Search Results (688)

High-strength biodegradable polymer composites have potential applications in a variety of biomedical applications. This study investigates the influence of silk fiber on the properties of the commonly used biodegradable polylactic acid-based composites, focusing on mechanical, rheological, morphological, and degradation characteristics. Mechanical tests revealed that the addition of 2.5 wt% silk fibers enhanced the ductility of PLA composites, increasing tensile strain at break from 7.39% for pure PLA to 11.51% for the composite. However, higher silk contents (≥10 wt%) resulted in lower elongation at breaks but higher moduli, indicating a trade-off between flexibility and the structural rigidity of the composite. Rheological tests demonstrated that the presence of silk fibers up to 7.5% improved the storage modulus, reflecting better network formation within the PLA matrix. Scanning Electron Microscopy (SEM) photomicrographs illustrated improved fiber dispersion, while higher contents introduced voids and stress concentrations, adversely affecting mechanical properties. Degradation tests in phosphate-buffered saline at 37 °C showed that silk additions slowed PLA degradation, suggesting controlled degradation suitable for biomedical applications. The optimal silk fiber content for balancing mechanical integrity and flexibility was identified to be ca 7.5 wt%, providing insights into the design of PLA/silk composites for enhanced performance in practical applications. Full article

Chronic kidney disease (CKD) is a leading cause of morbidity and mortality globally. Maternal obesity during pregnancy is linked to systemic inflammation and elevated levels of the pro-inflammatory cytokine interleukin-6 (IL-6). In our previous work, we demonstrated that increased maternal IL-6 during gestation impacts intrauterine development in mice. We hypothesized that IL-6-induced inflammation alters gene expression in the developing fetus. To test this, pregnant mice were administered IL-6 or saline during mid-gestation. Newborn mouse kidneys were analyzed using mRNA-seq, miRNA-seq and whole-genome bisulfite-seq (WGBS). A multi-omics approach was employed to quantify mRNA gene expression, miRNA expression and DNA methylation, using advanced bioinformatics and data integration techniques. Our analysis identified 19 key genes present in multiple omics datasets, regulated by epigenetics and miRNAs. We constructed a regulatory network for these genes, revealing disruptions in pathways such as Mannose type O-glycan biosynthesis, the cell cycle, apoptosis and FoxO signaling. Notably, the Atp7b gene was regulated by DNA methylation and miR-223 targeting, whereas the Man2a1 gene was controlled by DNA methylation affecting energy metabolism. These findings suggest that these genes may play a role in fetal programming, potentially leading to CKD later in life due to gestational inflammation. Full article

Low carbon management and policies should refer to local long-term inter-annual carbon uptake. However, most previous research has only focused on the quantity and spatial distribution of gross primary product (GPP) for the past 50 years because most satellite launches, the main GPP data source, were no earlier than 1980. We identified a close relationship between the tree-ring index (TRI) and vegetation carbon dioxide uptake (as measured by GPP) and then developed a nested TRI-GPP model to reconstruct spatially explicit GPP values since 1895 from seven tree-ring chronologies. The model performance in both phases was acceptable: We chose general regression neural network regression and random forest regression in Phase 1 (1895–1937) and Phase 2 (1938–1985). With the simulated and real GPP maps, we observed that the GPP for grassland and overall GPP were increasing. The GPP landscape patterns were stable, but in recent years, the GPP’s increasing rate surpassed any other period in the past 130 years. The main local climate driver was the Palmer Drought Severity Index (PDSI), and GPP had a significant positive correlation with PDSI in the growing season (June, July, and August). With the GPP maps derived from the nested TRI-GPP model, we can create fine-scale GPP maps to understand vegetation change and carbon uptake over the past century. Full article

