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23 pages, 2513 KiB  
Article
Overview of Salt Cavern Oil Storage Development and Site Suitability Analysis
by Nan Zhang, Xinrong Gao, Baoxu Yan, Yun Zhang, Songtao Ji and Xilin Shi
Processes 2024, 12(8), 1709; https://doi.org/10.3390/pr12081709 (registering DOI) - 14 Aug 2024
Abstract
Salt cavern storage, characterized by its safety, stability, large scale, economic viability, and efficiency, stands out as a cost-effective and relatively secure method for large-scale petroleum reserves. This paper provides an overview of the current development status of salt cavern storage technologies both [...] Read more.
Salt cavern storage, characterized by its safety, stability, large scale, economic viability, and efficiency, stands out as a cost-effective and relatively secure method for large-scale petroleum reserves. This paper provides an overview of the current development status of salt cavern storage technologies both domestically and internationally, analyzes the advantageous conditions and numerous challenges faced by salt cavern Strategic Petroleum Reserve (SPR) storage in China, and forecasts the development trends of this technology. The conclusions indicate that China possesses all of the necessary conditions for the development of salt cavern storage. Moreover, utilizing the Analytical Hierarchy Process (AHP), a macro suitability hierarchical evaluation system is constructed for the site selection and construction of salt cavern storage facilities. This system quantifies various site selection indicators, integrating expert opinions and findings from relevant theoretical research to establish grading standards for the suitability indices of salt cavern storage construction. Applied to the site evaluation of salt cavern storage at the Jintan Salt Mine in Jiangsu, the results indicate its high suitability for storage construction, making it an ideal location for establishing such facilities. The evaluation results are consistent with expert opinions, demonstrating the rationality of this method. Full article
(This article belongs to the Section Energy Systems)
Show Figures

Figure 1

Figure 1
<p>Outer dependency for oil of China and days of oil availability by country [<a href="#B1-processes-12-01709" class="html-bibr">1</a>].</p>
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<p>Distribution of U.S. strategic oil storage.</p>
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<p>Distribution of China’s strategic oil storage.</p>
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<p>The process of solution mining during the construction of SPR in rock salt.</p>
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<p>Construction of the judgment matrix in AHP. <span class="html-italic">O</span> represents the decision objective. <span class="html-italic">C<sub>i</sub></span> represents the evaluation criterion.</p>
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<p>Target hierarchy model of the suitability evaluation of the SPR salt cavern. <span class="html-italic">O</span> represents the decision objective; <span class="html-italic">C<sub>i</sub></span> represents the evaluation criterion; <span class="html-italic">C<sub>ij</sub></span> represents the <span class="html-italic">j</span>th basic indicator under the <span class="html-italic">i</span>th evaluation criterion in the criterion layer.</p>
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29 pages, 4717 KiB  
Article
Securing IPv6 Neighbor Discovery Address Resolution with Voucher-Based Addressing
by Zachary T. Puhl and Jinhua Guo
Network 2024, 4(3), 338-366; https://doi.org/10.3390/network4030016 (registering DOI) - 14 Aug 2024
Abstract
The majority of local IPv6 networks continue to remain insecure and vulnerable to neighbor spoofing attacks. The Secure Neighbor Discovery (SEND) standard and its concomitant Cryptographically Generated Addressing (CGA) scheme were accepted by large standard bodies to codify practical mitigations. SEND and CGA [...] Read more.
The majority of local IPv6 networks continue to remain insecure and vulnerable to neighbor spoofing attacks. The Secure Neighbor Discovery (SEND) standard and its concomitant Cryptographically Generated Addressing (CGA) scheme were accepted by large standard bodies to codify practical mitigations. SEND and CGA have never seen widespread adoption due to their complexities, obscurity, costs, compatibility issues, and continued lack of mature implementations. In light of their poor adoption, research since their standardization has continued to find new perspectives and proffer new ideas. The orthodox solutions for securing Neighbor Discovery have historically struggled to successfully harmonize three core ideals: simplicity, flexibility, and privacy preservation. This research introduces Voucher-Based Addressing, a low-configuration, low-cost, and high-impact alternative to IPv6 address generation methods. It secures the Neighbor Discovery address resolution process while remaining simple, highly adaptable, indistinguishable, and privacy-focused. Applying a unique concoction of cryptographic key derivation functions, link-layer address binding, and neighbor consensus on the parameters of address generation, the resolved address bindings are verifiable without the need for complex techniques that have hindered the adoption of canonical specifications. Full article
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Figure 1

Figure 1
<p>A classic Neighbor Discovery neighbor spoofing (traffic redirection; on-path) attack. Each arrow is colored to indicate its associated step in the process; an upward arrow indicates transmission of a message, and a downward arrow indicates receipt of a message. After the normative address resolution process is completed in steps 1 and 2, the listening malicious Node C sends a spoofed Neighbor Advertisement in step 3 to override the link-layer address value in Node A’s Neighbor Cache. Node A now unknowingly harbors a “poisoned” cache entry.</p>
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<p>A more subversive, “eager” approach to preemptively poisoning a target’s Neighbor Cache without requiring any prior interaction. Each arrow is colored to indicate its associated step in the process; an upward arrow indicates transmission of a message, and a downward arrow indicates receipt of a message. Nodes receiving SLLAO stubs on certain NDP messages are dictated by the protocol specification to accept them as-is for the sake of protocol optimization. This optimization is performed so that NS receivers can respond with unicast messages to the sending link-layer address without needing reverse address resolution and without a multicast response.</p>
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<p>The overall structure of a Voucher-Based Address.</p>
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<p>The Voucher-Based Address generation procedure is used via SLAAC to generate all the initial interface addresses from the interface on Host A. Router X is a Voucher Bearer authorized by local administrative policy to delegate Link Voucher information to its neighbors.</p>
