytical techniques to chemical analysis
(c) Be enthused to engage in research and rationalize ethical issues
At the end of the course, the students should be able to:
1. Apply the knowledge, skills, and principles of organic chemistry to medicinal and pharmaceutical chemistry.
2. Learn the Uses, synonyms and other information regarding Organic Medicinal of Pharmaceutical Importance.
3. Discuss the official Organic substances used as therapeutic and diagnostic agents.
4. Manifest an appreciation of the pharmacists social and professional responsibilities in maintaining or restoring the
health of men and animals.
5. Understand the High Moral and Ethical Standards of the Pharmacy Profession.
LEARNING STRATEGIES: Some possible Modes for Learning could include:
For Lecture Module:
Lectures, possibly including Guest Lectures from
Industry and Research
Literature Review of Medicinal Agents
Power Points Presentations
Case Studies / Analyses
For Laboratory Module:
Laboratory Exercises (Synthesis)
Visits to Laboratories & Industries (Optional)
Group & Individual Seat Work
Research Experimental Explorations
While practical work is not a requirement for this course, students would stand to benefit from learning
experiences which complement the study of Pharmaceutical Chemistry.
These include experiences which facilitate the development of skills or enhance familiarity with the processes
associated with drug design and synthesis, and also hands-on experiences for the various spectroscopic, separation
and purification techniques.
SYLLABUS DESIGN:
The syllabus is supposedly based on a 54 lectures hours of teaching and self-directed independent learning
out of Curriculum Time. But the allotted time for the complete discussion of the topics required per term will be about
65 hours, which will be gotten from the laboratory hours and or make Up Classes (to be scheduled).
The subject is pitched at undergraduate Junior Year of BS Pharmacy Curriculum. The students are expected
to perform and comply the following commitments & responsibilities:
1.
2.
3.
4.
5.
6.
Attend the class regularly. Ten absences without valid reasons will be considered dropped.
Submit requirements on time.
Participate actively in class discussion.
Observe the SAM House Rules, Department Policies and Implied Conduct of the Course.
Take the Examinations and Quizzes on time, following strictly NO PERMIT, NO EXAM POLICY.
Develop core values of the Universidad de Zamboanga such as Honesty, Integrity, Morality, Confidentiality,
and Trustworthiness.
Vision, Mission and Objectives of UZ, School of Allied Medicine and Department of Pharmacy.
GRADING SYSTEM:
For LECTURE:
MAJOR EXAMS
For LAB:
%
ITEMS
TIME(Hr
)
Frequency:
60%
Nlt
150
1.5
2.0
4 exams
(PM/MT/PF/Final
)
QUIZZES
TOTAL:
40%
100
%
Nlt 20
1 Q/Ch
3-5 / term
ITEMS
TIME(Hr
Frequency
MAJOR EXAMS
60%
NLT100
1.0-1.5
4 exams
QUIZZES/EXPT
s
40%
Eq. 30s
3Days
3 Expt / term
(AT/P/GWO/Pr)
(RUBRIC Based)
100%
COURSE OUTLINE
Time Allotted
PREMID Coverage
15 hours
Chapter 1:
INTRODUCTION
1 hour
Chapter 2:
Drug Design Strategies
2 hours
Chapter 2.5 Drug Product Development
Chapter 3:
(Optional)
2 hour
2 hours
Chapter 4:
Metabolic Changes of Drugs and
Related Organic Compounds
