Search Results (6,150)

Fuel consumption, fuel cost savings, environmental pollution, and navigation safety are significant factors for shipping companies. Maritime transport represents 3% of total greenhouse gas emissions globally. Trim optimization is one of the ways to save energy and reduce ship emissions. Thus, this study aimed to evaluate how the optimization of the trim of container ships at different speeds can decrease exhaust gas emissions and fuel consumption while considering the safety of navigation. This research was conducted by calculating the fuel consumption in real conditions and calculating the optimal trim for different speeds and gases of a container ship of 11,400 TEU. All obtained results were statistically processed to analyze fuel consumption at various speeds, considering the ship’s trim. It turns out that savings should never be at the expense of navigation safety, especially in limited maneuvering areas, such as canals. When maneuvering in such places it is necessary to adjust the trim to ensure navigation safety, i.e., to improve the rudder and propulsion device response, instead of reducing fuel consumption Full article

The aim of the present study was to investigate possible differences in the sensitivity of HNSCC cells to known EMT regulators. Three HNSCC cell lines (UM-SCC-1, -3, -22B) and the HaCaT control keratinocyte cell line were exposed to transforming growth factor beta 1 (TGF-β1), a known EMT master regulator, and the cellular response was evaluated by real-time cell analysis (RTCA), Western blot, quantitative PCR, flow cytometry, immunocytochemistry, and the wound closure (scratch) assay. Targeted sequencing on 50 cancer-related genes was performed using the Cancer Hotspot Panel v2. Mutant, and wild type SMAD4 cDNA was used to generate recombinant SMAD4 constructs for expression in mammalian cell lines. The most extensive response to TGF-β1, such as cell growth and migration, β-actin expression, or E-cadherin (CDH1) downregulation, was seen in cells with a more epithelial phenotype. Lower response correlated with higher basal p-TGFβ RII (Tyr424) levels, pointing to a possible autocrine pre-activation of these cell lines. Targeted sequencing revealed a homozygous SMAD4 mutation in the UM-SCC-22B cell line. Furthermore, PCR cloning of SMAD4 cDNA from the same cell line revealed an additional SMAD4 transcript with a 14 bp insertion mutation, which gives rise to a truncated SMAD4 protein. Overexpression of this mutant SMAD4 protein in the highly epithelial control cell line HaCaT resulted in upregulation of TGF-β1 and vimentin. Consistent with previous reports, the invasive and metastatic potential of HNSCC tumor cells appears associated with the level of autocrine secretion of EMT regulators such as TGF-β1, and it could be influenced by exogenous EMT cytokines such as those derived from immune cells of the tumor microenvironment. Furthermore, mutant SMAD4 appears to be a significant contributor to the mesenchymal transformation of HNSCC cells. Full article

Remembering software library components and mastering their application programming interfaces (APIs) is a daunting task for programmers, due to the sheer volume of available libraries. API completion tools, which predict subsequent APIs based on code context, are essential for improving development efficiency. Existing API completion techniques, however, face specific weaknesses that limit their performance. Pattern-based code completion methods that rely on statistical information excel in extracting common usage patterns of API sequences. However, they often struggle to capture the semantics of the surrounding code. In contrast, deep-learning-based approaches excel in understanding the semantics of the code but may miss certain common usages that can be easily identified by pattern-based methods. Our insight into overcoming these challenges is based on the complementarity between these two types of approaches. This paper proposes a combinatorial method of API completion that aims to exploit the strengths of both pattern-based and deep-learning-based approaches. The basic idea is to utilize a confidence-based selector to determine which type of approach should be utilized to generate predictions. Pattern-based approaches will only be applied if the frequency of a particular pattern exceeds a pre-defined threshold, while in other cases, deep learning models will be utilized to generate the API completion results. The results showed that our approach dramatically improved the accuracy and mean reciprocal rank (MRR) in large-scale experiments, highlighting its utility. Full article