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<p>The VBA verification procedure. The generation process is repeated at the verifier using various values known about the neighbor and the current voucher parameters. In step 1, the verifier (Node A) requests binding details from the advertiser (Node B), to which the advertiser responds with its reported VBA in step 2. In step 3, the verifier begins independently reconstructing the VBA to ensure the same IP address is created from all known inputs. In step 4, a simple equivalency check occurs, whose truthfulness determines whether the verifier should cache and accept traffic from the advertiser.</p>
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<p>Another comprehensive depiction of VBA verification is given. The steps are equal to <a href="#network-04-00016-f005" class="html-fig">Figure 5</a>, except step 5 considers the equivalence check its own process. As shown, VBA processes do not modify the typical Neighbor Discovery process or exchange. Instead, software local to each interface, if equipped, will act to verify the received IP addresses during NDAR transactions based on the interface’s selected Enforcement Mode.</p>
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<p>The binary structure and fields of the Link Voucher NDP option. This is only considered valid by receivers when attached to Router Advertisement and Redirect messages.</p>
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<p>The adjacent DER structure definitions for encoding the ECDSA PublicKey and Signature values in a Link Voucher option. This is not representative of program code; it is a familiar similitude of the declarative data structure notation used by the ITU for DER objects.</p>
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<p>The basic binary structure of a TLV field that is used in the Algorithm Type field of a Link Voucher option. The type and length fields are a maximum width of 16 bits. The angle brackets to the sides of the Value field indicate a variable length field.</p>
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<p>The three default key derivation functions are employed and benchmarked in VBA generation procedures with their minimum possible baseline difficulty settings. Each increase in the iteration count for each KDF expectedly shows mostly linear increases in the address generation times. All the outliers and deviations from the observable linear pattern are due to the spurious slowness of the local processor on which these tests were run.</p>
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<p>A high-difficulty setting with the PBKDF2_SHA256 algorithm (an ITERATIONS_FACTOR of 256) shows a mostly linear relationship between the baseline time required to generate a VBA and the input iteration count. The data gathered is not an averaged composite of multiple runs. As the iteration count increases, variations in the baseline computation time increase.</p>
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<p>A high-difficulty setting with the Argon2 KDF (more specifically, Argon2d; with a Parallelism of 32 and a MemorySize of 2,048) shows a mostly linear relationship between the baseline time required to generate a VBA and the input iteration count. The data gathered is not an averaged composite of multiple runs. As the iteration count increases, variations in the baseline computation time increase. The scale of the Time axis is much smaller than the other KDFs used in this experiment.</p>
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<p>A high-difficulty setting with the Scrypt KDF (a SCALING_FACTOR at its maximum of 5) shows a mostly linear relationship between the baseline time required to generate a VBA and the input iteration count. The data gathered is not an averaged composite of multiple runs. As the iteration count increases, variations in the baseline computation time increase, and the linearity of the graph gently curves downwards.</p>
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<p>A mixed local network is shown where a single valid Link Voucher is delegated to VBA-capable neighbors. Neighbors without VBA capabilities are shown in blue, and VBA-aware neighbors are shown in red, orange, yellow, and green for the IEMs AAD, AGO, AGVL, and AGV, respectively. Different links are shown between some hosts to indicate their connectivity and security within this transitioning network. Inbound traffic to verifying nodes is generally considered secure.</p>
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17 pages, 3350 KiB  
Systematic Review
Effects of Exercise on Cancer-Related Fatigue in Breast Cancer Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
by Runyu Zhou, Zhuying Chen, Shiyan Zhang, Yushu Wang, Chiyang Zhang, Yuanyuan Lv and Laikang Yu
Life 2024, 14(8), 1011; https://doi.org/10.3390/life14081011 (registering DOI) - 14 Aug 2024
Abstract
The primary objective of this study was to assess the influence of exercise interventions on cancer-related fatigue (CRF), specifically in breast cancer patients, with the ultimate goal of establishing an optimal exercise prescription for breast cancer patients. A comprehensive search was undertaken across [...] Read more.
The primary objective of this study was to assess the influence of exercise interventions on cancer-related fatigue (CRF), specifically in breast cancer patients, with the ultimate goal of establishing an optimal exercise prescription for breast cancer patients. A comprehensive search was undertaken across multiple databases, including Embase, PubMed, Cochrane Library, Web of Science, and Scopus, covering data published up to 1 September 2023. A meta-analysis was conducted to calculate the standardized mean difference (SMD) along with its corresponding 95% confidence interval (CI), thereby quantifying the effectiveness of exercise in alleviating CRF in the breast cancer patient population. Twenty-six studies met the inclusion criteria. Aerobic exercise (SMD, −0.17, p = 0.02), resistance exercise (SMD, −0.37, p = 0.0009), and combined exercise (SMD, −0.53, p < 0.0001) significantly improved CRF in breast cancer patients. In addition, exercise intervention conducted ≥3 times per week (SMD, −0.47, p = 0.0001) for >60 min per session (SMD, −0.63, p < 0.0001) and ≥180 min per week (SMD, −0.79, p < 0.0001) had greater effects on improving CRF in breast cancer patients, especially middle-aged patients (SMD, −0.42, p < 0.0001). Exercise is an effective approach to improving CRF in breast cancer patients. When devising an exercise program, the primary consideration should be the incorporation of combined exercise as the principal intervention. This entails ensuring that participants engage in the program at least three times weekly, with each session lasting for more than 60 min. The ultimate aim is to achieve a total weekly exercise duration of 180 min by progressively increasing the frequency of exercise sessions. Full article
(This article belongs to the Special Issue Focus on Exercise Physiology and Sports Performance)
19 pages, 1158 KiB  
Article
Biomass Allocation and Allometry in Juglans mandshurica Seedlings from Different Geographical Provenances in China
by Fang Wang, Yelei Yang, Jun Wang, Yue Liu, Hongyan Wang, Yanying Song, Zhimin Lu and Yuchun Yang
Forests 2024, 15(8), 1434; https://doi.org/10.3390/f15081434 (registering DOI) - 14 Aug 2024
Abstract
Abundant genetic variation among the geographical provenances of Juglans mandshurica. The biomass and allometry of 3-year-old J. mandshurica seedlings were studied among 21 Chinese provenances to understand the variations in biomass allocation in depth. Standardized major axis (SMA) regression analysis was used [...] Read more.
