Search Results (2,356)

Background and Objectives: Seliciclib (SEL) is the first selective, orally bioavailable potential drug containing cyclin-dependent kinase inhibitors. Preclinical studies showed antitumor activity in a broad range of human tumor xenografts, neurodegenerative diseases, renal dysfunctions, viral infections, and chronic inflammatory disorders. To support the pharmacokinetics and aid in therapeutic monitoring of SEL following its administration for therapy, an efficient analytical tool capable of quantifying the concentrations of SEL in blood plasma is needed. In the literature, there is no existing method for quantifying SEL in plasma samples. This study introduces the first HPLC method with a photodiode array (PDA) detector for the quantitation of SEL in plasma. Materials and Methods: The chromatographic resolution of SEL and linifanib as an internal standard (IS) was achieved on Zorbax Eclipse Plus C18 HPLC column (150 mm length × 4.6 mm internal diameter, 5 µm particle size), with a mobile phase composed of acetonitrile–ammonium acetate, pH 5 (50:50, v/v) at a flow rate of 1.0 mL min⁻¹. Both SEL and IS were detected by PDA at 230 nm. The method was validated according to the ICH guidelines for bioanalytical method validation. Results: The method exhibited linearity in concentrations ranging from 50 to 1000 ng mL⁻¹, with a limit of quantitation of 66.1 ng mL⁻¹. All remaining validation parameters satisfied the ICH validation criteria. The environmental sustainability of the method was verified using three extensive tools. The proposed HPLC-PDA method was effectively utilized to study the pharmacokinetics of SEL in rats after a single oral administration of 25 mg/kg. Conclusions: The proposed method stands as a valuable tool for studying SELs for pharmacokinetics in humans. It aids in achieving the targeted therapeutic advantages and safety of treatment with SEL by optimizing the SEL dosage and dosing schedule. Full article

The development of astronomy relies heavily on advances in high-resolution imaging techniques. With the growing demand for high-resolution astronomical observations, conventional optical interferometry has gradually revealed various limitations, especially in coping with atmospheric phase fluctuations and long baseline observations. However, intensity interferometry is becoming an important method to overcome these challenges due to its high robustness to atmospheric phase fluctuations and its excellent performance in long-baseline observations. In this paper, the basic principles and key technologies of intensity interferometry are systematically described, and the remarkable potential of this technique for improving angular resolution and detection sensitivity is comprehensively discussed in light of the recent advances in modern photon detector and signal processing techniques. The results show that the intensity interferometry technique is capable of realizing high-precision observation of long-range and low-brightness targets, especially in the field of exoplanet detection, which shows a wide range of application prospects. In the future, with the continuous development of telescope arrays and adaptive optics, the intensity interferometry technique is expected to further promote the precision and breadth of astronomical observations, and provide new opportunities for revealing the mysteries of the universe. Full article

Due to the increased prevalence of diabetes, the consumption of anti-diabetic drugs for its treatment has likewise increased. Metformin is an anti-diabetic drug that is commonly prescribed for patients with type 2 diabetes and has been frequently detected in surface water and wastewaters, thus representing an emerging contaminant. Metformin can be prescribed in combination with other classes of anti-diabetic drugs; however, these drugs are not sufficiently investigated in environmental samples. Fabric phase sorptive extraction (FPSE) has emerged as a simple and green method for the extraction of analytes in environmental samples. In this study, FPSE coupled with a high-performance liquid chromatography diode array detector (HPLC-DAD) was employed for the simultaneous analysis of different classes of anti-diabetic drugs (metformin, dapagliflozin, liraglutide, pioglitazone, gliclazide, glimepiride, glargine, repaglinide, sitagliptin, and vildagliptin) in environmental water samples. Four different fabric membranes were synthesized but the microfiber glass filter coated with sol-gel polyethylene glycol (PEG 300) was observed to be the best FPSE membrane. The parameters affecting the FPSE process were optimized using a combination of one-factor-at-a-time processes and the design of experiments. The FPSE was evaluated as a green extraction method, based on green sample preparation criteria. The FPSE-HPLC-DAD method achieved acceptable validation results and was applied for the simultaneous analysis of anti-diabetic drugs in surface and wastewater samples. Glimepiride was detected below the quantification limit in both lake and river water samples. Dapagliflozin, liraglutide, and glimepiride were detected at 69.0 ± 1.0 μg·L⁻¹, 71.9 ± 0.4 μg·L⁻¹, and 93.9 ± 1.3 μg·L⁻¹, respectively, in the city wastewater influent. Dapagliflozin and glimepiride were still detected below the quantification limit in city wastewater effluent. For the hospital wastewater influent, metformin and glimepiride were detected at 1158 ± 21 μg·L⁻¹ and 28 ± 0.8 μg·L⁻¹, respectively, while only metformin (392.6 ± 7.7 μg·L⁻¹) was detected in hospital wastewater effluent. Full article

