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Pathophysiology Leptospirosis

Leptospirosis is caused by bacteria of the genus Leptospira that are transmitted through contact with infected animal urine and can invade human tissues, inducing toxins and enzymes that cause capillary vasculitis. This leads to endothelial damage, bleeding, and organ dysfunction in the liver, kidneys, lungs, heart, and adrenal glands as seen in the laboratory findings of hemorrhage, edema, necrosis, and inflammatory cell infiltration in multiple organ systems.

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6K views1 page

Pathophysiology Leptospirosis

Leptospirosis is caused by bacteria of the genus Leptospira that are transmitted through contact with infected animal urine and can invade human tissues, inducing toxins and enzymes that cause capillary vasculitis. This leads to endothelial damage, bleeding, and organ dysfunction in the liver, kidneys, lungs, heart, and adrenal glands as seen in the laboratory findings of hemorrhage, edema, necrosis, and inflammatory cell infiltration in multiple organ systems.

Uploaded by

jeoffrey_castro
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Pathophysiology:

Age, Sex, Geographic, Season

Leptospire
from infected animals

Direct invasion of tissue on susceptible host; induced endotoxins,hemolysin & lipase

capillary vasculitis

endothelial edema, necrosis, lymphocytic infiltration

loss of RBC & fluid via enlarged conjunction & fenestrae

CBC PT Petechiae, intraparenchy mal bleeding, bleeding along serosa & mucosa; thrombocytope nia Jaundice, vascular congestion & disorganizati on of liver cell plates Alveolar capillary

x-ray

urinalysis

ECG

Tubular necrosis, interstitial nephritis

Cardiac lesions, epicardial & endocardial petechiae, myocardial interstitial edema, coronary arteritis

Hemorrhage, focal necrosis, infiltration within the adrenal gland

injury (focal/ diffuse), interstitial & intraalveolar edema & bleeding, frank hemorrhage

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