Search Results (401)

New environmentally friendly methods for extracting vegetable oils are in development, with a focus on pressurized liquid extraction (PLE) in an intermittent process. Ethanol, a renewable and generally recognized as safe (GRAS) solvent, is gaining prominence in this process. It is crucial for these methods to maintain the physicochemical characteristics of the extracted oils and be economically viable on a large scale. Using SuperPro Design software v 8.5, a simulation of PLE scaled up to industrial levels was conducted. Measurements of oils extracted with pressurized hexane and ethanol showed minimal density variations, with slightly higher viscosity for ethanol-extracted oil. Accelerated oxidative degradation revealed a longer induction period for hexane-extracted oil, indicating that ethanol-extracted oil degrades more easily. The antioxidant activity of the oil extracted with hexane was lower than that with ethanol. In the differential scanning calorimetry analysis, the oils extracted with hexane and ethanol presented onset melting point temperatures of −43.2 and −36.1 °C, respectively. The economic assessment considered 16 scenarios, showing a return on investment ranging from 9.0 to 133.5% in the first year and payback times from 0.7 to 11.1 years. Scenario 8, involving two 5000 L extractors, ethanol recycling, and an annual production of 3,325,300 L of soybean oil at USD 1.25/L, demonstrated the best return on investment (133.5%) in less than one year. Overall, this study suggests that industrial-scale soybean oil extraction via PLE in an intermittent process can be more cost-effective than conventional methods, making implementation feasible. Full article

A biorefinery process was developed to isolate phycobiliproteins, sulfated polysaccharides, and phenolic compounds from Palmaria palmata. The extraction process was carried out in three stages using ultrasound-assisted extraction (UAE) and pressurized liquid extraction (PLE) integrated with different natural deep eutectic solvents (NaDESs). In general, PLE provided higher phycobiliprotein contents than UAE in the first step of the process. In fact, the hydrolysis product of the PLE-NaDES extracts achieved a higher antioxidant capacity than that of the UAE-NaDES extracts. Particularly, glycerol:glucose (2:1) with 50% water in combination with PLE was the most suitable NaDES to recover the highest phycobiliprotein, protein, and sulfated polysaccharide contents from Palmaria palmata in the first and second steps of the biorefinery process. Finally, a PLE-NaDES using choline chloride:glycerol (1:2) with 60% water as the NaDES was employed for the recovery of antioxidant and neuroprotective phenolic compounds from the residue of the second step, obtaining a higher total phenolic content than employing PLE with ethanol/water (70:30, v/v) as the extraction solvent. Moreover, a forced stability study revealed that the NaDESs provided a protective effect compared to the water extracts against the degradation of phycobiliproteins, preserving their color over time. This study contributes to the recovery of high-value components from an undervalued biomarine source through a sustainable biorefinery process. Full article

Due to the extensively accessible bandwidth of many tens of GHz, millimeter-wave (mmWave) and sub-terahertz (THz) frequencies are anticipated to play a significant role in 5G and 6G wireless networks and beyond. This paper presents investigations on mmWave bands within the indoor environment based on extensive simulations; the study considers the behavior of the omnidirectional and directional propagation characteristics, including path loss exponents (PLE) delay spread (DS), the number of clusters, and the number of rays per cluster at different frequencies (28 GHz, 39 GHz, 60 GHz and 73 GHz) in both line-of-sight (LOS) and non-LOS (NLOS) propagation scenarios. This study finds that the PLE and DS show dependency on frequency; it was also found that, in NLOS scenarios, the number of clusters follows a Poisson distribution, while, in LOS, it follows a decaying exponential distribution. This study enhances understanding of the indoor channel behavior at different frequency bands within the same environment, as many research papers focus on single or two bands; this paper considers four frequency bands. The simulation is important as it provides insights into omnidirectional channel behavior at different frequencies, essential for indoor channel planning. Full article

A pressurized liquid extraction (PLE) method for the extraction of 31 organophosphate esters (OPEs) and novel organophosphate esters (NOPEs) has been developed. Unlike previously published methods, this method utilizes the high-throughput nature of PLE (as opposed to Soxhlet or sonication methods) without using potentially harmful organic solvents like methylene chloride. Combinations of hexane and acetone and hexane and ethyl acetate at various temperatures were examined. Extracts were concentrated and analyzed via gas chromatography–mass spectrometry. The final optimized method utilized 1:1 v/v hexane/ethyl acetate at 100 °C for three static cycles (5 min each) at 80% flush volume and a 100 s N₂ purge. This provided average surrogate corrected target analyte percent recoveries in spike and recovery experiments (n = 6) for OPEs and NOPEs of 106 ± 13%, with average surrogate recoveries of 88.6 ± 7.3%. The developed method was further validated using standard reference materials and was then applied to atmospheric particulate matter samples collected in the city of Providence, RI. The dataset reflected ambient concentrations of 16 OPEs and NOPEs (reported in pg m⁻³) for the first time in the greater Providence metropolitan area, including one of the first reports of NOPEs in atmospheric particulate matter in the U.S. Full article

