Search Results (575)

Turkey has been a hub for migrants since the Syrian crisis and has been home to 3.7 million refugees. The literature on migration focusses largely on Turkey’s response to refugees from Syria, host country citizens’ attitudes towards Syrians and their integration challenges, the EU–Turkey refugee deal, and its political implications for the EU and Turkey. Nonetheless, there has been a sharp rise in the number of Afghan migrants to Turkey since the complete withdrawal of US military forces from Afghanistan in 2020. Both scholarly and grey literature highlights that Turkey has recently been an attractive hub for Afghan migrants and other ethnic minorities, following Pakistan and Iran. Nonetheless, this literature has not substantially explored the Turkish government’s attitude towards the new influx of migrants. For this purpose, the article draws upon qualitative research based on secondary and grey literature (including semi-structured interviews with representatives from migration-related NGOs in Turkey). The article underpins its findings from the public policy framework of NATO (nodality, authority, treasure, organisation) by demonstrating how Turkey’s ambivalent response to the refugee inflow is shaped by limited information (nodality), weak legal mechanisms (authority), exploitation of new inflow as cheap labour (treasure), and migration system restructuring (organisation, treasure) after the withdrawal of external actors like the EU and UNHCR. Full article

Due to the increase in demand for water, the rapid growth of urbanization and industrialization is the main threat to the source and quality of groundwater. The present study aimed to assess the suitability of groundwater for agricultural purposes in coastal regions using integrated approaches such as the saltwater mixing index (SWMI), the mineral saturation index (MSI), the agriculture suitability index (ASI), and unsupervised machine learning (USML) techniques. The result of the SWMI revealed that 20 and 17 sample locations were highly affected by saltwater intrusion in the study region’s northern and southeastern parts during the pre- and post-monsoon seasons. The detailed analysis of electrical conductivity in groundwater revealed that 19.64% and 14.29% of the samples were unfit for irrigation purposes, especially five sample locations, during both seasons. Regarding the overall suitability of groundwater for irrigation uses, the ASI values divulged that 8.9% of the samples were unsuitable for irrigation purposes. The spatial analysis of the ASI value indicated that 43.19 and 85.33 sq. km of area were unsuitable for irrigation practices. Additionally, the USML techniques identified the most influenced parameters such as Ca²⁺, Mg²⁺, Cl⁻, and SO₄²⁻ during both seasons. The present study results help maintain proper, sustainable water management in the study region. Full article

Human coronaviruses are a continuous threat to the human population and have limited antiviral treatments, and the recent COVID-19 pandemic sparked interest in finding new antiviral strategies, such as natural products, to combat emerging coronaviruses. Rapid efforts in the scientific community to identify effective antiviral agents for coronaviruses remain a focus to minimize mortalities and global setbacks. In this study, an essential oil derived from Myrtus communis L. (MEO) is effective against HCoV-229E and HCoV-OC43 virus infections in comparison to two FDA-approved drugs, Remdesivir and Nirmatrelvir. Gas-chromatography and mass spectrometry were used to identify the chemical composition of MEO. Slight antioxidant activity was observed in MEO, indicating a role in oxidative stress. A dose–response curve measuring the EC₅₀ indicates a high potency against HCoV-229E and HCoV-OC43 virus infections on Huh7.5 cells with low cytotoxicity using a PrestoBlue cell viability assay. Our findings demonstrate that MEO exhibits potent antiviral activity against HCoV-229E and HCoV-OC43 on Huh7.5 cells within a low-cytotoxicity range, but not on SARS-CoV-2. Artificial bacterial chromosome plasmids that expressed SARS-CoV-2 used for replicon—to determine viral replication and viral assembly/egress on HEK293T/17 cells—and virus-like particles on Huh7.5-AT cells—to determine viral entry and assembly/egress—showed no antiviral activity with MEO in comparison to Remdesivir. This study reveals the potential effectiveness of MEO as an alternative natural remedy to treat human coronaviruses and a potential antiviral agent for future coronavirus infections. Full article

