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Background: Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs damages in DNA induced by abortive topoisomerase 1 activity; however, maintenance of genetic integrity may sustain cellular division of neoplastic cells. It follows that Tdp1-targeting chemical inhibitors could synergize well with existing chemotherapy drugs to deny cancer growth; therefore, identification of Tdp1 inhibitors may advance precision medicine in oncology. Objective: Current computational research efforts focus primarily on molecular docking simulations, though datasets involving three-dimensional molecular structures are often hard to curate and computationally expensive to store and process. We propose the use of simplified molecular input line entry system (SMILES) chemical representations to train supervised machine learning (ML) models, aiming to predict potential Tdp1 inhibitors. Methods: An open-sourced consensus dataset containing the inhibitory activity of numerous chemicals against Tdp1 was obtained from Kaggle. Various ML algorithms were trained, ranging from simple algorithms to ensemble methods and deep neural networks. For algorithms requiring numerical data, SMILES were converted to chemical descriptors using RDKit, an open-sourced Python cheminformatics library. Results: Out of 13 optimized ML models with rigorously tuned hyperparameters, the random forest model gave the best results, yielding a receiver operating characteristics-area under curve of 0.7421, testing accuracy of 0.6815, sensitivity of 0.6444, specificity of 0.7156, precision of 0.6753, and F1 score of 0.6595. Conclusions: Ensemble methods, especially the bootstrap aggregation mechanism adopted by random forest, outperformed other ML algorithms in classifying Tdp1 inhibitors from non-inhibitors using SMILES. The discovery of Tdp1 inhibitors could unlock more treatment regimens for cancer patients, allowing for therapies tailored to the patient’s condition. Full article

In this article, a deep neural network (DNN)-based underwater acoustic (UA) communication receiver is proposed. Conventional orthogonal frequency-division multiplexing (OFDM) receivers perform channel estimation using linear interpolation. However, due to the significant delay spread in multipath UA channels, the frequency response often exhibits strong non-linearity between pilot subcarriers. Since the channel delay profile is generally unknown, this non-linearity cannot be modeled precisely. A neural network (NN)-based receiver effectively tackles this challenge by learning and compensating for the non-linearity through NN training. The performance of the DNN-based UA communication receiver was tested recently in river trials in Western Australia. The results obtained from the trials prove that the DNN-based receiver performs better than the conventional least-squares (LS) estimator-based receiver. This paper suggests that UA communication using DNN receivers holds great potential for revolutionizing underwater communication systems, enabling higher data rates, improved reliability, and enhanced adaptability to changing underwater conditions. Full article

In urban forest management, individual street tree segmentation is a fundamental method to obtain tree phenotypes, which is especially critical. Most existing tree image segmentation models have been evaluated on smaller datasets and lack experimental verification on larger, publicly available datasets. Therefore, this paper, based on a large, publicly available urban street tree dataset, proposes YOLO-SegNet for individual street tree segmentation. In the first stage of the street tree object detection task, the BiFormer attention mechanism was introduced into the YOLOv8 network to increase the contextual information extraction and improve the ability of the network to detect multiscale and multishaped targets. In the second-stage street tree segmentation task, the SegFormer network was proposed to obtain street tree edge information more efficiently. The experimental results indicate that our proposed YOLO-SegNet method, which combines YOLOv8+BiFormer and SegFormer, achieved a 92.0% mean intersection over union (mIoU), 95.9% mean pixel accuracy (mPA), and 97.4% accuracy on a large, publicly available urban street tree dataset. Compared with those of the fully convolutional neural network (FCN), lite-reduced atrous spatial pyramid pooling (LR-ASPP), pyramid scene parsing network (PSPNet), UNet, DeepLabv3+, and HRNet, the mIoUs of our YOLO-SegNet increased by 10.5, 9.7, 5.0, 6.8, 4.5, and 2.7 percentage points, respectively. The proposed method can effectively support smart agroforestry development. Full article

In the footwear industry, occupational risks are significant, and work accidents are frequent. Professionals in the field prepare documents and reports about these accidents, but the need for more time and resources limits learning based on past incidents. Machine learning (ML) and deep learning (DL) methods have been applied to analyze data from these documents, identifying accident patterns and classifying the damage’s severity. However, evaluating the performance of these methods in different economic sectors is crucial. This study examined neural and non-neural methods for classifying the severity of workplace accidents in the footwear industry complex. The random forest (RF) and extreme gradient boosting (XGBoost) methods were the most effective non-neural methods. The neural methods 1D convolutional neural networks (1D-CNN) and bidirectional long short-term memory (Bi-LSTM) showed superior performance, with parameters above 98% and 99%, respectively, although with a longer training time. It is concluded that using these methods is viable for classifying accidents in the footwear industry. The methods can classify new accidents and simulate scenarios, demonstrating their adaptability and reliability in different economic sectors for accident prevention. Full article