The rapid pace of urbanization and global climate change necessitates a thorough assessment of urban ecological resilience to cultivate sustainable regional ecosystem development. Cities along the Yangtze River face an intensifying conflict between ecological preservation and socio-economic growth. Analyzing the ecological resilience of these urban centers is essential for achieving equilibrium in regional urban ecosystems. This study proposes a “system process space” attribute analysis framework, taking into account urban development processes, ecosystem structure, and resilience evolution stages. Utilizing data from 45 Yangtze River cities, we establish a “Driver, Pressure, State, Impact, and Response” (DPSIR) evaluation index system to evaluate changes in ecological resilience levels and evolution trends from 2011 to 2022. Our findings indicate that: (1) The ecological resilience index of Yangtze River cities increased from 0.177 to 0.307 between 2011 and 2022, progressing through three phases: ecological resilience construction, rapid development, and stable development. (2) At the city level, ecological resilience along the Yangtze River exhibits uneven development characteristics. Upstream cities display a significant “stepped” pattern, midstream cities exhibit a significant “Matthew effect”, and downstream cities present a pyramid-shaped pattern. While regional differences in ecological resilience persist, overall polarization is gradually decreasing, intercity connections are strengthening, and there is a growing focus on coordinated regional development. (3) The spatial distribution of ecological resilience in Yangtze River cities demonstrates both continuity and evolution, generally forming a “core-edge” clustered pattern. Based on these findings, we recommend enhancing inter-city cooperation and connectivity, addressing imbalances in urban ecological resilience, and promoting high-quality ecological resilience development along the Yangtze River through tailored development strategies for each city. Full article

The health-promoting properties of vitamin K stimulate the growing interest in this compound, which translates into the development of new analytical methodologies for its determination. New, more efficient methods of its isolation are sought, paying increasingly more attention to the methods within currently available extraction techniques that, owing to the optimization of the process, not only increase the extraction efficiency but are also economical and environmentally friendly. This article proposes a procedure for the extraction and analysis of one of the vitamin K vitamers, i.e., vitamin K1, using PLE and LC-MS/MS. It has been shown that the PLE technique can be optimized with a mathematical model—accelerating and reducing the costs of the extraction process—which, together with process automation, bodes well for industrial applications. The optimized process was used to extract vitamin K1 from various vegetables, showing very different contents of the test compound ranging from 1.22 to 114.30 µg/g dry weight for avocado and spinach, respectively. In addition, by showing the effect of water within the material subjected to extraction on the variable yield of vitamin K1, attention was drawn to the need to standardize the analytical methods used in assessing the quality of food products. Full article

Pomegranate (Punica granatum L.) peel is a potential source of bioactive phenolic compounds such as ellagic acid and α- and β-punicalagin. This work explores the efficiency of natural deep eutectic solvents combined with ultrasound-assisted extraction (UAE) and pressurized liquid extraction (PLE) for their extraction. Five NaDESs were evaluated by employing UAE (25 °C, for 50 min) to determine their total phenolic content (Folin–Ciocalteu assay) and ellagic acid and α- and β-punicalagin contents (high-performance liquid chromatography (HPLC-DAD)). The NaDES composed of choline chloride (ChCl) and glycerol (Gly) (1:2, molar ratio) was the most efficient in the UAE when compared with the rest of the NaDESs and water extracts. Therefore, ChCl:Gly was further evaluated using PLE at different temperatures (40, 80, 120 and 160 °C). The PLE-NaDES extract obtained at 80 °C for 20 min at 1500 psi exhibited the highest contents of ellagic acid and α- and β-punicalagin compared to the rest of the temperatures and PLE-water extracts obtained under the same extraction conditions. Combining UAE or PLE with a NaDES emerges as a sustainable alternative for extracting ellagic acid and α- and β-punicalagin from pomegranate peel. Full article