The Syrian civil war displaced more than half of the Syrian population, including over 660,000 registered refugees who fled to neighboring Jordan. Environmental health services (e.g., water, sanitation, hygiene, and solid waste management) are critical for refugee health. Still, they may strain resources in host communities and must evolve in protracted crises. We studied environmental health services in the Azraq refugee camp in Jordan to identify the stakeholders and their roles in service provision, assess stakeholder communication and coordination, and evaluate sustainability. We conducted 25 interviews with stakeholders involved in environmental health service provision. We found that non-governmental and United Nations organizations had well-defined responsibilities, but the roles of donors, the Jordanian government, refugees, and the host community needed clarification. Conflicting standards and mismatched donor expectations with on-the-ground needs sometimes created challenges for coordinated and efficient service provision. The basic needs of refugees were generally met and services improved somewhat over time, but political obstacles and inadequate resources complicated the path toward sustainable services. Early incorporation of sustainability in planning and increased efforts to build the capacity of refugees to contribute and take ownership of environmental health services will likely enhance long-term environmental health service provision and development outcomes. Full article

Immune activation status determines non-small cell lung cancer (NSCLC) prognosis, with reported positive/negative associations for T helper type 2 (TH2) responses, including allergen-specific IgE and eosinophils. Our study seeks to explore the potential impact of these comorbid immune responses on the survival rates of patients with NSCLC. Our retrospective study used data from the Data Warehouse of the German Center for Lung Research (DZL) and Lung Biobank at Thoraxklinik Heidelberg. We estimated the association of blood eosinophilia and neutrophilia on survival rates in an inflammatory cohort of 3143 patients with NSCLC. We also tested sensitization to food and inhalants and high-sensitivity C-reactive protein (hs-CRP) in a comorbidity cohort of 212 patients with NSCLC. Finally, we estimated the infiltration of immune-relevant cells including eosinophils, T-cells, and mast cells in a tissue inflammatory sub-cohort of 60 patients with NSCLC. Sensitization to at least one food or inhalant (sIgE) was higher in patients with adenocarcinoma (adeno-LC) than the non-adenocarcinoma (non-adeno-LC). Furthermore, hs-CRP was higher in non-adeno-LC compared with adeno-LC. Peripheral inflammation, particularly eosinophilia and neutrophilia, was associated with poor survival outcomes in NSCLC with a clear difference between histological subgroups. Finally, blood eosinophilia was paralleled by significant eosinophil infiltration into the peritumoral tissue in the lung. This study provides novel perspectives on the crucial role of peripheral inflammation, featuring eosinophilia and neutrophilia, with overall survival, underscoring distinctions between NSCLC subgroups (adeno-LC vs. non-adeno-LC). Peripheral eosinophilia enhances eosinophil infiltration into tumors. This sheds light on the complex interplay between inflammation, eosinophil infiltration, and NSCLC prognosis among various histological subtypes. Further studies are required to underscore the role of eosinophils in NSCLC among different histological subgroups and their role in shaping the tumor microenvironment. Full article

New technologies are being used to facilitate the recognition process during and after earthquakes. These advanced tools are essential to keep track of what is left from of the destruction suffered by the built stock. Among the new technologies are video recordings captured during seismic events, footage from drones, and satellite imagery acquired before and after the event. This review paper presents a series of examples collected from the 2023 Türkiye–Syria earthquakes to illustrate how these new technologies offer a unique and efficient way to capture, document, and transfer information among experts in seismology, earthquake engineering, and disaster management. Whenever possible, these examples are accompanied by simple qualitative explanations to enhance understanding. To demonstrate the potential of video cameras and drone imagery for quantitative analysis, in addition to the various simple examples provided, two case studies are provided—one on road blockages, and another on intensity assessment and wave attenuation as observed in video cameras. These technologies are critical and merit considerable focus, particularly video cameras, which have not received much attention recently, on helping to understand seismic wave passage and their impact on the built environment. Enhancing our use of video cameras in this context can significantly contribute to the sustainability and resilience of our society. With the rapid advancement of image analysis, we advocate for a collaborative platform for accessing and utilizing imagery materials, aiding current and future generations in analysing the causes of such tragedies. Full article

