Needle-free skin patch vaccination method for anthrax
GR Matyas, AM Friedlander, GM Glenn… - Infection and …, 2004 - Am Soc Microbiol
GR Matyas, AM Friedlander, GM Glenn, S Little, J Yu, CR Alving
Infection and immunity, 2004•Am Soc MicrobiolThree immunizations of mice with recombinant protective antigen (rPA) by transcutaneous
immunization (TCI) induced long-term neutralizing antibody titers that were superior to those
obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for
TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal
anthrax challenge.
immunization (TCI) induced long-term neutralizing antibody titers that were superior to those
obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for
TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal
anthrax challenge.
Abstract
Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal anthrax challenge.
American Society for Microbiology