The ecological and environmental problems of arid zones have become an urgent global concern. Current research on ecological risk is based mainly on the dominant functions of land use, with a primary focus on land use landscape projections and less consideration of potential risks to ecosystems, system resilience and interactions between nature and future sustainable development. In this study, a potential–connectivity–resilience ecological risk assessment model based on the SDGs was constructed using multisource data to spatially quantify indicators at the grid scale in the Turpan and Hami regions of Xinjiang, China. This model was used as a basis for studying ecological risk in arid zones from a production–living–ecological space (PLES) perspective. The results revealed that, during the period 2000–2020, PLESs in the Turpan and Hami regions presented significant spatial similarity, with an increasing trend in overall risk. The production space in the Turpan and Hami regions showed a parabolic trend of increasing and then decreasing, whereas the living space and ecological space in the Hami region showed continuous linear upward trends. The state of ecological security in the Turpan and Hami regions is gradually deteriorating, and comprehensive ecological protection and restoration measures are urgently needed to rationally allocate the structure and layout of the production-–living-–ecological space. The study of ecological risk from a PLES perspective not only helps in fully understanding the development trend of the arid zone; it also provides new ideas and methods for evaluating regional ecological environmental safety and scientific references for formulating regional sustainable development, ecological risk prevention and control and the rational allocation of resources. Full article

Background/Objectives: Constrictive pericarditis very rarely causes protein-losing enteropathy (PLE) induced by secondary intestinal lymphangiectasia. This study thoroughly reviewed the literature to shed light on the clinical management of PLE provoked by intestinal lymphangiectasia following constrictive pericarditis. Methods: We performed a PubMed search using the keywords enteropathy, protein-losing enteropathy, pericarditis, acute pericarditis, pericardial effusion, recurrent pericarditis, constrictive pericarditis, noninfectious pericarditis, idiopathic pericarditis, and infective pericarditis, with only English-language publications included. Results: Although constrictive pericarditis is primarily idiopathic, less common causes include infectious etiologies, connective/autoimmune tissue disorders, previous cardiac surgery, congenital syndromes, and cancer. On the one hand, PLE secondary to intestinal lymphangiectasia may cause a severe cellular immune deficiency that could raise infection hazards due to lymphocytopenia and hypogammaglobulinemia. On the other hand, lymphocytopenia may cause anergy and mask an underlying tuberculous etiology of constrictive pericarditis. Cardiac catheterization is the most useful diagnostic tool for constrictive pericarditis, though it may be misdiagnosed in rare cases. The videocapsule endoscopy and double-balloon enteroscopy techniques can detect small bowel lymphangiectasias distal to the Treitz ligament. MRI or a CT scan helps confirm constrictive pericarditis, visualize lymphangiectasias, and reveal features specific to the underlying etiology of PLE. Radioisotopic techniques may ensure PLE diagnosis in challenging cases, whereas fecal alpha1-antitrypsin can estimate gastrointestinal protein loss. Conclusions: Constrictive pericarditis is rarely associated with PLE. The cardio-intestinal abnormalities of PLE caused by constrictive pericarditis are frequently reversed following a complete pericardiectomy, though its ability to invert severe hypoalbuminemia is currently unknown. Full article

This research takes the construction companies and supervision units of megaprojects as the research objects and studies safety issues in construction decision-making for megaprojects. Using evolutionary game theory, we construct an evolutionary game model of safety decision-making behavior for construction companies and supervision units based on the bounded rationality assumption. The interaction and dynamic patterns of safety behaviors between the two construction entities are analyzed. Additionally, system dynamics Vensim PLE 10.2.1 software is employed to simulate and analyze the behavior of single entities as well as the impact of exogenous variables on the safety decision-making choices of both units. The research results indicate that positive choices in safety behavior decision-making contribute to enhancing the stability of megaproject construction. Exogenous variables significantly influence the safety behavior decisions of both the construction companies and the supervision units in megaprojects. An increase in cooperation benefits between the two parties fosters their active collaboration in completing mega engineering projects. This research promotes cooperation between construction companies and supervision units during a construction process and provides a reference for the safe and orderly implementation and development of megaprojects. Full article

The aim of this study is to identify autism spectrum disorder (ASD) and attention-deficit–hyperactivity disorder (ADHD) traits in adolescents who experience psychotic-like experiences (PLEs), often ignored in clinical practice but widely prevalent in the general population. A total of 57 adolescents and young adults (aged between 16 and 24 years old) were recruited consecutively in the outpatient services. A total of 37 were females (64.9%), 18 were males (31.6%), and two participants (3.5%) were non-binary or gender non-conforming, with a mean age at referral of 18.26 ± 2.06. To investigate these symptoms, three sets of standardized questionnaires were used, as follows: the Autism Spectrum Quotient–short form (AQ-10), the Community Assessment of Psychic Experiences (CAPE-42), and the Adult ADHD Self-Report Scale (ASRS). We found significant associations between the ASRS and AQ-10 total scores and all CAPE scales. The model which explained the highest variance was CAPE Score’s Total Frequency score (p < 0.001). Our findings underline the importance of investigating the presence of subthreshold ASD and ADHD symptoms in clinical populations, particularly in the period of adolescence and young adulthood, to promptly identify the presence of PLEs and, thus, prevent the onset of a frank psychotic disorder, particularly in the presence of a comorbid psychopathological condition, leading to better diagnosis and treatment for individuals with two or more of these conditions. Full article

