[go: up one dir, main page]

 
 
Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (37)

Search Parameters:
Keywords = elastica

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
12 pages, 3741 KiB  
Article
Analysis of the Stability of a Flat Textiles with a Two-Parameter Deflection Curve
by Piotr Szablewski
Materials 2024, 17(2), 503; https://doi.org/10.3390/ma17020503 - 20 Jan 2024
Viewed by 660
Abstract
The issue of large deflections of textiles occurs primarily when analyzing the “drape” of curtains, tablecloths and other flat textile products. The correct drape is particularly important from an aesthetic point of view. Additionally, there is a problem with the stability of the [...] Read more.
The issue of large deflections of textiles occurs primarily when analyzing the “drape” of curtains, tablecloths and other flat textile products. The correct drape is particularly important from an aesthetic point of view. Additionally, there is a problem with the stability of the folds created during the drape process. The analysis of this problem is difficult due to the occurrence of large deflections and non-linear properties of the material. In this article, a selected fragment of the above-mentioned issue was tested, relating only to the stability of the fold formed under given loading conditions. A typical example is a fabric resting on a flat surface and loaded with compressive forces. The presented considerations lead to obtaining the deflection curve for a given self-weight and compressive force. Additionally, the obtained shape was tested for stability. Two shape parameters used in the analysis can be applied for the simulation of different shapes of the deflection curve. The analysis has been made using the energy method relating to the total potential energy of the object. The obtained results may be used in algorithms and simulation programs for fabric folding, buckling and for another applications in the area of textile mechanics. Full article
(This article belongs to the Section Mechanics of Materials)
Show Figures

Figure 1

Figure 1
<p>The model of fabric approximated by elastica.</p>
Full article ">Figure 2
<p>Elastica loaded with compressive forces.</p>
Full article ">Figure 3
<p>Forces acting on an infinitesimal section of elastica.</p>
Full article ">Figure 4
<p>The different shapes of the deflection curve according to Equation (5).</p>
Full article ">Figure 5
<p>The graph of function <span class="html-italic">w</span>(<span class="html-italic">a</span>,<span class="html-italic">b</span>).</p>
Full article ">Figure 6
<p>The graph of function <span class="html-italic">p</span>(<span class="html-italic">a</span>,<span class="html-italic">b</span>).</p>
Full article ">Figure 7
<p>The sample point of state of equilibrium for <span class="html-italic">p</span> = 10 and <span class="html-italic">w</span> = 12.</p>
Full article ">Figure 8
<p>Areas of equilibrium states for <span class="html-italic">p</span> = 1.5.</p>
Full article ">Figure 9
<p>Areas of equilibrium states for <span class="html-italic">p</span> = 12.</p>
Full article ">Figure 10
<p>Admissible area of parameters <span class="html-italic">a</span> and <span class="html-italic">b</span>.</p>
Full article ">
18 pages, 409 KiB  
Review
Assessment of Connective Tissue in the Equine Uterus and Cervix: Review of Clinical Impact and Staining Options
by Łukasz Zdrojkowski, Bartosz Pawliński, Katarzyna Skierbiszewska, Tomasz Jasiński and Małgorzata Domino
Animals 2024, 14(1), 156; https://doi.org/10.3390/ani14010156 - 3 Jan 2024
Cited by 3 | Viewed by 1267
Abstract
Uterine diseases stand as the primary cause of infertility in mares; however, the diagnostic process often relies on obtaining endometrial biopsies and their hematoxylin–eosin staining. This review seeks to present the variability of uterine changes and their impact on fertility and underscore the [...] Read more.
Uterine diseases stand as the primary cause of infertility in mares; however, the diagnostic process often relies on obtaining endometrial biopsies and their hematoxylin–eosin staining. This review seeks to present the variability of uterine changes and their impact on fertility and underscore the utility of special stains, such as Masson trichrome, picrosirius red, elastica van Gieson, or periodic acid–Schiff, in enhancing diagnostic breadth. Connective tissue evaluation in the cervix is discussed, as it is subjected to cyclic changes and the impact on overall fertility. Vascular changes, particularly prevalent in multiparous mares, play a crucial role in adapting to physiological and pathological alterations, affecting early gestation and impeding placental development. Given that uterine vascular pathologies often involve fibrotic changes, connective tissue stains emerge as a valuable tool in this context. Moreover, equine endometriosis, predominantly associated with endometrial fibrosis, further highlights the relevance of special stains, suggesting their underutilization in the diagnostic process. Recognizing the subjective nature of diagnosing uterine pathologies and the need for additional diagnostic tools, we advocate for using dedicated stains in the histopathological evaluation of uterine samples. In conclusion, we encourage scientists and diagnosticians to embrace additional tools that enhance pathology visualization, enabling more reliable diagnoses concerning expected fertility. Full article
(This article belongs to the Special Issue Advances in Equine Reproduction)
13 pages, 7529 KiB  
Article
Indication of Light Stress in Ficus elastica Using Hyperspectral Imaging
by Pavel A. Dmitriev, Boris L. Kozlovsky, Anastasiya A. Dmitrieva, Vladimir S. Lysenko, Vasily A. Chokheli and Tatyana V. Varduni
AgriEngineering 2023, 5(4), 2253-2265; https://doi.org/10.3390/agriengineering5040138 - 1 Dec 2023
Viewed by 1159
Abstract
Hyperspectral imaging techniques are widely used to remotely assess the vegetation and physiological condition of plants. Usually, such studies are carried out without taking into account the light history of the objects (for example, direct sunlight or light scattered by clouds), including light-stress [...] Read more.
Hyperspectral imaging techniques are widely used to remotely assess the vegetation and physiological condition of plants. Usually, such studies are carried out without taking into account the light history of the objects (for example, direct sunlight or light scattered by clouds), including light-stress conditions (photoinhibition). In addition, strong photoinhibitory lighting itself can cause stress. Until now, it is unknown how light history influences the physiologically meaningful spectral indices of reflected light. In the present work, shifts in the spectral reflectance characteristics of Ficus elastica leaves caused by 10 h exposure to photoinhibitory white LED light, 200 μmol photons m−2 s−1 (light stress), and moderate natural light, 50 μmol photons m−2 s−1 (shade) are compared to dark-adapted plants. Measurements were performed with a Cubert UHD-185 hyperspectral camera in discrete spectral bands centred on wavelengths from 450 to 950 nm with a 4 nm step. It was shown that light stress leads to an increase in reflection in the range of 522–594 nm and a decrease in reflection at 666–682 nm. The physiological causes of the observed spectral shifts are discussed. Based on empirical data, the light-stress index (LSI) = mean(R666:682)/mean(R552:594) was calculated and tested. The data obtained suggest the possibility of identifying plant light stress using spectral sensors that remotely fix passive reflection with the need to take light history into account when analysing hyperspectral data. Full article
Show Figures