A silicon photonics-based optical phased array (OPA) is promising for realizing solid-state and miniature beam steering. In our work, a 1 × 16 silicon optical phased array (OPA) hybrid integrated with a III–V laser is proposed and demonstrated. The III–V laser chip is vertically coupled with a silicon OPA chip based on a chirped grating coupler with a large bandwidth. The coupling efficiency reaches up to 90% through utilizing the metal reflector underneath the silicon oxide layer. The one-dimensional antenna array comprising silicon waveguides with half-wavelength spacing enables beam steering with none high-order grating lobes in a 180° field of view. The measured beam steering angle of the hybrid integrated OPA chip is ±25°, without grating lobes, and the suppression ratio of the side-lobes is larger than 9.8 dB with phase calibration. Full article

For the first time, two direct and eco-friendly chromatographic approaches were adapted for the simultaneous estimation of pheniramine maleate (PAM) and its major toxic impurity, 2-benzyl pyridine (BNZ). Method A used reversed-phase ultra-performance liquid chromatography; separation was achieved within 4 min using a C₁₈ column with a developing system of methanol/water (60:40 v/v) with a 0.1 mL/min flow rate. Photodiode array detection was adjusted at 215 nm. The method was linear in the ranges of 5.0–70.0 and 0.05–10.0 µg/mL for PAM and BNZ, correspondingly. Method B used thin-layer chromatography; separation was applied on silica gel TLC F₂₅₄ using ethanol/ethyl acetate/liquid ammonia (8:2:0.1, in volumes) at room temperature, at 265 nm. Linearity was assured at concentration ranges 0.5–8.0 and 0.1–3.0 µg/band for the two components, respectively. Generally, the new UPLC and TLC methods outperform the old ones in terms of quickness, greenness, and sensitivity. Concisely, the greenness features were partially achieved using the Green Analytical Procedure Index (GAPI) and the Analytical Greenness (AGREE) pictograms. In contrast, the usefulness of the novel approaches was assured via the Blue Applicability Grade Index (BAGI) tool. Full article

Bose metals are metals made of Cooper pairs, which form at very low temperatures in superconducting films and Josephson junction arrays as an intermediate phase between superconductivity and superinsulation. We predicted the existence of this 2D metallic phase of bosons in the mid 1990s, showing that they arise due to topological quantum effects. The observation of Bose metals in perfectly regular Josephson junction arrays fully confirms our prediction and rules out alternative models based on disorder. Here, we review the basic mechanism leading to Bose metals. The key points are that the relevant vortices in granular superconductors are core-less, mobile XY vortices which can tunnel through the system due to quantum phase slips, that there is no charge-phase commutation relation preventing such vortices from being simultaneously out of condensate with charges, and that out-of-condensate charges and vortices are subject to topological mutual statistics interactions, a quantum effect that dominates at low temperatures. These repulsive mutual statistics interactions are sufficient to increase the energy of the Cooper pairs and lift them out of condensate. The result is a topological ground state in which charge conduction along edges and vortex movement across them organize themselves so as to generate the observed metallic saturation at low temperatures. This state is known today as a bosonic topological insulator. Full article

