Search Results (93,700)

The available research findings suggest that non-suicidal self-injury (NSSI) constitutes an important public health issue, with identified risk factors for NSSI having been found to include exposure to adverse childhood experiences (ACEs) and comorbidity with various mental disorders. However, the available findings have, for the most part, been based on the experiences of individuals living in predominantly high-income countries located in the Global North, and it is not clear whether these findings can be confidently generalised to individuals living in low-resourced countries. As such, this cross-sectional study assessed risk factors for NSSI in a non-clinical sample of 636 South African adolescents (12–18 years old), with the data being analysed using a multi-mediation analysis. ACEs were assessed using a revised version of the ACEs Questionnaire, and NSSI was assessed using items adapted from the Self-Harm subscale of the Risk-Taking and Self-Harm Inventory for Adolescents, with emotion dysregulation, depression, and PTSD being considered as possible mediators. High prevalence rates for NSSI and exposure to five or more ACEs were reported by the participants, with the mediation analysis indicating that significant direct effects of adverse childhood experiences on NSSI were partially mediated by emotion dysregulation. These findings are discussed with respect to their implications for primary, secondary, and tertiary prevention. Full article

Introduction: Drug incompatibilities are among the most common medication errors in intensive care units. A precipitate can form and block the catheter or cause an adverse event in the patient. Intensive care units have implemented various strategies for limiting the occurrence of these incompatibilities, which have already been studied in vitro under standardized conditions. The objective of the present in vitro study was to continue these assessments by determining the impact of the infusion line geometry and the drugs’ position in the infusion set-up on the prevention of vancomycin–piperacillin/tazobactam incompatibility. Methods: Infusion lines with a different common volume, a multilumen medical infusion device, a dilute vancomycin solution, and separate infusions of incompatible drugs were evaluated separately. The infusion line outlet was connected to a dynamic particle counter. Results: Reducing the common volume, using multilumen medical devices, or spacing out the two incompatible drugs on the infusion line did not prevent the occurrence of a significant particulate load. Only dilution of the vancomycin solution was associated with a significantly lower particulate load and the absence of drug incompatibility. Conclusions: Our results show that under specific conditions, it is possible to reduce particulate contamination considerably. Full article

Due to being lightweight, fine-grained sediments easily flow with water and thus amplify the destructive effect of debris flow hazards. In such hazards, water content and shear strength are key inter-controlled factors relating to the stability of fine-grained sediments and thus control the density, scale, and danger of debris flow hazards. Although the correlation between water content and sediment stability has been studied, there are still some issues to be solved: what is the changing trend of shear strength with increasing water content? What is the water content spatial distribution pattern of fine-grained sediments in debris flow? What is the role/impact of this pattern on debris flow hazards prevention? Therefore, the objective of this research is to show the spatial distribution pattern of water content and establish a correlation between the water content and the shear strength of fine-grained sediments to provide a scientific basis for debris flow hazard prevention. Taking the Beichuan debris flow for our study, with a length of 37.6 km, and a 341 km² study area, the results show that (1) the average water content shows an increasing trend, from 9.9% in the upstream of the river (SP01–SP05) to 21.7% in the downstream of the river (SP13–SP15). (2) When unsaturated, the correlation between the water content and shear strength is determined by combining the cohesion, normal stress, and internal friction angle; when saturated, the water content is negatively correlated with shear strength. (3) Water content and shear strength are the key inter-controlled factors relating to the stability of fine-grained sediments, and the water content distribution pattern of this research indicates the key locations that require attention: locations with high water content in the downstream river or with high curvature, which is of some significance for debris flow hazard prevention. Full article

Cyclic weight loss and subsequent regain after dieting and non-dieting periods, a phenomenon termed yoyo dieting, places individuals at greater risk of metabolic complications and alters gut microbiome composition. Resistant starch (RS) improves gut health and systemic metabolism. This study aimed to investigate the effect of yoyo dieting and RS on the metabolism and gut microbiome. C57BL/6 mice were assigned to 6 diets for 20 weeks, including control, high fat (HF), yoyo (alternating HF and control diets every 5 weeks), control with RS, HF with RS, and yoyo with RS. Metabolic outcomes and microbiota profiling using 16S rRNA sequencing were examined. Yoyo dieting resulted in short–term weight loss, which led to improved liver health and insulin tolerance but also a greater rate of weight gain compared to continuous HF feeding, as well as a different microbiota profile that was in an intermediate configuration between the control and HF states. Mice fed HF and yoyo diets supplemented with RS gained less weight than those fed without RS. RS supplementation in yoyo mice appeared to shift the gut microbiota composition closer to the control state. In conclusion, yoyo dieting leads to obesity relapse, and increased RS intake reduces weight gain and might help prevent rapid weight regain via gut microbiome restoration. Full article

