Abstract
Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides that were from the carboxy terminal end of the protein conferred significant survival. Our work shows that vaccination with peptides from the carboxy-terminal positions of SAG1 major surface protein of Toxoplasma protects mice against a lethal challenge.
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Protozoan / biosynthesis
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Antigens, Protozoan / chemistry
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Antigens, Protozoan / immunology*
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Antigens, Surface / chemistry
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Antigens, Surface / immunology
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Immunization, Secondary
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Male
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Mice
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Mice, Inbred C3H
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Molecular Sequence Data
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Peptides / chemistry
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Peptides / immunology
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Protozoan Proteins / chemistry
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Protozoan Proteins / immunology*
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Protozoan Vaccines* / immunology
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Toxoplasma / immunology*
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Toxoplasmosis, Animal / prevention & control*
Substances
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Antibodies, Protozoan
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Antigens, Protozoan
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Antigens, Surface
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Peptides
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Protozoan Proteins
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Protozoan Vaccines
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SAG1 antigen, Toxoplasma