| ID/Version |
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Sequence description from provider |
RecName: Full=Bone morphogenetic protein 6; Short=BMP-6;AltName: Full=VG-1-related protein; Short=VGR-1;Flags: Precursor; | ||||||||||||||
| Provider | SWISS-PROT | ||||||||||||||
| Sequence |
Polypeptide
510
aa
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| Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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| Sequence references in MGI |
J:9842
Lyons K, et al., Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4554-8
J:20320 Gitelman SE, et al., Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. J Cell Biol. 1994 Sep;126(6):1595-609 J:38921 Gitelman SE, et al., Structure and sequence of the mouse Bmp6 gene. Mamm Genome. 1997 Mar;8(3):212-4 J:48561 Solloway MJ, et al., Mice lacking Bmp6 function. Dev Genet. 1998;22(4):321-39 J:86665 Laurikkala J, et al., Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol. 2003 Dec 1;264(1):91-105 J:233140 Andriopoulos B Jr, et al., BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009 Apr;41(4):482-7 J:270227 Arezes J, et al., Erythroferrone inhibits the induction of hepcidin by BMP6. Blood. 2018 Oct 4;132(14):1473-1477 J:335613 Wang CY, et al., Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type Ireceptor ALK3. Blood. 2020;135(6):453-456 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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