The transition from coal to more sustainable energy sources represents a critical shift for economies reliant on coal production. To investigate the intricate processes involved in such a transition, the use of powerful analytical tools is essential. This study assesses the impact of the delignification process on GDP growth over a 20-year horizon (2015–2035) in the Region of Western Macedonia, Greece, using the Vensim PLE Plus 9.0.1 software, a robust tool for system dynamics modeling. By developing a dynamic model that captures the key variables and feedback loops associated with coal transition, this research examines economic, social, and investment variables, emphasizing their causal relationships. The study integrates societal, economic, and educational impacts on production transition, addressing issues such as unemployment, financial support, and investments in human resources and R&D. Additionally, it considers the influence of climate change on GDP. The model highlights population dynamics, economic development, and education as critical factors. Scenarios explore the impact of increased funding on education, research, and financial aid efficiency, providing insights into enhancing GDP in decarbonizing regions. The study reveals that increased investment in education and human capital leads to slight improvements in local GDP, though the effects are not immediate. Enhanced efficiency in government and European spending significantly boosts local GDP by creating strong value chains and local economies of scale. It is found that the increase in financial support to the regions in transition is of the utmost importance and has a multiplicative nature, something that should encourage the European Union to increase its financial support tools. The model’s simulations align closely with historical GDP data, validating its accuracy. The contributions of the present work offer valuable insights to policymakers and stakeholders engaged in the transition processes. Full article

Urban agglomerations are products of urban development, and their regional spaces and functions are more diverse than other cities, which have very high spatial and functional complexity. It is important to clarify the relationships between production–living–ecological (PLE) functions in urban agglomerations to achieve sustainable development. In this study, we took the Middle Reaches of the Yangtze River Urban Agglomerations (MRYRUA) as an example to construct an evaluation index system of regional PLE functions in urban agglomerations. Then, the Pearson correlation model and geographically weighted regression were applied to investigate the relationships between PLE functions and their driving forces. The results showed that the PLE functions in the MRYRUA increased from 2008 to 2018, with the level of the ecological function being higher than the production and living functions. The relationships among PLE functions were dominated by synergies in most cities, though trade-offs had become more evident in the last few years for the whole study area. Trade-offs and synergies among PLE functions were influenced by both natural and socioeconomic factors, with the latter having a stronger effect. Our findings provide a reference for understanding the spatial variations and trade-offs among PLE functions in MRYRUA as well as for balancing the development of PLE functions. Full article

Background: Psychotic-like experiences (PLEs) are a part of the continuum of psychosis and are common in the general population. While most of these experiences are transient, they are strongly correlated with an increased risk of various adverse psychological outcomes. Anxiety and depressive symptoms also occur frequently in the adolescent population. Much research has previously demonstrated a correlation between these two symptoms and PLEs. However, few investigations have examined what influences this association, and sex and resilience may be important moderators. Methods: This study selected a sample of first-year students from a university in Shanghai. A total of 2970 adolescents completed questionnaires measuring sociodemographic characteristics, anxiety/depressive symptoms by SCL-90, resilience by CD-RISC, and self-reported PLEs by PQ-16. Results: The findings indicated that PLEs were prevalent in the sample, with at least one PQ-16 item present in 42.5% of individuals. Anxiety/depressive symptoms were significantly associated with PLEs, and there was a sex difference in this association (p < 0.001). What is more, this relationship was stronger in males than in females. Additionally, we found a significant interaction (p < 0.001) between resilience and anxiety/depressive symptoms when looking at the correlates of PLEs. Those with stronger resilience showed a considerably weaker connection between PLEs and symptoms of anxiety and depression. Conclusions: These findings can potentially inform the development of targeted new clinical interventions. Full article

The paper focused on the Xining marginal area, providing the concept of land use competitive advantage, employing the PLUS and PFCI model to simulate production–living–ecological (PLE) land in 2030, and revealing the relationship between regional land interactions and sustainable land allocation. The results indicate that the following: (1) By 2030, the land use of the Xining marginal area is primarily production and ecological land, with approximately 0.1% of living land; however, living and production land will increase while ecological land will decrease in general, and the growth momentum of urban and other living space in government-seated regions is stronger. (2) The PLE land does not exhibit a piecemeal expansion pattern, as it is influenced by mountains and rivers. Agricultural production land and grassland ecological land have advantages for development, whereas urban living land has just development potential. (3) Developing the corresponding lands in the dominant regions can result in sustainable land allocation, and five nexus approaches are proposed for the sustainable allocation of PLE land in the Xining marginal region. The study addresses the interaction of different land use types across regions rather than examining them separately, and we provide significant insight into whether the Qinghai Tibet Plateau should be urbanized. Full article