Gastrodia elata, commonly known as Tian Ma, is a perennial mycoheterotrophic orchid. Qianyang Tian Ma (QTM), a geographical indication agricultural product from Hongjiang City, Hunan Province, China, is primarily characterized by the red variety, G. elata f. elata. A severe outbreak of tuber brown rot disease was documented in QTM during the harvesting season in Hunan. The fungal pathogen associated with the disease was isolated on potato saccharose agar (PSA) and identified through morphological and phylogenetic analyses. Pathogenicity tests were performed on healthy tubers of G. elata f. elata. The results showed that the representative isolate, named TMB, produced white hyphal colonies with a ring structure, broom-like phialides, partially curved ellipsoidal conidia, and orange–yellow spherical ascocarps on PSA. Phylogenetic analysis of the ITS, LSU, rpb2 and tub2 sequences using Bayesian and maximum-likelihood methods identified the isolate TMB as Clonostachys rosea, based on morphological and phylogenetic data. Pathogenicity tests revealed typical disease symptoms on healthy G. elata tubers 15 days post-inoculation with the isolate TMB. C. rosea is known to cause diseases in economically important crops, but there are no reports of its occurrence on G. elata f. elata in China. This study provides valuable insights into the occurrence, prevention, and control of brown rot disease in G. elata f. elata. Full article

As network technology evolves, cyberattacks are not only increasing in frequency but also becoming more sophisticated. To proactively detect and prevent these cyberattacks, researchers are developing intrusion detection systems (IDSs) leveraging machine learning and deep learning techniques. However, a significant challenge with these advanced models is the increased training time as model complexity grows, and the symmetry between performance and training time must be taken into account. To address this issue, this study proposes a fast-persistent-contrastive-divergence-based deep belief network (FPCD-DBN) that offers both high accuracy and rapid training times. This model combines the efficiency of contrastive divergence with the powerful feature extraction capabilities of deep belief networks. While traditional deep belief networks use a contrastive divergence (CD) algorithm, the FPCD algorithm improves the performance of the model by passing the results of each detection layer to the next layer. In addition, the mix of parameter updates using fast weights and continuous chains makes the model fast and accurate. The performance of the proposed FPCD-DBN model was evaluated on several benchmark datasets, including NSL-KDD, UNSW-NB15, and CIC-IDS-2017. As a result, the proposed method proved to be a viable solution as the model performed well with an accuracy of 89.4% and an F1 score of 89.7%. By achieving superior performance across multiple datasets, the approach shows great potential for enhancing network security and providing a robust defense against evolving cyber threats. Full article

Buildings account for over 40% of global carbon dioxide (CO₂) emissions, with supply and return fans in air handling units consuming a significant portion of energy. To address this, researchers have explored innovative economizer damper control methods and identified the “split-signal” strategy, which optimizes supply airflow using a single damper as a promising approach. In this study, split-signal was further refined for practical application and energy simulation, aiming to demonstrate its effectiveness and encourage adoption in real-world building mechanical systems. Laboratory testing on chilled water variable air volume (VAV) system showed fan energy savings of 0.2–5% compared to traditional “three-coupled” control, depending on ventilation air proportions, and prevented reverse airflow. A statistical regression model, based on experimental data, was developed to predict energy savings and streamline comparisons. Energy simulations were conducted across various U.S. climate zones and revealed potential savings of 15–20% in energy use, operational costs, and CO₂ emissions. With minimal financial investment, split-signal control offers a cost-effective solution to improve energy efficiency and reduce environmental impact, promoting its adoption in real-world building applications. Full article

At-risk older adults and older survivors of sexual violence (SV) remain largely absent from SV prevention and intervention, owing to ageism and sexism, as well as other intersectional forms of prejudice, including among service providers (e.g., social workers, healthcare professionals, practitioners in SV organizations, and practitioners who serve older adults). This study explored perceptions, knowledge and experiences with SV against adults 50 years and older. Service providers who work with older adults and/or survivors were recruited, owing to where SV in later life is reported (e.g., healthcare, long-term care, and social service organizations, and to police in addition to SV service organizations), to contribute to the limited research in this area and to advance prevention and intervention. A survey was conducted on SV in later life, exploring knowledge, perceptions and experiences with SV in later life along with potential solutions for prevention and intervention among 126 service providers who worked with survivors and/or older adults. Their responses were thematically analyzed. Five themes were identified: (a) misconceptions of SV in later life and unique barriers to preventing it; (b) needs for knowledge, awareness, research and education; (c) policy and resource development; (d) victim blame and internalized stigma, and (e) ageism, intersectional prejudice and rape culture. The findings offer an in-depth understanding of barriers to prevention, and intervention, and multi-level recommendations for addressing them, which are provided by a diverse group of service providers who have worked with older adults and/or with survivors, reflecting multidisciplinary practice wisdom and experience. Full article