Lilium lancifolium Thunb. is a herbal medicine that is widely used to treat inflammation and lung diseases. In this study, a simultaneous quantitative method was developed for the quality control of BLL using high-performance liquid chromatography coupled with a photodiode array detector (HPLC–PDA), and their antioxidant effects were evaluated. Eight regalosides (i.e., regaloside A, B, C, E, F, H, I, and K) were selected as marker substances and separated on a Gemini C₁₈ reversed-phase analytical column by gradient elution with distilled water–acetonitrile mobile phase containing 0.1% (v/v) formic acid. The method was validated with respect to linearity, sensitivities (limit of detection (LOD) and limit of quantitation (LOQ)), accuracy, and precision. The antioxidant effects of the extract and each component were evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay and 2-2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assay. The coefficients of determination values used as indicators of linearity for all components were ≥0.9999. LOD and LOQ concentrations were 0.10–0.66 μg/mL and 0.29–2.01 μg/mL, respectively. The recovery was 95.39–103.925% (relative standard deviation; RSD ≤ 2.55%), and precision RSD was <2.78%. The HPLC–PDA method was applied to real samples, and all components were detected at 1.12–29.76 mg/freeze-dried g. The evaluation of antioxidant effects showed that regalosides C, E, and K exhibited significant antioxidant effects. Our knowledge will be appropriately utilized in raw material management and conducting clinical and non-clinical studies on L. lancifolium or herbal medicine prescriptions containing L. lancifolium. Full article

Multiple-input multiple-output (MIMO) technology is widely used in the field of radar imaging. Array sparse optimization reduces the hardware cost of MIMO radar, while virtual aperture and the equivalent phase center (EPC) principle simplify the radar signal model and reduce the computation and complexity of imaging algorithms. However, the application of sparse array structure and the EPC principle produces a non-negligible phase error, which affects the imaging quality. This paper simplifies the MIMO radar signal model based on the phase center approximation, analyzes the phase error generated by this method, and proposes an improved phase error correction method to solve the problem that the target cannot be well-focused at non-reference distance during imaging. In addition, this paper designs a sparse linear MIMO array with a periodic structure, which reduces the number of transmitting and receiving units, system complexity, and hardware costs. The proposed phase correction method was combined with the wavenumber domain algorithm to simulate and experiment on the designed antenna array, and good experimental results were obtained to verify the effectiveness of the proposed method. Full article

Bearings play a key role in rolling mills, and the uniformity of their lubricant film directly affects the degree of wear of bearings and the safety of equipment. Due to long-term stress, the lubricant film inside the bearing is not uniformly distributed, resulting in uneven wear between the journal and the shaft tile, which increases the potential safety hazards in production. Traditional disassembly inspection methods are complex and time-consuming. Ultrasonic nondestructive testing technology, which has the advantages of nondestructive and adaptable, has become an effective means of assessing the thickness of the oil film in bearings. In this study, an experimental platform for calibrating the lubricant film thickness in bearings was constructed for the first time, and the acoustic characteristics of different thicknesses of the oil film were measured using ultrasonic detection equipment to verify the accuracy of the simulation process. The experimental results show that after discrete Fourier transform processing, the main features of the frequency channels of the reflected acoustic signals of different thicknesses of the oil film are consistent with the finite element simulation results, and the errors of the oil film thicknesses calculated from the reflection coefficients are within 10% of the set thicknesses, and the measurement ranges cover from 5 μm to 250 μm. Therefore, the above method can realize the accurate measurement of the thicknesses of the oil film in bearings. Full article

