Search Results (812)

Traditionally, garlic has a valuable role in preventing and reducing the incidence of many diseases and pathophysiological disorders. Consequently, some researchers have focused on the beneficial cardiovascular properties of diallyl trisulfide (DATS), the most potent polysulfide isolated from garlic. Therefore, in this review, we collected the available data on DATS, its biochemical synthesis, metabolism and pharmacokinetics, and gathered the current knowledge and the role of DATS in cardiovascular diseases. Overall, this review summarizes the cardioprotective effects of DATS and brings together all previous findings on its protective molecular mechanisms, which are mainly based on the potent anti-apoptotic, anti-inflammatory, and antioxidant potential of this polysulfide. Our review is an important cornerstone for further basic and clinical research on DATS as a new therapeutic agent for the treatment of numerous heart diseases. Full article

The Allium genus belongs to the family Amaryllidaceae. These species are native to the Northern Hemisphere and grow in various regions. Among Lithuania’s perennial Allium plant species, the most well known and cultivated are Allium schoenoprasum L., Allium angulosum L., Allium nutans L., Allium fistulosum L., and Allium ursinum L. These Allium species are important for practical insights and are discussed in this review to present their specific features. The changing climate impacts perennial plants’ agrobiological and nutritional properties, but not all kinds can adapt to new conditions, reducing species diversity. Perennial Allium species adapt well in local growing areas, but yields remain constant or may increase when the bulbs are transplanted under conditions similar to the plant’s native growing location. In addition, the susceptibility of garlic to pests and pathogens also poses a serious threat to genetic resources stored in uncontrolled field collections. Since ancient times, Allium species have played a significant role in the human diet, in traditional medicine for many ailments the treatment of, and in official medicine as a supplemental ingredient. This review analyzes the nutritional importance and consumption of the perennial Allium species, their biochemical composition, and their tolerance to environmental conditions. Full article

Garlic constitutes a significant small-scale agricultural commodity in China. A key factor influencing garlic prices is the planted area, which can be accurately and efficiently determined using remote sensing technology. However, the spectral characteristics of garlic and winter wheat are easily confused, and the widespread intercropping of these crops in the study area exacerbates this issue, leading to significant challenges in remote sensing image analysis. Additionally, remote sensing data are often affected by weather conditions, spatial resolution, and revisit frequency, which can result in delayed and inaccurate area extraction. In this study, historical data were utilized to restore Sentinel-2 remote sensing images, aimed at mitigating cloud and rain interference. Feature combinations were devised, incorporating two vegetation indices into a comprehensive time series, along with Sentinel-1 synthetic aperture radar (SAR) time series and other temporal datasets. Multiple classification combinations were employed to extract garlic within the study area, and the accuracy of the classification results was systematically analyzed. First, we used passive satellite imagery to extract winter crops (garlic, winter wheat, and others) with high accuracy. Second, we identified garlic by applying various combinations of time series features derived from both active and passive remote sensing data. Third, we evaluated the classification outcomes of various feature combinations to generate an optimal garlic cultivation distribution map for each region. Fourth, we developed a garlic fragmentation index to assess the impact of landscape fragmentation on garlic extraction accuracy. The findings reveal that: (1) Better results in garlic extraction can be achieved using active–passive time series remote sensing. The performance of the classification model can be further enhanced by incorporating short-wave infrared bands or spliced time series data into the classification features. (2) Examination of garlic cultivation fragmentation using the garlic fragmentation index aids in elucidating variations in accuracy across the study area’s six counties. (3) Comparative analysis with validation samples demonstrated superior garlic extraction outcomes from the six primary garlic-producing counties of the North China Plain in 2021, achieving an overall precision exceeding 90%. This study offers a practical exploration of target crop identification using multi-source remote sensing data in mixed cropping areas. The methodology presented here demonstrates the potential for efficient, cost-effective, and accurate garlic classification, which is crucial for improving garlic production management and optimizing agricultural practices. Moreover, this approach holds promise for broader applications, such as nationwide garlic mapping. Full article