Abundant genetic variation among the geographical provenances of Juglans mandshurica. The biomass and allometry of 3-year-old J. mandshurica seedlings were studied among 21 Chinese provenances to understand the variations in biomass allocation in depth. Standardized major axis (SMA) regression analysis was used to analyze the allometry relationship between the organs and whole plants or between the organs of plants from different provenances. Pearson correlation analysis determined the correlation of various biomass traits and the geographical and climatic factors of provenances. Significant variations (p < 0.001) in seedling biomass and its distribution were observed among the different provenances. The root, stem, leaf, aboveground, and total biomasses of Hongshi, Ji’an, Fangzheng, and Kuandian provenances were the highest, but their root allocation and root–shoot ratios were all lower. This phenomenon is just the opposite in the Lushuihe provenance. An extremely marked positive correlation (p < 0.001) was detected among the root, stem, leaf, aboveground, and total biomasses, but there were significant negative correlations (p < 0.001) among the biomass allocation ratios (except between root allocation and root–shoot ratios). The organs, aboveground, and total biomasses were mainly positively affected by annual mean precipitation except for leaf biomass. The allometric growth relationship between the organs or between the organs (except roots) and whole plants of J. mandshurica changed remarkably among the provenances (p < 0.05). The organ–biomass allocation in J. mandshurica seedlings conspicuously varied among the different provenances, which was mainly caused by the genetic variations in the seeds. This study provided the basis for the selection of optimal provenances for J. mandshurica seedlings. Full article
(This article belongs to the Section Forest Ecophysiology and Biology)
19 pages, 861 KiB  
Article
Integral-Valued Pythagorean Fuzzy-Set-Based Dyna Q+ Framework for Task Scheduling in Cloud Computing
by Bhargavi Krishnamurthy and Sajjan G. Shiva
Sensors 2024, 24(16), 5272; https://doi.org/10.3390/s24165272 (registering DOI) - 14 Aug 2024
Abstract
Task scheduling is a critical challenge in cloud computing systems, greatly impacting their performance. Task scheduling is a nondeterministic polynomial time hard (NP-Hard) problem that complicates the search for nearly optimal solutions. Five major uncertainty parameters, i.e., security, traffic, workload, availability, and price, [...] Read more.
Task scheduling is a critical challenge in cloud computing systems, greatly impacting their performance. Task scheduling is a nondeterministic polynomial time hard (NP-Hard) problem that complicates the search for nearly optimal solutions. Five major uncertainty parameters, i.e., security, traffic, workload, availability, and price, influence task scheduling decisions. The primary rationale for selecting these uncertainty parameters lies in the challenge of accurately measuring their values, as empirical estimations often diverge from the actual values. The integral-valued Pythagorean fuzzy set (IVPFS) is a promising mathematical framework to deal with parametric uncertainties. The Dyna Q+ algorithm is the updated form of the Dyna Q agent designed specifically for dynamic computing environments by providing bonus rewards to non-exploited states. In this paper, the Dyna Q+ agent is enriched with the IVPFS mathematical framework to make intelligent task scheduling decisions. The performance of the proposed IVPFS Dyna Q+ task scheduler is tested using the CloudSim 3.3 simulator. The execution time is reduced by 90%, the makespan time is also reduced by 90%, the operation cost is below 50%, and the resource utilization rate is improved by 95%, all of these parameters meeting the desired standards or expectations. The results are also further validated using an expected value analysis methodology that confirms the good performance of the task scheduler. A better balance between exploration and exploitation through rigorous action-based learning is achieved by the Dyna Q+ agent. Full article
(This article belongs to the Special Issue AI Technology for Cybersecurity and IoT Applications)
35 pages, 12134 KiB  
Systematic Review
The Emerging Hemp Industry: A Review of Industrial Hemp Materials and Product Manufacturing
by Dolor R. Enarevba and Karl R. Haapala
AgriEngineering 2024, 6(3), 2891-2925; https://doi.org/10.3390/agriengineering6030167 (registering DOI) - 14 Aug 2024
Abstract
There is a growing need for resilient and renewable materials to aid society in global sustainability. It is incumbent upon the agricultural and manufacturing industries to work together to achieve this vision. In particular, the hemp plant has been identified as an emerging [...] Read more.
There is a growing need for resilient and renewable materials to aid society in global sustainability. It is incumbent upon the agricultural and manufacturing industries to work together to achieve this vision. In particular, the hemp plant has been identified as an emerging industrial crop that will be pivotal in achieving the United Nations Sustainable Development Goals. However, this nascent industry has received an influx of research and development activity, resulting in various methods and practices globally, challenging the repeatability of results, research advancement, standards development, and sustainability assessment. A systematic literature review is conducted to identify and document (1) the various practices for harvesting and converting industrial hemp into materials and products and (2) existing hemp-derived products and those under development. Using the PRISMA methodology, 5295 articles were identified, and 109 articles were included for review. Unlike prior reviews focusing on specific hemp plant components, materials, or products, this study systematically evaluates the utilization pathways of the whole plant (stalk, flower, leaf, and seed) to traditional, industrial, and emerging products. Further, myriad opportunities for hemp material and product applications, sustainability performance assessment, and future research are discussed. This review will benefit future hemp research, advancing process technologies, developing novel products, establishing policies and standards, and assessing sustainability performance. Full article
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Graphical abstract

Graphical abstract
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<p>Increase in global hemp research productivity (annually for 2000–2023).</p>
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<p>Selection process flowchart using the PRISMA methodology.</p>
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<p>Review publication statistics by country.</p>
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<p>Publication statistics by hemp application (year vs. classification).</p>
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<p>Publication statistics by hemp application (classification vs. year).</p>
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<p>Field of hemp plants (<b>left</b>) with a closeup view of its flower (<b>center</b>) and stalk showing fibrous and woody hurd parts (<b>right</b>).</p>
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<p>Hemp plant indoor drying (<b>left</b>) and hemp stalks (<b>right</b>).</p>
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<p>Hemp fiber extraction processes: (<b>a</b>) mechanical processing of unretted stalk, (<b>b</b>) mechanical processing of retted straw, and (<b>c</b>) traditional processing of hemp fiber.</p>
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<p>Extraction processes and products from hemp seed.</p>
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<p>Saccharification process for the extraction of biomass bioenergy.</p>
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<p>Extraction processes for hemp flowers.</p>
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<p>Publication statistics by journals and conference proceedings.</p>
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26 pages, 4754 KiB  
Article
Skin and Scalp Health Benefits of a Specific Botanical Extract Blend: Results from a Double-Blind Placebo-Controlled Study in Urban Outdoor Workers
by Vincenzo Nobile, Enza Cestone, Sabrina Ghirlanda, Andrea Poggi, Pau Navarro, Adrián García, Jonathan Jones and Nuria Caturla
Cosmetics 2024, 11(4), 139; https://doi.org/10.3390/cosmetics11040139 (registering DOI) - 14 Aug 2024
Abstract
Environmental pollution is increasingly recognized as a significant contributor to skin and scalp damage. Oral supplementation with a specific blend of four standardized botanical extracts (Rosmarinus officinalis, Lippia citriodora, Olea europaea leaf, and Sophora japonica) has been previously demonstrated [...] Read more.
