New Insights in Hypoxic Response Modulation
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 74
Special Issue Editor
Interests: HIF-1; HIF-2; HIF-3; unfolded protein response; IRE1; XBP1
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The imbalance between oxygen availability and demand at both tissue and cellular levels, termed “hypoxia”, triggers a rapid global reprogramming of gene expression to ensure survival and restore oxygen homeostasis. Additionally, since oxygen supply can be quickly restored, the hypoxia response also minimizes the risk of oxidative damage and activates cell death if oxygen levels cannot be restored.
Recent breakthroughs in research and technology have provided better insights into the metabolism of hypoxic cells and have highlighted the complexity of the tumor microenvironment (TME). Moreover, novel molecular mechanisms, including noncoding RNA-related regulatory networks, have introduced new regulatory circuits and therapeutic opportunities for hypoxic response. MicroRNAs, long noncoding RNAs, PiRNA, and other RNA molecules can significantly influence Hypoxia-Inducible Factor (HIF) activity and determine the fate of hypoxic cells. Furthermore, the development of synthetic analogs of these molecules and targeted delivery methods opens new therapeutic avenues that could significantly impact patients’ lives.
The ability to develop therapeutic strategies based on the molecular mechanisms underlying the hypoxic response is crucial for modern treatments of ischemic events, stroke, myocardial infarction, and various human tumors, as well as macular degeneration, glaucoma progression, and diabetic retinopathy. Although HIFs are recognized as master regulators of the hypoxic response, disease-specific therapeutic modulation of their activity remains challenging.
This Special Issue focuses on novel advances in our understanding of the biological and therapeutic roles of molecular mechanisms in regulating cell signaling and fate under hypoxia or ischemia.
Dr. Rafał Bartoszewski
Guest Editor
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Keywords
- hypoxia
- oxygen homeostasis
- oxidative damage
- cell death
- ischemic events
- stroke
- myocardial infarction
- tumor microenvironment (TME)
- noncoding RNA
- MicroRNAs
- long noncoding RNAs
- PiRNA
- hypoxia-inducible factors (HIFs)
- targeted delivery
- hypoxic cells
- regulatory networks
- therapeutic opportunities
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