In fashion e-commerce, predicting item compatibility using visual features remains a significant challenge. Current recommendation systems often struggle to incorporate high-dimensional visual data into graph-based learning models effectively. This limitation presents a substantial opportunity to enhance the precision and effectiveness of fashion recommendations. In this paper, we present the Visual-aware Graph Convolutional Network (VAGCN). This novel framework helps improve how visual features can be incorporated into graph-based learning systems for fashion item compatibility predictions. The VAGCN framework employs a deep-stacked autoencoder to convert the input image’s high-dimensional raw CNN visual features into more manageable low-dimensional representations. In addition to improving feature representation, the GCN can also reason more intelligently about predictions, which would not be possible without this compression. The GCN encoder processes nodes in the graph to capture structural and feature correlation. Following the GCN encoder, the refined embeddings are input to a multi-layer perceptron (MLP) to calculate compatibility scores. The approach extends to using neighborhood information only during the testing phase to help with training efficiency and generalizability in practical scenarios, a key characteristic of our model. By leveraging its ability to capture latent visual features and neighborhood-based learning, VAGCN thoroughly investigates item compatibility across various categories. This method significantly improves predictive accuracy, consistently outperforming existing benchmarks. These contributions tackle significant scalability and computational efficiency challenges, showcasing the potential transformation of recommendation systems through enhanced feature representation, paving the way for further innovations in the fashion domain. Full article

Snow cover distribution is of great significance for climate change and water resource management. Current deep learning-based methods for extracting snow cover from remote sensing images face challenges such as insufficient local detail awareness and inadequate utilization of global semantic information. In this study, a snow cover extraction algorithm integrating cross-scale edge perception and an attention mechanism on the U-net model architecture is proposed. The cross-scale edge perception module replaces the original jump connection of U-net, enhances the low-level image features by introducing edge detection on the shallow feature scale, and enhances the detail perception via branch separation and fusion features on the deep feature scale. Meanwhile, parallel channel and spatial attention mechanisms are introduced in the model encoding stage to adaptively enhance the model’s attention to key features and improve the efficiency of utilizing global semantic information. The method was evaluated on the publicly available CSWV_S6 optical remote sensing dataset, and the accuracy of 98.14% indicates that the method has significant advantages over existing methods. Snow extraction from Landsat 8 OLI images of the upper reaches of the Irtysh River was achieved with satisfactory accuracy rates of 95.57% (using two, three, and four bands) and 96.65% (using two, three, four, and six bands), indicating its strong potential for automated snow cover extraction over larger areas. Full article

Adaptive radiotherapy (ART) workflows are increasingly adopted to achieve dose escalation and tissue sparing under dynamic anatomical conditions. However, recontouring and time constraints hinder the implementation of real-time ART workflows. Various auto-segmentation methods, including deformable image registration, atlas-based segmentation, and deep learning-based segmentation (DLS), have been developed to address these challenges. Despite the potential of DLS methods, clinical implementation remains difficult due to the need for large, high-quality datasets to ensure model generalizability. This study introduces an InterVision framework for segmentation. The InterVision framework can interpolate or create intermediate visuals between existing images to generate specific patient characteristics. The InterVision model is trained in two steps: (1) generating a general model using the dataset, and (2) tuning the general model using the dataset generated from the InterVision framework. The InterVision framework generates intermediate images between existing patient image slides using deformable vectors, effectively capturing unique patient characteristics. By creating a more comprehensive dataset that reflects these individual characteristics, the InterVision model demonstrates the ability to produce more accurate contours compared to general models. Models are evaluated using the volumetric dice similarity coefficient (VDSC) and the Hausdorff distance 95% (HD95%) for 18 structures in 20 test patients. As a result, the Dice score was 0.81 ± 0.05 for the general model, 0.82 ± 0.04 for the general fine-tuning model, and 0.85 ± 0.03 for the InterVision model. The Hausdorff distance was 3.06 ± 1.13 for the general model, 2.81 ± 0.77 for the general fine-tuning model, and 2.52 ± 0.50 for the InterVision model. The InterVision model showed the best performance compared to the general model. The InterVision framework presents a versatile approach adaptable to various tasks where prior information is accessible, such as in ART settings. This capability is particularly valuable for accurately predicting complex organs and targets that pose challenges for traditional deep learning algorithms. Full article