I will read Genesis 3:16 through the lens of Genesis 4. While Eve has become a fixed object in traditional interpretation as a dangerous temptress for man and the cause of humanity’s fall into sin, her story does not end in this chapter. Eve’s creative agency as “mother of all living” becomes the framework for the drama that unfolds in Genesis 4. Her body and her voice carry the story of life into the future. This essay shows the connection between Genesis 3:16 and the story in Genesis 4 by moving beyond a linguistic analysis of the common verbs, mashal and teshuqah. I will read the two texts together with the ancient scribes who distinguished Genesis 3:16 by placing this one verse between two setumah markers. Likewise, the story of Eve in Genesis 4:1–5:2 is placed between two setumah markers, thereby showing that ancient Hebrew readings emphasized a close relationship between Genesis 3:16 and Genesis 4:1–5:2. This is opposed to the Christian chapter division, which separates Genesis 3 from the story in Genesis 4, and places Genesis 3 in an authoritative position for the sake of extrapolating the doctrine of the fall into sin with the woman playing the central role in the fall story. I will further engage in deep reading, literary analysis, and performance criticism, and argue that Eve tells her own creation story with masterful subversiveness and creative audacity. The attempt of the essay is to reorient the dominant negative view of Eve toward a more positive, complex, and nuanced reading of her character in the Genesis text. Full article

This study presents the implementation and results of the Annual Physical Training Program for Masters +45 Half Marathoners (PASm-12), focused on optimizing athletic performance through rigorous planning of training volume and intensity. PASm-12, structured over 12 mesocycles and 52 microcycles, was applied to 6 female runners with over 10 years of experience. The results indicate that the total running volume achieved (2347 km) was 90.2% of the volume proposed by PASm-12 (2603.2 km), with statistically significant differences in most mesocycles (Cohen’s f² = 6.24, t = −5.997, p = 0.002, indicating a large effect size). The training intensity was achieved at an average of 94.8% of what was proposed by PASm-12, with significant differences in several mesocycles (Cohen’s f² = 0.45, t = −1.972 to −3.984, p < 0.05, indicating a moderate to large effect size). The female runners’ performances in field tests generally showed faster times than the maximum and average values proposed in PASm-12, with the exception of the final competition, where performance was slightly lower due to external competitive factors (Cohen’s d = −0.53, t = −1.192, p = 0.3). This plan, demonstrating good practice, could serve as a guideline model for amateur runners who do not have specialist counseling. PASm-12 can reduce the risk of injury, prevent excessive fatigue, and support ongoing participation in sports activities. Additionally, the implementation of this plan could provide amateur runners with a safe and effective training structure, contributing to improved health and athletic performance. Full article

Protecting sensitive patient data, such as electrocardiogram (ECG) signals, during RF wireless transmission is essential due to the increasing demand for secure telemedicine communications. This paper presents an innovative chaotic-based encryption system designed to enhance the security and integrity of telemedicine data transmission. The proposed system utilizes a multi-scroll chaotic system for ECG signal encryption based on master–slave synchronization. The ECG signal is encrypted by a master system and securely transmitted to a remote location, where it is decrypted by a slave system using an extended state observer. Synchronization between the master and slave is achieved through the Lyapunov criteria, which ensures system stability. The system also supports Orthogonal Frequency Division Multiplexing (OFDM) and adaptive n-quadrature amplitude modulation (n-QAM) schemes to optimize signal discretization. Experimental validations with a custom transceiver scheme confirmed the system’s effectiveness in preventing channel overlap during 2.5 GHz transmissions. Additionally, a commercial RF Power Amplifier (RF-PA) for LTE applications and a development board were integrated to monitor transmission quality. The proposed encryption system ensures robust and efficient RF transmission of ECG data, addressing critical challenges in the wireless communication of sensitive medical information. This approach demonstrates the potential for broader applications in modern telemedicine environments, providing a reliable and efficient solution for the secure transmission of healthcare data. Full article

