Search Results (5,651)

The space environment can affect the function of all physiological systems, including the properties of cell membranes. Our goal in this study was to explore the effect of simulated microgravity (SMG) on the cellular uptake of small molecules based on reported microgravity-induced changes in membrane properties. SMG was applied to cultured cells using a random-positioning machine for up to three hours. We assessed the cellular accumulation of compounds representing substrates of uptake and efflux transporters, and of compounds not shown to be transported by membrane carriers. Exposure to SMG led to an increase of up to 60% (p < 0.01) in the cellular uptake of efflux transporter substrates, whereas a glucose transporter substrate showed a decrease of 20% (p < 0.05). The uptake of the cathepsin activity-based probe GB123 (MW, 1198 g/mol) was also enhanced (1.3-fold, p < 0.05). Cellular emission of molecules larger than ~3000 g/mol was reduced by up to 50% in SMG (p < 0.05). Our findings suggest that short-term exposure to SMG could differentially affect drug distribution across membranes. Longer exposure to microgravity, e.g., during spaceflight, may have distinct effects on the cellular uptake of small molecules. Full article

Background: This study contributes to expanding the existing literature on learning technical skills in youth soccer by comparing the effectiveness of different training approaches in the development of passing skills. The ecological-dynamic approach, which emphasizes the continuous and adaptive interaction between the athlete and the environment, is analyzed in comparison to the traditional prescriptive approach, which relies on predefined techniques and exercises. The aim of the study is to determine which of the two approaches is more effective in improving the performance of young soccer players. Methods: Thirty players (age 12 ± 1.2 years) were randomly assigned to two groups: the ecological-dynamic group (ECG) and a control group (CON). Both groups underwent an eight-week training program with equal sessions. The ECG group’s training focused on adjusting constraints like the learning environment, game rules, and visual restrictions to boost adaptability and problem-solving skills. The CON group followed a traditional prescriptive approach with specific instructions, goal setting, immediate feedback, and structured exercise progression. Passing abilities were evaluated before and after the program using the Loughborough Soccer Passing Test, with a retention test administered five weeks later. Descriptive statistics, including mean values and percentage improvements, were used. A repeated measures ANOVA compared differences between the groups. Results: The analysis revealed a significant Occasion × Group interaction for all performance variables, indicating that the ECG group experienced greater improvements than the CON group. Specifically, the ECG group showed significant reductions in Trial Time (p = 0.001, η_p² = 0.6), Penalty Time (p = 0.016, η_p² = 0.4), and Overall Performance (p = 0.011, η_p² = 0.8) from pre-test to post-test. However, these improvements did not persist into the retention test (p = 0.131, p = 0.792, and p = 0.192, respectively). The CON group also improved significantly in Trial Time (p = 0.003), Penalty Time (p = 0.002), and Overall Performance (p = 0.001) from pre-test to post-test, but with smaller effect sizes and no sustained gains at retention. Conclusions: The ecological-dynamic approach (EDG) has proven to be more effective in enhancing passing skills compared to the traditional prescriptive approach (CON). Although both methods led to performance improvements, the EDG group achieved more significant progress. Full article

The seventeen UN SDGs address critical global challenges. Among them, Goal 10—reducing inequality—and Goal 16—promoting peace, justice, and strong institutions—serve as foundational pillars in democracies, enabling the achievement of all other goals. Children, youth, and persons with disabilities are among those who stand to benefit most from these goals. Insights from the naturalistic decision-making practices of intentional communities, often framed as Contenders or Deviants in social construction theory, could be instrumental in advancing these objectives. This study examines the decision-making practices of three intentional communities representing youth, disabled persons, and children, each fostering a different version of equitable, peaceful, and justice-oriented governance to build strong institutions. The communities studied include a self-producing Korean popular music (K-pop) group representing youth Contenders, a mental health-supporting annual English conference for individuals on the autistic spectrum, and a Canadian alternative education, self-directed public senior elementary and secondary school—both considered Deviant societies in social construction theory, one focusing on disabled persons and the other on children. The historical method assesses the effectiveness of these communities’ preferred practices in achieving Goals 10 and 16. The results offer actionable insights for enhancing equality, peace, and justice while strengthening institutions to realize the full range of UN SDGs in democratic societies. Full article