Figure 1

Figure 1
<p>Hyperspectral imaging of <span class="html-italic">F. elastica</span> leaves. (<b>A</b>) Cubert UHD-185; (<b>B</b>) object of study; (<b>C</b>) artificial light sources for HSI.</p>
Full article ">Figure 2
<p>Integral spectrum of artificial light sources reflected from a white standard. Measured with a Cubert UHD 185 camera with a 4 nm step.</p>
Full article ">Figure 3
<p>Block diagram of an experiment to study shifts in the spectral reflection characteristics of <span class="html-italic">F. elastica</span> leaves in the range of 450–950 nm. Var 1, light stress—10 h exposure to the photoinhibitory light (200 µmol photons m<sup>−2</sup> s<sup>−1</sup>); Var. 2, shade—moderate light (50 µmol photons m<sup>−2</sup> s<sup>−1</sup>); Var 3—dark-adapted plants. HSI 1–4—plant HSI; LC 0–2—light conditions; Rp 1–2—repetition of the experiment.</p>
Full article ">Figure 4
<p>The −log<sub>10</sub><span class="html-italic">p</span> values, depending on the SB, when comparing variants (Var. 1, Var. 2, Var. 3; LC 2) by pairs. (<b>A</b>)—<span class="html-italic">t</span>-test (HSI 3); (<b>B</b>)—<span class="html-italic">t</span>-test (HSI 5).</p>
Full article ">Figure 5
<p>Ranking SBs by their contribution to mean decrease accuracy and mean decrease Gini.</p>
Full article ">Figure 6
<p>Pairs of SBs that make the greatest contribution to the decrease in the OOB estimate of the error rate.</p>
Full article ">Figure 7
<p>Boxplots of LSI 1, LSI 2, and LSI 3 values of three LC 2 variants (Var. 1, Var. 2, and Var. 3) based on the results of HSI 3 and HSI 5.</p>
Full article ">Figure 8
<p>The most significant SB and LSI for indicating light stress in ficuses, depending on the mean decrease accuracy and the mean decrease Gini.</p>
Full article ">Figure 9
<p>Boxplots of LSI 3 values compared to the values of the individual most significant SB.</p>
Full article ">Figure 10
<p>The most significant VIs for identifying ficus light stress, depending on the mean decrease accuracy and mean decrease Gini.</p>
Full article ">Figure 11
<p>Boxplots of LSI 3 values compared to individual most significant VIs.</p>
Full article ">Figure 12
<p>Distribution of the LSI 3 values of three LC 2 variants (Var. 1, Var. 2, and Var. 3) according to the results of HSI 3 and HSI 5 simultaneously.</p>
Full article ">Figure 13
<p>Distribution of mean(R<sub>666:682</sub>) against mean(R<sub>522:594</sub>) values of three variants (Var. 1, Var. 2, and Var. 3) for HSI 3 and HSI 5.</p>
Full article ">
17 pages, 6322 KiB  
Article
Three-Dimensional Surface Reconstruction from Point Clouds Using Euler’s Elastica Regularization
by Jintao Song, Huizhu Pan, Yuting Zhang, Wenqi Lu, Jieyu Ding, Weibo Wei, Wanquan Liu, Zhenkuan Pan and Jinming Duan
Appl. Sci. 2023, 13(23), 12695; https://doi.org/10.3390/app132312695 - 27 Nov 2023
Cited by 1 | Viewed by 892
Abstract
Euler’s elastica energy regularizer, initially employed in mathematical and physical systems, has recently garnered much attention in image processing and computer vision tasks. Due to the non-convexity, non-smoothness, and high order of its derivative, however, the term has yet to be effectively applied [...] Read more.
Euler’s elastica energy regularizer, initially employed in mathematical and physical systems, has recently garnered much attention in image processing and computer vision tasks. Due to the non-convexity, non-smoothness, and high order of its derivative, however, the term has yet to be effectively applied in 3D reconstruction. To this day, the industry is still searching for 3D reconstruction systems that are robust, accurate, efficient, and easy to use. While implicit surface reconstruction methods generally demonstrate superior robustness and flexibility, the traditional methods rely on initialization and can easily become trapped in local minima. Some low-order variational models are able to overcome these issues, but they still struggle with the reconstruction of object details. Euler’s elastica term, on the other hand, has been found to share the advantages of both the TV regularization term and the curvature regularization term. In this paper, we aim to address the problems of missing details and complex computation in implicit 3D reconstruction by efficiently using Euler’s elastica term. The main contributions of this article can be outlined in three aspects. Firstly, Euler’s elastica is introduced as a regularization term in 3D point cloud reconstruction. Secondly, a new dual algorithm is devised for the proposed model, significantly improving solution efficiency compared to the commonly used TV model. Lastly, numerical experiments conducted in 2D and 3D demonstrate the remarkable performance of Euler’s elastica in enhancing features of curved surfaces during point cloud reconstruction. The reconstructed point cloud surface adheres more closely to the initial point cloud surface when compared to the classical TV model. However, it is worth noting that Euler’s elastica exhibits a lesser capability in handling local extrema compared to the TV model. Full article
Show Figures

Figure 1

Figure 1
<p>The distance function calculated from point cloud data is shown in (<b>c</b>,<b>d</b>). (<b>a</b>) represents 2D point cloud data, while (<b>b</b>) represents 3D point cloud data. The distance function for (<b>a</b>) is shown in (<b>c</b>), and the distance function for (<b>b</b>) is shown in (<b>d</b>).</p>
Full article ">Figure 2
<p>Analyzing annular binary images to extract enclosed pictures. (<b>a</b>) refers to annular binary images for 2D point cloud data, (<b>b</b>) for 3D point cloud data, (<b>c</b>) shows cross sections of the related image in (<b>a</b>), and (<b>d</b>) shows cross sections of the related image in (<b>b</b>).</p>
Full article ">Figure 3
<p>A signed distance function is calculated from binary images. (<b>a</b>) represents a binary image for 2D point cloud data, (<b>b</b>) for 3D point cloud data, (<b>c</b>) displays the corresponding signed distance map for (<b>a</b>), and (<b>d</b>) displays the corresponding signed distance map for (<b>b</b>).</p>
Full article ">Figure 4
<p>The 2D reconstruction results by different models; the first row shows the reconstruction result of point clouds 1, and the second line shows the reconstruction result of point clouds 2. The 1st line: initial surface; the 2nd line: final result by the Chan–Vese model; the 3rd line: final result by the GAC model; the 4th line: final result by the TV method; the 5th line: final results by the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-L1 model; the 6th line: final results by the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-B method; the 7th line: final results by the proposed method.</p>
Full article ">Figure 5
<p>Detailed comparison of the reconstruction results between the TV model and proposed model. From left to right: ground truth; initial surface; reconstruction of the “ball” using the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-B model; reconstruction of the “ball” using the proposed model.</p>
Full article ">Figure 6
<p>Bunny reconstruction results by different models. The 1st line: initial surface; the 2nd line: final result by the Chan–Vese model; the 3rd line: final result by the GAC model; the 4th line: final result by the TV method; the 5th line: final results by the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-L1 model; the 6th line: final results by the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-B method; the 7th line: final results by the proposed method.</p>
Full article ">Figure 7
<p>Hand reconstruction results by different models. The 1st line: initial surface; the 2nd line: final result by the Chan–Vese model; the 3rd line: final result by the GAC model; the 4th line: final result by the TV method; the 5th line: final results by the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-L1 model; the 6th line: final results by the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-B method; the 7th line: final results by the proposed method.</p>
Full article ">Figure 8
<p>Function convergence analysis for bunny and hand. (<b>left</b>) Convergence curve of the different energy function for bunny; (<b>right</b>) convergence curve of the different energy function for hand.</p>
Full article ">Figure 9
<p>Comparison with different <math display="inline"><semantics> <mi>β</mi> </semantics></math>. From left to right are the results of proposed method with <math display="inline"><semantics> <mrow> <mi>β</mi> <mo>=</mo> <mn>0.5</mn> <mo>,</mo> <mn>1</mn> <mo>,</mo> <mn>1.5</mn> <mo>,</mo> <mn>2</mn> </mrow> </semantics></math>. The number of iterations required to reach the convergence condition are 17, 31, 38, and 42.</p>
Full article ">Figure 10
<p>Detailed comparison of the reconstruction results between the TV model and proposed model. The 1st line: reconstruction of the “bunny” using the TV model; the 2nd line: reconstruction of the “bunny” using the proposed model; the 3rd line: reconstruction of the “hand” using the TV model; the 4th line: reconstruction of the “hand” using the proposed model.</p>
Full article ">Figure 11
<p>The errors of the bunny and hand with different reconstruction models. (<b>left</b>) Delaunay tetrahedron errors of different methods in the point clouds data of the bunny; (<b>right</b>) Delaunay tetrahedron errors of different methods in the point clouds data of the hand.</p>
Full article ">Figure 12
<p>Surface reconstruction from point clouds using the proposed method. The 1st row: point clouds; the 2nd row: reconstructed results by the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-B method; the 3rd row: reconstructed results by the proposed variational model.</p>
Full article ">Figure 13
<p>Surface reconstruction from point clouds using the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-B method and the proposed variational method. (<b>a</b>) is the result of the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-B method, (<b>b</b>) is the result of the proposed method, the top of (<b>c</b>) is the result of the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-B method, and the bottom of (<b>c</b>) is the result of the proposed variational method.</p>
Full article ">Figure 14
<p>Face reconstruction from point clouds using the proposed variational method. The 1st row: point clouds; the 2nd row: face reconstructed results by the TV<math display="inline"><semantics> <msub> <mrow/> <mi>g</mi> </msub> </semantics></math>-B method; the 3rd row: face reconstructed results by the proposed variational model.</p>
Full article ">
14 pages, 2568 KiB  
Article
Glissonean Pedicle Isolation Focusing on the Laennec’s Capsule for Minimally Invasive Anatomical Liver Resection
by Mamoru Morimoto, Yoichi Matsuo, Keisuke Nonoyama, Yuki Denda, Hiromichi Murase, Tomokatsu Kato, Hiroyuki Imafuji, Kenta Saito and Shuji Takiguchi
J. Pers. Med. 2023, 13(7), 1154; https://doi.org/10.3390/jpm13071154 - 18 Jul 2023
Cited by 2 | Viewed by 2221
Abstract
Background: Inflow control is one of the most important procedures during anatomical liver resection (ALR), and Glissonean pedicle isolation (GPI) is one of the most efficacious methods used in laparoscopic anatomical liver resection (LALR). Recognition of the Laennec’s capsule covering the liver parenchyma [...] Read more.
Background: Inflow control is one of the most important procedures during anatomical liver resection (ALR), and Glissonean pedicle isolation (GPI) is one of the most efficacious methods used in laparoscopic anatomical liver resection (LALR). Recognition of the Laennec’s capsule covering the liver parenchyma is essential for safe and precise GPI. The purpose of this study was to verify identification of the Laennec’s capsule, to confirm the validity of GPI in minimally invasive surgery, and to demonstrate the value of GPI focusing on the Laennec’s capsule using a robotic system that has been developed in recent years. Methods: We used a cadaveric model to simulate the Glissonean pedicle and the surrounding liver parenchyma for pathologic verification of the layers. We performed 60 LALRs and 39 robotic anatomical liver resections (RALRs) using an extrahepatic Glissonean approach, from April 2020 to April 2023, and verified the layers of the specimens removed during LALR and RALR based on pathologic examination. In addition, the surgical outcomes of LALR and RALR were compared. Results: Histologic examination facilitated by Elastica van Gieson staining revealed the presence of Laennec’s capsule covering the liver parenchyma in a cadaveric model. Similar findings were obtained following LALR and RALR, thus confirming that the gap between the Glissonean pedicle and the Laennec’s capsule can be dissected without injury to the parenchyma. The mean GPI time was 32.9 and 27.2 min in LALR and RALR, respectively. The mean blood loss was 289.7 and 131.6 mL in LALR and RALR, respectively. There was no significant difference in the incidence of Clavien–Dindo grade ≥III complications between the two groups. Conclusions: Laennec’s capsule is the most important anatomical landmark in performing a safe and successful extrahepatic GPI. Based on this concept, it is possible for LALR and RALR to develop GPI focusing on the Laennec’s capsule. Furthermore, a robotic system has the potential to increase the safety and decrease the difficulty of this challenging procedure. Full article
(This article belongs to the Section Methodology, Drug and Device Discovery)
Show Figures