Objective: The purpose was to examine clinical profiles in concussed children aged 5–9 and 10–12 years and compare them with those of adolescents >12 years. Methods: This study included patients aged 5–18 years presenting to a specialty care concussion program with a sports- and recreation-related (SRR) concussion ≤28 days postinjury. Demographics, injury mechanisms, symptoms, and clinical features were assessed. Chi-squared tests, one-way ANOVA, and Kruskal-Wallis were used for comparisons across age groups. Results: A total of 3280 patients with SRR concussion were included: 5.0% were 5–9 years, 18.4% were 10–12 years, and 76.6% were 13–18 years. Younger age groups had more males than females (5–9 years: 70.7% vs. 29.3%) and more commonly sustained their injury during limited- (28.7%), and non-contact (7.9%) activities compared to other age groups (p < 0.01). Younger children presented less symptoms frequently (p ≤ 0.042), but higher symptom severity in somatic and emotional domains (p ≤ 0.016). Fewer 5–9-year-olds reported changes in school (25.6%), sleep (46.3%), and daily habits (40.9%) than adolescents (p < 0.001). Conclusions: Among SRR-concussed children and adolescents, we found significant age-related variations in demographics, injury mechanism, symptoms, and clinical features. Recognizing these unique features in younger children may facilitate targeted management and treatment. Full article

Background: Despite clinical interventional studies on the influence of diet on periodontal inflammatory parameters, there has been no practice-based cross-sectional study from a German population to date that has conducted both a comprehensive dental and periodontal examination and a thorough validated assessment of dietary behavior. Therefore, the aim of this pilot study was to evaluate, in a proof of concept, whether there is a correlation between the overall periodontal inflammatory surface area (PISA), periodontal clinical parameters (pocket probing depths (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), furcation involvement (FI), tooth mobility (TM)), and the dietary behavior of patients with periodontal disease when utilizing a practice-based research network. The primary outcome was the correlation between the periodontal inflammatory surface (PISA) and the dietary assessment data. Materials and Methods: The practice-based research network, consisting of eight Master’s graduates, recruited patients who met the inclusion and exclusion criteria and performed a periodontal examination together with the assessment of dietary behavior using a digital version of the validated retrospective dietary recall (DEGS/RKI). Statistical analyses included linear regression models adjusted for age and smoking and unpaired t-tests, conducted using STATA 17.0 with a significance level of 5%. In addition, the data obtained were classified according to the currently recommended amounts of daily intake. Results: A total of 1283 teeth were analyzed, with 60.25% (773 teeth) requiring treatment. The average PISA was 753.16 mm² (SD ± 535.75 mm). Based on dietary guidelines, the studied population consumed excessive amounts of extrinsic sugars and fats, while their fiber and legume intake was insufficient. The intake of certain nutrients, including water-soluble fibers, specific fatty acids, vitamins (D, B1, B2, B6, and B12), iron, and zinc, was associated with reduced PISA, PPD, CAL, and BOP. Conclusion: Within the limits of the current study, including its cross-sectional design and cohort size, the outcomes demonstrated the influence of nutrition on periodontal health. Full article

Olivine-like NaFePO₄ glasses and nanocomposites are promising materials for cathodes in sodium batteries. Our previous studies focused on the preparation of NaFePO₄ glass, transforming it into a nanocomposite using high-pressure–high-temperature treatment, and comparing both materials’ structural, thermal, and DC electric conductivity. This work focuses on specific features of AC electric conductivity, containing messages on the dynamics of translational processes. Conductivity spectra measured at various temperatures are scaled by apparent DC conductivity and plotted against frequency scaled by DC conductivity and temperature in a so-called master curve representation. Both glass and nanocomposite conductivity spectra are used to test the (effective) exponent using Jonscher’s scaling law. In both materials, the values of exponent range from 0.3 to 0.9, with different relation to temperature. It corresponds to the electronic conduction mechanism change from low-temperature Mott’s variable range hopping (between Fe²⁺/Fe³⁺ centers) to phonon-assisted hopping, which was suggested by previous DC measurements. Following the pressure treatment, AC conductivity activation energies were reduced from $E_{AC}\approx 0.40 \mathrm{e}\mathrm{V}$ for glass to $E_{AC}\approx 0.18 \mathrm{e}\mathrm{V}$ for nanocomposite and are lower than their DC counterpart, following a typical empirical relation with the value of the exponent. While pressure treatment leads to a 2–3-orders-of-magnitude rise in the AC and apparent DC conductivity due to the reduced distance between the hopping centers, a nonmonotonic relation of AC power exponent and temperature is observed. It occurs due to the disturbance of polaron interactions with Na⁺ mobile ions. Full article