Environmental pollution is increasingly recognized as a significant contributor to skin and scalp damage. Oral supplementation with a specific blend of four standardized botanical extracts (Rosmarinus officinalis, Lippia citriodora, Olea europaea leaf, and Sophora japonica) has been previously demonstrated to enhance skin health in individuals exposed to high environmental stress. Thus, it might represent a convenient strategy to also improve their scalp health aspect, particularly in subjects with sensitive scalps. To support these effects, a 12-week double-blind, randomized, placebo-controlled trial was performed in 66 women working outdoors in urban areas with high particulate matter (PM) levels and taking 250 mg of the botanical blend daily. Product efficacy was measured as follows: skin antioxidant status (FRAP); skin and scalp moisturization (corneometer), transepidermal water loss (tewameter), and oiliness (sebumeter); skin radiance and colour (spectrophotometer), elasticity and firmness (cutometer) and wrinkle depth (image analysis); and scalp clinical evaluation. Despite constant exposure to increased levels of PM, the tested product positively influenced all monitored parameters compared to both baseline and the placebo-treated group, in as early as 4 weeks. At the end of the study, key improvements included increased skin FRAP (21.9%), moisturization (9.5%), radiance (24.9%) and reduced wrinkle depth (−16.5%), dark spot pigmentation (−26.2%), and skin oiliness (−19.3%). For the scalp, moisturization increased (14.1%), TEWL decreased (−13.8%), and sebum content reduced by 16.2%. Additionally, 71% of subjects with sensitive scalps experienced reduced redness. These findings highlight the extensive benefits of the ingredient, expanding its application beyond conventional skin treatments to also alleviate scalp issues. Full article
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Figure 1

Figure 1
<p>Participants flow diagram.</p>
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<p>Change on facial skin FRAP analysis versus baseline after 28 and 84 days in the ZP treatment (blue bars) and placebo (yellow bars) group. Data are means ± SEM. Intergroup (vs. placebo) statistical analysis is reported inside the bars of the histograms. **** <span class="html-italic">p</span> &lt; 0.001.</p>
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<p>Change in facial skin moisturisation. (<b>a</b>) Skin moisturisation variation versus baseline after 28, 56, and 84 days in the ZP treatment (blue bars) and placebo (yellow bars) group. (<b>b</b>) Changes in skin hydration versus baseline in subjects in the dry skin type subgroup in the ZP (dark blue bars) and placebo groups (orange bars). Data are means ± SEM. Intergroup (vs. placebo) statistical analysis is reported inside the bars of the histograms as follows: * <span class="html-italic">p</span> &lt; 0.05, ** <span class="html-italic">p</span> &lt; 0.01, and *** <span class="html-italic">p</span> &lt; 0.001.</p>
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<p>Change in skin transepidermal water loss (TEWL). (<b>a</b>) TEWL variation a variation versus baseline after 28, 56, and 84 days in the ZP treatment (blue bars) and placebo groups (yellow bar). (<b>b</b>) Changes in TEWL versus baseline in the TEWL subgroups: (TEWL &lt; 15 g·h<sup>−1</sup>·m<sup>−2</sup> (healthy condition)) and TEWL between 15–25 g × h<sup>−1</sup> × m<sup>−2</sup> (normal condition) both in the ZP treatment (blue and dark blue bars) and placebo groups (blue and orange bars). Data are means ± SEM. Intergroup (vs. placebo) statistical analysis is reported on the bars of the histograms. Statistical analysis is reported as follows: * <span class="html-italic">p</span> &lt; 0.05, *** <span class="html-italic">p</span> &lt; 0.01 and **** <span class="html-italic">p</span> &lt; 0.001. Inter-subgroup statistical analysis is reported with + upon the bars of the histograms as follows: + <span class="html-italic">p</span> &lt; 0.05 and ++ <span class="html-italic">p</span> &lt; 0.01.</p>
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<p>Periocular wrinkles evaluated with Primos<sup>CR</sup> of one the volunteers (volunteer 62) in the ZP treatment group. The skin surface is red in colour value, corresponding approximatively to a height of 0 mm (according to the colour scale present in the upper part of the figure). Green and blue colours represent negative values, indicating the presence of wrinkles. Orange and yellow colours represent values higher than zero.</p>
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<p>Change in skin sebum content. (<b>a</b>) Skin sebum variation versus baseline after 28, 56, and 84 days in the ZP treatment (blue bars) and placebo (yellow bars) group. (<b>b</b>) Changes in the skin sebum versus baseline in subjects with &gt;100 µg/cm<sup>2</sup> of sebum (oily skin subgroup in the ZP (dark blue bars) and placebo groups (orange bars). Data are means ± SEM. Intergroup (vs. placebo) statistical analysis is reported inside the bars of the histograms as follows: ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001 and **** <span class="html-italic">p</span> &lt; 0.0001.</p>
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<p>Changes in TEWL versus baseline in the TEWL subgroups: (TEWL &lt; 15 g·h<sup>−1</sup>·m<sup>−2</sup> (healthy condition)) and TEWL between 15–25 g × h<sup>−1</sup> × m<sup>−2</sup> (normal condition) both in the ZP treatment (blue and dark blue bars) and placebo groups (blue and orange bars). Data are means ± SEM. Intergroup (vs. placebo) statistical analysis is reported on the bars of the histograms. Statistical analysis is reported as follows: * <span class="html-italic">p</span> &lt; 0.05, ** <span class="html-italic">p</span> &lt; 0.01. Inter-subgroup statistical analysis is reported with + upon the bars of the histograms as follows: +++ <span class="html-italic">p</span> &lt; 0.001.</p>
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<p>Change in scalp sebum content. (<b>a</b>) Scalp sebum variation versus baseline after 28, 56, and 84 days in the ZP treatment (blue bars) and placebo (yellow bars) groups. (<b>b</b>) Changes in skin sebum versus baseline in subjects with &gt;100 µg/cm<sup>2</sup> of sebum (oily skin subgroup) in the ZP (dark blue bars) and placebo group (orange bars). Data are means ± SEM. Intergroup (vs. placebo) statistical analysis is reported inside the bars of the histograms as follows: * <span class="html-italic">p</span> &lt; 0.05, ** <span class="html-italic">p</span> &lt; 0.01, and *** <span class="html-italic">p</span> &lt; 0.001.</p>
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<p>Scalp aspect improvement. (<b>a</b>) Percentage of subjects that improved their scalp condition in the entire panel and in the sensitive subgroup. (<b>b</b>) Images of the scalp of a volunteer with sensitive scalp in the active treatment group at baseline (T0) and at the different checkpoints. Digital pictures were acquired by means of DermoGenius ultra (DermoScan GmbH, Regensburg, Germany). Starting from T28, scalp redness is less evident.</p>
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20 pages, 16326 KiB  
Article
Multiplatform Computer Vision System to Support Physical Fitness Assessments in Schoolchildren
by José Sulla-Torres, Bruno Santos-Pamo, Fabrizzio Cárdenas-Rodríguez, Javier Angulo-Osorio, Rossana Gómez-Campos and Marco Cossio-Bolaños
Appl. Sci. 2024, 14(16), 7140; https://doi.org/10.3390/app14167140 (registering DOI) - 14 Aug 2024
Abstract
Currently, the lack of physical activity can lead to health problems, with the increase in obesity in children between 8 and 18 years old being of particular interest because it is a formative stage. One of the aspects of trying to solve this [...] Read more.