Platelets are small cell fragments that play a crucial role in hemostasis, requiring fast response times and fine signaling pathway regulation. For this regulation, platelets require a balance between two pathway types: the activatory and negative signaling pathways. Activatory signaling mediators are positive responses that enhance stimuli initiated by a receptor in the platelet membrane. Negative signaling regulates and controls the responses downstream of the same receptors to roll back or even avoid spontaneous thrombotic events. Several blood-related pathologies can be observed when these processes are unregulated, such as massive bleeding in activatory signaling inhibition or thrombotic events for negative signaling inhibition. The study of each protein and metabolite in isolation does not help to understand the role of the protein or how it can be contrasted; however, understanding the balance between active and negative signaling could help develop effective therapies to prevent thrombotic events and bleeding disorders. Full article

Introduction: The importance of diet in shaping the gut microbiota is well established and may help improve an individual’s overall health. Many other factors, such as genetics, age, exercise, antibiotic therapy, or tobacco use, also play a role in influencing gut microbiota. Aim: This narrative review summarizes how three distinct dietary types (plant-based, Mediterranean, and Western) affect the composition of gut microbiota and the development of non-communicable diseases (NCDs). Methods: A comprehensive literature search was conducted using the PubMed, Web of Science, and Scopus databases, focusing on the keywords “dietary pattern”, “gut microbiota” and “dysbiosis”. Results: Both plant-based and Mediterranean diets have been shown to promote the production of beneficial bacterial metabolites, such as short-chain fatty acids (SCFAs), while simultaneously lowering concentrations of trimethylamine-N-oxide (TMAO), a molecule associated with negative health outcomes. Additionally, they have a positive impact on microbial diversity and therefore are generally considered healthy dietary types. On the other hand, the Western diet is a typical example of an unhealthy nutritional approach leading to an overgrowth of pathogenic bacteria, where TMAO levels rise and SCFA production drops due to gut dysbiosis. Conclusion: The current scientific literature consistently highlights the superiority of plant-based and Mediterranean dietary types over the Western diet in promoting gut health and preventing NCDs. Understanding the influence of diet on gut microbiota modulation may pave the way for novel therapeutic strategies. Full article

This study uses a triple-sensor collocation approach to evaluate the performance of small-holder irrigation schemes in the Zamra catchment of Northern Ethiopia. Crop water productivity (CWP), as an integrator of biomass production and water use, was used to compare the overall efficiencies of three types of irrigation systems: traditional and modern diversions, and dam-based irrigation water supply. Farmer-reported data often rely on observations, which can introduce human estimation and measurement errors. As a result, the evaluation of irrigation scheme performance has frequently been insufficient to fully explain crop water productivity. To overcome the challenges of using one single estimation method, we used a triple-sensor collocation approach to evaluate the efficiency of three small-scale irrigation schemes, using water productivity as an indicator. It employed three independent methods: remotely sensed data, a model-based approach, and farmer in-situ estimates to assess crop yields and water consumption. To implement the triple collocation appraisal, we first applied three independent evaluation methods, i.e., remotely sensed, model-based, and farmer in-situ estimates of crop yields and water consumption, to assess the crop water productivities of the systems. Triple-sensor collocation allows for the appraisal and comparison of estimation errors of measurement sensor systems, and enables the ranking of the estimators by their quality to represent the de-facto unknown true value, in our case: crop yields, water use, and its ratio CWP, in small-holder irrigated agriculture. The study entailed four main components: (1) collecting in-situ information and data from small-holder farmers on crop yields and water use; (2) derivation of remote sensing-based CWP from the FAO WaPOR open database and time series; (3) evaluation of biomass, crop yields and water use (evapotranspiration) using the AquaCrop model, integrating climate, soil data, and irrigation management practices; (4) performing and analysis of a categorical triple collocation analysis of the independent estimator data and performance ranking of the three sensing and small-holder irrigation systems. Maize and vegetables were used as main crops during three consecutive irrigation seasons (2017/18, 2018/19, 2019/20). Civil war prevented further field surveying, in-situ research, and data collection. The results indicate that remote sensing products are performed best in the modern and dam irrigation schemes for maize. For vegetables, AquaCrop performed best in the dam irrigation scheme. Full article