This experiment was conducted to determine the nutrient composition of three agricultural by-products, namely garlic peel, sweet potato vine, and cotton straw, calculate their relative feeding value, effective energy value, and other indexes, and comprehensively evaluate their nutrient value by combining with rumen in vitro fermentation technology, with the aim of providing data references for the development and utilization of non-conventional feed resources for ruminants. The results showed that: 1) the dry matter (DM), ash, ether extract (EE), and crude protein (CP) contents of cotton straw were significantly higher than the other two feeds (p < 0.05), while the acid detergent fiber (ADF) and neutral detergent fiber (NDF) contents of garlic peel were highly significantly higher than the others (p < 0.05); 2) the relative feed value (DMI, DDM, TDN, RFV, and RFQ) and effective energy value (GE, DE, ME, NE_m, NE_g, and NE_L) indexes of cotton straw were significantly higher than garlic peel and sweet potato vine (p < 0.01); 3) after 48 h of in vitro fermentation, the dry matter degradation rate (IVDMD) of sweet potato vine was significantly higher than the other two feeds (p < 0.01), and the cumulative gas productions (mL) and estimated gas parameters (a, b, a + b, and c) of sweet potato vine were significantly (p < 0.01) higher than those of garlic peel and cotton straw; 4) the sweet potato vine had lower pH but higher NH₃-N compared to garlic peel and cotton straw (p < 0.05). The sweet potato vine had higher propionate, iso-butyrate, butyrate, iso-valerate, and total VFA than the other two roughages, which also had the lowest acetate-to-propionate ratio. Garlic peel produced the lowest acetate, while it produced the highest valerate (p < 0.05). These findings demonstrate that all three by-products have high potential as livestock feed based on their nutritive value parameters. Comparatively, sweet potato vines exhibit higher feeding value due to their relatively moderate NDF content and superior rumen fermentation performance. Full article

Chronic inflammation is a recognized risk factor for various cancers, including prostate cancer (PCa). We aim to explore the potential protective effects of aged black garlic extract (ABGE) against inflammation-induced prostate damage and its impact on prostate cancer cell lines. We used an ex vivo model of inflammation induced by Escherichia coli lipopolysaccharide (LPS) on C57BL/6 male mouse prostate specimens to investigate the anti-inflammatory properties of ABGE. The gene expression levels of pro-inflammatory biomarkers (COX-2, NF-κB, and TNF-α, IL-6) were measured. Additionally, we evaluated ABGE’s therapeutic effects on the prostate cancer cell lines through in vitro functional assays, including colony formation, tumorsphere formation, migration assays, and phosphorylation arrays to assess the signaling pathways (MAPK, AKT, JAK/STAT, and TGF-β). ABGE demonstrated significant anti-inflammatory and antioxidant effects in preclinical models, partly attributed to its polyphenolic content, notably catechin and gallic acid. In the ex vivo model, ABGE reduced the gene expression levels of COX-2, NF-κB, TNF-α, and IL-6. The in vitro studies showed that ABGE inhibited cell proliferation, colony and tumorsphere formation, and cell migration in the prostate cancer cells, suggesting its potential as a therapeutic agent. ABGE exhibits promising anti-inflammatory and anti-cancer properties, supporting further investigation into ABGE as a potential agent for managing inflammation and prostate cancer. Full article

Fried potato products are the largest dietary source of acrylamide, a potential carcinogen formed at high temperatures. Previous studies suggested that garlic powder could decrease the development of acrylamide; however, there has not been much focus on the effect of garlic extract. The aim of this study was to investigate the effect of garlic extract exposure on the development of acrylamide in French fries in popular home cooking techniques such as pan-frying, air-frying, and oven-frying. Initially, the antioxidative profile, total phenolic content, and chlorogenic acid content of garlic were analyzed. Subsequently, potatoes were treated with garlic extract and fried using pan-frying, air-frying, and oven-frying techniques. Acrylamide levels were then quantified through HPLC and compared to control groups. The findings showed that garlic exposure increased the acrylamide formation in French fries obtained with air-frying (311.95 ± 0.5 μg/kg) and with oven-frying (270.32 ± 23.4 μg/kg) (p < 0.005 *). This study offers new insights into varying acrylamide formation levels in domestic practices. Unlike previous studies, this study is the first to question the effect of aqueous garlic extract exposure. Further research is required to comprehend the interaction between garlic exposure and acrylamide formation in household settings. Full article