Graphical abstract

Graphical abstract
Full article ">Figure 1
<p><b>Extrahepatic left Glissonean pedicle isolation in a cadaveric model.</b> After dissection between the arantius plate and the liver parenchyma, the dorsal aspect of the left Glissonean pedicle is non-blindly dissected while preserving the Laennec’s capsule (<b>A</b>). The right side of the left Glissonean pedicle and the Laennec’s capsule were separated (<b>B</b>). Pathologic examination using Elastica van Gieson staining proved the presence of the Laennec’s capsule in low- (<b>C</b>) and in high-power fields (black arrows)) (<b>D</b>).</p>
Full article ">Figure 2
<p><b>Laparoscopic second and third branches of the Glissonean pedicle isolation in a live body.</b> Right anterior Glissonean pedicle isolation was performed in laparoscopic right hepatectomy to validate the appropriate layer to be dissected. The space between the cystic plate and the Laennec’s capsule was dissected to expose the Laennec’s capsule (<b>A</b>). The dissection in the same layer as the cystic plate cholecystectomy was continued to the ventral side of the right anterior Glissonean pedicle (<b>B</b>). The Laennec’s capsule on the liver parenchyma and exfoliated right anterior Glissonean pedicle of a live body is shown in low- (<b>C</b>) and high-power fields (black arrows) (<b>D</b>). Glissonean pedicle 8 isolation was performed during a laparoscopic segmentectomy 8. Blunt dissection between the right anterior Glissonean pedicle and the Laennec’s capsule in the direction of the peripheral Glissonean pedicle allowed identification of the Glissonean pedicle 8 (G8) and Glissonean pedicle 5 (G5) (<b>E</b>). The dissection was performed while looking directly at the dorsal aspect of G8 using the laparoscopic magnification effect (<b>F</b>). The Laennec’s capsule on the liver parenchyma and exfoliated G8 is shown in low- (<b>G</b>) and high-power fields (black arrows) (<b>H</b>).</p>
Full article ">Figure 3
<p><b>Robotic second and third branches of Glissonean pedicle isolation in a live body.</b> Right posterior Glissonean pedicle isolation was performed during robotic right posterior sectionectomy. The junction of the right anterior and posterior Glissonean pedicles was identified and exposed the Laennec’s capsule (<b>A</b>). Blunt dissection between the Laennec’s capsule and the right posterior Glissonean pedicle from the caudal view while directly observing the dorsal view with a robotic endoscope (<b>B</b>). The Laennec’s capsule on the liver parenchyma and the exfoliated right posterior Glissonean pedicle of a live body is shown in low- (<b>C</b>) and high-power fields (black arrows) (<b>D</b>). Glissonean pedicle 4a (G4a), 4b (G4b), and 4c (G4c) isolation was performed in robotic segmentectomy 4b. The gap between the umbilical plate and the Laennec’s capsule was separated (<b>E</b>). All responsible branches of the Glissonean pedicle can be isolated without misidentification while directly observing the branches (<b>F</b>). The Laennec’s capsule on the liver parenchyma and the exfoliated Glissonean pedicle is in low- (<b>G</b>) and high-power fields (black arrows0 (<b>H</b>).</p>
Full article ">
8 pages, 34107 KiB  
Communication
Histopathological Characterization of Abdominal Aortic Aneurysms from Patients with Multiple Aneurysms Compared to Patients with a Single Abdominal Aortic Aneurysm
by Daniel Körfer, Philipp Erhart, Susanne Dihlmann, Maani Hakimi, Dittmar Böckler and Andreas S. Peters
Biomedicines 2023, 11(5), 1311; https://doi.org/10.3390/biomedicines11051311 - 28 Apr 2023
Cited by 1 | Viewed by 1368
Abstract
The aim of this study was to investigate histopathological differences in abdominal aortic aneurysms (AAAs) between patients with multiple and single arterial aneurysms, as we suspect that there are different underlying mechanisms in aneurysm formation. Analysis was based on a previous retrospective study [...] Read more.
The aim of this study was to investigate histopathological differences in abdominal aortic aneurysms (AAAs) between patients with multiple and single arterial aneurysms, as we suspect that there are different underlying mechanisms in aneurysm formation. Analysis was based on a previous retrospective study on patients with multiple arterial aneurysms (mult-AA; defined as at least four, n = 143) and a single AAA (sing-AAA, n = 972) who were admitted to our hospital for treatment between 2006 and 2016. Available paraffin-embedded AAA wall specimens were derived from the Vascular Biomaterial Bank Heidelberg (mult-AA, n = 12 vs. sing-AAA, n = 19). Sections were analyzed regarding structural damage of the fibrous connective tissue and inflammatory cell infiltration. Alterations to the collagen and elastin constitution were assessed by Masson–Goldner trichrome and Elastica van Gieson staining. Inflammatory cell infiltration, response and transformation were assessed by CD45 and IL-1β immunohistochemistry and von Kossa staining. The extent of aneurysmal wall alterations was assessed by semiquantitative gradings and was compared between the groups using Fisher’s exact test. IL-1β was significantly more present in the tunica media in mult-AA compared to sing-AAA (p = 0.022). The increased expression of IL-1β in mult-AA compared to sing-AAA indicates inflammatory processes play a role in aneurysm formation in patients with multiple arterial aneurysms. Full article
(This article belongs to the Special Issue The Role of Cytokines in Health and Disease)
Show Figures