The majority of cultural heritage tourism globally lacks the diversity of young tourists since there is a universal trend among youth worldwide considering that cultural and heritage stories are unrelated to their lifestyles and not designed for them. This research therefore makes use of classic Thai literature that the target group (grade 12) has studied, “Khun Chang Khun Phaen (KCKP)”, which includes actual heritage places in the province of Suphan Buri. It aims to create and evaluate design guidelines applying classic literature to facilitate cultural heritage tourism and interest in learning classic literature and history, specifically for youth, in three phases. In Phase 1, design guidelines are developed based on the answers of on-site questionnaires distributed to 600 young people. In Phase 2, a multimedia KCKP e-book is created, and in Phase 3, this multimedia KCKP e-book is evaluated using the results from 100 on-site questionnaires—serving as the research’s success criterion. The findings indicate that this e-book may spark a strong interest in youth for KCKP literature (mean = 4.53/5), cultural heritage tourism (mean = 4.56/5), and history (mean = 4.72/5). These findings affirm that the design guidelines effectively engage young tourists and promote an appreciation for cultural heritage, history, and classic literature. Full article

The capacity of schools to address behavioral health concerns presents an emerging challenge, exacerbated by major shortages in the workforce. Schools across the U.S. are struggling to hire licensed behavioral health professionals, with additional barriers encountered when seeking to hire practitioners with experience in educational settings. In 2023, a school district in the suburbs of Columbus, Ohio, partnered with The Ohio State University to launch a “grow your own” policy pilot. The priorities focused on addressing workforce shortages and leveraging the experiences of current teachers/staff to support growing needs related to student mental health and well-being. More specifically, the district utilized COVID-19 relief funds to recruit, train, and transition 25 teachers/staff into school mental health positions by underwriting the costs of each professional’s Master of Social Work (MSW) degree. Here, we (a) describe the district–university partnership and the processes guiding the implementation of the “grow your own” model, (b) distill preliminary findings about district needs regarding behavioral health, and (c) explore facilitators, barriers, and outcomes associated with learning among participants in the program. The findings from a district-wide staff survey indicated a high level of need for individual counseling, crisis intervention, and small group interventions. Additionally, qualitative interviews revealed that learning among the program’s participants was facilitated by effective classroom strategies and specific learning experiences integral to the program’s design. These facilitators supported key learning outcomes, including general social work knowledge, self-awareness, and therapeutic skills that are foundational for engaging with students, parents/families, teachers/staff, and the broader school community. This innovative policy pilot and training model demonstrate how universities and local educational agencies can partner to address workforce development challenges at the intersection of behavioral health and education. Full article

Youth risk-taking behaviors present important public health concerns due to their prevalence and potential adverse consequences, underscoring the need for research and prevention strategies to promote youth’s healthy development. The present research examined the relationship between parental psychological control and risk-taking behaviors via benefit perception among high school and college students in Taiwan. Using a cross-sectional design, the study surveyed 378 participants to assess maternal and paternal psychological control, benefit perception, and engagement in risk-taking behaviors. Results indicated no significant difference in psychological control or benefit perception between high school and college students. However, college students reported higher levels of risk-taking behaviors, such as risky driving, alcohol use, and unprotected sex. Both maternal and paternal psychological control positively correlated with benefit perception and risk-taking behaviors. Furthermore, benefit perception mediated the relationship between psychological control and risk-taking behavior among high school and college students. These findings suggested that parental psychological control indirectly influenced youth risk-taking by shaping their perceptions of the benefits of such behaviors. The study highlights the importance of promoting autonomy-supportive parenting to reduce risk-taking behaviors and advocates for programs that enhance decision-making skills among adolescents and emerging adults. Full article