Hypertension is a major risk factor for heart disease and stroke. Garlic has a long history of use in traditional medicine for various conditions, including hypertension. This narrative review examined the scientific evidence on the efficacy of garlic in lowering blood pressure. It explores the historical uses of garlic in different cultures for medicinal purposes and delves into the phytochemical composition of garlic, highlighting key components, like allicin and ajoene, that are believed to contribute to its potential health benefits. Clinical studies that investigated the effects of garlic and garlic-based supplements on blood pressure are presented, with the findings suggesting that garlic consumption may modestly reduce blood pressure, particularly in individuals with mild hypertension. Potential mechanisms of action include increased nitric oxide production, improved endothelial function, and antioxidant properties. While garlic may offer some benefits for blood pressure management, it should not be considered a substitute for conventional antihypertensive medications. Further large-scale, long-term clinical trials are warranted to establish the efficacy of garlic in managing hypertension, including the optimal dosage and formulation. Full article

Garlic is an important vegetable and condiment that has good medical and health care effects. At present, the origin of Chinese garlic and its association with other types of quality are limited to the molecular marker level, and there are few reports at the genome level. Therefore, this study is based on the specific length amplified fragment sequencing (SLAF-seq) of 102 copies of garlic germplasm resources, the group structure, and further screening of the core germplasm. SLAF-seq of 102 garlic cultivars yielded 1949.85 Mb of clean data and 526,432,275 SNPs. Through principal component analysis, evolutionary tree, population structure, and genetic relationship analysis, all garlic cultivars were divided into 3 groups. Among them, Group 1 contains 45 Chinese cultivars and 1 Egyptian cultivar, which are distributed mainly in the coastal and central areas of China. Group 2 contains 36 Chinese cultivars and 1 U.S. cultivar, which are distributed mainly in Northwest China. Group 3 contains 19 Chinese cultivars, which are distributed mainly in Xinjiang, China. The genetic diversity results indicate that the fixation index (Fst) values of Group 1 and Group 2 are lower than those of Group 1 and Group 3 and that the diversity of nucleotides (π) of Group 3 is greater than those of Group 2 and Group 1. Finally, the 30 parts of the cultivars were used as the core germplasms, and there was no difference between the two cultivars in terms of core quality. In summary, this study provides tags for the determination of garlic molecular markers and genotypes and provides a theoretical basis for subsequent resource protection and utilization, genetic positioning of important agronomic traits, and molecular marking agglomeration breeding. Full article

To seek a restoration plan for the safe use of agricultural land around mining areas, this study focuses on the regions around a mining plant in Huidong County, western Sichuan Province, affected by lead–zinc mining, and the precise remediation of heavy metal pollution through large-scale synthesis of iron silicate. In this study, we investigated heavy metal pollution in the vicinity of the mining area and proposed a treatment strategy using large-scale synthesis of iron silicate to mitigate this pollution. According to field investigation and sampling analysis, the collected soil samples contained excessive Cd, Pb, and Zn. Cd is a heavy metal related to lead–zinc mining. The planting of crops such as loquats and garlic with a high accumulation coefficient for Cd was found inappropriate for the research area. Instead, it was recommended to plant economically important crops like mangoes and peaches which had lower heavy metal accumulation. On the basis of field investigation, the study area was seriously polluted by heavy metals, among which Cd was 4.0 times higher than the standard of agricultural land. In order to accurately passivate excessive Cd, Zn, and Pb, iron silicate material was put into mass production. In situ passivation experiments showed that when the soil water content was between 25% and 20%, adding 4% silicate material could rapidly reduce the content of effective heavy metals in the soil and the heavy metal content of garlic and other cash crops in the research area by about 8%. After conducting a field investigation, it has been determined that the large-scale preparation of iron silicate can accurately repair soil contaminated by heavy metals in the vicinity of mining areas. In conclusion, iron silicate is capable of effectively reducing the pollution of heavy metals on agricultural land and facilitating the safe utilization of such land. Full article