Figure 1

Figure 1
<p>AAA wall sections of patient from mult-AA and sing-AAA groups following staining/immunohistochemistry: (<b>a</b>) hematoxylin eosin, (<b>b</b>) Masson–Goldner trichrome, (<b>c</b>) Elastica van Gieson, (<b>d</b>) von Kossa, (<b>e</b>) CD45 and (<b>f</b>) IL-1β. I = tunica intima. M = tunica media. A = tunica adventitia. x = internal elastic membrane. Scale bar, 250 µm.</p>
Full article ">Figure 2
<p>Extent of aneurysmal wall alterations compared dichotomously between mult-AA and sing-AAA groups in respective staining/immunohistochemistry by Fisher’s exact test. The <span class="html-italic">y</span>-axis describes the number of specimens. * statistical significance. (<b>a</b>) Extent of collagen alteration (grade 0–1 vs. grade 2). Masson–Goldner trichrome, <span class="html-italic">p</span> = 0.705. (<b>b</b>) Extent of internal elastic membrane alteration (grade 0–1 vs. grade 2). Elastica van Gieson, <span class="html-italic">p</span> = 0.130. (<b>c</b>) Extent of calcification in tunica media (grade 0–1 vs. grade 2). von Kossa, <span class="html-italic">p</span> = 1. (<b>d</b>) Extent of CD45-associated cell infiltration (grade 0–1 vs. 2–3), CD45. <span class="html-italic">p</span> = 0.262. (<b>e</b>) Extent of IL-1β expression in tunica media (grade 0 vs. grade 1). IL-1β, <span class="html-italic">p</span> = 0.022.</p>
Full article ">
15 pages, 4846 KiB  
Article
Carbon Stock Mapping Utilizing Accumulated Volume of Sequestrated Carbon at Bangladesh Agricultural University, Bangladesh
by Murad Ahmed Farukh, Kamona Rani, Sayed Mohammed Nashif, Rimi Khatun, Lotifa Tamanna Toma, Kimihiko Hyakumura and Kazi Kamrul Islam
Sustainability 2023, 15(5), 4300; https://doi.org/10.3390/su15054300 - 28 Feb 2023
Viewed by 2061
Abstract
The potential to sequester carbon by tree species in tropical regions such as Bangladesh is promising in regard to carbon sequestration (CS) potentiality and reducing CO2 emissions. This study focuses on perennial tree species within 488 hectares of Bangladesh Agricultural University (BAU) [...] Read more.
The potential to sequester carbon by tree species in tropical regions such as Bangladesh is promising in regard to carbon sequestration (CS) potentiality and reducing CO2 emissions. This study focuses on perennial tree species within 488 hectares of Bangladesh Agricultural University (BAU) to assess the CS and to produce a C stock map for BAU. To compute the green and dry weight, weight of C and CO2 sequestration in the tree, a simplified methodology from the National Computational Science Institute of the Shodor Education Foundation was applied. A total of 27,543 trees comprising 424 species were taken into consideration, dividing the whole study area into four segments. B. ceiba and L. acidissima received the maximum and minimum green, dry, and C weight values. The topmost five carbon stock accumulating trees are M. longifolium (264,768 kg yr−1), S. mahagoni (257,290), A. lebbeck (118,310), M. indica (78,906), and T. grandis (51,744) whilst A. lebbeck is the major C stock accumulating tree within BAU. The top five CS potential are found for B. ceiba (181 kg), A. columnaris (139 kg), S. siamea (116 kg), F. elastica (113 kg), and F. religiosa (83 kg). To reveal the prospects of tree species in Bangladesh for emission reduction, the CS potential could be incorporated with the C trading scheme of the CDM (clean development mechanism) of the Kyoto Protocol. Full article
Show Figures

Figure 1

Figure 1
<p>Detailed map of Bangladesh Agricultural University.</p>
Full article ">Figure 2
<p>The major tree species (green bars) with their (<b>a</b>) height (black dashed line, in m), (<b>b</b>) diameter (blue dashed line, in cm), and (<b>c</b>) age (brown dashed line, in yr) within Bangladesh Agricultural University. Here the ‘major’ refers to trees having at least 25 or more in numbers.</p>
Full article ">Figure 3
<p>The major (≥25 in number) tree species with their (<b>a</b>) green weight (green line, in kg), (<b>b</b>) dry weight (blue line, in kg), and (<b>c</b>) C weight or C stock (black line, in kg) within Bangladesh Agricultural University.</p>
Full article ">Figure 4
<p>The major tree species with the amount of sequestrated C tree<sup>−1</sup> within Bangladesh Agricultural University.</p>
Full article ">Figure 5
<p>The interrelation between CS and C stock by the major trees at Bangladesh Agricultural University.</p>
Full article ">Figure 6
<p>C stock accumulation by total tree species year<sup>−1</sup> at Bangladesh Agricultural University.</p>
Full article ">Figure 7
<p>Inverse distance weighted (IDW) interpolation to show C stock at Bangladesh Agricultural University. A comparatively bigger area in the middle of F<sub>AS</sub> contributes zero (0) C stock due to existence of experimental crop fields.</p>
Full article ">Figure 8
<p>Inverse distance weighted (IDW) interpolation to show C stock at Botanical Garden (<b>left panel</b>) and Germ-Plasm Center (<b>right panel</b>) of Bangladesh Agricultural University.</p>
Full article ">
6 pages, 1342 KiB  
Communication
Kirchhoff’s Analogy between the Kapitza Pendulum Stability and Buckling of a Wavy Beam under Tensile Loading
by Rahul Ramachandran and Michael Nosonovsky
Appl. Mech. 2023, 4(1), 248-253; https://doi.org/10.3390/applmech4010014 - 21 Feb 2023
Viewed by 1539
Abstract
The Kirchhoff analogy between the oscillation of a pendulum (in the time domain) and the static bending of an elastic beam (in the spatial domain) is applied to the stability analysis of an inverted pendulum on a vibrating foundation (the Kapitza pendulum). The [...] Read more.
The Kirchhoff analogy between the oscillation of a pendulum (in the time domain) and the static bending of an elastic beam (in the spatial domain) is applied to the stability analysis of an inverted pendulum on a vibrating foundation (the Kapitza pendulum). The inverted pendulum is stabilized if the frequency and amplitude of the vibrating foundation exceed certain critical values. The system is analogous to static bending a wavy (patterned) beam subjected to a tensile load with appropriate boundary conditions. We analyze the buckling stability of such a wavy beam, which is governed by the Mathieu equation. Micro/nanopatterned structures and surfaces have various applications including the control of adhesion, friction, wettability, and surface-pattern-induced phase control. Full article
Show Figures

Figure 1

Figure 1
<p>Ince–Strutt stability diagram for the Mathieu equation. The shaded region represents the domain of stable solutions for a tensile-loaded beam.</p>
Full article ">Figure 2
<p>Solutions to the Mathieu equation for a tensile loaded beam with boundary conditions <italic>z</italic> = 0 at <italic>κ</italic> = 0 and <italic>dz/dκ</italic> = 0 at <italic>κ</italic> = 0. (<bold>a</bold>) Stable solution for <italic>δ</italic> = −0.00025, <italic>ε</italic> = 0.05, and (<bold>b</bold>) unstable solution for <italic>δ</italic> = −0.00035, <italic>ε</italic> = 0.05.</p>
Full article ">Figure 3
<p>The deflection of a beam due to (<bold>a</bold>) compressive load <italic>F</italic> (corresponding to the stable equilibrium of a regular pendulum), and (<bold>b</bold>) tensile load <italic>F</italic> (corresponding to the unstable equilibrium of an inverted pendulum). (<bold>c</bold>) The waviness of the beam would stabilize the equilibrium similarly to the vibrations stabilizing an inverted pendulum (reproduced with permission from [<xref ref-type="bibr" rid="B11-applmech-04-00014">11</xref>]).</p>
Full article ">
11 pages, 1580 KiB  
Article
The Approximate Solution of the Nonlinear Exact Equation of Deflection of an Elastic Beam with the Galerkin Method
by Chencheng Lian, Ji Wang, Baochen Meng and Lihong Wang
Appl. Sci. 2023, 13(1), 345; https://doi.org/10.3390/app13010345 - 27 Dec 2022
Cited by 5 | Viewed by 1980
Abstract
Calculating the large deflection of a cantilever beam is one of the common problems in engineering. The differential equation of a beam under large deformation, or the typical elastica problem, is hard to approximate and solve with the known solutions and techniques in [...] Read more.
Calculating the large deflection of a cantilever beam is one of the common problems in engineering. The differential equation of a beam under large deformation, or the typical elastica problem, is hard to approximate and solve with the known solutions and techniques in Cartesian coordinates. The exact solutions in elliptic functions are available, but not the explicit expressions in elementary functions in expectation. This paper attempts to solve the nonlinear differential equation of deflection of an elastic beam with the Galerkin method by successfully solving a series of nonlinear algebraic equations as a novel approach. The approximate solution based on the trigonometric function is assumed, and the coefficients of the trigonometric series solution are fitted with Chebyshev polynomials. The numerical results of solving the nonlinear algebraic equations show that the third-order approximate solution is highly consistent with the exact solution of the elliptic function. The effectiveness and advantages of the Galerkin method in solving nonlinear differential equations are further demonstrated. Full article
Show Figures

