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T Cell Maturation

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Mudit Misra

1. The document discusses T cell activation and differentiation, which involves signals from the T cell receptor and co-receptors like CD4 that lead to intracellular signaling pathways and gene expression changes. 2. T cell activation is initiated by the binding of antigen peptides to the TCR complex, which also requires binding to MHC proteins and co-stimulatory signals through receptors like CD28. 3. The strength and duration of the signal determines whether the T cell becomes activated and differentiated, or becomes anergic or dies by apoptosis.

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T Cell Maturation

Uploaded by

Mudit Misra
105 views5 pages
1. The document discusses T cell activation and differentiation, which involves signals from the T cell receptor and co-receptors like CD4 that lead to intracellular signaling pathways and gene expression changes. 2. T cell activation is initiated by the binding of antigen peptides to the TCR complex, which also requires binding to MHC proteins and co-stimulatory signals through receptors like CD28. 3. The strength and duration of the signal determines whether the T cell becomes activated and differentiated, or becomes anergic or dies by apoptosis.

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t Cell Maturation

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1. The document discusses T cell activation and differentiation, which involves signals from the T cell receptor and co-receptors like CD4 that lead to intracellular signaling pathways and gene expression changes. 2. T cell activation is initiated by the binding of antigen peptides to the TCR complex, which also requires binding to MHC proteins and co-stimulatory signals through receptors like CD28. 3. The strength and duration of the signal determines whether the T cell becomes activated and differentiated, or becomes anergic or dies by apoptosis.

Copyright:

Attribution Non-Commercial (BY-NC)
Download as PDF, TXT or read online from Scribd
Download as pdf or txt
105 views5 pages

T Cell Maturation

Uploaded by

Mudit Misra
1. The document discusses T cell activation and differentiation, which involves signals from the T cell receptor and co-receptors like CD4 that lead to intracellular signaling pathways and gene expression changes. 2. T cell activation is initiated by the binding of antigen peptides to the TCR complex, which also requires binding to MHC proteins and co-stimulatory signals through receptors like CD28. 3. The strength and duration of the signal determines whether the T cell becomes activated and differentiated, or becomes anergic or dies by apoptosis.

Copyright:

Attribution Non-Commercial (BY-NC)
Download as PDF, TXT or read online from Scribd
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