This paper presents a study on residual stress measurement in wire-arc additively manufactured (WAAM) titanium samples using the non-destructive method of phased array ultrasonics. The contour method (CM) was used for the verification of the phased array ultrasonic results. This allowed for a comparison of measurement methods to understand the effects on the distribution of residual stress (RS) within Ti-6Al-4V samples and the effectiveness of measurement of residual stress using phased array ultrasonics. From the results of the experiments, the phased array ultrasonic data were found to be in good agreement with the CM results and displayed similar residual stress distributions in the samples. The results of the individual elements of the phased array were also compared and an improvement in accuracy was found. From per-element results, anomalies were found and could be mitigated with the ability to average the results by using phased array ultrasonics. Therefore, based on these results, there is a strong case for the benefits of using phased array ultrasonics as a method of residual stress measurement for WAAM Ti-6Al-4V components over other existing residual stress measurement techniques. Full article

In food authentication, it is important to compare different analytical procedures and select the best method. The aim of this study was to determine the fingerprints of Zweigelt and Rondo wines through headspace analysis using ultra-fast gas chromatography (ultra-fast GC) and to compare the effectiveness of this approach at classifying wines based on grape variety and type of malolactic fermentation (MLF) as well as its greenness and practicality with three other chromatographic methods such as headspace solid-phase microextraction/gas chromatography-mass spectrometry with carboxen-polydimethylosiloxane fiber (SPME/GC-MS with CAR/PDMS fiber), headspace solid-phase microextraction/gas chromatography-mass spectrometry with polyacrylate fiber (SPME/GC-MS with PA fiber), and ultra performance liquid chromatography–photodiode array detector-tandem mass spectrometry (UPLC-PDA-MS/MS). Principal Component Analysis (PCA) revealed that fingerprints obtained using all four chromatographic methods were suitable for classification using machine learning (ML). Random Forest (RF) and Support Vector Machines (SVM) yielded accuracies of at least 99% in the varietal classification of Zweigelt and Rondo wines and therefore proved suitable for robust fingerprinting-based Quality Assurance/Quality Control (QA/QC) procedures. In the case of wine classification by the type of MLF, the classifiers performed slightly worse, with the poorest accuracy of 91% for SVM and SPME/GC-MS with CAR/PDMS fiber, and no less than 93% for the other methods. Ultra-fast GC is the greenest and UPLC-PDA-MS/MS is the most practical of the four chromatographic methods. Full article

Background/Objectives: Focused ultrasound (FUS) and microbubble (MB) exposure is a promising technique for targeted drug delivery to the brain; however, refinement of protocols suitable for large-volume treatments in a clinical setting remains underexplored. Methods: Here, the impacts of various sonication parameters on blood–brain barrier (BBB) permeability enhancement and tissue damage were explored in rabbits using a clinical-prototype hemispherical phased array developed in-house, with real-time 3D MB cavitation imaging for exposure calibration. Initial experiments revealed that continuous manual agitation of MBs during infusion resulted in greater gadolinium (Gd) extravasation compared to gravity drip infusion. Subsequent experiments used low-dose MB infusion with continuous agitation and a low burst repetition frequency (0.2 Hz) to mimic conditions amenable to long-duration clinical treatments. Results: Key sonication parameters—target level (proportional to peak negative pressure), number of bursts, and burst length—significantly affected BBB permeability enhancement, with all parameters displaying a positive relationship with relative Gd contrast enhancement (p < 0.01). Even at high levels of BBB permeability enhancement, tissue damage was minimal, with low occurrences of hypointensities on T2*-weighted MRI. When accounting for relative Gd contrast enhancement, burst length had a significant impact on red blood cell extravasation detected in histological sections, with 1 ms bursts producing significantly greater levels compared to 10 ms bursts (p = 0.03), potentially due to the higher pressure levels required to generate equal levels of BBB permeability enhancement. Additionally, albumin and IgG extravasation correlated strongly with relative Gd contrast enhancement across sonication parameters, suggesting that protein extravasation can be predicted from non-invasive imaging. Conclusions: These findings contribute to the development of safer and more effective clinical protocols for FUS + MB exposure, potentially improving the efficacy of the approach. Full article