The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) was one of the earliest healthcare systems globally to implement the International Classification of Diseases, Eleventh Revision (ICD-11) across its 140 clinics serving 5.9 million Palestine refugees. This paper discusses the integration of ICD-11 into UNRWA’s cloud-based electronic medical record (EMR) system, identifying both the barriers and facilitators involved and analyzing trends in clinical documentation and healthcare utilization. The key challenges included data privacy provisions, integration into a coordinated care model, complex classification schema for primary care settings, frequent staff turnover, and limited data analysis capabilities. Conversely, facilitators included physician-tailored training and on-site support, system compatibility, a multidisciplinary team approach, policy support from UNRWA and the World Health Organization (WHO), and leadership commitment and effective change management. Medical officers (MOs) using ICD-11 reported greater satisfaction with the system’s capabilities in managing and visualizing health information. This article contributes to the discourse on health data management in complex humanitarian settings, offering insights into the benefits and challenges of implementing advanced classification systems like ICD-11. Future research should explore longitudinal impacts and further integration with global health systems, ensuring that the advancements in classification continue to support the overarching goal of health equity and access in vulnerable and hard-to-reach populations. Full article

Multi-track synthetic aperture radar interferometry (InSAR) provides a good approach for the monitoring of long-term multi-dimensional earthquake deformation, including pre-, co-, and post-seismic data. However, the removal of atmospheric errors in both single- and multi-track InSAR data presents significant challenges. In this paper, a method of spatio-temporal correlation analysis using independent component analysis (ICA) is proposed, which can extract multi-track deformation components for the accurate retrieval of earthquake deformation time series. Sentinel-1 data covering the double earthquakes in Turkey and Syria in 2023 are used to demonstrate the effectiveness of the proposed method. The results show that co-seismic displacement in the east–west and up–down directions ranged from −114.7 cm to 82.8 cm and from −87.0 cm to 63.9 cm, respectively. Additionally, the deformation rates during the monitoring period ranged from −137.9 cm/year to 123.3 cm/year in the east–west direction and from −51.8 cm/year to 45.7 cm/year in the up–down direction. A comparative validation experiment was conducted using three GPS stations. Compared with the results of the original MSBAS method, the proposed method provides results that are smoother and closer to those of the GPS data, and the average optimization efficiency is 43.08% higher. The experiments demonstrated that the proposed method could provide accurate two-dimensional deformation time series for studying the pre-, co-, and post-earthquake events of the 2023 Turkey–Syria Earthquakes. Full article

Prior research has highlighted important healthcare access and utilization issues among new forced immigrants. We aimed to explore the role that public and patient involvement (PPI) might play in enhancing accessibility and specific contributions to migration health studies. We conducted open and in-depth interactive virtual discussions with asylum seekers and refugees from Eritrea and Syria in Switzerland. The PPI establishment consisted of three phases: inception, training and contribution. Prior to training, the concept of PPI was not straightforward to grasp, as it was a new approach—however, after training and consecutive discussions, participants were ardent to engage actively. We conclude that PPI holds promise in regard to raising awareness, improving healthcare system accessibilities and utilization, and enhancing and strengthening migration health research. Indeed, PPI volunteers were keen to raise their community’s awareness through their networks and bridge an important gap between researchers and the public. Full article

