Search Results (11)

Currently studies on the correlation between obesity and Alzheimer’s disease (AD) are still unclear. In addition, few indicators have been used to evaluate obesity, which has failed to comprehen-sively study the correlations between body fat mass, body fat distribution, and AD. Thus, this study innovatively utilized bioinformatics and Mendelian randomization (MR) to explore the key targets of obesity-induced AD, and investigate the causal associations between different types of obesity and key targets. The common targets of obesity and AD were screened using the GeneCards database, and functional and pathway annotations were carried out, thereby revealing the key target. MR analysis was conducted between body anthropometric indexes of obesity and the key target using an IVW model. Bioinformatics analysis revealed Apolipoprotein E (APOE) as the key target of obesity-induced AD. MR results showed that body mass index (BMI) had a negative causal association with APOE2, while body fat percentage (BFP) and trunk fat percentage (TFP) had no significant causal association with APOE2; BMI, BFP, and TFP had a negative causal association with APOE3, and none had any significant causal association with APOE4. In conclusion, there is a correlation between obesity and AD, which is mainly due to the polymorphism of the APOE gene rather than adipose tissue distribution. APOE3 carriers may be more susceptible to obesity, while the risk of AD caused by APOE2 and APOE4 may not be induced by obesity. This study sheds new light on current disputes. At the same time, it is suggested to regulate the body fat mass of APOE3 carriers in the early stage, and to reduce the risk of AD. Full article

The research and development of deep learning methods are heavily reliant on large datasets, and there is currently a lack of scene-rich datasets for synthetic aperture radar (SAR) image vehicle detection. To address this issue and promote the development of SAR vehicle detection algorithms, we constructed the SAR Image dataset for VEhicle Detection (SIVED) using Ka, Ku, and X bands of data. Rotatable bounding box annotations were employed to improve positioning accuracy, and an algorithm for automatic annotation was proposed to improve efficiency. The dataset exhibits three crucial properties: richness, stability, and challenge. It comprises 1044 chips and 12,013 vehicle instances, most of which are situated in complex backgrounds. To construct a baseline, eight detection algorithms are evaluated on SIVED. The experimental results show that all detectors achieved high mean average precision (mAP) on the test set, highlighting the dataset’s stability. However, there is still room for improvement in the accuracy with respect to the complexity of the background. In summary, SIVED fills the gap in SAR image vehicle detection datasets and demonstrates good adaptability for the development of deep learning algorithms. Full article

Echinococcosis is considered a neglected disease in most European countries. However, migratory flows of populations, long-term stays in endemic areas, uninterrupted tourism (travel to Echinococcus-endemic countries), traveling dogs and dog translocations from endemic areas, and inappropriate hygiene practices are potential factors that alarm public health officials. Identifying a cyst-like mass in the liver or lung of an individual with a travel history of likely exposure to sheepdogs in an area where the parasite Echinococcus (E.) granulosus (sive cysticus) is endemic advocates for a prompt preliminary diagnosis of cystic echinococcosis (CE), no matter the age of the affected individuals. Routine imaging techniques, including ultrasonography, computed tomography (CT) scans, and magnetic resonance imaging (MRI) scans, are used to detect cysts. After a cyst has been discovered, serologic investigations are used to confirm the diagnosis. Typically, alveolar echinococcosis (AE) is found in older individuals. Yet young people are also affected because frequent oral exploration of the environment is a regular behavior for infants and toddlers. In this review, therapeutic considerations for pediatric echinococcosis—drug-based benzimidazole therapy; AE: atypical liver resection, the resection of individual or multiple segments, a right or left hemi-hepatectomy, or an extended hemi-hepatectomy; CE: PAIR-technique, cyst excision, liver segment(s) resection (laparoscopically or conventionally)—are revised following experience in one of the most affected regions of Europe. In addition, we performed a systematic review using three databases (i.e., PubMed, EMBASE, and Scopus) to evaluate the quality of evidence in published studies on pediatric echinococcosis. Full article