Figure 1

Figure 1
<p>An elastic cantilever beam with essential properties and deformation variables under a point load.</p>
Full article ">Figure 2
<p>A comparison of deflection of the first-order approximation and exact solution of deflection at the end of the beam.</p>
Full article ">Figure 3
<p>A comparison of deflection of the second-order approximation and exact solution of deflection at the end of the beam.</p>
Full article ">Figure 4
<p>A comparison of deflection of the third-order approximation and exact solution of deflection at the end of the beam.</p>
Full article ">
10 pages, 7447 KiB  
Article
Elastic Fibers and F-Box and WD-40 Domain-Containing Protein 2 in Bovine Periosteum and Blood Vessels
by Mari Akiyama
Biomimetics 2023, 8(1), 7; https://doi.org/10.3390/biomimetics8010007 - 23 Dec 2022
Cited by 1 | Viewed by 1584
Abstract
Elastic fibers form vessel walls, and elastic fiber calcification causes serious vascular diseases. Elastin is a well-known elastic fiber component; however, the insoluble nature of elastic fibers renders elastic fiber component analysis difficult. A previous study investigated F-box and WD-40 domain-containing protein 2 [...] Read more.
Elastic fibers form vessel walls, and elastic fiber calcification causes serious vascular diseases. Elastin is a well-known elastic fiber component; however, the insoluble nature of elastic fibers renders elastic fiber component analysis difficult. A previous study investigated F-box and WD-40 domain-containing protein 2 (FBXW2) in the cambium layer of bovine periosteum and hypothesized that fiber structures of FBXW2 are coated with osteocalcin during explant culture. Here, FBXW2 was expressed around some endothelial cells but not in all microvessels of the bovine periosteum. The author hypothesized that FBXW2 is expressed only in blood vessels with elastic fibers. Immunostaining and Elastica van Gieson staining indicated that FBXW2 was expressed in the same regions as elastic fibers and elastin in the cambium layer of the periosteum. Alpha-smooth muscle actin (αSMA) was expressed in microvessels and periosteum-derived cells. Immunostaining and observation of microvessels with serial sections revealed that osteocalcin was not expressed around blood vessels at 6 and 7 weeks. However, blood vessels and periosteum connoted elastic fibers, FBXW2, and αSMA. These findings are expected to clarify the processes involved in the calcification of elastic fibers in blood vessels. Full article
Show Figures

Figure 1

Figure 1
<p>Localization of FBXW2 expression matched that of elastic fibers. (<b>a</b>–<b>d</b>) Fluorescent immunostaining of the periosteum on day 0. Scale bar: 100 μm: (<b>a</b>) Von Willebrand factor: green, 4′,6-diamidino2-phenylindole (DAPI): blue; (<b>b</b>) Alpha-smooth muscle actin (αSMA): green, DAPI: blue; (<b>c</b>) FBXW2: red, Von Willebrand factor: green, DAPI: blue, arrow: microvessel with FBXW2; (<b>d</b>) Elastin: green, DAPI: blue, arrow: microvessel. (<b>e</b>,<b>f</b>) Histology of the periosteum and bone on day 0. P: periosteum, C: cambium layer, B: bone. Scale bar: 100 μm; (<b>e</b>) Elastin: green, DAPI: blue; (<b>f</b>) FBXW2: red, DAPI: blue. For the image, the antibody used was the same as that used in Akiyama’s study (2021); (<b>g</b>) Elastica van Gieson (EVG) staining. Scale bar: 200 μm.</p>
Full article ">Figure 2
<p>Histology of blood vessels: (<b>a</b>) Elastin: red; (<b>b</b>) FBXW2: blue; (<b>c</b>) FBXW2: red, DAPI: blue; (<b>d</b>) FBXW2: red, Von Willebranfactor: green, DAPI: blue; (<b>e</b>) Osteocalcin: green, DAPI: blue. Scale bar: 100 μm.</p>
Full article ">Figure 3
<p>αSMA-positive cells increased during explant culture: (<b>a</b>–<b>e</b>) Fluorescent immunostaining of the periosteum. αSMA: green, DAPI: blue. PDC: Periosteum-derived cells at (<b>a</b>) 1 week; (<b>b</b>) 2 weeks; (<b>c</b>) 3 weeks; (<b>d</b>) 4 weeks; and (<b>e</b>) 5 weeks. Scale bar: 100 μm.</p>
Full article ">Figure 4
<p>Observation of microvessels in serial sections of periosteum after explant culture: (<b>a</b>–<b>d</b>) At 6 weeks. Scale bar: 100 μm. (<b>a</b>) EVG staining; (<b>b</b>) FBXW2: red, DAPI: blue; (<b>c</b>) αSMA: green, DAPI: blue; (<b>d</b>) Osteocalcin: green, DAPI: blue. (<b>e</b>–<b>h</b>) At 7 weeks. Scale bar: 100 μm; (<b>e</b>) EVG staining; (<b>f</b>) FBXW2: red, DAPI: blue; (<b>g</b>) αSMA: green, DAPI: blue; (<b>h</b>) Osteocalcin: green, DAPI: blue. Arrows: blood vessels.</p>
Full article ">
17 pages, 3347 KiB  
Article
Green Synthesis of NiO-SnO2 Nanocomposite and Effect of Calcination Temperature on Its Physicochemical Properties: Impact on the Photocatalytic Degradation of Methyl Orange
by Sirajul Haq, Anum Sarfraz, Farid Menaa, Nadia Shahzad, Salah Ud Din, Hanadi A. Almukhlifi, Sohad A. Alshareef, Ethar M. Al Essa and Muhammad Imran Shahzad
Molecules 2022, 27(23), 8420; https://doi.org/10.3390/molecules27238420 - 1 Dec 2022
Cited by 7 | Viewed by 1750
Abstract
Background: Nickel stannate nanocomposites could be useful for removing organic and toxic water pollutants, such as methyl orange (MO). Aim: The synthesis of a nickel oxide–tin oxide nanocomposite (NiO-SnO2 NC) via a facile and economically viable approach using a leaf extract from [...] Read more.
Background: Nickel stannate nanocomposites could be useful for removing organic and toxic water pollutants, such as methyl orange (MO). Aim: The synthesis of a nickel oxide–tin oxide nanocomposite (NiO-SnO2 NC) via a facile and economically viable approach using a leaf extract from Ficus elastica for the photocatalytic degradation of MO. Methods: The phase composition, crystallinity, and purity were examined by X-ray diffraction (XRD). The particles’ morphology was studied using scanning electron microscopy (SEM). The elemental analysis and colored mapping were carried out via energy dispersive X-ray (EDX). The functional groups were identified by Fourier transform infrared spectroscopy (FTIR). UV–visible diffuse reflectance spectroscopy (UV–vis DRS) was used to study the optical properties such as the absorption edges and energy band gap, an important feature of semiconductors to determine photocatalytic applications. The photocatalytic activity of the NiO-SnO2 NC was evaluated by monitoring the degradation of MO in aqueous solution under irradiation with full light spectrum. The effects of calcination temperature, pH, initial MO concentration, and catalyst dose were all assessed to understand and optimize the physicochemical and photocatalytic properties of NiO-SnO2 NC. Results: NiO-SnO2 NC was successfully synthesized via a biological route using F. elastica leaf extract. XRD showed rhombohedral NiO and tetragonal SnO2 nanostructures and the amorphous nature of NiO-SnO2 NC. Its degree of crystallinity, crystallite size, and stability increased with increased calcination temperature. SEM depicted significant morphological changes with elevating calcination temperatures, which are attributed to the phase conversion from amorphous to crystalline. The elemental analysis and colored mapping show the formation of highly pure NiO-SnO2 NC. FTIR revealed a decrease in OH, and the ratio of oxygen vacancies at the surface of the NC can be explained by a loss of its hydrophilicity at increased temperatures. All the NC samples displayed significant absorption in the visible region, and a blue shift is seen and the energy band gap decreases when increasing the calcination temperatures due to the dehydration and formation of compacted large particles. NiO-SnO2 NC degrades MO, and the photocatalytic performance decreased with increasing calcination temperature due to an increase in the crystallite size of the NC. The optimal conditions for the efficient NC-mediated photocatalysis of MO are 100 °C, 20 mg catalyst, 50 ppm MO, and pH 6. Conclusions: The auspicious performance of the NiO-SnO2 NCs may open a new avenue for the development of semiconducting p–n heterojunction catalysts as promising structures for removing undesirable organic pollutants from the environment. Full article
(This article belongs to the Special Issue Thermal and Photocatalytic Analysis of Nanomaterials)
Show Figures