In the last few years, the isolation and amplification of DNA or RNA from the environment (eDNA/eRNA) has proven to be an alternative and non-invasive approach for molecular identification of pathogens and pests in beekeeping. We have recently demonstrated that bee pollen and bee bread represent suitable biological material for the molecular identification of viral RNA. In the present study, we extracted total RNA from different bee products (pollen, n = 25; bee bread, n = 17; and royal jelly, n = 15). All the samples were tested for the presence of six of the most common honey bee-associated viruses—Deformed wing virus (DWV), Acute bee paralysis virus (ABPV), Chronic bee paralysis virus (CBPV), Sacbrood virus (SBV), Kashmir bee virus (KBV), and Black queen cell virus (BQCV)—using a reverse transcription polymerase chain reaction (RT-PCR). We successfully detected six records of DWV (10.5%, 6/57), four of ABPV (7.0%, 4/57), three of Israeli acute paralysis virus (IAPV) (5.3%, 3/57), and two of BQCV (3.5%, 2/57). Using ABPV primers, we also successfully detected the presence of IAPV. The obtained viral sequences were analyzed for phylogenetic relationships with the highly similar sequences (megablast) available in the GenBank database. The Bulgarian DWV isolates revealed a high homology level with strains from Syria and Turkey. Moreover, we successfully detected a DWV strain B for the first time in Bulgaria. In contrast to DWV, the ABPV isolates formed a separate clade in the phylogenetic tree. BQCV was closely grouped with Russian isolates, while Bulgarian IAPV formed its own clade and included a strain from China. In conclusion, the present study demonstrated that eRNA can be successfully used for molecular detection of honey bee-associated viruses in bee products. The method can assist the monitoring of the health status of honey bee colonies at the local, regional, and even national levels. Full article

Identifying seismic CH₄ anomalies via remote sensing has been verified as a legitimate method. However, there are still some problems, such as unknown reliability due to the complex characteristics of seismic anomalies. In this study, a multi-dimensional and multi-scale methane seismic anomaly extraction process for remote sensing was constructed with the Robust Satellite Technique (RST) based on the Atmospheric Infrared Sounder (AIRS) CH₄ data and then applied to the 2023 Türkiye–Syria earthquake. This study obtained the two-dimensional temporal–spatial distribution of methane anomalies and temporal variation in the anomaly index. Based on this, the three-dimensional profile structure of the 8-day methane anomaly was extracted to determine the reliability of the anomaly. Finally, based on the daily methane anomaly, combined with atmospheric circulation and backward trajectory analysis as auxiliary tools, the influence of air mass migration was excluded to enhance the accuracy of CH₄ anomaly determination. The results show that the three-dimensional anomalous structure is consistent with the geological characteristics of tectonic activities, and it appears as a “pyramid” or “inverted pyramid” type in a three-dimensional space. The anomalies caused by air mass migration can be eliminated by combining them with synoptic-scale circulation motion. The time series calculated at the epicenter or a certain point in a region may not accurately reflect the influence of regional or specific tectonic activity in the atmosphere. Thus, the optimal determination of the range and magnitude of atmospheric anomalies caused by tectonic activities is a difficult task for future research. Full article

The aim of this study is to provide an overview of the specificities (milk characteristics, production process, ripening biochemistry, composition, and sensory properties) and novelties of the world-famous traditional cheeses of the Eastern Mediterranean (EM). The EM area is remarkably heterogeneous (11 countries—Egypt, Israel, Lebanon, Syria, Türkiye, Cyprus, Greece, Albania, Montenegro, Bosnia and Herzegovina, and Croatia) in terms of cheese production, but there are some common features that can be associated with EM which are connected to the difficult geoclimaticconditions (hilly terrain and hot summers). Cheesemakers resort to some preservation methods, such as high salt content (in white-brined cheeses), high total solids content (in hard cheeses), the use of hot water in the treatment of the curd (in pasta filata cheeses), the addition of some local herbs with antimicrobial properties, and the use of animal skin sacks for cheese ripening. Due to the high proportion of whey as a by-product, whey is traditionally used in EM for the production of whey cheeses. Preserving the production of traditional EM cheeses is critical to maintaining their cultural significance and meeting the demand of consumers interested in the provenance, craftsmanship, and nutritional value of these unique products. Full article

