Is there a role for herpes simplex virus type 1 in multiple sclerosis?

Microbes Infect. 2023 Jun;25(5):105084. doi: 10.1016/j.micinf.2022.105084. Epub 2022 Dec 28.

Authors

Luisa F Duarte¹, Sebastian Gatica¹, Almendra Castillo¹, Alexis M Kalergis², Susan M Bueno³, Claudia A Riedel¹, Pablo A González⁴

Affiliations

¹ Millennium Institute on Immunology and Immunotherapy, Departamento de Ciencias Biológicas, Facultad de Ciencias de La Vida, Universidad Andres Bello, Santiago, Chile.
² Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile; Departamento de Endocrinología, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica, Chile.
³ Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile.
⁴ Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile. Electronic address: pagonzalez@bio.puc.cl.

PMID: 36586461
DOI: 10.1016/j.micinf.2022.105084

Abstract

Numerous studies relate the onset and severity of multiple sclerosis (MS) with viral infections. Herpes simplex virus type 1 (HSV-1), which is neurotropic and highly prevalent in the brain of healthy individuals, has been proposed to relate to MS. Here, we review and discuss the reported connections between HSV-1 and MS.

Keywords: Blood–brain barrier (BBB); Epstein–barr virus (EBV); Experimental autoimmune encephalomyelitis (EAE); Herpes simplex virus (HSV-1); Multiple sclerosis (MS); Neurodegeneration.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

DNA, Viral
Epstein-Barr Virus Infections*
Herpes Simplex*
Herpesvirus 1, Human*
Humans
Multiple Sclerosis*
Virus Diseases*

Substances

DNA, Viral