Purpose: Clinical significance and durability of serological response after mRNA COVID-19 vaccines is under investigation. Data on early virological response are limited. To iden-tify potential predictors of antibody durability, circulating antibody levels were longitudinally ex-plored in healthcare workers included in a follow-up program for SARS-CoV-2 infection. Meth-ods: Subjects meeting the inclusion criteria signed an informed consent. Serum samples were col-lected at baseline, before the first BNT162b2 vaccine, at days 7, 21, 31, 90, and 180 days after the first dose. Serological evaluation was performed by QuantiVac Euroimmune anti-S1 antibody as-say. Only subjects followed-up until day 90 are here considered. Results: Of 340 taken into consid-eration, 265 subjects were naive, and 75 COVID-19 experienced. The former showed a progres-sive increase in their antibody levels before day 90 decline, while the latter showed antibody levels reaching a plateau at day 7 and slightly declining at day 90. All showed antibody levels higher than the assay cut-off at day 31 and 90. Among naive, 108 had an early response whose predic-tors were younger age and female gender (OR 0.94, 95% CI 0.91–0.96, p < 0.0001; and OR 2.58, 95% CI 1.48–4.51, p = 0.0009). Naive subjects experienced a day 30/90 decline in antibody levels, whereas experienced did not. Early response was an independent predictor of higher day 30/90 antibody levels decline (OR = 2.05, 95% CI 1.04–4.02; p = 0.037). Conclusions: Our results suggest that in healthcare workers early response might be inversely associated with antibody levels 90 days after BNT162b2 vaccine. Full article

Non-human primates (NHPs) are the most relevant model of Acquired Immunodeficiency Syndrome (AIDS) and neuroAIDS, being of great importance in explaining the pathogenesis of HIV-induced nervous system damage. Simian Immunodeficiency Virus (SIV)/ Simian-Human Immunodeficiency Virus (SHIV)-infected monkeys have provided evidence of complex interactions between the virus and host that include host immune response, viral genetic diversity, and genetic susceptibility, which may explain virus-associated central nervous system (CNS) pathology and HIV-associated neurocognitive disorders (HAND). In this article, we review the recent progress contributions obtained using monkey models of HIV infection of the CNS, neuropathogenesis and SIV encephalitis (SIVE), with an emphasis on pharmacologic therapies and dependable markers that predict development of CNS AIDS. Full article

Background: Continuous monitoring of seasonal influenza vaccine effectiveness (SIVE) is needed due to the changing nature of influenza viruses and it supports the decision on the annual update of vaccine composition. Age-specific SIVE was evaluated against different influenza subtypes in the hospitalized population in Lithuania during four influenza seasons. Methods: A test-negative case-control study design was used. SIVE and its 95% confidence intervals (95% CI) were calculated as (1 – odds ratio (OR)) × 100%. Results: Adjusted SIVE in 18–64-year-old individuals against influenza A, A(H1N1)pdm09 and B/Yamagata were 78.0% (95% CI: 1.7; 95.1%), 88.6% (95% CI: −47.4; 99.1%), and 76.8% (95% CI: −109.9; 97.4%), respectively. Adjusted SIVE in individuals aged 65 years and older against influenza A, influenza B, and B/Yamagata were 22.6% (95% CI: −36.5; 56.1%), 75.3% (95% CI: 12.2; 93.1%) and 73.1% (95% CI: 3.2; 92.5%), respectively. Unadjusted SIVE against influenza A(H3N2) among 18–64-year-old patients was 44.8% (95% CI: −171.0; 88.8%) and among those aged 65 years and older was 5.0% (95% CI: −74.5; 48.3%). Conclusions: Point estimates suggest high SIVE against influenza A in 18–64-year-old participants, and against influenza B and B/Yamagata in those 65 years old and older. Full article

In 1639, the treatise Prodromi catoptricorum et dioptricorum sive Conicorum operis ad abdita radii reflexi et refracti mysteria praevij et facem praeferentis. Libri quatuor priores by Claude Mydorge was printed in Paris. This volume, which followed the printing of his first two books in 1631, has resonance especially in the writings of those who, after him, addressed the conics. This fact raises the question of who Mydorge was and what his knowledge of the “doctrine” of the conics was, what is the most appropriate cultural context in which to properly read this writing, and finally, what is the place of its content in the development of thought placed between the Veteres and the Recentiores. In this paper, I attempt to elaborate an answer to these different questions, with the aim of emphasizing how the author reads and interprets the first books of Apollonius’ Conics. Neither the treatise, nor the figure of Mydorge, have received much attention in the current literature, although he was estimated as a savant in Paris and he was believed by Descartes to be one of the greatest mathematicians of his time. Full article