The capacity of schools to address behavioral health concerns presents an emerging challenge, exacerbated by major shortages in the workforce. Schools across the U.S. are struggling to hire licensed behavioral health professionals, with additional barriers encountered when seeking to hire practitioners with experience in educational settings. In 2023, a school district in the suburbs of Columbus, Ohio, partnered with The Ohio State University to launch a “grow your own” policy pilot. The priorities focused on addressing workforce shortages and leveraging the experiences of current teachers/staff to support growing needs related to student mental health and well-being. More specifically, the district utilized COVID-19 relief funds to recruit, train, and transition 25 teachers/staff into school mental health positions by underwriting the costs of each professional’s Master of Social Work (MSW) degree. Here, we (a) describe the district–university partnership and the processes guiding the implementation of the “grow your own” model, (b) distill preliminary findings about district needs regarding behavioral health, and (c) explore facilitators, barriers, and outcomes associated with learning among participants in the program. The findings from a district-wide staff survey indicated a high level of need for individual counseling, crisis intervention, and small group interventions. Additionally, qualitative interviews revealed that learning among the program’s participants was facilitated by effective classroom strategies and specific learning experiences integral to the program’s design. These facilitators supported key learning outcomes, including general social work knowledge, self-awareness, and therapeutic skills that are foundational for engaging with students, parents/families, teachers/staff, and the broader school community. This innovative policy pilot and training model demonstrate how universities and local educational agencies can partner to address workforce development challenges at the intersection of behavioral health and education. Full article

Pharmacy is not only a science; it is also a profession, a trade and an art. As such, it frequently encounters society, where it leaves its impact in a way which is probably unique among the natural and life sciences. In turn, individuals and society have become increasingly dynamic and also often critical of modern pharmacy and its products. This poses a multitude of intra- and extra-scientific questions which cannot be studied with the traditional tools of pharmacy. Addressing them requires additional expertise from a wide range of disciplines, including social sciences, psychology, ethics and other branches of philosophy. Pharmasophy aims to bring this kind of wisdom to pharmacy by taking a holistic view of pharmacy and pharmaceuticals, from the process of research and development to regulation, distribution, application and compliance. In doing so, it aims to master some of the challenges facing pharmacy in the 21st century Full article

Background: Osteoarthritis (OA) is a complex disease marked by the degradation of articular cartilage. Objective: This study aimed to explore the relationship between cartilage volume/thickness and clinical outcomes in knee OA patients treated with intra-articular injections over one year. Methods: Twenty-four patients with mild-to-moderate OA were retrospectively analyzed using knee MRI. OA features were assessed semiquantitatively with the Whole-Organ Magnetic Resonance Imaging Score (WORMS), while cartilage thickness and volume in the medial femoral condyle (MFC) and medial tibial plateau (MTP) were measured. T1ρ and T2 values for MFC cartilage were also recorded. Clinical outcomes were evaluated using the Korean Western Ontario and McMaster Universities (K-WOMAC) and Knee Injury Osteoarthritis Outcomes (KOOS) scores. Spearman’s rank test assessed the associations between imaging changes and clinical outcomes. Results: The baseline MTP and MFC cartilage thickness and MTP cartilage volume showed significant correlations with clinical outcomes. Additionally, less progressive cartilage loss in the medial femorotibial joint (MFTJ) and overall joint was linked to a better clinical response over 12 months. Conclusions: In conclusion, thicker baseline MFTJ cartilage and minimal cartilage loss were associated with favorable clinical outcomes in knee OA patients receiving intra-articular injections. Full article