Attitude information is as important as position information in describing and localizing objects. Based on this, this paper proposes a method for object attitude sensing utilizing ultra-high frequency passive RFID technology. This method adopts a double tag array strategy, which effectively enhances the spatial freedom and eliminates phase ambiguity by leveraging the phase difference information between the two tags. Additionally, we delve into the issue of the phase shift caused by coupling interference between the two tags. To effectively compensate for this coupling effect, a series of experiments were conducted to thoroughly examine the specific impact of coupling effects between tags, and based on these findings, a coupling model between tags was established. This model was then integrated into the original phase model to correct for the effects of phase shift, significantly improving the sensing accuracy. Furthermore, we considered the influence of the object rotation angle on phase changes to construct an accurate object attitude recognition and tracking model. To reduce random errors during phase measurement, we employed a polynomial regression method to fit the measured tag phase information, further enhancing the precision of the sensing model. Compared to traditional positioning modes, the dual-tag array strategy essentially increases the number of virtual antennas available for positioning, providing the system with more refined directional discrimination capabilities. The experimental results demonstrated that incorporating the effects of inter-tag coupling interference and rotation angle into the phase model significantly improved the recognition accuracy for both object localization and attitude angle determination. Specifically, the average error of object positioning was reduced to 12.3 cm, while the average error of attitude angle recognition was reduced to 8.28°, making the method suitable for various practical application scenarios requiring attitude recognition. Full article

This article presents a symmetrical reduced-size eight-element MIMO antenna array with high electromagnetic isolation among radiators. The array utilizes easy-to-build techniques to cover the n77 and n78 new radio (NR) bands. It is based on an octagonal double-negative metamaterial split-ring resonator (SRR), which enables a size reduction of over 50% for the radiators compared to a conventional disc monopole antenna by increasing the slow-wave factor. Additionally, due to the extreme proximity between the radiating elements in the array, the modal significance (MS) method was employed to identify which propagation modes had the most impact on the electromagnetic coupling among elements. This approach aimed to mitigate their effect by using an electromagnetic barrier, thereby enhancing electromagnetic isolation. The electromagnetic barriers, implemented with strip lines, achieved isolation values exceeding 20 dB for adjacent elements (<0.023 λ) and approaching 40 dB for opposite ones (<0.23 λ) after analyzing the surface current distribution by the MS method. The elements are arranged in axial symmetry, forming an octagon with each antenna port located on a side. The array occupies an area of 0.32 λ² at 3.5 GHz, significantly smaller than previously published works. It exhibits excellent performance for MIMO applications, demonstrating an envelope correlation coefficient (ECC) below 0.0001, a total active reflection coefficient (TARC) lower than −10 dB for various incoming signals with random phases, and a diversity gain (DG) close to 20 dB. Full article

Photovoltaic energy (PV) is considered one of the pillars of the energy transition. However, this energy source is limited by a power density per unit surface lower than 200 W/m², depending on the latitude of the installation site. Compared to fossil fuels, such low power density opens a sustainability issue for this type of renewable energy in terms of its competition with other land uses, and forces us to consider areas suitable for the installation of photovoltaic arrays other than farmlands. In this frame, floating PV plants, installed in internal water basins or even offshore, are receiving increasing interest. On the other hand, this kind of installation might significantly affect the water ecosystem environment in various ways, such as by the effects of solar shading or of anchorage installation. As a result, monitoring of floating PV (FPV) plants, both during the ex ante site evaluation phase and during the operation of the PV plant itself, is therefore necessary to keep such effects under control. This review aims to examine the technical and academic literature on FPV plant monitoring, focusing on the measurement and discussion of key physico-chemical parameters. This paper also aims to identify the additional monitoring features required for energy assessment of a floating PV system compared to a ground-based PV system. Moreover, due to the intrinsic difficulty in the maintenance operations of PV structures not installed on land, novel approaches have introduced autonomous solutions for monitoring the environmental impacts of FPV systems. Technologies for autonomous mapping and monitoring of water bodies are reviewed and discussed. The extensive technical literature analyzed in this review highlights the current lack of a cohesive framework for monitoring these impacts. This paper concludes that there is a need to establish general guidelines and criteria for standardized water quality monitoring (WQM) and management in relation to FPV systems. Full article