Objective: Adenoid cystic carcinoma (ACC) is a rare malignant tumor that mainly arises in the head and neck area. We aimed to compare the long-term survival of patients with ACC based on their geographic regions within the United States using the Surveillance, Epidemiology, and End Results (SEER) registry data. Methods: We queried the SEER database to evaluate the geographic distribution of ACC patients based on inpatient admissions. The states included in the study were divided into four geographical regions (Midwest, Northeast, South, and West) based on the U.S. Census Bureau-designated regions and divisions. Demographic and clinical variables were compared between the groups. Kaplan–Meier curves and Cox regression were used to assess late mortality. Results: A total of 5150 patients were included (4.2% from the Midwest, 17.2% from the Northeast, 22.5% from the South, and 56.1% from the West regions). The median follow-up was 12.3 (95% CI: 11.6–13.1 years). Median overall survival was 11.0 (95% CI: 9.2-NR years), 14.3 (95% CI: 12.4–16.4 years), 11.3 (95% CI: 9.7–14.8 years), and 12.0 (95% CI: 11.3–13.0 years) for Midwest, Northeast, South, and West regions, respectively. In multivariable analysis, older age, male sex, thoracic cancer, the presence of regional and distal disease, receiving chemotherapy, not undergoing surgical resection, and being treated in the West vs. Northeast region were found to be independent predictors of poor survival. We identified a significant survival difference between the different regions, with the West exhibiting the worst survival compared to the Northeast region. Conclusions: In addition to the well-known predictors of late mortality in ACC (tumor location, stage, and treatment modalities), our study identified a lack of social support (being unmarried) and geographic location (West region) as independent predictors of late mortality in multivariable analysis. Further research is needed to explore the causal relationships. Full article

The purpose of this research is to examine current alignment of tourism, hospitality, culinary, events, and sports management curriculum with the United Nations Sustainable Development Goals (SDG’s) across two departments in Higher Education Institutions in Ireland. To do this, a quantitative approach was adopted utilising a content analysis of programme learning outcomes and surveys with programme specific educators. This permitted an evaluation on the current status of incorporation of SDG’s within existing curricula and an insight into the motivations and challenges of Education for Sustainable Development (ESD) integration from the perspective of educators. Findings revealed weak levels of current alignment of learning outcomes to SDG’s for tourism, hospitality, culinary, events, and sports management curriculum across two sampled departments while educators emphasised a need to upskill on the subject matter in an effort to ensure more comprehensive ESD integration across modules and programmes. The Results overall highlighted the need to ensure future curriculum review and development takes appropriate cognisance of ESD and through communities of Practice within Higher Education Institutions, educators can better embed and advance ESD within third level curricula. The findings presented in this study may have lessons to be learned for other Higher Education Institutions across Ireland and internationally. Full article

The use of computer vision in the industry has become fundamental, playing an essential role in areas such as quality control and inspection, object recognition/tracking, and automation. Despite this constant growth, robotic cell systems employing computer vision encounter significant challenges, such as a lack of flexibility to adapt to different tasks or types of objects, necessitating extensive adjustments each time a change is required. This highlights the importance of developing a system that can be easily reused and reconfigured to address these challenges. This paper introduces a versatile and adaptable framework that exploits Computer Vision and the Robot Operating System (ROS) to facilitate pick-and-place operations within robotic cells, offering a comprehensive solution for handling and sorting random-flow objects on conveyor belts. Designed to be easily configured and reconfigured, it accommodates ROS-compatible robotic arms and 3D vision systems, ensuring adaptability to different technological requirements and reducing deployment costs. Experimental results demonstrate the framework’s high precision and accuracy in manipulating and sorting tested objects. Thus, this framework enhances the efficiency and flexibility of industrial robotic systems, making object manipulation more adaptable for unpredictable manufacturing environments. Full article

Both hydrodynamic cavitation (HC) and temperature elevation are important pretreatments for improving the performance of liquid food processing by reducing viscosity. In this study, we assessed the impact of HC and elevated temperature on the functionality of milk protein concentrate powder with 80% protein (MPC80) prepared from nanofiltration (NF) of ultrafiltration (UF) retentate. Skim milk was concentrated using UF, and the retentate was further subjected to HC and concentrated using NF, then spray dried to obtain MPC80 powder. The functionality of these powders processed using NF at 22 °C, NF at 50 °C, HC and NF at 22 °C, and HC and NF at 50 °C were evaluated. Rennet coagulation time of reconstituted MPC80 from different NF treatments was like skim milk when treated with 0.1% CaCl₂. High-temperature NF reduced the water solubility of MPC80 powder (70.03 to 79.20%) at room temperature, but it was similar when measured at 50 °C (86.05 to 92.91%). The HC improved foaming (92.22 to 112.89%) but did not impact the emulsifying capacity (59.58 to 61.38%) and heat stability (18.04 to 20.22 min). Results showed that the HC and high-temperature NF utilized to increase the production efficiency of MPC80 also maintained the functionality of the powders after spray drying. Full article