Currently, the lack of physical activity can lead to health problems, with the increase in obesity in children between 8 and 18 years old being of particular interest because it is a formative stage. One of the aspects of trying to solve this problem is the need for a standardized, less subjective, and more efficient method of evaluating physical condition in these children compared to traditional approaches. Objective: Develop a multiplatform based on computer vision technology that allows the evaluation of the physical fitness of schoolchildren using smartphones. Methodology: A descriptive cross-sectional study was carried out on schoolchildren aged 8 to 18 years of both sexes. The sample was 228 schoolchildren (128 boys and 108 girls). Anthropometric measurements of weight, height, and waist circumference were evaluated. Body mass index (BMI) was calculated. Four physical tests were evaluated: flexibility (sit and reach), horizontal jump (explosive strength), biceps curl (right arm strength resistance), and sit-ups (abdominal muscle resistance). With the information collected traditionally and by filming the physical tests, a computer vision system was developed to evaluate physical fitness in schoolchildren. Results: The implemented system obtained an acceptable level of precision, reaching 94% precision in field evaluations and a percentage greater than 95% in laboratory evaluations for testing. The developed mobile application also obtained a high accuracy percentage, greater than 95% in two tests and close to 85% in the remaining two. Finally, the Systematic Software Quality Model was used to determine user satisfaction with the presented prototype. Regarding usability, a satisfaction level of 97% and a reliability level of 100% was obtained. Conclusion: Compared to traditional evaluation and computer vision, the proposal was satisfactorily validated. These results were obtained using the Expanded Systematic Software Quality Model, which reached an “advanced” quality level, satisfying functionality, usability, and reliability characteristics. This advance demonstrates that the integration of computer vision is feasible, highly effective in the educational context, and applicable in the evaluations of physical education classes. Full article
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<p>View of body tracking on Unity while the bicep curl test is running.</p>
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<p>Frontal distribution of the test.</p>
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<p>Joint map provided by LightBuzz.</p>
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<p>Vector representation of the sit-up test.</p>
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<p>Vector representation of the biceps curls test.</p>
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<p>Example of sit-up test evaluation.</p>
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<p>Example of biceps flexion test evaluation.</p>
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<p>Example of horizontal jump test evaluation without impulse.</p>
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<p>Flexibility bending test evaluation example.</p>
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<p>Mobile application initial interfaces.</p>
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<p>Mobile application execution test interfaces.</p>
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<p>Abdominal flexion test by control and software.</p>
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<p>Biceps curl test by control and software.</p>
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<p>Flexibility test by control and software.</p>
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<p>Horizontal jump test without impulse by control and software.</p>
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15 pages, 1557 KiB  
Article
CastelLact Project: Exploring the Nutritional Status and Dietary Patterns of Pregnant and Lactating Women—A Comprehensive Evaluation of Dietary Adequacy
by Carmen I. Sáez Lleó, Carla Soler, Jose M. Soriano and Nadia San Onofre
Nutrients 2024, 16(16), 2705; https://doi.org/10.3390/nu16162705 (registering DOI) - 14 Aug 2024
Abstract
Promoting optimal nutrition in pregnant and lactating women is crucial for maternal and infant health. This study evaluated their nutritional status and dietary habits, assessing macro and micronutrient intake based on recommendations. A descriptive study with Spanish participants examined social, obstetric, dietary, and [...] Read more.