Figure 1

Figure 1
<p>XRD diffractograms of NiO-SnO<sub>2</sub> NCs calcined at the indicated temperature.</p>
Full article ">Figure 2
<p>SEM micrographs of NiO-SnO<sub>2</sub> NCs calcined at (<b>A</b>) 100 °C, (<b>B</b>) 300 °C, (<b>C</b>) 600 °C, and (<b>D</b>) 900 °C. The magnification and scale bar are indicated.</p>
Full article ">Figure 3
<p>DRS spectra of the NiO-SnO<sub>2</sub> NCs calcined at the indicated temperature.</p>
Full article ">Figure 4
<p>Determination by Tauc’s plot of the band gap of NiO-SnO<sub>2</sub> NCs calcined at the indicated temperature.</p>
Full article ">Figure 5
<p>The FTIR spectrum of NiO-SnO<sub>2</sub> NCs calcined at (<b>A</b>) 100 °C and (<b>B</b>) over 100 °C (temperature indicated).</p>
Full article ">Figure 6
<p>(<b>A</b>) EDX spectra of NiO-SnO<sub>2</sub> NCs calcined at different temperatures. (<b>B</b>) EDX mapping images of NiO-SnO<sub>2</sub> NCs calcined at 900 °C; red = O; blue = Sn; green = Ni.</p>
Full article ">Figure 7
<p>(<b>A</b>) Degradation profile, (<b>B</b>) percentage degradation, (<b>C</b>) kinetic isotherms/rate constant, and (<b>D</b>) schematic mechanism of photodegradation of MO in the presence of NiO-SnO<sub>2</sub> NCs calcined at the indicated temperature.</p>
Full article ">Figure 8
<p>Effect of (<b>a</b>) annealing temperature (100–900 °C), (<b>b</b>) pH (2–10), (<b>c</b>) catalyst dose (5–30 mg), and (<b>d</b>) initial methyl orange (MO) concentration (10–60 ppm) on the NiO-SnO<sub>2</sub> NC-induced photodegradation of MO. For each effect to be analyzed, all other variables were optimized and kept constant.</p>
Full article ">
16 pages, 5318 KiB  
Article
Leucine Supplementation in Middle-Aged Male Mice Improved Aging-Induced Vascular Remodeling and Dysfunction via Activating the Sirt1-Foxo1 Axis
by Zhujing Hao, Guiwen Xu, Mengyang Yuan, Ruopeng Tan, Yunlong Xia, Yang Liu and Xiaomeng Yin
Nutrients 2022, 14(18), 3856; https://doi.org/10.3390/nu14183856 - 17 Sep 2022
Cited by 8 | Viewed by 2703
Abstract
Vascular aging is associated with metabolic remodeling, and most studies focused on fatty acid and glucose metabolism. Based on our metabolomic data, leucine was significantly reduced in the aortas of aged mice. Whether leucine supplementation can reverse aging-induced vascular remodeling remains unknown. To [...] Read more.
Vascular aging is associated with metabolic remodeling, and most studies focused on fatty acid and glucose metabolism. Based on our metabolomic data, leucine was significantly reduced in the aortas of aged mice. Whether leucine supplementation can reverse aging-induced vascular remodeling remains unknown. To investigate the effectiveness of leucine, male mice at 15 or 18 months were supplemented with leucine (1.5%) for 3 months. All the aged mice, with or without leucine, were sacrificed at 21 months. Blood pressure and vascular relaxation were measured. H&E, Masson’s trichrome, and Elastica van Gieson staining were used to assess aortic morphology. Vascular inflammation, reactive oxidative stress (ROS), and vascular smooth muscle cell (VSMC) phenotype were also measured in mouse aortas. Compared with the 21-month-old mice without leucine, leucine supplementation from 15 months significantly improved vascular relaxation, maintained the contractile phenotype of VSMCs, and repressed vascular inflammation and ROS levels. These benefits were not observed in the mice supplemented with leucine starting from 18 months, which was likely due to the reduction in leucine transporters Slc3a2 or Slc7a5 at 18 months. Furthermore, we found benefits from leucine via activating the Sirt1-induced Foxo1 deacetylation. Our findings indicated that leucine supplementation in middle-aged mice improved aging-induced vascular remodeling and dysfunction. Full article
(This article belongs to the Section Proteins and Amino Acids)
Show Figures

Figure 1

Figure 1
<p><b>Leucine supplementation from 15M alleviated aging</b><b>-induced vascular dysfunction.</b> The design of study is shown in (<b>A</b>). Measurements of leucine levels in plasma and aorta are shown in (<b>B</b>,<b>C</b>). Acetylcholine-mediated endothelium-dependent relaxation and SNP-mediated endothelium-independent relaxation are presented in (<b>D</b>,<b>E</b>). Statistical analysis of leucine measurements was performed using one-way ANOVA, * <span class="html-italic">p</span> &lt; 0.05, ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, **** <span class="html-italic">p</span> &lt; 0.0001. Statistical analysis of vascular relaxation curves was performed using two-way ANOVA, * <span class="html-italic">p</span> &lt; 0.05 18M + Leu vs. 2M group, <sup>†</sup> <span class="html-italic">p</span> &lt; 0.05 21M vs. 2M group, <sup>††</sup> <span class="html-italic">p</span> &lt; 0.01 21M vs. 2M group, <sup>†††</sup> <span class="html-italic">p</span> &lt; 0.001 21M vs. 2M group, <sup>#</sup> <span class="html-italic">p</span> &lt; 0.05 18M + Leu vs. 15M + Leu group. All data are presented as mean ± SEM, <span class="html-italic">n</span> = 6/group.</p>
Full article ">Figure 2
<p><b>Leucine supplementation from 15M improved aging</b><b>-induced vascular remodeling.</b> Representative images of H&amp;E (<b>A</b>), Masson’s (<b>B</b>), and van Gieson’s (<b>C</b>) staining show the aortic structure of different groups at low and high magnifications. Lumen diameter and wall thickness of each group were measured (<b>D</b>,<b>E</b>). The percentage of collagen deposition area is shown in (<b>F</b>). Quantification of elastin area is shown in (<b>G</b>). Statistical analysis was performed using one-way ANOVA; data are presented as mean ± SEM, <span class="html-italic">n</span> = 6/group. ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, and **** <span class="html-italic">p</span> &lt; 0.0001. ND: normal diet.</p>
Full article ">Figure 3
<p>Leucine supplementation from 15M relieved aging-induced vascular inflammatory responses, ROS generation, and VSMC phenotype transformation. Representative images of CD45 immunohistochemistry staining showed inflammatory cell infiltration (<b>A</b>). Representative images of DHE staining (<b>B</b>). Quantitative analysis of CD45 positive cells is shown in (<b>C</b>). Quantitative analysis of the red dots is shown in (<b>D</b>). Representative immunohistochemistry staining and quantification of contractile markers calponin, ɑ-SMA, vimentin, and synthetic marker osteopontin are shown in (<b>E</b>,<b>F</b>). Statistical analysis was performed using one-way ANOVA; data are presented as mean ± SEM, n = 6/group. * <span class="html-italic">p</span> &lt;0.05, ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, and **** <span class="html-italic">p</span> &lt; 0.0001. ND: normal diet.</p>
Full article ">Figure 4
<p><b>Leucine protected against aging</b><b>-induced vascular damage via Sirt1–Foxo1 pathway.</b> Representative Western blot and quantification of vascular leucine transporters Slc3a2 and Slc7a5 from mice at different ages are in (<b>A</b>,<b>B</b>). Representative Western blot and quantification of Sirt1, Foxo1, and acetyl-Foxo1 from mice at different ages are shown in (<b>C</b>,<b>D</b>). Representative Western blot and quantification of vascular Slc3a2 and Slc7a5 from mice in different intervention groups are shown in (<b>E</b>,<b>F</b>). Representative Western blot and quantification of Sirt1, Foxo1, and acetyl-Foxo1 from mice in different intervention groups are shown in (<b>G</b>,<b>H</b>). Statistical analysis was performed using one-way ANOVA; data are presented as mean ± SEM, n = 6/group. * <span class="html-italic">p</span> &lt; 0.05, ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, and **** <span class="html-italic">p</span> &lt; 0.0001. ND: Normal diet.</p>
Full article ">Figure 5
<p><b>Inhibition of Foxo1 activity reversed the protective effects of leucine supplementation on vascular dysfunction and remodeling</b>. Quantification of Foxo1 activation (<b>A</b>). Dose–response curves for acetylcholine-mediated endothelium-dependent relaxation (<b>B</b>) and SNP-mediated endothelium-independent relaxation (<b>C</b>). Representative images of H&amp;E, Masson’s, and van Gieson’s in aortas from mice at 2M and 21M, and 21M mice with leucine supplementation from 15M, with or without Foxo1 inhibitor AS1842856 (<b>D</b>–<b>F</b>). Quantitative analysis is shown in (<b>G</b>–<b>J</b>). Statistical analysis of vascular relaxation curves was performed with two-way ANOVA, * <span class="html-italic">p</span> &lt; 0.05 15M + Leu + AS1842856 vs. 2M group, <sup>†</sup> <span class="html-italic">p</span> &lt; 0.05 21M vs. 2M group, <sup>††</sup> <span class="html-italic">p</span> &lt; 0.01 21M vs. 2M group. Histological statistical analysis was performed with one-way ANOVA, * <span class="html-italic">p</span> &lt; 0.05, ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, and **** <span class="html-italic">p</span> &lt; 0.0001. All data are presented as mean ± SEM, n = 6/group. ND: normal diet.</p>
Full article ">Figure 6
<p>Inhibition of Foxo1 activity reversed the protective effects of leucine supplementation on VSMC phenotype transformation. Representative images and quantification of CD45 immunohistochemistry and DHE staining are shown in (<b>A–D</b>). Representative immunohistochemistry staining and quantification of contractile markers calponin, ɑ-SMA, vimentin, and synthetic marker osteopontin are shown in (<b>E</b>,<b>F</b>). Statistical analysis was performed using one-way ANOVA; data are presented as mean ± SEM, n = 6/group. * <span class="html-italic">p</span> &lt; 0.05, *** <span class="html-italic">p</span> &lt; 0.001, and **** <span class="html-italic">p</span> &lt; 0.0001. ND: normal diet.</p>
Full article ">Figure 7
<p><b>Mechanisms of leucine in the protection of aging</b><b>-induced vascular remodeling.</b> Transport of leucine depends on amino acid transporters Slc7a5 and Slc3a2. Intracellular leucine increases protein level of Sirt1, which subsequently induces Sirt1-mediated Foxo1 deacetylation. Foxo1 deacetylation enhances Foxo1 activity in nucleus, which represses VSMC transition to a synthetic phenotype, vascular inflammatory responses, and excessive ROS generation. Meanwhile, leucine or Sirt1 may also relieve vascular inflammation and ROS level via Foxo1-independent mechanisms. Dietary leucine supplementation at middle-age stage reversed aging-induced vascular remodeling and dysfunction.</p>
Full article ">
8 pages, 470 KiB  
Article
The Geometry of the Kiepert Trefoil
by Vladimir I. Pulov, Magdalena D. Toda, Vassil M. Vassilev and Ivaïlo M. Mladenov
Mathematics 2022, 10(18), 3357; https://doi.org/10.3390/math10183357 - 15 Sep 2022
Viewed by 1345
Abstract
This article presents a comparative study of Kiepert’s trefoil and its related curves, combining a variety of tools from differential and algebraic geometry, integrable systems, elastica theory, and special functions. While this curve was classically known and well studied in the literature, some [...] Read more.
This article presents a comparative study of Kiepert’s trefoil and its related curves, combining a variety of tools from differential and algebraic geometry, integrable systems, elastica theory, and special functions. While this curve was classically known and well studied in the literature, some related open problems were recently solved, and the goal of this paper is to present and characterize the general solution of the equation that governs this trefoil’s family of curves by involving elliptic functions and elastica theory in the mechanics. Full article
(This article belongs to the Special Issue Differential Geometry and Related Integrable Systems)
Show Figures