Heterostructures are highly promising photocatalyst candidates for water splitting due to their advanced properties than those of pristine components. The ZnO/Sc₂CF₂ heterostructure was designed in this work, and its electronic structure was investigated to explore its potential for water splitting. The assessments of binding energy, phonon spectrum, ab initio molecular dynamics, and elastic constants provide strong evidence for its stability. The ZnO/Sc₂CF₂ heterostructure has an indirect band gap of 1.93 eV with a type-Ⅰ band alignment. The electronic structure can be modified with strain, leading to a transition in band alignment from type-Ⅰ to type-Ⅱ. The heterostructure is suitable for water splitting since its VBM and CBM stride over the redox potential. The energy barrier and built-in electric field, resulting from the charge transfer, facilitate the spatial separation of photogenerated carriers, enhancing their utilization efficiency for redox processes. The photogenerated carriers in the heterostructures with lattice compression greater than 6% follow the direct-Z transfer mechanism. The ZnO/Sc₂CF₂ heterostructure is confirmed with high photocatalytic activity by a Gibbs free energy change of HER, which is 0.89 eV and decreases to −0.52 eV under an 8% compressive strain. The heterostructure exhibits a remarkable enhancement in both absorption range and intensity, which can be further improved with strains. All these findings suggest that the ZnO/Sc₂CF₂ heterostructure is an appreciated catalyst for efficient photocatalytic water splitting. Full article

Intense rainfall events frequently occur in Brazil, often leading to rapid flooding. Despite their recurrence, there is a notable lack of sub-daily studies in the country. This research aims to assess patterns related to the structure and microphysics of clouds driving intense rainfall in Brazil, resulting in high accumulation within 1 h. Employing a 40 mm/h threshold and validation criteria, 83 events were selected for study, observed by both single and dual-polarization radars. Contoured Frequency by Altitude Diagrams (CFADs) of reflectivity, Vertical Integrated Liquid (VIL), and Vertical Integrated Ice (VII) are employed to scrutinize the vertical cloud characteristics in each region. To address limitations arising from the absence of polarimetric coverage in some events, one case study focusing on polarimetric variables is included. The results reveal that the generating system (synoptic or mesoscale) of intense rain events significantly influences the rainfall pattern, mainly in the South, Southeast, and Midwest regions. Regional CFADs unveil primary convective columns with 40–50 dBZ reflectivity, extending to approximately 6 km. The microphysical analysis highlights the rapid structural intensification, challenging the event predictability and the issuance of timely, specific warnings. Full article

Visceral leishmaniasis (VL) is a neglected tropical disease that is potentially fatal when untreated. Current diagnostic methods have limitations that contribute to ongoing transmission and poor prognosis. Thus, new tests are needed to provide quick, accurate diagnoses and evaluate clinical progression and treatment efficacy. The monokine induced by interferon-gamma (MIG) and interferon-gamma-inducible protein 10 (IP-10) has been associated with the host susceptibility to VL with potential diagnostic and prognostic purposes. We performed a systematic review using four search databases (Scopus, PubMed, Web of Science, and MEDLINE) to identify studies assessing MIG and IP-10 as potential biomarkers in patients with VL across various clinical conditions. A total of 13 studies were potentially eligible and included in this review. The articles, in general, reveal that the chemokines MIG and IP-10 are elevated in response to infection by Leishmania spp., acting on the host’s resistance to the development of the disease. They are associated with asymptomatic conditions and after VL treatment, and this relationship can be observed in both immunocompetent and immunocompromised individuals. Consequently, these chemokines hold relevance in the diagnoses and appropriate management of individuals with VL. Full article

Background/Objectives: The objective of this study was to determine the treatment effect of foselutoclax in neovascular age-related macular degeneration (AMD) by multifocal electroretinography (mfERG) and evaluate mfERG as a potential clinical endpoint in AMD studies. Methods: A total of five subjects were included in the study who had active choroidal neovascularization and a history of at least two anti-vascular endothelial growth factor (VEGF) injections in the last 6 months. Subjects received a 50 µL intravitreal injection of foselutoclax at the baseline visit and Weeks 4, 24, and 28 of the study period. Results: After foselutoclax treatment, the largest improvement in the mfERG N1-P1 response density occurred at Week 8 as three of five subjects achieved a ≥20% gain. In addition, three of five subjects demonstrated a BCVA improvement of ≥5 ETDRS letters over baseline at Weeks 4, 8, and 24. The mean change in BCVA demonstrated statistical significance in Weeks 4 and 8, showing increases of 5 (p = 0.02) and 6.2 (p = 0.02) letters, respectively. Conclusions: Foselutoclax treatment was shown to have the potential to recover outer retinal function as determined by mfERG and BCVA at approximately Week 8 of treatment. Full article