Right heart catheterization remains necessary for the diagnosis of pulmonary hypertension and, therefore, for the prognostic evaluation of patients with chronic heart failure. The non-invaSive Assessment of Pulmonary vasculoPathy in Heart failure (SAPPHIRE) study was designed to assess the feasibility and prognostic relevance of a non-invasive evaluation of the pulmonary artery vasculature in patients with heart failure and pulmonary hypertension. Patients will undergo a right heart catheterization, cardiac resonance imaging, and a pulmonary function test in order to identify structural and functional parameters allowing the identification of combined pre- and postcapillary pulmonary hypertension, and correlate these findings with the hemodynamic data. Full article

Recent advances in technology have brought humanity to a unique point in history where theodicy is no more just a religious matter but also a matter of science and technology. Ray Kurzweil offers a non-religious Singularity theodicy of this-worldly subjective immortality (the survival of the soul after the dissolution of the body) with three strategies: the freezing strategy in cryonics, the cloning strategy in genetics, and the transference strategy in information technology. I argue that three challenges need to be met for the Singularity theodicy to be successful. The first challenge is related to the technological plausibility of human brain scanning and whether one can scan unconsciousness without making it into something other than unconsciousness. Based on the philosophies of Alfred North Whitehead and Derek Parfit, I offer the second criticism that the non-identity problem arises, due to personal identity being a temporal seriality of experiences between the biological person and the unloaded data. Lastly, even if intelligent patterns become immortal in the Singularity, this would not be what Christianity has called the immortality of the soul. Full article

In the past, the study of old age often focused on the losses and problems associated with ageing. In recent times, the focus has been on the positive aspects, such as quality of life, inner strength, and enjoying life. The aims of this study were to highlight the ways in which chronically ill older persons experience the meaning of daily life and to understand what it means to live at home with chronic dis- ease. In-depth interviews were used to illus- trate individual experiences. The sample con- sisted of 13 chronically ill persons, aged 80 to 94 years, living at home and receiving assis- tance in the form of home nursing care. Data were analyzed using the phenomenological hermeneutical method. After a naïve reading and a structural analysis of the text, we identi- fied three themes: being insufficient, becoming dependent , and enjoying life . The comprehen- sive understanding suggested that daily life involved bad days , described as illness with dysfunctions, limited energy, and dependency on others. Daily life also had its positive aspects, described as enjoying life . Dignity was threatened by feelings of being a burden to others and was affirmed by experiencing a will to live. It was concluded that bad days with experiences of suffering and good days that provided the older with experiences of enjoy- ing life could help them meet adversity through qualities of resilience that gave mean- ing to daily life and helped them to think posi- tively in times of greater difficulty Full article

The aims: (1) comparison ofNSCLC stages according to bronchoscopic and radiological findings with pathological outcome (mediastinoscopy), (2) efficacy of the neoadjuvant ChT by means of nodal involvement and primary tumour (downstaging), (3) influence ofChT on the surgical procedures' extension and its morbidity Material and methods: I 00 consecutive patients with resectable NSCLC in stages 11B (13 pts) or IIIA (57 pts), who were qualified to neoadjuvant ChT, participated in this study (77 men and 23 women, aged 42–73). Tumour and lymph nodes (mediastinal and hilar) were measured in CT scan. Mediastinoscopy was performed in 70 pts (70%). Majority of patients (87%) received two cycles ofneoadjuvant ChT (cisplatin 80 mg/m² iv on day 1 and vinorelbine 25 mg/m² on day 1 and 5) administered every 21 days. After ChT 85 patients were qualified to surgery. The results: The metastases in mediastinoscopy were excluded in 32 out of 45 patients (71%), whose lymph nodes were enlarged in CT scan (radiological false positive). Metastases were confirmed in 4 out of 25 patients (16%), whose lymph nodes were normal in CT scan (radiological false negative). After ChT the regression of the disease (PR+CR) was noted in 37% of patients. Pneumonectomy was performed in 23 (27%) pts, bilobectomy in 11 (13%) pts, lobectomy in 39 (46%) pts and “extended” (sleeve) lobectomy in 12 (14%) pts. Resected material was exam­ined microscopically very exactly in patients, in whom mediastinoscopy was performed before treatment. Down­staging was confirmed in 6 out of 15 patients (40%). Conclusions: Neoadjuvant ChT was effective in 37% of patients and allowed us to perform less exten­ sive surgery in these patients. 22 (64.7%) out of 34 patients who responded to ChT underwent lobecto­ my. Only 17 (36%) out of 51 patients who did not respond to ChT had lobectomy performed. Generally, 85 pts were operated with postroperative complications in 22.3% patients and 2.3% mortality rate. Full article