Promoting optimal nutrition in pregnant and lactating women is crucial for maternal and infant health. This study evaluated their nutritional status and dietary habits, assessing macro and micronutrient intake based on recommendations. A descriptive study with Spanish participants examined social, obstetric, dietary, and anthropometric data using quantitative and qualitative methods. The analysis of fatty acids by gas chromatography revealed significant variability, with notable deviations in specific fatty acids like C:10:0 and C:12:0. Despite some differences, the overall composition aligns with standards. During pregnancy, 53.8% consumed five meals/day. Grilling (92.3%) and baking (76.9%) were common. Food consumption frequency differed from recommendations. Lactating mothers’ mean energy intake was 2575.88 kcal/day ± 730.59 standard deviation (SD), with 45% from carbohydrates and 40% from lipids, including 37.16 g ± 10.43 of saturated fatty acids. Diets during pregnancy lacked fruits, vegetables, legumes, nuts, and cereals. Lactating mothers partially met nutritional objectives, with an energy distribution skewed towards lipids and deficiencies in calcium, iodine, vitamin D, E, and folic acid. Promoting proper nutrition during pregnancy and lactation is essential to safeguard health and prevent chronic diseases. Full article
(This article belongs to the Special Issue Maternal Diet, Body Composition and Offspring Health)
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<p>Gas–liquid chromatogram of fatty acid methyl esters.</p>
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<p>Anthropometric variations of mothers: evolution of body mass index before and after pregnancy.</p>
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<p>Frequency of consumption of the different food groups by mothers during pregnancy according to recommendations [<a href="#B24-nutrients-16-02705" class="html-bibr">24</a>,<a href="#B25-nutrients-16-02705" class="html-bibr">25</a>,<a href="#B26-nutrients-16-02705" class="html-bibr">26</a>,<a href="#B27-nutrients-16-02705" class="html-bibr">27</a>]. R: Ration.</p>
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<p>Oral supplementation during pregnancy and lactation.</p>
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<p>Distribution of the percentage of total caloric value by food group in the diet of nursing mothers.</p>
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17 pages, 557 KiB  
Article
Effects of Moringa Oleifera Leaf Powder on the Growth Performance, Meat Quality, Blood Parameters, and Cecal Bacteria of Broilers
by Md G. Akib, Al Rifat, Chondhon Bormon, Amitush Dutta, Mohammad Shamsul Ataher, Mahmoud Azzam, Mohammed Hamdy Farouk, Razib Das, Md Abul Kalam Azad and Shad Mahfuz
Vet. Sci. 2024, 11(8), 374; https://doi.org/10.3390/vetsci11080374 - 14 Aug 2024
Abstract
The effect of dietary inclusion of Moringa oleifera leaf powder (MLP) on the growth, meat quality, carcass characteristics, hematobiochemical profile, and cecal bacteria of broiler chicken was investigated in this research trial. In this study, 192-day-old Arbor Acre broiler chicks were assigned in [...] Read more.
The effect of dietary inclusion of Moringa oleifera leaf powder (MLP) on the growth, meat quality, carcass characteristics, hematobiochemical profile, and cecal bacteria of broiler chicken was investigated in this research trial. In this study, 192-day-old Arbor Acre broiler chicks were assigned in a completely randomized design to three groups: control, antibiotic, and MLP. A standard basal diet was given to the control group, while the antibiotic group received 75 mg/kg chlortetracycline, and the MLP group received 100 mg/kg M. oleifera leaf powder supplemented basal diet. Each group was further divided into eight replicates consisting of eight birds each, and the trial ran for 35 days. Among the groups, the MLP-fed broilers achieved the highest final body weight (FBW), average daily gain (ADG), and average daily feed intake (ADFI). Notably, the FCR for the whole experimental period was lower in the MLP group, indicating a more efficient use of feed for growth. Supplementation of MLP with basal diet significantly increased (p < 0.05) the weight of thighs and drumsticks relative to live weight %, while the spleen and abdominal fat weight (% of live weight) were significantly decreased (p < 0.05). Adding MLP to the diet improved the meat quality of broilers, as indicated by the highest pH of meat at 45 min and the lowest cooking loss (%) observed in this group. MLP exhibited hypocholesterolemic and hypolipidemic effects, with the lowest total cholesterol and triglyceride levels compared to non-supplemented groups. The hematological profile revealed that the MLP group exhibited the highest RBC count and Hb level, while also showing the lowest H/L ratio. Moringa supplementation significantly (p < 0.05) modulated the cecal bacterial population, reducing pathogenic E. coli and Shigella spp. while increasing beneficial Lactobacillus spp. and the total aerobic plate count (TAPC). In conclusion, Moringa oleifera leaf powder (MLP) can be used as a natural feed supplement for promoting the growth, meat quality, healthy blood, and sound health of broilers. Full article
37 pages, 2269 KiB  
Article
Linked Links—A Research Project: The Multiple Superimposed Soft Networks as Network Profiles
by Gianfranco Minati
Systems 2024, 12(8), 303; https://doi.org/10.3390/systems12080303 - 14 Aug 2024
Abstract
This article, based on network science, aims to contribute to overcoming its geometric and technological phases. The novelty consists in considering links of networks as linked by superimposed networks, termed here multiple superimposed soft networks (MSSN), which is introduced as a research issue. [...] Read more.
This article, based on network science, aims to contribute to overcoming its geometric and technological phases. The novelty consists in considering links of networks as linked by superimposed networks, termed here multiple superimposed soft networks (MSSN), which is introduced as a research issue. Such links of links (termed here as passive links) concern, for instance, correspondences, incompatibilities, and temporal synchronizations between the occurrences of pairs of active links of effective networks, such as those based on electrical and telecommunication. A possible constitutive mechanism of such passive linkage consists of linkage representations for practices and histories of use expressed by their validating statistical reoccurrences. We consider the possible emergent nature of the passive linkage. The reason for introducing the design and usage of MSSN properties as a research issue involves making new approaches to profile and manage networks available. Correspondence between active linkage and MSSN properties should be a matter for an experiential, machine-learning approach. Research issues relate their possible usage on the active linkage such as for classification, comparations, detection of criticalities, diagnosis, performance evaluation, and regulatory as weak forces. Furthermore, the possible identification of standard corresponding configurations of passive and active linkage is finalized to avoid their establishment or, conversely, in facilitating their establishment and keeping their replication in different contexts (or partially and in combinations) and identifying related standardized approaches (also for classes of configurations having significant levels of equivalence). This research project has methodological generalizing aspects of trans-disciplinarity. We conclude by mentioning related research issues. Full article
(This article belongs to the Section Systems Theory and Methodology)
30 pages, 394 KiB  
Review
CPT Symmetry Searches in the Neutral Meson System
by Ágnes Roberts
Particles 2024, 7(3), 717-746; https://doi.org/10.3390/particles7030042 - 14 Aug 2024
Abstract
A review of the landscape of CPT symmetry tests is presented, centered around the Standard-Model Extension and focusing on tests in the neutral meson system. A discussion of the relevant theories summarizes original ideas. It is followed by a short transition into phenomenology. [...] Read more.
A review of the landscape of CPT symmetry tests is presented, centered around the Standard-Model Extension and focusing on tests in the neutral meson system. A discussion of the relevant theories summarizes original ideas. It is followed by a short transition into phenomenology. A more detailed parameterization is presented. Various experiments are used to deliver an overview of testing CPT from every angle that the theory suggested and that the neutral meson (NM) system could accommodate. Full article
(This article belongs to the Special Issue Feature Papers for Particles 2023)
16 pages, 561 KiB  
Review
A Splice Form of VEGF, a Potential Anti-Angiogenetic Form of Head and Neck Squamous Cell Cancer Inhibition
by Cristina Stefania Dumitru and Marius Raica
Int. J. Mol. Sci. 2024, 25(16), 8855; https://doi.org/10.3390/ijms25168855 - 14 Aug 2024
Abstract
Angiogenesis, primarily mediated by vascular endothelial growth factor (VEGF), is a fundamental step in the progression and metastasis of head and neck squamous cell carcinoma (HNSCC). Traditional anti-angiogenic therapies that target the VEGF pathway have shown promise but are often associated with significant [...] Read more.
