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Asymmetric total syntheses of (-)-renieramycin M and G and (-)-jorumycin using aziridine as a lynchpin

Org Lett. 2009 Dec 3;11(23):5558-61. doi: 10.1021/ol9024919.

Abstract

By exploring the triple reactivity of two aziridines and double nucleophilicity of two aromatics, convergent and versatile syntheses of the above four natural products were developed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aziridines / chemistry*
  • Catalysis
  • Molecular Structure
  • Porifera / chemistry
  • Stereoisomerism
  • Tetrahydroisoquinolines / chemical synthesis*
  • Tetrahydroisoquinolines / chemistry

Substances

  • Aziridines
  • Tetrahydroisoquinolines
  • jorumycin
  • renieramycin G
  • renieramycin M
  • aziridine