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Bioreactor Design Basics

The document discusses various types of bioreactors used in industrial applications including batch, continuous, continuous with recycle, and semi-continuous reactors. It defines limiting substrates as those that are first exhausted during batch growth and directly influence cell growth kinetics, while excess substrates do not affect growth. Rate equations for substrate utilization are presented, showing the relationship between rate, substrate concentration, and maximum transport rate.

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643 views42 pages

Bioreactor Design Basics

The document discusses various types of bioreactors used in industrial applications including batch, continuous, continuous with recycle, and semi-continuous reactors. It defines limiting substrates as those that are first exhausted during batch growth and directly influence cell growth kinetics, while excess substrates do not affect growth. Rate equations for substrate utilization are presented, showing the relationship between rate, substrate concentration, and maximum transport rate.

Uploaded by

orion57854375
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Bioreactor Design Fundamentals

The most widely used Industrial Bioreactors are: Batch Reactors Continuous Reactors Continuous Reactors With Recycle Semi Continuous Reactors (Fill/Draw Reactors including Sequencing Batch Reactors)

Bioreactor Design Fundamentals (Contd)

DEFINITIONS Limiting Substrate The substrate or substrate(s) (energy source, carbon source and/or nutrient source) which is/are first exhausted in batch growth. This substrate(s) has a direct influence on the kinetics of cell growth.

Bioreactor Design Fundamentals (Contd)

DEFINITIONS In Excess The substrate or substrate(s) (energy source, carbon source and/or nutrient source) which is/are NOT exhausted at the end of batch growth. This substrate(s) has NO EFFECT on the kinetics of cell growth.

Bioreactor Design Fundamentals (Contd)

Bioeactor Design Fundamentals (Contd) k1* and A are combined to form another constant k and the rate expression becomes: RATE = k (S / KS + S) Where k = maximum rate of transport of S ( mol / h) When S is much larger than KS : RATE k f (S) When S is similar to KS : RATE = f (S)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

THE LAG PHASE

Bioreactor Design Fundamentals (Contd)

THE LAG PHASE

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

Bioreactor Design Fundamentals (Contd)

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