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Usually means: Large, powerful computer for enterprises.
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We found 41 dictionaries that define the word mainframe:

General dictionaries General (25 matching dictionaries)
  1. mainframe: Merriam-Webster.com
  2. mainframe: Oxford Learner's Dictionaries
  3. mainframe: American Heritage Dictionary of the English Language
  4. mainframe: Collins English Dictionary
  5. mainframe: Vocabulary.com
  6. Mainframe, mainframe: Wordnik
  7. mainframe: Cambridge Advanced Learner's Dictionary
  8. mainframe: Wiktionary
  9. mainframe: Webster's New World College Dictionary, 4th Ed.
  10. mainframe: The Wordsmyth English Dictionary-Thesaurus
  11. mainframe: Infoplease Dictionary
  12. mainframe: Dictionary.com
  13. mainframe: Online Etymology Dictionary
  14. mainframe: Cambridge Essential American English Dictionary
  15. Mainframe (G.I. Joe), Mainframe (comics), Mainframe (disambiguation), Mainframe: Wikipedia, the Free Encyclopedia
  16. mainframe: Rhymezone
  17. mainframe: Free Dictionary
  18. mainframe: Mnemonic Dictionary
  19. mainframe: LookWAYup Translating Dictionary/Thesaurus
  20. mainframe: Dictionary/thesaurus

Art dictionaries Art (2 matching dictionaries)
  1. English-Chinese Dictionary of Graphic Communications (Big 5) (No longer online)
  2. ODLIS: Online Dictionary of Library and Information Science (No longer online)

Computing dictionaries Computing (12 matching dictionaries)
  1. mainframe: Free On-line Dictionary of Computing
  2. mainframe: Netlingo
  3. Mainframe, mainframe, mainframe: CCI Computer
  4. mainframe: Computer Telephony & Electronics Dictionary and Glossary
  5. Mainframe: Tech Terms Computer Dictionary
  6. Mainframe: Linktionary Networking Glossary
  7. Karbo's Dictionary (No longer online)
  8. Webopedia (No longer online)
  9. Data Formats and Their Sugggested File Extensions (No longer online)
  10. I T Glossary (No longer online)
  11. Technopedia (No longer online)
  12. mainframe: Encyclopedia

Medicine dictionaries Medicine (1 matching dictionary)
  1. online medical dictionary (No longer online)

Slang dictionaries Slang (1 matching dictionary)
  1. mainframe: Urban Dictionary

(Note: See mainframes as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
noun:  (computer hardware) A large, powerful computer able to manage very many simultaneous tasks and communicate with very many connected terminals; used by large, complex organizations (such as banks and supermarkets) where continuously sustained operation is vital.
noun:  (computer hardware) A computer chassis that hosts and interconnects modules that perform various tasks.
noun:  The main frame of a vehicle etc., more commonly main frame.

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Crossword clues:
early computer,   ibm mainstay,   simple computer,   early supercomputer,   central computer,   old computer,   big computer


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