Figure 1

Figure 1
<p>Trifoliums specified by Equations (<a href="#FD1-mathematics-10-03357" class="html-disp-formula">1</a>), (<a href="#FD2-mathematics-10-03357" class="html-disp-formula">2</a>) and (<a href="#FD7-mathematics-10-03357" class="html-disp-formula">7</a>) (from left to right), depicted with parameters <math display="inline"><semantics> <mrow> <mi>a</mi> <mo>=</mo> <mn>5</mn> </mrow> </semantics></math>, <math display="inline"><semantics> <mrow> <mi>b</mi> <mo>=</mo> <mo>−</mo> <mn>1</mn> <mo>/</mo> <mn>4</mn> </mrow> </semantics></math>, and <math display="inline"><semantics> <mrow> <mi>c</mi> <mo>=</mo> <mo>−</mo> <mn>1</mn> <mo>/</mo> <mn>2</mn> </mrow> </semantics></math>.</p>
Full article ">Figure 2
<p>Trifoliums specified by Equations (<a href="#FD2-mathematics-10-03357" class="html-disp-formula">2</a>) and (<a href="#FD3-mathematics-10-03357" class="html-disp-formula">3</a>) and the combination of their graphics.</p>
Full article ">Figure 3
<p>The first two graphics here represent the Kiepert trefoils drawn via Equations (<a href="#FD30-mathematics-10-03357" class="html-disp-formula">30</a>) (solid curve) and (<a href="#FD38-mathematics-10-03357" class="html-disp-formula">38</a>) (dashed line) with the same <span class="html-italic">a</span>, while the third one illustrates the difference between the Kiepert trefoil (solid curve) and the trefoil associated with Equation (<a href="#FD3-mathematics-10-03357" class="html-disp-formula">3</a>) (after rotation of 30°).</p>
Full article ">
11 pages, 803 KiB  
Article
The Approximate Solution of Nonlinear Flexure of a Cantilever Beam with the Galerkin Method
by Jun Zhang, Rongxing Wu, Ji Wang, Tingfeng Ma and Lihong Wang
Appl. Sci. 2022, 12(13), 6720; https://doi.org/10.3390/app12136720 - 2 Jul 2022
Cited by 7 | Viewed by 1645
Abstract
For the optimal design and accurate prediction of structural behavior, the nonlinear analysis of large deformation of elastic beams has broad applications in various engineering fields. In this study, the nonlinear equation of flexure of an elastic beam, also known as an elastica, [...] Read more.
For the optimal design and accurate prediction of structural behavior, the nonlinear analysis of large deformation of elastic beams has broad applications in various engineering fields. In this study, the nonlinear equation of flexure of an elastic beam, also known as an elastica, was solved by the Galerkin method for a highly accurate solution. The numerical results showed that the third-order solution of the rotation angle at the free end of the beam is more accurate and efficient in comparison with results of other approximate methods, and is perfectly consistent with the exact solution in elliptic functions. A general procedure with the Galerkin method is demonstrated for efficient solutions of nonlinear differential equations with the potential for adoption and implementation in more applications. Full article
Show Figures

Figure 1

Figure 1
<p>The solutions of <span class="html-italic">A</span><sub>0</sub> vs. parameter <span class="html-italic">α</span>.</p>
Full article ">Figure 2
<p>The rotation angle at the free end <span class="html-italic">θ<sub>B</sub></span> vs. <span class="html-italic">α</span> with different solutions.</p>
Full article ">Figure 3
<p>The rotation angle at the free end <span class="html-italic">θ<sub>B</sub></span> vs. <span class="html-italic">α</span> with solutions of different orders.</p>
Full article ">
17 pages, 7594 KiB  
Article
FM2 Path Planner for UAV Applications with Curvature Constraints: A Comparative Analysis with Other Planning Approaches
by Santiago Garrido, Javier Muñoz, Blanca López, Fernando Quevedo, Concepción A. Monje and Luis Moreno
Sensors 2022, 22(9), 3174; https://doi.org/10.3390/s22093174 - 21 Apr 2022
Cited by 4 | Viewed by 2126
Abstract
This paper studies the Fast Marching Square (FM2) method as a competitive path planner for UAV applications. The approach fulfills trajectory curvature constraints together with a significantly reduced computation time, which makes it overperform with respect to other planning [...] Read more.
This paper studies the Fast Marching Square (FM2) method as a competitive path planner for UAV applications. The approach fulfills trajectory curvature constraints together with a significantly reduced computation time, which makes it overperform with respect to other planning methods of the literature based on optimization. A comparative analysis is presented to demonstrate how the FM2 approach can easily adapt its performance thanks to the introduction of two parameters, saturation α and exponent β, that allow a flexible configuration of the paths in terms of curvature restrictions, among others. The main contributions of the method are twofold: first, a feasible path is directly obtained without the need of a later optimization process to accomplish curvature restrictions; second, the computation speed is significantly increased, up to 220 times faster than other optimization-based methods such as, for instance, Dubins, Euler–Mumford Elastica and Reeds–Shepp. Simulation results are given to demonstrate the superiority of the method when used for UAV applications in comparison with the three previously mentioned methods. Full article
(This article belongs to the Special Issue Frontiers in Mobile Robot Navigation)
Show Figures