Angiogenesis, primarily mediated by vascular endothelial growth factor (VEGF), is a fundamental step in the progression and metastasis of head and neck squamous cell carcinoma (HNSCC). Traditional anti-angiogenic therapies that target the VEGF pathway have shown promise but are often associated with significant side effects and variable efficacy due to the complexity of the angiogenic signaling pathway. This review highlights the potential of a specific VEGF splice form, VEGF165b, as an innovative therapeutic target for HNSCC. VEGF165b, unlike standard VEGF, is a natural inhibitor that binds to VEGF receptors without triggering pro-angiogenic signaling. Its distinct molecular structure and behavior suggest ways to modulate angiogenesis. This concept is particularly relevant when studying HNSCC, as introducing VEGF165b’s anti-angiogenic properties offers a novel approach to understanding and potentially influencing the disease’s dynamics. The review synthesizes experimental evidence suggesting the efficacy of VEGF165b in inhibiting tumor-induced angiogenesis and provides insight into a novel therapeutic strategy that could better manage HNSCC by selectively targeting aberrant vascular growth. This approach not only provides a potential pathway for more targeted and effective treatment options but also opens the door to a new paradigm in anti-angiogenic therapy with the possibility of reduced systemic toxicity. Our investigation is reshaping the future of HNSCC treatment by setting the stage for future research on VEGF splice variants as a tool for personalized medicine. Full article
(This article belongs to the Section Molecular Oncology)
15 pages, 5966 KiB  
Article
Long-Term Survival and Regeneration Following Transplantation of 3D-Printed Biodegradable PCL Tracheal Grafts in Large-Scale Porcine Models
by Sen-Ei Shai, Yi-Ling Lai, Yi-Wen Hung, Chi-Wei Hsieh, Kuo-Chih Su, Chun-Hsiang Wang, Te-Hsin Chao, Yung-Tsung Chiu, Chia-Ching Wu and Shih-Chieh Hung
Bioengineering 2024, 11(8), 832; https://doi.org/10.3390/bioengineering11080832 - 14 Aug 2024
Abstract
Polycaprolactone (PCL) implants in large animals show great promise for tracheal transplantation. However, the longest survival time achieved to date is only about three weeks. To meet clinical application standards, it is essential to extend the survival time and ensure the complete integration [...] Read more.
Polycaprolactone (PCL) implants in large animals show great promise for tracheal transplantation. However, the longest survival time achieved to date is only about three weeks. To meet clinical application standards, it is essential to extend the survival time and ensure the complete integration and functionality of the implant. Our study investigates the use of three-dimensional (3D)-printed, biodegradable, PCL-based tracheal grafts for large-scale porcine tracheal transplantation, assessing the feasibility and early structural integrity crucial for long-term survival experiments. A biodegradable PCL tracheal graft was fabricated using a BIOX bioprinter and transplanted into large-scale porcine models. The grafts, measuring 20 × 20 × 1.5 mm, were implanted following a 2 cm circumferential resection of the porcine trachea. The experiment design was traditionally implanted in eight porcines to replace four-ring tracheal segments, only two of which survived more than three months. Data were collected on the graft construction and clinical outcomes. The 3D-printed biosynthetic grafts replicated the native organ with high fidelity. The implantations were successful, without immediate complications. At two weeks, bronchoscopy revealed significant granulation tissue around the anastomosis, which was managed with laser ablation. The presence of neocartilage, neoglands, and partial epithelialization near the anastomosis was verified in the final pathology findings. Our study demonstrates in situ regenerative tissue growth with intact cartilage following transplantation, marked by neotissue formation on the graft’s exterior. The 90-day survival milestone was achieved due to innovative surgical strategies, reinforced with strap muscle attached to the distal trachea. Further improvements in graft design and granulation tissue management are essential to optimize outcomes. Full article
(This article belongs to the Special Issue Tissue Engineering and Regenerative Medicine in Bioengineering)
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<p>A schematic representation of the experimental design of the tracheal transplantation using 3D-printed biodegradable PCL grafts in female LY porcines. Method I, which did not involve fixation of the distal trachea, resulted in exclusions due to various complications. In contrast, Method II, which employed fixation, led to successful inclusions and prolonged survival. The evaluation process included bronchoscopy, laser ablation, gross investigation, and histological analysis with H&amp;E staining to assess neocartilage development and address complications.</p>
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<p>Neotissue growth outside the graft from the proximal to the distal region with gross and histology images following implantation into large-scale porcine models for over 90 days. This figure illustrates the growth of neotissue in two porcine subjects, one with a soft tissue infection and the other without, following the implantation of tracheal grafts for over 90 days. The histological analysis of the neotissue was conducted at the proximal (<b>A</b>,<b>B</b>), middle (<b>C</b>,<b>D</b>), and distal (<b>E</b>,<b>F</b>) regions of the infected Pig1. Red circles indicate areas of heterotopic ossification. Similarly, the histology of the neotissue was examined at the proximal (<b>G</b>,<b>H</b>), middle (<b>I</b>,<b>J</b>), and distal (<b>K</b>,<b>L</b>) regions of the non-infected Pig2. The gross images display intact tracheal rings, while the histology images, stained with H&amp;E, highlight the development of cartilage and areas of heterotopic ossification, indicated by red circles. The neotissue extends from the proximal to the distal region outside the graft. Intact cylindrical neotissue, including cartilage, is visible in sections (<b>A</b>,<b>C</b>,<b>E</b>,<b>I</b>,<b>K</b>), with section (<b>G</b>) displaying only a half-ring of neotissue. The scale bars in the histology images represent 10 mm, providing a reference for the size of the observed features.</p>