Accurate face detection and subsequent localization of facial landmarks are mandatory steps in many computer vision applications, such as emotion recognition, age estimation, and gender identification. Thanks to advancements in deep learning, numerous facial applications have been developed for human faces. However, most have to employ multiple models to accomplish several tasks simultaneously. As a result, they require more memory usage and increased inference time. Also, less attention is paid to other domains, such as animals and cartoon characters. To address these challenges, we propose an input-agnostic face model, AnyFace++, to perform multiple face-related tasks concurrently. The tasks are face detection and prediction of facial landmarks for human, animal, and cartoon faces, including age estimation, gender classification, and emotion recognition for human faces. We trained the model using deep multi-task, multi-domain learning with a heterogeneous cost function. The experimental results demonstrate that AnyFace++ generates outcomes comparable to cutting-edge models designed for specific domains. Full article

This study introduces a novel deep learning framework for detecting leakage in water distribution systems (WDSs). The key innovation lies in a two-step process: First, the WDS is partitioned using a K-means clustering algorithm based on pressure sensitivity analysis. Then, an encoder–decoder neural network (EDNN) model is employed to extract and process the pressure and flow sensitivities. The core of the framework is the PP-LCNetV2 architecture that ensures the model’s lightweight, which is optimized for CPU devices. This combination ensures rapid, accurate leakage detection. Three cases are employed to evaluate the method. By applying data augmentation techniques, including the demand and measurement noises, the framework demonstrates robustness across different noise levels. Compared with other methods, the results show this method can efficiently detect over 90% of leakage across different operating conditions while maintaining a higher recognition of the magnitude of leakages. This research offers a significant improvement in computational efficiency and detection accuracy over existing approaches. Full article

Scientific evaluation of cultivated land quality (CLQ) is necessary for promoting rational utilization of cultivated land and achieving one of the Sustainable Development Goals (SDGs): Zero Hunger. However, the CLQ evaluation system proposed in previous studies was diversified, and the methods were inefficient. In this study, based on China’s first national standard “Cultivated Land Quality Grade” (GB/T 33469-2016), we constructed a unified county-level CLQ evaluation system by selecting 15 indicators from five aspects—site condition, environmental condition, physicochemical property, nutrient status and field management—and used the Delphi method to calculate the membership degree of the indicators. Taking Jimo district of Shandong Province, China, as a case study, we compared the performance of three machine learning models, including random forest, AdaBoost, and support vector regression, to evaluate CLQ using multi-temporal remote sensing data. The comprehensive index method was used to reveal the spatial distribution of CLQ. The results showed that the CLQ evaluation based on multi-temporal remote sensing data and machine learning model was efficient and reliable, and the evaluation results had a significant positive correlation with crop yield (r was 0.44, p < 0.001). The proportions of cultivated land of high-, medium- and poor-quality were 27.43%, 59.37% and 13.20%, respectively. The CLQ in the western part of the study area was better, while it was worse in the eastern and central parts. The main limiting factors include irrigation capacity and texture configuration. Accordingly, a series of targeted measures and policies were suggested, such as strengthening the construction of farmland water conservancy facilities, deep tillage of soil and continuing to construct well-facilitated farmland. This study proposed a fast and reliable method for evaluating CLQ, and the results are helpful to promote the protection of cultivated land and ensure food security. Full article

Remembering software library components and mastering their application programming interfaces (APIs) is a daunting task for programmers, due to the sheer volume of available libraries. API completion tools, which predict subsequent APIs based on code context, are essential for improving development efficiency. Existing API completion techniques, however, face specific weaknesses that limit their performance. Pattern-based code completion methods that rely on statistical information excel in extracting common usage patterns of API sequences. However, they often struggle to capture the semantics of the surrounding code. In contrast, deep-learning-based approaches excel in understanding the semantics of the code but may miss certain common usages that can be easily identified by pattern-based methods. Our insight into overcoming these challenges is based on the complementarity between these two types of approaches. This paper proposes a combinatorial method of API completion that aims to exploit the strengths of both pattern-based and deep-learning-based approaches. The basic idea is to utilize a confidence-based selector to determine which type of approach should be utilized to generate predictions. Pattern-based approaches will only be applied if the frequency of a particular pattern exceeds a pre-defined threshold, while in other cases, deep learning models will be utilized to generate the API completion results. The results showed that our approach dramatically improved the accuracy and mean reciprocal rank (MRR) in large-scale experiments, highlighting its utility. Full article