Aims: It was the scope of this study to explore the biomechanical implications of retraction force application point modifications in lingual orthodontics, aiming to mitigate the bowing effect and enhance anchorage stability in the anterior teeth. Methods: Using the FE method on an idealized maxillary model, en masse retraction was simulated using a modified lingual fixed appliance including edgewise lingual brackets, a 0.017″ × 0.025″ mushroom-shaped archwire, and power arms between lateral incisors and canines, with a transpalatal arch (TPA) connecting the first molars. Applying bilateral retraction forces of 1.5 N at twelve positions, initial tooth displacements during space closure were evaluated. Results: Shifting power arms gingivally did not effectively counteract palatal tipping of incisors but reduced posterior and palatal tipping of canines with a power arm length of 11.3 mm preventing posterior tipping. Apically displacing the TPA retraction force increased mesiobuccal rotation while preventing mesial molar tipping for retraction forces applied 12.6 mm from the archwire. Conclusions: Apically shifting retraction forces can mitigate vertical bowing effects in lingual orthodontics, yet it also highlights the challenges in maintaining torque in the anterior teeth. Further research and clinical validation are essential in order to confirm these results, emphasizing the complexity and need for advanced biomechanical strategies in personalized lingual orthodontic treatments. Full article

Fiber-based sorbent materials are an essential part of containing oil spills, thus preventing ecological damage. Poly(styrene-b-isobutylene-b-styrene) thermoplastic elastomer fibers were successfully produced by centrifugal spinning. Scanning electron microscopy revealed that the fibers were bead free and smooth-surfaced, with an average fiber diameter of 5.9 ± 2.3 μm. Contact angle measurements proved the highly hydrophobic (water contact angle of 126.8 ± 6.4°) and highly oleophilic nature of the fiber mat. The sorption and retention capacities of the fiber mat were tested for various oils and benchmarked against polypropylene as the industry standard and polystyrene, which is widely used in the literature. The oil uptake of the fiber mat showed a strong correlation with the viscosity of the oil, resulting in sorption capacities of 10.1 ± 0.8 g/g for sunflower oil, 19.9 ± 2.1 g/g for motor oil, and 23.8 ± 1.8 g/g for gear oil. Oil–water separation tests were also conducted, resulting in ~100% oil removal. The thermoplastic elastomer fiber mat outperformed the industry standard; however, the polystyrene fiber mat demonstrated the best oil sorption performance. Full article

Xyleborus beetles, a diverse group of ambrosia beetles, present challenges to forestry and agriculture due to their damaging burrowing behavior and symbiotic relationships with fungi. This review synthesizes current knowledge on the biology, ecology, and management of Xyleborus. We explore the beetles’ life cycle, reproductive strategies, habitat preferences, and feeding habits, emphasizing their ecological and economic impacts. Control and management strategies, including preventive measures, chemical and biological control, and integrated pest management (IPM), are critically evaluated. Recent advances in molecular genetics and behavioral studies offer insights into genetic diversity, population structure, and host selection mechanisms. Despite progress, managing Xyleborus effectively remains challenging. This review identifies future research needs and highlights innovative control methods, such as biopesticides and pheromone-based trapping systems. Full article

Background: Offspring hypertension arising from adverse maternal conditions can be mitigated through dietary nutritional supplementation, including resveratrol. Previously, we identified derivatives of resveratrol butyrate ester (RBE), specifically 3,4′-di-O-butanoylresveratrol (ED2) and 3-O-butanoylresveratrol (ED4), demonstrating their superior antioxidant capabilities compared to RBE itself. This study sought to assess the protective impact of maternal supplementation with ED2 or ED4 on offspring hypertension in a rat model subjected to a high-fructose (HF) diet during pregnancy and lactation. Methods: Female Sprague–Dawley rats were distributed into distinct dietary groups throughout pregnancy and lactation: (1) standard chow; (2) HF diet (60%); (3) HF diet supplemented with ED2 (25 mg/L); and (4) HF diet supplemented with ED4 (25 mg/L). Male offspring were euthanized at the age of 12 weeks. Results: The maternal HF diet induced hypertension in the offspring, which was mitigated by perinatal supplementation with either ED2 or ED4. These protective effects were attributed to the antioxidant properties of ED2 and ED4, resulting in an increased availability of nitric oxide (NO). Additionally, supplementation with ED2 was connected to an increased abundance of Bifidobacterium and Clostridium genera, which was accompanied by a decrease in Angelakisella and Christensenella. On the other hand, ED4 supplementation shielded rat offspring from hypertension by elevating concentrations of short-chain fatty acids (SCFAs) and their receptors while reducing trimethylamine-N-oxide (TMAO) levels. Conclusions: These findings highlight the potential of purified RBE monomers, ED2 and ED4, as preventive measures against hypertension resulting from a maternal high-fructose diet. Further research is warranted to explore their clinical applications based on these promising results. Full article