This study reflects the evidence-building journey for the Colorado Kinnected kinship navigator program. Colorado Kinnected expands the scope of services, resources, and supports offered to kinship families through an innovative approach that enhances an earlier Kinship Supports Demonstration Project. The Colorado Kinnected target population includes kinship caregivers caring for children and youth of any age with an open child welfare case. The primary purpose of the program is to reduce child welfare involvement by limiting traditional foster care and congregate care use when out-of-home placements are required. A randomized controlled trial was conducted from June to November 2020 to examine the impact of the Colorado Kinnected kinship navigator program on the kinship placement outcomes of 402 children and youth with an open child welfare case in seven Colorado counties. The initial study found that children and youth placed with kinship caregivers who received Colorado Kinnected services were significantly more likely to reunify with their parents after their kinship placements ended than were children and youth who received kinship supports as usual. The sustained effects study featured additional analyses of traditional foster and congregate care entry rates within six months of kinship placement for the same sample of children and youth. Children and youth in the intervention group were significantly less likely than children and youth in the control group to enter foster care or congregate care within six months after the end of their kinship placements. Overall, both analyses indicate that the Colorado Kinnected program promotes sustained permanency among children and youth in formal kinship placements. Data equity analyses to explore the contextual sensitivity of the intervention are detailed, and implications for practice, policy, and research are discussed. Full article

Background: Rare diseases constitute a heterogeneous group of approximately 7000–8000 conditions, distinguished by their low prevalence. Collectively, they present a significant global health challenge, affecting millions of people worldwide. It is estimated that rare diseases affect approximately 10% of the global population, which places a significant burden on individuals, families, and society. It is, therefore, important to consider strategies to improve the overall well-being and quality of life of individuals with rare diseases. One potential avenue for exploration is the incorporation of physical activity (PA). The scope of this study was to ascertain whether PA has a positive impact on measures of well-being and to determine its potential to enhance the quality of life of these individuals. Methods: The data were collected via an online survey. The one-way ANOVA test for multiple groups and multivariate Poisson models were employed to identify the significant predictors of the outcomes of interest. Results: The protective effects of PA become evident with a minimum of six hours of activity per week. Our data confirm that the weekly hours devoted to PA can serve as a significant protective factor for QoL. The study also provided some insights into the motivations behind patients’ engagement in PA. These included improving QoL and physical well-being, as well as the desire to interact socially, with the goal of meeting friends or making new acquaintances. Finally, for adults and older adults, engaging in PA can also be a way to control weight. Conclusions: It is becoming increasingly clear that individuals with rare diseases stand to benefit greatly from PA, so it is only sensible to educate them on the advantages of an active lifestyle. Full article

Background: Condoms have proven to be an effective contraceptive barrier method of family planning and have played a vital role in preventing sexually transmitted diseases including HIV. However, existing evidence shows that utilization of condoms remains low, especially among youth and adolescents. We aimed to determine the condom use rate and associated factors among the students of Gulu University in Uganda. Methods: A cross-sectional study was conducted among undergraduate students of Gulu University between June and December 2023. The students were accessed from their respective faculties and chosen using a simple random sampling method. Data were collected using a pretested self-administered structured questionnaire. Condom use was defined as use of either male or female condom in any sexual encounter within the previous six months. Results: A total of 404 participants, with a median age of 23 years (interquartile range (21.5–24) years) were enrolled in this study, 54.2% (n = 219) of whom were men. The response rate of the respondents was 94.1%. Overall, 81.4% (n = 329) of the participants were in senior classes (year 2, 3, 4, and 5), and 18.6% (n = 75) were in their first year of study. The condom use rate was 53.7% (n = 217). Condom use rate was 50.2% (n = 109) among male and 49.8% (n = 108) among female students. Sex (men) (aPR = 0.82, 95% CI = 0.71, 0.95, p = 0.01), nature of sexual relationship (married) (aPR = 1.4, 95% CI = 1.07, 1.85, p < 0.015), place of HIV testing (University health unit) (aPR =1.22, 95% CI = 1.06, 1.41, p = 0.005), and having sex in the absence of condoms (aPR = 1.22, 95% CI = 1.01, 1.46, p = 0.021) were significantly associated with consistent condom use. Conclusions: Just over half of undergraduate students of Gulu University used condoms in their sexual encounters in the past six months. There should be heightened campaigns on condom use to prevent unintended pregnancies and sexually transmitted infections. Full article