Figure 1

Figure 1
<p>The Fréchet distance between two curves is the maximum length of all the gray lines.</p>
Full article ">Figure 2
<p>Process of obtaining the FMM trajectory. (<b>a</b>) Raw data obtained by the laser sensor; (<b>b</b>) enlargement of the previous subfigure; (<b>c</b>) expansion of the wave starting from the destination point; (<b>d</b>) path obtained by the gradient method over the potential corresponding to the previous subfigure.</p>
Full article ">Figure 3
<p>Process of obtaining the <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> trajectory with the same raw data obtained by the laser sensor of <a href="#sensors-22-03174-f001" class="html-fig">Figure 1</a>. (<b>a</b>) First potential <math display="inline"><semantics> <mrow> <mi>W</mi> <mo>(</mo> <mi>x</mi> <mo>)</mo> </mrow> </semantics></math> obtained with the expansion of the wave from the walls and obstacles, saturated with <math display="inline"><semantics> <mrow> <mi>α</mi> <mo>=</mo> <mn>0.8</mn> </mrow> </semantics></math>; (<b>b</b>) expansion of the wave starting from the destination point; (<b>c</b>) path obtained by the gradient method over the potential corresponding to the previous subfigure.</p>
Full article ">Figure 4
<p>Process of obtaining the <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> trajectory with the same raw data obtained by the laser sensor of <a href="#sensors-22-03174-f001" class="html-fig">Figure 1</a>. (<b>a</b>) First potential <math display="inline"><semantics> <mrow> <mi>W</mi> <mo>(</mo> <mi>x</mi> <mo>)</mo> </mrow> </semantics></math> obtained with the expansion of the wave from the walls and obstacles, saturated with <math display="inline"><semantics> <mrow> <mi>α</mi> <mo>=</mo> <mn>0.6</mn> </mrow> </semantics></math>; (<b>b</b>) expansion of the wave starting from the destination point; (<b>c</b>) path obtained by the gradient method over the potential corresponding to the previous subfigure.</p>
Full article ">Figure 5
<p>Obtaining <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> path in a city environment. (<b>a</b>) First potential <math display="inline"><semantics> <mrow> <mi>W</mi> <mo>(</mo> <mi>x</mi> <mo>)</mo> </mrow> </semantics></math>; (<b>b</b>) second potential and the path obtained with the gradient method.</p>
Full article ">Figure 6
<p>Two <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> paths in a city environment for different values of the exponent <math display="inline"><semantics> <mi>β</mi> </semantics></math> of the first potential <math display="inline"><semantics> <mrow> <mi>W</mi> <mo>(</mo> <mi>x</mi> <mo>)</mo> </mrow> </semantics></math>. (<b>a</b>) City environment; (<b>b</b>) first potential <math display="inline"><semantics> <mrow> <mi>W</mi> <mo>(</mo> <mi>x</mi> <mo>)</mo> </mrow> </semantics></math> and the path for <math display="inline"><semantics> <mrow> <mi>β</mi> <mo>=</mo> <mn>0.9</mn> </mrow> </semantics></math>; (<b>c</b>) first potential <math display="inline"><semantics> <mrow> <mi>W</mi> <mo>(</mo> <mi>x</mi> <mo>)</mo> </mrow> </semantics></math> and the path for <math display="inline"><semantics> <mrow> <mi>β</mi> <mo>=</mo> <mn>0.4</mn> </mrow> </semantics></math>.</p>
Full article ">Figure 6 Cont.
<p>Two <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> paths in a city environment for different values of the exponent <math display="inline"><semantics> <mi>β</mi> </semantics></math> of the first potential <math display="inline"><semantics> <mrow> <mi>W</mi> <mo>(</mo> <mi>x</mi> <mo>)</mo> </mrow> </semantics></math>. (<b>a</b>) City environment; (<b>b</b>) first potential <math display="inline"><semantics> <mrow> <mi>W</mi> <mo>(</mo> <mi>x</mi> <mo>)</mo> </mrow> </semantics></math> and the path for <math display="inline"><semantics> <mrow> <mi>β</mi> <mo>=</mo> <mn>0.9</mn> </mrow> </semantics></math>; (<b>c</b>) first potential <math display="inline"><semantics> <mrow> <mi>W</mi> <mo>(</mo> <mi>x</mi> <mo>)</mo> </mrow> </semantics></math> and the path for <math display="inline"><semantics> <mrow> <mi>β</mi> <mo>=</mo> <mn>0.4</mn> </mrow> </semantics></math>.</p>
Full article ">Figure 7
<p>Trajectories obtained by varying <math display="inline"><semantics> <mi>α</mi> </semantics></math> and <math display="inline"><semantics> <mi>β</mi> </semantics></math> parameters to study which set of parameters makes the <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> trajectories more similar to those obtained by the (<b>a</b>) Dubins, (<b>b</b>) Euler–Mumford Elastica, and (<b>c</b>) Reeds–Shepp methods.</p>
Full article ">Figure 8
<p>Cost functions (Fréchet distance) obtained by varying <math display="inline"><semantics> <mi>α</mi> </semantics></math> and <math display="inline"><semantics> <mi>β</mi> </semantics></math> parameters to study which set of parameters makes the <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> trajectories more similar to those obtain by the (<b>a</b>) Dubins, (<b>b</b>) Euler–Mumford Elastica, and (<b>c</b>) Reeds–Shepp methods.</p>
Full article ">Figure 9
<p>Curves corresponding to the best <math display="inline"><semantics> <mi>α</mi> </semantics></math> and <math display="inline"><semantics> <mi>β</mi> </semantics></math> values for the <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> method in yellow in comparison with the (<b>a</b>) Dubins, (<b>b</b>) Euler–Mumford Elastica, and (<b>c</b>) Reeds–Shepp curves in red. The Fréchet distance between two curves is used as cost function.</p>
Full article ">Figure 10
<p>Curvatures corresponding to the (<b>a</b>) Dubins, the (<b>b</b>) Euler–Mumford Elastica, and the (<b>c</b>) Reeds–Shepp curves (left, from top to bottom, respectively) and their corresponding best approximations (<b>d</b>–<b>f</b>) using <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> method (right). The Fréchet cost function is used for comparison. The Fréchet distance between two curves is used as cost function. The curvatures in red are obtained after applying a smoothing process to the raw curvature data.</p>
Full article ">Figure 11
<p>Area between two curves as a metric to measure the distance between the curves.</p>
Full article ">Figure 12
<p>Cost functions (area between two curves) obtained by varying <math display="inline"><semantics> <mi>α</mi> </semantics></math> and <math display="inline"><semantics> <mi>β</mi> </semantics></math> parameters to study which set of parameters makes the <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> trajectories more similar to those obtain by the (<b>a</b>) Dubins, (<b>b</b>) Euler–Mumford Elastica, and (<b>c</b>) Reeds–Shepp methods.</p>
Full article ">Figure 13
<p>Curves corresponding to the best <math display="inline"><semantics> <mi>α</mi> </semantics></math> and <math display="inline"><semantics> <mi>β</mi> </semantics></math> values for the <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> method in yellow in comparison with the (<b>a</b>) Dubins, (<b>b</b>) Euler–Mumford Elastica, and (<b>c</b>) Reeds–Shepp curves in red. The area between the two curves is used as cost function.</p>
Full article ">Figure 14
<p>Curvatures corresponding to the (<b>a</b>) Dubins, (<b>b</b>) Euler–Mumford Elastica, and (<b>c</b>) Reeds–Shepp curves (left, from top to bottom, respectively) and their corresponding best approximations (<b>d</b>–<b>f</b>) using <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> method (right). The area between the curves is used as cost function for comparison. The curvatures in blue correspond to the point to point representations. The curvatures in red are obtained after applying a smoothing process.</p>
Full article ">Figure 15
<p>Matlab Simulink model to simulate the influence of the vehicle dynamics when executing the paths.</p>
Full article ">Figure 16
<p>Original paths (approximation of <math display="inline"><semantics> <mrow> <mi>F</mi> <msup> <mi>M</mi> <mn>2</mn> </msup> </mrow> </semantics></math> to Dubins method) versus executed paths considering (<b>a</b>) a fixed-wing UAV and (<b>b</b>) a quadcopter.</p>
Full article ">
Back to TopTop