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<p>A Comparative Histological Analysis of Tracheal Tissue Regeneration in Two Large-Scale Porcine Models 90 Days Post-Implantation. (<b>A</b>–<b>D</b>) exhibit a regenerated tracheal section with a fully integrated structure, showcasing robust neocartilage formation at the tip (<b>B</b>), dense clusters of newly formed submucosal glands (<b>C</b>), and a smooth epithelial lining (<b>D</b>). The total view (<b>A</b>) highlights the well-organized tissue with clear chondrogenesis and glandular development. (<b>E</b>–<b>H</b>) display a contrasting tracheal section where irregularities are more pronounced. There is evident heterotopic ossification (<b>E</b>), with the central area (<b>F</b>) showing lamellar bone trabeculae amidst fibrotic-like marrow tissue. The submucosal glands are irregularly clustered (<b>G</b>), and the epithelium appears uneven (<b>H</b>). The total view (<b>E</b>) underscores the disparity in tissue organization compared to the left panels.</p>
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<p>Histology at the Proximal Area of Neotissue Features Following Implantation into Large-Scale Porcine for Over 90 Days. (<b>A</b>) Heterotopic ossification; (<b>B</b>) Polyp; (<b>C</b>) Bacterial clump; (<b>D</b>) Congestion in the submucosal area. Yellow, red, blue, and green squares are magnified at each indicated image (<b>B</b>–<b>E</b>) at 100×.</p>
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<p>Features of Perichondrial Papillae (PP), Pre-resorptive Layers (PRL), and Various Stains of Vascular Canals (VCs) in Neocartilage after Graft Implantation for over 19 Days. (<b>A</b>–<b>C</b>) The PP and PRL were detected by H&amp;E, safranin O/fast green, and IHC with αSMA antibodies. “P” is indicated in the perichondrium; black arrows represent PRL. (<b>D</b>–<b>L</b>) The VCs were detected by H&amp;E, safranin O/fast green, alcian blue stains, and IHC with antibodies for type II collagen, Sox9, aggrecan, PCNA, αSMA, and CD31. Protein expression is indicated in brown; safranin O/fast green appears red; alcian blue is shown in blue. These data were magnified at 200×.</p>
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<p>Proposed Four-Stage Chondrogenesis within the Graft Neotissue as Revealed by H&amp;E, Alcian Blue, Safranin O/Fast Green, and IHC (Type II Collagen, Sox9, Aggrecan, and PCNA Antibodies) Stains. (<b>A</b>–<b>D</b>) Different stages of cartilage during chondrogenesis were investigated through H&amp;E staining. (<b>E</b>–<b>H</b>) The histology and GAG content of the different stages of cartilage during chondrogenesis were investigated using Alcian blue stain. The GAGs of the cartilage matrix were detected by Alcian blue and are indicated in blue. (<b>I</b>–<b>L</b>) The histology and GAG content of the different stages of cartilage during chondrogenesis were investigated with safranin O/Fast Green stain. The GAGs of the cartilage matrix were detected with safranin O/Fast Green, indicating a red color. Black arrows: the modulator structure of the vascular canal (VC). Images were at 400× magnification. (<b>M</b>) Chondrocyte numbers quantified for different stages of chondrogenesis of graft neotissue using H&amp;E stain (<span class="html-italic">n</span> = 4 views at 400× magnification for each group). (<b>N</b>–<b>P</b>) Ratios of protein expressions (Sox9, Aggrecan, and PCNA) quantified for different stages of chondrogenesis of graft neotissue based on IHC stainings (<span class="html-italic">n</span> = 4 views at 200× magnification for each group). Data are shown as mean ± SD values, and statistically significant differences across various stages were determined at <span class="html-italic">p</span> &lt; 0.05.</p>
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20 pages, 3648 KiB  
Article
Development of a Non-Structural Prefabricated Panel Based on Construction and Demolition Waste for Sustainable Construction
by Haidee Yulady Jaramillo, July Andrea Gómez Camperos and Nelson Afanador García
Infrastructures 2024, 9(8), 135; https://doi.org/10.3390/infrastructures9080135 - 14 Aug 2024
Abstract
The study focuses on developing a prefabricated panel for non-structural purposes by optimizing mortar mix designs incorporating recycled microplastic (RMP) and construction demolition waste (CDW) at various ratios (0, 10, 20, 30, and 100%). Experimental procedures encompassed material characterization, mortar specimen manufacturing, compression [...] Read more.
The study focuses on developing a prefabricated panel for non-structural purposes by optimizing mortar mix designs incorporating recycled microplastic (RMP) and construction demolition waste (CDW) at various ratios (0, 10, 20, 30, and 100%). Experimental procedures encompassed material characterization, mortar specimen manufacturing, compression resistance testing, and thermal/acoustic panel tests following Colombian technical standards. Results indicate that incorporating 20% CDW enhances material strength, with cylinder number 3 (20% of CDW) achieving a resistance of 31.45 MPa. Panels incorporating recyclable waste materials show improved acoustic and thermal insulation properties, with up to 39 dB reduction in sound transmission and a 21 °C decrease in thermal transmission observed (5.6% and 35% for panel and door, respectively). This research advances sustainable construction practices demonstrating the potential of prefabricated panels using recyclable materials, offering eco-friendly solutions with enhanced performance characteristics for construction applications. Full article
(This article belongs to the Section Infrastructures Materials and Constructions)
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<p>Experimental procedure. Source: the authors.</p>
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<p>Mixture obtention process and hand mortar mixing. Source: the authors.</p>
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<p>CDW panel dimensions.</p>
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<p>Thermal and acoustic test, (<b>a</b>) Equipment used, and (<b>b</b>) Sonometer. Source: the authors.</p>
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<p>River sand granulometric curve. Source: Authors.</p>
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<p>CDW material granulometric curve. Source: Authors.</p>
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<p>%CDW vs. Resistance. Source: Authors.</p>
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<p>%CDW vs. Weight. Source: Authors. Note: Where black is the %CDW and gray is the Weight absorption.</p>
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<p>CDW panel temperature test result. Source: Authors.</p>
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<p>Thermal test result, CDW panel to relative humidity (RH). Source: Authors.</p>
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<p>CDW panel acoustic test results with maximum limits. Source: Authors.</p>
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<p>(<b>a</b>) Developed panel, and (<b>b</b>–<b>d</b>) Microcracks over the panel surface in different sections. Source: Authors.</p>
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<p>Compression test simulation of the CDW panel: (<b>a</b>) diagonal and (<b>b</b>) horizontal. Source: the authors.</p>
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