Suicide research is directed at understanding social, economic, and biological causes of suicide thoughts and behaviors. (1) Background: Worldwide, certain countries have high suicide mortality rates (SMRs) compared to others. Age-standardized suicide mortality rates (SMRs) published by the World Health Organization (WHO) plus numerous bibliographic records of the Web of Science (WoS) database provide resources to understand these disparities between countries and regions. (2) Methods: Hierarchical clustering was applied to age-standardized suicide mortality rates per 100,000 population from 2000–2019. Keywords of country-specific suicide-related publications collected from WoS were analyzed by network and association rule mining. Keyword embedding was carried out using a recurrent neural network. (3) Results: Countries with similar SMR trends formed naturally distinct groups of high, medium, and low suicide mortality rates. Major themes in suicide research worldwide are depression, mental disorders, youth suicide, euthanasia, hopelessness, loneliness, unemployment, and drugs. Prominent themes differentiating countries and regions include: alcohol in post-Soviet countries; HIV/AIDS in Sub-Saharan Africa, war veterans and PTSD in the Middle East, students in East Asia, and many others. (4) Conclusion: Countries naturally group into high, medium, and low SMR categories characterized by different keyword-informed themes. The compiled dataset and presented methodology enable enrichment of analytical results by bibliographic data where observed results are difficult to interpret. Full article

The present research was carried out in stands of Scots pine and black pine, pure or mixed with deciduous trees, installed on degraded lands from the Curvature Subcarpathian area, Romania, in a representative network of permanent research plots and followed the analysis of the structural diversity and stability indicators of these stands at different ages and in different conditions of degraded lands. The relationships between the quantitative variables with reference to the structure were established by analyzing the significance of the Pearson correlation coefficient (r) and also including datasets of slenderness indexes, which were classed into three domains of vulnerability to abiotic factors (like wind and snow). The compositional diversity of pine stands (pure or mixed with deciduous ones) is different in relation to age and is correlated with the structural diversity. The obtained correlation coefficients (r Pearson) express very strong and significant relationships between biometric parameters (h x Dbh, h x Lc%, Dc x Dbh, and Lc% x Dbh) of the structural diversity (r = 0.800–0.930), which is important for the analysis of the stability and vulnerability of pine forests. The strong correlation between the analyzed variables expresses a weak vulnerability to the action of harmful abiotic factors and the increase in the stability and resilience of the studied stands, especially of over 50 years old. In the old pine stands, the low-vulnerability domain (I < 0.80) is the best represented one, with an average of 64.01% from the total number of trees. At this age, trees with DBH > 22 cm fall into the low-vulnerability category. The explanation is that the stands were affected in their youth by the action of snow and wind, which, combined with the silvotechnical works performed, led to their compositional and structural diversification and increased stability. The young (<45 years) and pure-pine stands with higher consistency (>0.8) and even-aged structure are the most vulnerable to abiotic factors due to the fact that a large number of trees are passing gradually into the higher cenotic classes. Full article

Background: Attention Deficit Hyperactivity Disorder (ADHD) is a pressing concern in pediatric public health, with its prevalence rising among children and teenagers. This study explored the relationship between group-based physical activity and the well-being, resilience, and distress levels of Israeli youth, with a specific focus on those with ADHD symptoms. Methods: This cross-sectional study surveyed 699 Israeli teenagers, assessing their participation in three types of physical activities: unorganized, structured, and the “Five Fingers” program. Data were collected through an online platform and analyzed using ANOVA, t-tests, and multivariable regression models to identify predictors of resilience. Results: Structured, group-based sport activities are associated with higher resilience (p < 0.01) and lower distress (p < 0.01) in adolescents. Adolescents with ADHD symptoms exhibited lower resilience (p < 0.001) and well-being (p < 0.001), and higher distress (p < 0.001). However, those with ADHD symptoms who participated in group-based activities fared better in terms of distress (p < 0.01) and well-being (p = 0.018) than those who did not. Participation in any sport activity, older age, male gender, and a higher socio-economic status predicted greater resilience in youth, generally. Conclusions: This study presents the potential of structured physical activities that involve psychosocial and group integration training to improve the mental health of adolescents, especially in the context of ADHD symptoms. Full article