Biotechnology & Drug Discovery
Chapter 5:
IMMUNOBIOLOGICALS
2 hours
Chapter 6:
Anti-Infective Agents
4 hours
MIDTERM Coverage
Chapter 7:
2 hours
15 hours
ANTIMALARIALS
2 hours
Chapter 8:
Antibacterial Antibiotics
4 hours
Chapter 9:
Antiviral Agents
2 hours
Chapter 10: Antineoplastic Agents
2 hours
Chapter 11: Agents for Diagnostic Imaging
2 hours
Chapter 12: Central Nervous System Depressants
3 hours
PREFINAL Coverage
15 hours
Chapter 13: Dopaminergic Signaling Agents
2 hours
Chapter 14:
2 hours
ANTICONVULSANTS
Chapter 15: Central Nervous System Stimulants
2 hours
Chapter 16: Adrenergic Agents
2 hours
Chapter 17:
2 hours
Cholinergic Drugs & Related Compounds
Chapter 18: Drugs acting on the Renal System
1 hour
Chapter 19: Cardiovascular Agents
4 hours
FINAL Coverage
20 hours
Chapter 20: Hormone-Related Disorders: Non-Steroidal Therapies 2 hours
Chapter 21: Agents Treating Bone Disorders
2 hour
Chapter 22:
2 hour
ANESTHETICS
Chapter 23: Histamine and Antihistaminic Agents
2 hours
Chapter 24:
2 hours
ANALGESICS
Chapter 25: Steroid Hormones and Therapeutically
Related Compounds
Chapter 26: Prostaglandins, Leukotrienes and
Essential and Fatty Acids
Chapter 27: Proteins, Enzymes & Peptide Hormones
2 hours
Chapter 28:
2 hour
VITAMINS
Chapter 29: An Introduction to the Medicinal Chemistry of Herbs
Laboratory
LaboratoryEquipment:
REFERENCES:
(Old Sources)
2 hours
2 hours
2 hours
Synthesis of simple molecules changes in structure
Biological activity testing
Toxicity testing
Standard Chemistry Laboratory Equipment
Burger, Alfred, etal, (1995) Vol.I, Principles and Practice [in Burgers
Medicinal Chemistry and Drug Discovery, Manfred E. Wolff, ed.], New York,
John Wiley and Sons, Inc., xi, 1064 p.
Burger, Alfred, (1970). Medicinal Chemistry, 3rd edition. New York, WileyInterscience, xix, 1712, 4183 p.
Burley, Denis, Joan Clarke and Louis Lasagna,(1993). Pharmaceutical
Medicine, 2nd ed., London, Edward Arnold, 361 p.
Doerge, Robert (Ed.), (1982). Wilson and Gisvolds Textbook of Organic
Medicinal and Pharmaceutical Chemistry, 8th ed., Philadelphia, Lippincott
Co.,
Foye, William O. (1989). Principles of Medicinal Chemistry, 3rd edition,
Philadelphia, Lea and Febiger, 925 p.
Kennewell, Peter and John Taylor, (1993). Modern Medicinal Chemistry.
New York, Ellis Hornwood, 290 p.
Roberts, Stanley and Barry Price, (1985). Medicinal Chemistry: The Role of
Organic Chemistry in Drug Research, London, academic Press, xix, 296 p.
Wolff, Manfred E. and Alfred Burger, (1995). Burgers Medicinal Chemistry
and Drug Discovery, 5th ed., New York, Wiley and Sons, 1354 p.
Gennaro, Alfonso R. (Ed.), (2000). Remingtons Pharmaceutical Sciences,
20th ed., Pennsylvania, Mack Publishing Company, xvi, 2000 p.
Main Reference:
Block, John & Beale, John (Ed) (2011) Wilson and Gisvolds Textbook of
Organic Medicinal and Pharmaceutical Chemistry, 12th ed., 2011,
Philadelphia, Lippincott Co.
Alagarsamy, V. (2014). TEXTBOOK OF MEDICINAL CHEMISTRY. Volume
1 & 2 . 2nd Edition. Reed Elsevier India Private Limited. New Delhi, India.
Additional References: Alagarsamy, V. (2014). TEXTBOOK OF MEDICINAL CHEMISTRY. Volume 1 & 2
(New Books)
2nd Edition. Reed Elsevier India Private Limited. New Delhi, India.