This study investigates the effect of daily consumption of a concentrated garlic and onion extract on COVID-19 symptoms among elderly nursing home residents. Volunteers consumed a daily capsule of the concentrated powder rich in organosulfur compounds over 36 weeks during lunch. The incidence and severity of COVID-19 symptoms between the treatment and control groups were compared, along with monitoring the safety of consumption, incidence of other diseases, and medicine usage. The treatment group showed a significant reduction in both the number and severity of COVID-19 symptoms compared to the control group, with no significant adverse effects observed. No significant reduction in symptom duration was detected. This study provides preliminary evidence that concentrated garlic and onion extract may aid in the treatment of COVID-19 among older adults. These findings suggest potential public health benefits, emphasizing the need for further research to explore the immunomodulatory properties of these natural compounds. Full article

A survey of plant parasitic nematodes was carried out in 650 garlic fields in Korea from 2020 to 2022. Migratory endoparasite nematodes (Ditylenchus sp.) were recovered from 6% of the garlic samples, with an average density of 494 individuals per garlic bulb. The morphological characteristics of males and females from the 2022 survey were very similar to D. destructor, but D. dipsaci was not found. The Korean population traits have a lateral field containing six incisures, and the posterior esophagus part overlaps the intestine dorsally. PCR and DNA sequencing were performed for the D2/D3 region of the ribosomal DNA 28S and the ITS region, and the phylogenetic analysis strongly supports the monophyly of D. destructor. This is the first report of D. destructor parasitizing garlic in the Republic of Korea. In Korea, due to changes in agricultural or environmental conditions, the most damaging potential PPNs changed from D. dipsaci to D. destructor in garlic cultivation. Full article

Dehydrated integral forage palm cladode flour (FPF) presents a promising nutritional and functional approach to enriching fettuccine-type pasta. This study investigated the use of microwave-dehydrated FPF (at 810 W) as a partial wheat flour substitute (0, 5, 10, 15, and 20% w/w) in fresh and dry fettuccine-type pasta. The thermomechanical properties of flour blends and the technological and sensory attributes of the resulting pasta were evaluated. FPF displayed a high protein (15.80%), mineral (15.13%), dietary fiber (67.35%), and total soluble phenolic compound (251 mg EAG·100 g⁻¹) content. While water absorption (~58%) and dough stability remained consistent across formulations, a decrease in maximum torque during heating was observed (p < 0.05). Fettuccine-type pasta containing 10% FPF exhibited an acceptable optimal cooking time, solid loss, weight gain, and textural properties for both fresh and dry pasta. Sensory evaluation revealed acceptability above 63% for pasta with 10% FPF, with a slight preference for the fresh version. Fresh pasta flavored with garlic and extra virgin olive oil (garlic and oil pasta) achieved a sensory acceptance rate of 79.67%. These findings demonstrate the potential of FPF for fettuccine-type pasta production, contributing desirable technological characteristics and achieving acceptable sensory profiles. Full article