Introduction: In South Africa over the past 20 years, immunisation has saved countless lives as well as prevented illnesses and disabilities. Despite this, vaccine-preventable illnesses remain a danger. The demand for and uptake of immunisation services are shaped by a variety of factors that can either act as barriers or facilitators to immunisation uptake. The aim of this project was to identify the supply and demand barriers and develop local strategies to improve childhood immunisation in four zero-dose districts in South Africa. Materials and Methods: This study used a mixed-method approach. In each of these four districts, 15 in-depth key informant interviews with health workers and local health managers and four focus group discussions (10 participants per focus group discussion) with community members and caregivers were held over a three-month period. Transcribed interviews were thematically analysed using qualitative analysis software (Nvivo^®) into 10 factors as identified as important in influencing immunisation demand and uptake in previous studies. A further four were identified during the data analysis process. Results: Despite the varying role of factors affecting demand and uptake of immunisation services, three consistent findings stand out as major barriers across all districts. The first is interaction with healthcare staff. This clearly highlights the crucial role that the interactions between patients and staff play in shaping perceptions and behaviours related to immunisation services. The second is the overall experience of care at healthcare facilities. This emphasises the role that patient experience of services plays in perceptions and behaviours related to immunisation services. The third is family dynamics. This highlights the important role family dynamics play in shaping individuals’ decisions regarding immunisation uptake as well as the impact it has on the ability of people to access health services. Discussion: The role played by the different factors in the demand and uptake of immunisation services varied across the four districts examined in this study. Each of the districts presents a unique landscape where different factors have varying degrees of importance in affecting the utilisation of immunisation services. In some districts, certain factors are major barriers, clearly hindering the demand and uptake of immunisation services, while in others, these same factors might be a relatively minor barrier. This discrepancy highlights the unique nature of healthcare challenges across the districts and the need for tailored strategy recommendations to address them effectively. Full article

Monitoring training load, recovery, and wellness in maturation ages is even more relevant than in adulthood, especially during congested schedules. The objective of this study was to quantify and describe the differences in external and internal load, recovery, and perceived wellness in elite under-16 female players during a period of three competitions in seven days based on their participation during matches. An observational design was used to quantify the external load (total distance, high-speed distance, and PlayerLoad) and internal load (differential sRPE), as well as the recovery and wellness of 18 international under-16 players during a development tournament. The external load pattern of the starting players was undulating, with matches showing the highest internal load values compared to training sessions and non-starters. Non-starter players (whether training or matches) showed similar external load and differential sRPE values throughout the tournament (p > 0.05). Starting players experienced higher internal load than non-starters during matches (p < 0.037), without differences between training sessions (p > 0.05). No changes were seen in wellness or recovery (all p-values > 0.05), except for non-starters in Session 3 compared to Session 7 (p = 0.024). Starting players had more weekly total minutes (p = 0.018), differential sRPE (breath: p = 0.002; leg: p = 0.002; cognitive: p = 0.003), total distance (p = 0.003), and PlayerLoad (p = 0.008) than non-starters. Our results indicate differing load patterns between starters and non-starters, which do not affect wellness and recovery differently. Starters accumulate more weekly total load. Coaches can use these findings to guide decisions and load compensations in high competition contexts for young female soccer players. Full article

Family characteristics and service barriers influence children’s access to health and social care. Systematic assessment of family service barriers may help practitioners in their efforts to support family engagement with needed services. To address this need, this study utilized data from a 12-week service navigation intervention to examine associations between family characteristics, service barriers, service need, and service access. Twenty-nine caregivers of youth under age 18 participated. Pre-test measures included a family demographic questionnaire, service barriers checklist, and family service plan. Post-test outcome measures were the type and number of services accessed in the family service plan. At baseline, participants reported an average of 10 barriers to care. The family characteristics, caregiver age, child age, and community group involvement, were associated with a greater number of service barriers. Over the course of the intervention, the service barrier “provider waitlists” was associated with an increased service access, while having a male child was associated with a decrease in service access. Results indicate families experience multiple service barriers and specific family characteristics influence service access. Systematic assessment of service barriers and consideration of family characteristics can assist practitioner efforts to support youth and family engagement with health and social care. Full article