Background and Objectives: Neglected patellar dislocation in the presence of end-stage osteoarthritis (OA) is a rare condition characterized by the patella remaining laterally dislocated without reduction. Due to the scarcity of reported cases, the optimal management approach is still uncertain. However, primary total knee arthroplasty (TKA) can serve as an effective treatment option. This study aimed to present the clinical and radiological outcomes achieved using our surgical technique. Materials and Methods: A retrospective review of 12 knees in 8 patients with neglected patellar dislocation and end-stage OA who underwent primary TKA was conducted. The surgical procedure involved conventional TKA techniques (e.g., medial parapatellar arthrotomy) and additional procedures specific to the individual pathologies of neglected patellar dislocation (e.g., lateral release, medial plication, and quadriceps lengthening). Clinical outcomes, including patient-reported outcome measures (PROMs) (Knee Society Scores and the Western Ontario and McMaster Universities Osteoarthritis Index) and knee range of motion (ROM), were assessed preoperatively and two years postoperatively. Radiological measures including mechanical femorotibial angle and patellar tilt angle were assessed preoperatively and until the last follow-up examinations. Any complications were also reviewed. Results: There were significant improvements in all PROMs, knee ROM, and radiological outcomes, including mechanical femorotibial angle and patellar tilt angle (all p < 0.05). At a mean follow-up of 68 months, no major complications requiring revision surgery, including patellar dislocation, were reported. Conclusions: Primary TKA is an effective procedure for correcting various pathologies associated with neglected patellar dislocation in end-stage OA without necessitating additional bony procedures. Satisfactory clinical and radiological outcomes can be expected using pathology-specific procedures. Full article

Water has the disadvantages of low viscosity, poor lubrication, and easy leakage, which leads to many problems in water hydraulic flow control valves, such as low working pressure and large flow fluctuations. To address these issues, this paper proposes a novel digital flow control valve. The valve uses a linear stepper motor as the driving device. Compared to proportional electromagnets, the thrust and stroke of the linear stepper motor are larger, making the valve more suitable for high-pressure working conditions. Simultaneously, the valve innovatively incorporates a set of pilot valve spool strings at the front end of the pilot valve damping hole. Through controlling the two pilot valves to regulate the pressure difference before and after the damping hole, the flow passing through the pilot valve is maintained stable, thereby making the pressure of the upper chamber of the master valve spool more stable. In comparison to a single pilot valve structure, this design ensures a more stable main valve core position and reduces flow fluctuation. A mathematical and simulation model of the valve has been established, confirming the performance advantages of the new structure. The impact of structural parameters (such as valve core diameter, spring stiffness, and diameter of damping hole) on the stability of flow regulation has been investigated. A genetic algorithm has been employed to optimize the key parameters that influence valve flow stability, resulting in the identification of optimal parameters. The simulation results indicate that the optimized parameters lead to a reduction of approximately 45% in the maximum overshoot oscillation amplitude of the valve flow regulation. A prototype of the new flow control valve was developed, and a test system was established for conducting tests. The test results also confirmed the performance advantages of the valve and the accuracy of the optimal design. Full article

This article intends to highlight and reconstruct the relationships between humans (harvesters, woodworkers and master artisans) and non-humans (raw materials, tools, places, products, etc.) in the Barniz de Pasto mopa-mopa tradition. These relationships were lost when the focus came to be primarily on the objects, as happens in most popular art forms worldwide. This text is organised in ethnographic overviews: the home workshops of masters of Barniz de Pasto; woodworker workshops; montañas-selvas (Andean rainforest highlands) and mopa-mopa harvesters; until we reach the objects. Unlike a conventional article, it does not end with firm and immutable conclusions. Our reflections from our eleven years (2013–2024) of accompanying men and women artisans and collectors, during the process of including the traditional knowledge and techniques associated with Barniz de Pasto mopa-mopa as Intangible Cultural Heritage (patrimonialización) and its safeguarding, are always open for discussion. Full article