AmnioFix
Injectable is composed of micronized, dehydrated amniotic
membrane allograft that provides anti-inammatory cytokines and
growth factors for enhanced soft tissue healing.
Injectable Micronized Amniotic
Membrane Allograft for
Enhanced Soft Tissue Healing
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Description
AmnioFix Injectable is composed of
micronized amniotic tissue, uniquely
processed to optimize surgical performance
and ease of use. The proprietary Purion,
SM
Process retains the amniotic growth factors
and cytokines inherent in this tissue. The
result is an injectable product that offers
surgeons a clear advantage.
Conta|ns a comb|nat|on ol rowtH
factors unique to placental tissue
beduces |nNammat|on at tHe |nject|on s|te
LnHances tHe norma| wound Hea||n
process
Anti-Inammatory and
Healing Properties
In vivo and in vitro studies have shown that
the properties of amniotic membrane help
to reduce |nNammat|on and solt t|ssue
healing.
1,2,3,4
Nat|ve 0rowtH be|at|ve /mount be|ease lroh|e
Factors Present Determined by Initial (w/in 11 minutes)
ELISA Assay Delayed (after 11 minutes)
PDGF-AA +++++
PDGF-BB +
bFGF ++
TGF-b1 ++
EGF +
Inammation Reduction
Human amniotic tissue has been proven to
conta|n ant| |nNammatory prote|ns sucH as
interleukin (IL)-1 receptor antagonist; tissue
inhibitors of metalloproteinase (TIMPs) -1,
-2, -4; IL-4 and IL-10.
1,2,3,4
Growth Factors
Growth Factors contained in Purion processed
dehydrated amniotic membrane, relative
amounts and re|ease proh|e.
Safety and Ease of Use
AmnioFix Injectable is processed using
Purion, a unique approach that provides an
added level of tissue safety and ease of use.
Lllect|ve m|crob|a| reduct|on, us|n
Purion Process
0eHydrated, m|cron|zed membrane lor
simple mixing and application
byear sHe|l ||le at room temperature;
no special storage required
0ver 4b,CCC Human membrane |mp|ants to
date
AmnioFix
is a registered trademark of MiMedx Group, Inc. www.mimedx.com
/mn|ol|x |s processed by 3ur|ca| B|o|o|cs, a l|ledx 0roup Company.
bC CHasta|n Center B|vd., 3u|te bC, bennesaw, 0/ 3C44 ZCZ l|ledx 0roup, lnc. /|| b|Hts beserved.
/lb.CCZ
beduces lnNammat|on
Enhanced Soft Tissue Healing
Non-Immunogenic
Item Number Size
/lbCbC C.bm|
/lbZb .Zbm|
/lbZCC Z.Cm|
1
3o|omon /, bosenb|att l, lonroy 0. 3uppress|on ol |nter|euk|n a and |nter|euk|n |n Human ||mba| ep|tHe||a| ce||s
cu|tured on tHe amn|ot|c membrane stroma| matr|x. Br J 0pHtHa|mo| ZCC;b:444449.
2
3H|mmura 3, 3H|mazak| J, 0HasH| Y, 1subota b. /nt||nNammatory ellects ol amn|ot|c membrane transp|antat|on |n
ocu|ar surlace d|sorders. Cornea ZCC;ZC:4C3.
3
1oda /. et a| 1He lotent|a| ol /mn|ot|c lembrane//mn|on0er|ved Ce||s lor beenerat|on ol Var|ous 1|ssues.
J. lHarmaco| 3c| Cb |ZCC/, ZbZZ
4
Hao Y, la 0H, Hwan 00, b|m w3, ZHan l. ldent|hcat|on ol ant|an|oen|c and ant||nNammatory prote|ns |n Human
amn|ot|c membrane. Cornea. ZCCC;9:34-3bZ.
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Ordering Information
Customer 3erv|ce: bb.4//.4Z9
Lma||: customerserv|ce@m|medx.com
www.amn|ohx.com/|njectab|e
Product Offering
leasured by Lll3/ test|n un|ysed and |ysed t|ssue |n suspens|on
21%
46%
47%
41%
50%
79%
54%
53%
59%
50%
Non-immunogenic
Human amniotic tissue is non-immunogenic and
does not elicit a substantial immune response