Allen, Jr. Lloyd V., et al. (2013) Remington: The Science and Practice of Pharmacy
22nd Edition. University of the Sciences in Philadelphia. Pharmaceutical Press.
Michigan, USA.
Lemke, Thomas, (2012). Review of Organic Functional Groups: Introduction to Medicinal
Organic Chemistry. 5th Edition. Lippincott Williams & Wilkins - Wolters Kluwer Co.
Philadelphia, USA
Block, John & Beale, John (Ed) (2011) Wilson and Gisvolds Textbook of Organic
Medicinal and Pharmaceutical Chemistry, 12th ed., 2011, Philadelphia, Lippincott
Co. USA
Hendrickson, Randy, (2006) Remington: The Science and Practice of Pharmacy.
21st Edition. University of the Sciences in Philadelphia. Lippincott Williams & Wilkins,
Baltimore, Maryland, USA. 361-384 p. Ch-24
E-Book References :
Seager, Spencer L.; Slabaugh, Michael R. (2014). Chemistry for Today: General,
Organic and Biochemistry. 8th Edition.Brooks/Cole, Cengage Learning Belmont, CA
USA
Atkins, Peter; Jones, Loretta; Laverman, Leroy. (2013). Chemical Principles. The
Quest For Insight. 6th Edition. W. H. Freeman and Company. New York, USA.
Allen, Jr. Lloyd V. (editor) (2013). Remington: An Introduction to Pharmacy. Royal
Pharmaceutical Society of Great Britain 2012. Pharmaceutical Press London, UK.
Felton, Linda A. (editor). (2013). Remington: Essentials of Pharmaceutics. 1st Edition.
Royal Pharmaceutical Society of Great Britain 2012. Pharmaceutical Press London,
UK
Lemke, Thomas, (2012). Review of Organic Functional Groups: Introduction to Medicinal
Organic Chemistry. 5th Edition. Lippincott Williams & Wilkins - Wolters Kluwer Co.
Philadelphia, USA.
Cairns, Donald. (2012). Essentials of Pharmaceutical Chemistry. 4th Edition.
Pharmaceutical Press: Royal Pharmaceutical Society of Great Britain, UK.
Alagarsamy, V. (2010). TEXTBOOK OF MEDICINAL CHEMISTRY. Volume 1 & 2
1st Edition. Reed Elsevier India Private Limited. New Delhi, India.
Hendrickson, Randy, (2006) Remington: The Science and Practice of Pharmacy
21st Edition.University of the Sciences in Philadelphia. Lippincott Williams & Wilkins,
Baltimore, Maryland, USA. 361-384 p. Ch-24
Pharmacy Reviewers: ACE Learning Specialist Review Lecture Compilation. June 2015.
BREX Pharmacy Review Program for Local Pharmacy and Foreign
Pharmacy 2013 Edition. March 2014
BREX Pharmacy Review Program for Local Pharmacy and Foreign
Pharmacy 2011 Edition. March 2012
PACOP Comprehensive Pharmacy Reviewer 2012 Edition. June 2012
University of the Philippines (UP) Manila Comprehensive Pharmacy
Reviewer January 2012 Edition. March 2012
San Carlos University Comprehensive Pharmacy Reviewer March 2011
INRESS Review Center Comprehensive Pharmacy Reviewer May 1998.
South Western University Pharmaceutical Chemistry Review Notes, March 1998.
Enhanced by:
Reviewed by:
BEN-FRAZIER U. SABTULA, RPh, MSPharm (CAR)
Instructor
MARY BELEN T. MOGOL, RPh. MS Pharm, Ph.D
Program Head Pharmacy Department
Noted by:
Approved by:
MADELYN F. CANDIDO, MLS, Ph.D
Chief Librarian
NENITA SJ. EUSTAQUIO, RMT, MSMT
DEAN School of Allied Medicine
Adapted from:
Philippine Association of Colleges of Pharmacy (PACOP)
Revision #-07. November, 2016