Research on electroencephalogram-based motor imagery (MI-EEG) can identify the limbs of subjects that generate motor imagination by decoding EEG signals, which is an important issue in the field of brain–computer interface (BCI). Existing deep-learning-based classification methods have not been able to entirely employ the topological information among brain regions, and thus, the classification performance needs further improving. In this paper, we propose a multi-view graph convolutional attention network (MGCANet) with residual learning structure for multi-class MI decoding. Specifically, we design a multi-view graph convolution spatial feature extraction method based on the topological relationship of brain regions to achieve more comprehensive information aggregation. During the modeling, we build an adaptive weight fusion (Awf) module to adaptively merge feature from different brain views to improve classification accuracy. In addition, the self-attention mechanism is introduced for feature selection to expand the receptive field of EEG signals to global dependence and enhance the expression of important features. The proposed model is experimentally evaluated on two public MI datasets and achieved a mean accuracy of 78.26% (BCIC IV 2a dataset) and 73.68% (OpenBMI dataset), which significantly outperforms representative comparative methods in classification accuracy. Comprehensive experiment results verify the effectiveness of our proposed method, which can provide novel perspectives for MI decoding. Full article

Underwater cracks are difficult to detect and observe, posing a major challenge to crack detection. Currently, deep learning-based underwater crack detection methods rely heavily on a large number of crack images that are difficult to collect due to their complex and hazardous underwater environments. This study proposes a new underwater image-processing method that combines a novel white balance method and bilateral filtering denoising method to transform underwater crack images into high-quality above-water images with original crack features. Crack detection is then performed based on an improved YOLOv9-OREPA model. Through experiments, it is found that the new image-processing method proposed in this study significantly improves the evaluation indicators of new images, compared with other methods. The improved YOLOv9-OREPA also exhibits a significantly improved performance. The experimental results demonstrate that the method proposed in this study is a new approach suitable for detecting underwater cracks in dams and achieves the goal of transforming underwater images into above-water images. Full article

With the offshore oil–gas fields entering a decline phase, the high-efficiency separation of oil–gas–water mixtures becomes a significant challenge. As essential equipment for separation, the three-phase separators play a key role in offshore oil–gas production. However, level control is critical in the operation of three-phase gravity separators on offshore facilities, as it directly affects the efficacy and safety of the separation process. This paper introduces an advanced deep deterministic policy gradient with the adaptive learning rate weights (ALRW-DDPG) control algorithm, which improves the convergence and stability of the conventional DDPG algorithm. An adaptive learning rate weight function has been meticulously designed, and an ALRW-DDPG algorithm network has been constructed to simulate three-phase separator liquid level control. The effectiveness of the ALRW-DDPG algorithm is subsequently validated through simulation experiments. The results show that the ALRW-DDPG algorithm achieves a 15.38% improvement in convergence rate compared to the traditional DDPG algorithm, and the control error is significantly smaller than that of PID and DDPG algorithms. Full article

Compared to traditional manual methods for assessing the cotton verticillium wilt (CVW) hazard level, utilizing deep learning models for foliage segmentation can significantly improve the evaluation accuracy. However, instance segmentation methods for images with complex backgrounds often suffer from low accuracy and delayed segmentation. To address this issue, an improved model, YOLO-VW, with high accuracy, high efficiency, and a light weight, was proposed for CVW hazard level assessment based on the YOLOv10n model. (1) It replaced conventional convolutions with the lightweight GhostConv, reducing the computational time. (2) The STC module based on the Swin Transformer enhanced the expression of foliage and disease spot boundary features, further reducing the model size. (3) It integrated a squeeze-and-excitation (SE) attention mechanism to suppress irrelevant background information. (4) It employed the stochastic gradient descent (SGD) optimizer to enhance the performance and shorten the detection time. The improved CVW severity assessment model was then deployed on a server, and a real-time detection application (APP) for CVW severity assessment was developed based on this model. The results indicated the following. (1) The YOLO-VW model achieved a mean average precision (mAP) of 89.2% and a frame per second (FPS) rate of 157.98 f/s in assessing CVW, representing improvements of 2.4% and 21.37 f/s over the original model, respectively. (2) The YOLO-VW model’s parameters and floating point operations per second (FLOPs) were 1.59 M and 7.8 G, respectively, compressed by 44% and 33.9% compared to the original YOLOv10n model. (3) After deploying the YOLO-VW model on a smartphone, the processing time for each image was 2.42 s, and the evaluation accuracy under various environmental conditions reached 85.5%, representing a 15% improvement compared to the original YOLOv10n model. Based on these findings, YOLO-VW meets the requirements for real-time detection, offering greater robustness, efficiency, and portability in practical applications. This model provides technical support for controlling CVW and developing cotton varieties resistant to verticillium wilt. Full article