Pastas enriched with vegetables are premium nutritious products and their consumption can bring significant health benefits. Recent studies have reported a high content of bioavailable phytochemical compounds in Allium ursinum L.; as such, it can be used in the development of functional food products. This study involved the evaluation of 10 varieties of pasta. Five of these varieties were made from white flour and varying amounts of egg (Ctrl_1–Ctrl_5). The other five varieties (AU_1–AU_5) contained fresh shredded wild garlic leaves in equal proportions (20 g) in addition to the corresponding ingredients (white flour and egg). All pasta variants were investigated for their cooking properties and the presence of bioactive compounds and antioxidant capacity in the raw and cooked pasta. Sensory analysis was conducted on all types of cooked pasta, and results indicated that the pasta with the least quantity of eggs was the most favoured variant. Additionally, the pasta that was enhanced with wild garlic leaves received the highest rating for “overall quality”. According to our results, the optimal cooking time (OCT) increased when the quantity of eggs was raised, but when wild garlic leaves were present, OCT decreased in comparison to the control samples. A significant decrease (p < 0.05) in the cooking parameters, swelling index, and water absorption was observed in both egg pasta (Ctrl) and egg pasta enriched with A. ursinum L. (AU). However, compared to the corresponding egg pasta, the presence of wild garlic in pasta generally produced higher values in SI and WA. Pastas enriched with wild garlic are rich in polyphenols (TPh), with a content ranging from 82.44 to 94.62 µg GAE/g dw, and also exhibit antioxidant properties. The amount of total polyphenol significantly decreases (p < 0.05) during cooking varies depending on the composition of the pasta. The pasta with the highest egg content (AU_5) had the lowest loss of polyphenols, equivalent to 55.35%. Our investigations indicate that producing pasta with eggs and fresh wild garlic leaves results in a valuable food product with a good sensory score, enriched in bioactive components, with essential nutrients that maintains cooking qualities. Full article

Zinc oxide nanoparticles (ZnO NPs) have gathered interest because of their unique characteristics and potential applications. In the current work, ZnO NPs underwent an eco-friendly biosynthesis process using garlic peel extract. The biosynthesized ZnO NPs were characterized using different analyses including Ultraviolet-visible (UV-vis) spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FTIR). The produced ZnO NPs exhibited a UV–vis spectrum absorption peak at 365 nm, thus indicating the formation of ZnO NPs. The SEM showed that the biosynthesized ZnO NPs had an irregular surface morphological shape with an average size of 17 nm, according to the DLS analysis. Based on the FTIR findings, the bioactive functional groups responsible for stabilizing and capping the ZnO-NPs were confirmed. The biosynthesized ZnO NPs exhibited 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and antimicrobial activities against Gram-positive (Bacillus cereus) and Gram-negative bacteria (Klebsiella pneumonia). Therefore, the plant-mediated biosynthesized ZnNPs can be considered a promising candidate as an antioxidant and antimicrobial agent against pathogenic microbes found in different areas such as food safety and agriculture. Through the utilization of bioinformatics, we identified six potential targets for drug development in K. pneumonia and B. cereus, along with their corresponding interacting residues with zinc oxide nanoparticles. Additionally, our research revealed that the zinc oxide nanoparticles exhibited binding capabilities with the sulfiredoxin domain located at the specific targets of K. pneumonia, a crucial mechanism responsible for the repair of bacterial cells under oxidative stress. Full article

The increasing consumption of food supplements demands the development of improved analytical methodologies to ensure their quality and authenticity. In this paper, two new approaches, liquid chromatography coupled to mass spectrometry (LC-MS) and flow injection analysis-(electrospray ionization) mass spectrometry (FIA-(ESI)MS), were optimized and validated for their application in the quantitative analysis of bioactive S-allyl-L-cysteine (SAC) in commercial aged garlic supplements (AGS). Although both methodologies were found to be useful for the sensitive and precise quantitation of SAC, the LC-MS approach allowed the differential determination of SAC and its bioactive diastereoisomer, S-1-propenyl-L-cysteine (S1PC), together with the identification of a number of organosulfur compounds typical of garlic. Mass fingerprints by FIA-(ESI)MS were proposed as an advantageous alternative to LC-MS analysis when the fast (4 min/sample) screening of AGS for their SAC content is intended, as in applications aimed at high-throughput quality control or standardization. Finally, the results gathered by the application of these two methodologies evidenced the highly variable composition of commercial AGS, as well as the identification of a number of potential composition frauds affecting their genuineness and benefits on health. Full article