Colorectal cancer (CRC) is a significant public health issue, particularly in low- and middle-income countries like Thailand. While numerous studies advocate for regular screenings and health promotion programs to mitigate CRC risk, there is a notable lack of tailored health promotion models specifically designed for high-risk groups in Thailand. This research aims to develop a health promotion model to prevent CRC in high-risk groups through a quasi-experimental design. The study involved 68 Thai participants aged 40–70 years, divided equally into experimental and comparison groups. Independent-Samples t-test, Paired-Samples t-test, and one-way variance test (F-test) were employed to analyze the data. The comparison of baseline average scores for physical health, mental health, social health, and knowledge on health-promoting behaviors between the experimental and comparison groups revealed no significant differences. However, following the experiment, the average scores in physical health (t = −2.81, p = 0.01) and mental health (t = −10.30, p < 0.001) were significantly higher compared to pre-experiment levels, with the exception of social health (t = 0.07, p = 0.94). Furthermore, the average knowledge scores related to promoting physical, mental, and social health in the experimental group also showed a significant increase after the experiment (t = −4.53, p < 0.001). The findings suggest that health personnel should advocate for annual CRC screening and the implementation of health promotion programs, especially focusing on physical, mental, and social aspects for at-risk populations. This study underscores the need for long-term health promotion models to achieve continuous and sustainable health improvements in these groups. Full article

While LGBTQ+-parented families share many similarities with their cis-het parent counterparts, they still experience unique factors exclusive to them. One such factor is access to the LGBTQ+ community. Utilizing a diverse sample of LGBTQ+ parents with adolescents in the U.S., primarily living in Southern and Midwest states, we examined the potential moderating impact of a parent’s sense of LGBTQ+ community on the relationship between parenting stress, parent mental health, and child adjustment. Regression analyses demonstrated a series of positive associations between LGBTQ+ parent stress, parent mental health concerns, and child adjustment issues. However, sense of community failed to moderate these associations. Parent sexual identity, age, and recruitment method were found to have unique associations with outcome variables. Implications for policy, clinical practice, and future research are discussed. Full article

Identified as a potential reference pathogen by the WHO Guidelines for Drinking-Water Quality, Rotavirus (RV) is among the main enteric viruses that cause waterborne diseases. The aim of this study was to identify and correlate the presence of RV in collective and individual water sources of rural communities in the state of Goiás, within the seasons in which the collections were made (rainy and dry seasons). For this, 86 water samples in the dry period and 160 samples in the rainy period were collected. Concentration of water samples, extraction of viral genetic material and molecular tests were performed. When analyzing the presence of RV in the samples, taking into consideration the period studied, RV was found to be more prevalent in the dry season (54.7%) than in the rainy season (20%), showing a strong statistical association with the dry season (p-value < 0.001). The presence of pathogenic microorganisms in water is a public risk issue, enabling the emergence of outbreaks, endemics and epidemics. In the present research, there was an association between the presence of Rotavirus and the dry period of the year when compared to the rainy period. Full article

Needle-free buccal anesthesia improves dental treatment outcomes for both patients and dentists. In this study, we report on an assessment of the enhancement effects of α-bisabolol on the in vitro transmucosal permeation of prilocaine hydrochloride (PCl) and lidocaine hydrochloride (LCl) from needleless buccal films. We also evaluated the mechanical properties of the film, which consisted of Methocel™ K100 LV as the film-forming polymer (3% m·m⁻¹), PEG 400 as a cosolvent (15% m·m⁻¹ based on drug loading), α-bisabolol (15 and 30% m·m⁻¹ based on drug loading), and the drugs combined at a 1:1 ratio (15 mg·unit⁻¹). The porcine esophageal epithelium was used as a membrane barrier, and artificial saliva was the release medium. After a 1 h experiment at 25 ± 2 °C, α-bisabolol significantly decreased, rather than enhanced, the permeation fluxes (five-fold), permeability coefficients (seven-fold), and retentions (two-fold) of both PCl and LCl through the epithelium, regardless of the concentration. Moreover, the resistance and flexibility of the films markedly decreased compared to those without α-bisabolol. Therefore, under the experimental conditions, using α-bisabolol as a buccal permeation enhancer for the hydrophilic local anesthetics PCl and LCl from buccal films is not feasible. Full article