Gully erosion is a serious environmental threat, compromising soil health, damaging agricultural lands, and destroying vital infrastructure. Pinpointing regions prone to gully erosion demands careful selection of an appropriate machine learning algorithm. This choice is crucial, as the complex interplay of various environmental factors contributing to gully formation requires a nuanced analytical approach. To develop the most accurate Gully Erosion Susceptibility Map (GESM) for India’s Raiboni River basin, researchers harnessed the power of two cutting-edge machine learning algorithm: Extreme Gradient Boosting (XGBoost) and Random Forest (RF). For a comprehensive analysis, this study integrated 24 potential control factors. We meticulously investigated a dataset of 200 samples, ensuring an even balance between non-gullied and gullied locations. To assess multicollinearity among the 24 variables, we employed two techniques: the Information Gain Ratio (IGR) test and Variance Inflation Factors (VIF). Elevation, land use, river proximity, and rainfall most influenced the basin’s GESM. Rigorous tests validated XGBoost and RF model performance. XGBoost surpassed RF (ROC 86% vs. 83.1%). Quantile classification yielded a GESM with five levels: very high to very low. Our findings reveal that roughly 12% of the basin area is severely affected by gully erosion. These findings underscore the critical need for targeted interventions in these highly susceptible areas. Furthermore, our analysis of gully characteristics unveiled a predominance of V-shaped gullies, likely in an active developmental stage, supported by an average Shape Index (SI) value of 0.26 and a mean Erosivness Index (EI) of 0.33. This research demonstrates the potential of machine learning to pinpoint areas susceptible to gully erosion. By providing these valuable insights, policymakers can make informed decisions regarding sustainable land management practices. Full article

Antibiotic resistance is a major problem and a major global health concern. In total, there are 16 million deaths yearly from infectious diseases, and at least 65% of infectious diseases are caused by microbial communities that proliferate through the formation of biofilms. Antibiotic overuse has resulted in the evolution of multidrug-resistant (MDR) microbial strains. As a result, there is now much more interest in non-antibiotic therapies for bacterial infections. Among these revolutionary, non-traditional medications is quorum sensing inhibitors (QSIs). Bacterial cell-to-cell communication is known as quorum sensing (QS), and it is mediated by tiny diffusible signaling molecules known as autoinducers (AIs). QS is dependent on the density of the bacterial population. QS is used by Gram-negative and Gram-positive bacteria to control a wide range of processes; in both scenarios, QS entails the synthesis, identification, and reaction to signaling chemicals, also known as auto-inducers. Since the usual processes regulated by QS are the expression of virulence factors and the creation of biofilms, QS is being investigated as an alternative solution to antibiotic resistance. Consequently, the use of QS-inhibiting agents, such as QSIs and quorum quenching (QQ) enzymes, to interfere with QS seems like a good strategy to prevent bacterial infections. This review sheds light on QS inhibition strategy and mechanisms and discusses how using this approach can aid in winning the battle against resistant bacteria. Full article

Anise (Pimpinella anisum L.) seeds have various nutritional and therapeutic benefits and are thus considered a valuable addition to animal and human health. Hence, in this study, we aimed to induce the nutritive and biological value of anise seeds. To this end, the potential biofortification effect of the endophytic Actinomycetota sp. JW0824 strain, isolated during the fall of 2023 from the medicinal plant Achyranthes aspera, exhibiting natural distribution in the Jazan region of Saudi Arabia, was investigated in four varieties of anise seeds from Egypt, Tunisia, Syria, and Morocco. Results revealed significant increments (p < 0.05) in the seed dry weight percentage (DW%) and oil yields. In line with increased biomass accumulation, the metabolism of the primary and secondary metabolites was increased. There were differential increases in proteins, sugars, flavonoids, alkaloids, phenols, vitamins (e.g., β-carotene, ascorbic acid), and essential oil components (e.g., phenylpropanoids and monoterpenes), along with their precursor phenylalanine. Consistently, the activity of L-phenylalanine aminolyase (PAL) was increased in the Egyptian and Tunisian varieties at 83.88% and 77.19%, respectively, while 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) activity increased in all varieties, with a significant 179.31% rise in the Egyptian variety. These findings highlight the beneficial effects of Actinomycetota sp. JW0824 as a bioinoculant for anise seeds, suggesting its potential application in agricultural practices to improve seed yield and quality. Further field trials are recommended to assess the commercial viability of this endophyte for enhancing anise seed production and potentially benefiting other plant species. Full article